Sh2d3c (SH2 domain containing 3C) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Sh2d3c (SH2 domain containing 3C) Rattus norvegicus
Analyze
Symbol: Sh2d3c
Name: SH2 domain containing 3C
RGD ID: 1307287
Description: Predicted to enable guanyl-nucleotide exchange factor activity and phosphotyrosine residue binding activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to be located in cytosol. Orthologous to human SH2D3C (SH2 domain containing 3C); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC362111; NSP3; SH2 domain-containing protein 3C
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,408,305 - 36,444,191 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl336,408,304 - 36,444,716 (+)EnsemblGRCr8
mRatBN7.2316,010,622 - 16,046,491 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl316,010,625 - 16,046,484 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx319,078,919 - 19,114,707 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,663,924 - 27,699,712 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,915,240 - 25,951,556 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,756,427 - 11,793,547 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,756,384 - 11,793,593 (+)Ensemblrn6Rnor6.0
Rnor_5.0317,095,296 - 17,130,517 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4311,687,031 - 11,731,868 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera310,751,515 - 10,786,059 (+)NCBICelera
RGSC_v3.1311,617,288 - 11,627,810 (+)NCBI
Cytogenetic Map3p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:29966723  


Genomics

Comparative Map Data
Sh2d3c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,408,305 - 36,444,191 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl336,408,304 - 36,444,716 (+)EnsemblGRCr8
mRatBN7.2316,010,622 - 16,046,491 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl316,010,625 - 16,046,484 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx319,078,919 - 19,114,707 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,663,924 - 27,699,712 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,915,240 - 25,951,556 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,756,427 - 11,793,547 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,756,384 - 11,793,593 (+)Ensemblrn6Rnor6.0
Rnor_5.0317,095,296 - 17,130,517 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4311,687,031 - 11,731,868 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera310,751,515 - 10,786,059 (+)NCBICelera
RGSC_v3.1311,617,288 - 11,627,810 (+)NCBI
Cytogenetic Map3p11NCBI
SH2D3C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389127,738,317 - 127,778,666 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9127,738,317 - 127,778,727 (-)Ensemblhg38GRCh38
GRCh379130,500,596 - 130,540,945 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,540,419 - 129,580,733 (-)NCBIBuild 36Build 36hg18NCBI36
Celera9101,151,465 - 101,191,912 (-)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9100,117,130 - 100,157,604 (-)NCBIHuRef
CHM1_19130,652,151 - 130,692,598 (-)NCBICHM1_1
T2T-CHM13v2.09139,945,763 - 139,986,120 (-)NCBIT2T-CHM13v2.0
Sh2d3c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,611,072 - 32,645,008 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl232,611,067 - 32,645,524 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38232,721,037 - 32,755,007 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,721,055 - 32,755,512 (+)Ensemblmm10GRCm38
MGSCv37232,576,592 - 32,610,514 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36232,543,081 - 32,577,003 (+)NCBIMGSCv36mm8
Celera232,427,779 - 32,461,735 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
Sh2d3c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955419891,133 - 921,062 (+)Ensembl
ChiLan1.0NW_004955419891,133 - 921,062 (+)NCBIChiLan1.0ChiLan1.0
SH2D3C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21111,569,377 - 11,616,556 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1911,571,776 - 11,618,903 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0998,858,018 - 98,899,661 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19127,530,733 - 127,571,016 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9127,530,733 - 127,571,016 (-)EnsemblpanPan2panpan1.1
SH2D3C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,626,379 - 55,656,667 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,626,360 - 55,656,507 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha954,819,942 - 54,850,176 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0956,547,903 - 56,578,173 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,547,816 - 56,578,171 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1955,308,165 - 55,338,424 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,622,873 - 55,653,134 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,714,308 - 55,744,373 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sh2d3c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947195,642,351 - 195,671,839 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648715,410,877 - 15,440,347 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648715,410,878 - 15,440,326 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SH2D3C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,238,973 - 268,270,361 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11268,238,967 - 268,270,395 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,129,597 - 302,137,809 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SH2D3C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11210,352,947 - 10,395,023 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1210,354,061 - 10,396,230 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660795,826,055 - 5,867,966 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sh2d3c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247607,771,456 - 7,800,464 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247607,771,646 - 7,800,487 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Sh2d3c
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v152,883,392 - 2,914,307 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sh2d3c
512 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:160
Count of miRNA genes:129
Interacting mature miRNAs:146
Transcripts:ENSRNOT00000031511, ENSRNOT00000065915
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)33083238444921701Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
RH127491  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2316,046,208 - 16,046,413 (+)MAPPERmRatBN7.2
Rnor_6.0311,793,272 - 11,793,476NCBIRnor6.0
Rnor_5.0317,130,242 - 17,130,446UniSTSRnor5.0
RGSC_v3.4311,731,593 - 11,731,797UniSTSRGSC3.4
Celera310,785,784 - 10,785,988UniSTS
RH 3.4 Map371.1UniSTS
Cytogenetic Map3p11UniSTS
RH138706  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2316,036,423 - 16,036,650 (+)MAPPERmRatBN7.2
Rnor_6.0311,783,487 - 11,783,713NCBIRnor6.0
Rnor_5.0317,120,457 - 17,120,683UniSTSRnor5.0
RGSC_v3.4311,721,808 - 11,722,034UniSTSRGSC3.4
Celera310,775,999 - 10,776,225UniSTS
RH 3.4 Map360.6UniSTS
Cytogenetic Map3p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000078366   ⟹   ENSRNOP00000072798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl316,017,500 - 16,046,484 (+)Ensembl
Rnor_6.0 Ensembl311,763,706 - 11,793,547 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087762   ⟹   ENSRNOP00000070659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl336,408,304 - 36,444,191 (+)Ensembl
mRatBN7.2 Ensembl316,010,625 - 16,046,484 (+)Ensembl
Rnor_6.0 Ensembl311,756,384 - 11,793,593 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098941   ⟹   ENSRNOP00000079271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl336,415,209 - 36,438,726 (+)Ensembl
mRatBN7.2 Ensembl316,034,838 - 16,041,141 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106524   ⟹   ENSRNOP00000084559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl316,034,838 - 16,046,484 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110408   ⟹   ENSRNOP00000078942
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl336,415,193 - 36,444,716 (+)Ensembl
mRatBN7.2 Ensembl316,017,500 - 16,046,484 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113142   ⟹   ENSRNOP00000088575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl336,408,304 - 36,444,716 (+)Ensembl
mRatBN7.2 Ensembl316,014,594 - 16,046,484 (+)Ensembl
RefSeq Acc Id: NM_001108579   ⟹   NP_001102049
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,408,326 - 36,444,191 (+)NCBI
mRatBN7.2316,010,625 - 16,046,484 (+)NCBI
Rnor_6.0311,756,427 - 11,793,547 (+)NCBI
Rnor_5.0317,095,296 - 17,130,517 (+)NCBI
RGSC_v3.4311,687,031 - 11,731,868 (+)RGD
Celera310,751,515 - 10,786,059 (+)RGD
Sequence:
RefSeq Acc Id: XM_008761759   ⟹   XP_008759981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,415,038 - 36,444,191 (+)NCBI
mRatBN7.2316,017,336 - 16,046,491 (+)NCBI
Rnor_6.0311,762,339 - 11,793,547 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761760   ⟹   XP_008759982
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,425,248 - 36,444,191 (+)NCBI
mRatBN7.2316,030,174 - 16,046,491 (+)NCBI
Rnor_6.0311,777,946 - 11,793,547 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591882   ⟹   XP_017447371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,425,248 - 36,444,191 (+)NCBI
mRatBN7.2316,030,174 - 16,046,491 (+)NCBI
Rnor_6.0311,777,946 - 11,793,547 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105377   ⟹   XP_038961305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,408,305 - 36,444,191 (+)NCBI
mRatBN7.2316,010,622 - 16,046,491 (+)NCBI
RefSeq Acc Id: XM_039105378   ⟹   XP_038961306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,430,103 - 36,444,191 (+)NCBI
mRatBN7.2316,032,393 - 16,046,491 (+)NCBI
RefSeq Acc Id: XM_063284070   ⟹   XP_063140140
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,415,285 - 36,444,191 (+)NCBI
RefSeq Acc Id: NP_001102049   ⟸   NM_001108579
- UniProtKB: A0A0G2JYH7 (UniProtKB/TrEMBL),   A6JU82 (UniProtKB/TrEMBL),   A0A8I6A5D5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759981   ⟸   XM_008761759
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZME7 (UniProtKB/TrEMBL),   A0A2Z5DT54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759982   ⟸   XM_008761760
- Peptide Label: isoform X3
- UniProtKB: A0A2Z5DT54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447371   ⟸   XM_017591882
- Peptide Label: isoform X4
- UniProtKB: A0A2Z5DT54 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070659   ⟸   ENSRNOT00000087762
Ensembl Acc Id: ENSRNOP00000072798   ⟸   ENSRNOT00000078366
RefSeq Acc Id: XP_038961305   ⟸   XM_039105377
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A5D5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961306   ⟸   XM_039105378
- Peptide Label: isoform X5
- UniProtKB: A0A8I6GAN0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000088575   ⟸   ENSRNOT00000113142
Ensembl Acc Id: ENSRNOP00000084559   ⟸   ENSRNOT00000106524
Ensembl Acc Id: ENSRNOP00000078942   ⟸   ENSRNOT00000110408
Ensembl Acc Id: ENSRNOP00000079271   ⟸   ENSRNOT00000098941
RefSeq Acc Id: XP_063140140   ⟸   XM_063284070
- Peptide Label: isoform X6
Protein Domains
Ras-GEF   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JYH7-F1-model_v2 AlphaFold A0A0G2JYH7 1-853 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692001
Promoter ID:EPDNEW_R2517
Type:single initiation site
Name:Sh2d3c_1
Description:SH2 domain containing 3C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0311,763,690 - 11,763,750EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307287 AgrOrtholog
BioCyc Gene G2FUF-50125 BioCyc
Ensembl Genes ENSRNOG00000054560 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087762.3 UniProtKB/TrEMBL
  ENSRNOT00000098941.2 UniProtKB/TrEMBL
  ENSRNOT00000110408 ENTREZGENE
  ENSRNOT00000110408.2 UniProtKB/TrEMBL
  ENSRNOT00000113142 ENTREZGENE
  ENSRNOT00000113142.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.840.10 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
InterPro Ras_GEF_dom UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/TrEMBL
  RasGRF_CDC25 UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2-Ras-GEF_adapter UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH2_SHEP1/BCAR3/NSP1 UniProtKB/TrEMBL
KEGG Report rno:362111 UniProtKB/TrEMBL
NCBI Gene 362111 ENTREZGENE
PANTHER BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN UniProtKB/TrEMBL
  SH2 DOMAIN-CONTAINING PROTEIN 3C UniProtKB/TrEMBL
Pfam RasGEF UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
PhenoGen Sh2d3c PhenoGen
PRINTS SH2DOMAIN UniProtKB/TrEMBL
PROSITE RASGEF_CAT UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054560 RatGTEx
SMART RasGEF UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
Superfamily-SCOP Ras_GEF UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A0G2JYH7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2Z5DT54 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZME7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A5D5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GAN0 ENTREZGENE
  A6JU82 ENTREZGENE, UniProtKB/TrEMBL
  B0BN10_RAT UniProtKB/TrEMBL
UniProt Secondary A0A8I5ZMD8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Sh2d3c  SH2 domain containing 3C   Sh2d3c_predicted  SH2 domain containing 3C (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Sh2d3c_predicted  SH2 domain containing 3C (predicted)      Symbol and Name status set to approved 70820 APPROVED