Naaa (N-acylethanolamine acid amidase)

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Gene: Naaa (N-acylethanolamine acid amidase) Rattus norvegicus

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Symbol:

Naaa

Name:

N-acylethanolamine acid amidase

RGD ID:

1307267

Description:

Enables N-(long-chain-acyl)ethanolamine deacylase activity. Involved in N-acylethanolamine metabolic process. Predicted to be located in lysosome and membrane. Orthologous to human NAAA (N-acylethanolamine acid amidase); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

acylsphingosine deacylase NAAA; ASAH-like protein; Asahl; Asahl_predicted; LOC305237; MGC124515; N-acylethanolamine-hydrolyzing acid amidase; N-acylsphingosine amidohydrolase (acid ceramidase)-like; N-acylsphingosine amidohydrolase (acid ceramidase)-like (predicted); N-acylsphingosine amidohydrolase-like

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NAAA (N-acylethanolamine acid amidase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Naaa (N-acylethanolamine acid amidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Naaa (N-acylethanolamine acid amidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NAAA (N-acylethanolamine acid amidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NAAA (N-acylethanolamine acid amidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Naaa (N-acylethanolamine acid amidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NAAA (N-acylethanolamine acid amidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NAAA (N-acylethanolamine acid amidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Naaa (N-acylethanolamine acid amidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	NAAA (N-acylethanolamine acid amidase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Naaa (N-acylethanolamine acid amidase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	Y55D5A.3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	naaa	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	16,061,599 - 16,080,703 (+)	NCBI		GRCr8
mRatBN7.2	14	15,777,306 - 15,796,411 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	15,777,306 - 15,796,410 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	15,786,134 - 15,805,104 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	17,104,987 - 17,123,957 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	15,800,429 - 15,819,399 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	17,283,262 - 17,302,364 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	17,283,124 - 17,302,366 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	17,199,739 - 17,218,991 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	17,338,759 - 17,358,274 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	17,338,760 - 17,356,973 (+)	NCBI
Celera	14	15,171,712 - 15,190,788 (+)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

progressive myoclonus epilepsy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

arsenous acid (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

carbon nanotube (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

dorsomorphin (ISO)

epoxiconazole (ISO)

ethanol (ISO)

fenvalerate (EXP)

folic acid (ISO)

furan (EXP)

genistein (ISO)

lead diacetate (ISO)

methylseleninic acid (ISO)

mono(2-ethylhexyl) phthalate (ISO)

nickel sulfate (ISO)

potassium chromate (ISO)

progesterone (ISO)

SB 431542 (ISO)

silicon dioxide (EXP)

sodium arsenite (ISO)

Soman (EXP)

sunitinib (ISO)

tacrolimus hydrate (ISO)

temozolomide (ISO)

testosterone (EXP)

thimerosal (ISO)

thioacetamide (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

triclosan (ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

fatty acid metabolic process (IEA,ISO,ISS)

lipid catabolic process (IEA)

N-acylethanolamine metabolic process (IDA,ISO,ISS)

N-acylphosphatidylethanolamine metabolic process (ISO,ISS)

sphingosine metabolic process (ISO,ISS)

Cellular Component

cytoplasm (ISO)

lysosome (ISO,ISS)

membrane (ISO,ISS)

Molecular Function

DNA-binding transcription factor binding (ISO)

fatty acid amide hydrolase activity (ISO,ISS)

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds (IBA,ISO)

N-(long-chain-acyl)ethanolamine deacylase activity (IDA,ISO,ISS)

N-acylsphingosine amidohydrolase activity (ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Endogenous molecules stimulating N-acylethanolamine-hydrolyzing acid amidase (NAAA).	Tai T, etal., ACS Chem Neurosci. 2012 May 16;3(5):379-85. doi: 10.1021/cn300007s. Epub 2012 Jan 27.

Additional References at PubMed

PMID:10610717	PMID:11463796	PMID:12477932	PMID:15655246	PMID:17462942	PMID:17980170	PMID:21106534	PMID:23376485	PMID:23533145	PMID:29514215	PMID:30301806	PMID:31063807

Genomics

Comparative Map Data

Naaa
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	16,061,599 - 16,080,703 (+)	NCBI		GRCr8
mRatBN7.2	14	15,777,306 - 15,796,411 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	15,777,306 - 15,796,410 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	15,786,134 - 15,805,104 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	17,104,987 - 17,123,957 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	15,800,429 - 15,819,399 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	17,283,262 - 17,302,364 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	17,283,124 - 17,302,366 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	17,199,739 - 17,218,991 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	17,338,759 - 17,358,274 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	17,338,760 - 17,356,973 (+)	NCBI
Celera	14	15,171,712 - 15,190,788 (+)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

NAAA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	75,910,655 - 75,941,013 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	75,910,655 - 75,941,013 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	76,831,808 - 76,862,166 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	77,050,832 - 77,081,190 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	77,195,814 - 77,219,325	NCBI
Celera	4	74,132,297 - 74,162,693 (-)	NCBI		Celera
Cytogenetic Map	4	q21.1	NCBI
HuRef	4	72,584,423 - 72,614,591 (-)	NCBI		HuRef
CHM1_1	4	76,808,474 - 76,838,830 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	79,251,154 - 79,281,501 (-)	NCBI		T2T-CHM13v2.0

Naaa
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	92,405,519 - 92,426,040 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	92,405,518 - 92,426,029 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	92,257,660 - 92,278,181 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	92,257,659 - 92,278,170 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	92,686,686 - 92,707,207 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	93,333,459 - 93,353,381 (-)	NCBI		MGSCv36	mm8
Celera	5	90,401,548 - 90,422,177 (-)	NCBI		Celera
Cytogenetic Map	5	E2	NCBI
cM Map	5	46.35	NCBI

Naaa
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955433	630,483 - 674,675 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955433	630,627 - 674,675 (-)	NCBI	ChiLan1.0	ChiLan1.0

NAAA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	54,131,808 - 54,162,106 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	54,321,585 - 54,351,911 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	48,264,567 - 48,294,872 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	54,102,384 - 54,133,725 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	54,102,384 - 54,128,776 (+)	Ensembl	panpan1.1		panPan2

NAAA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	483,317 - 504,304 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	41,379,385 - 41,398,991 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	507,696 - 527,349 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	32	507,868 - 527,523 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	460,034 - 485,704 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	39,688,753 - 39,708,408 (+)	NCBI		UU_Cfam_GSD_1.0

Naaa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	11,590,682 - 11,604,990 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936598	42,751 - 56,261 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NAAA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	71,573,788 - 71,603,338 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	71,573,783 - 71,603,256 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	75,709,382 - 75,738,808 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NAAA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	24,420,378 - 24,450,010 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	24,423,052 - 24,449,793 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	2,765,526 - 2,792,410 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Naaa
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624757	15,074,189 - 15,099,876 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624757	15,074,137 - 15,101,342 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Naaa
174 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	192
Count of miRNA genes:	144
Interacting mature miRNAs:	155
Transcripts:	ENSRNOT00000003102
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300114	Srn2	Serum renin concentration QTL 2	3.27		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	14	3813074	21217635	Rat
2293089	Iddm31	Insulin dependent diabetes mellitus QTL 31	4.7		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	14	3813074	18274691	Rat
1581500	Renag1	Renal agenesis QTL 1			kidney development trait (VT:0000527)	percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)	14	8170668	68298175	Rat
731183	Pia20	Pristane induced arthritis QTL 20	3.55		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	9088978	39057237	Rat
631212	Bw5	Body weight QTL5	5.43		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	14	11030812	30320092	Rat
2302277	Gluco38	Glucose level QTL 38	5.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11030622	28035204	Rat
1331740	Bw26	Body weight QTL 26	3.028		body mass (VT:0001259)	body weight (CMO:0000012)	14	3813074	30767156	Rat
619619	Rf4	Renal disease susceptibility QTL 4	4.1	0.002	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	14	1	32754612	Rat
1358296	Ael3	Aortic elastin QTL 3	3.7	0.00051	aorta elastin amount (VT:0003905)	aortic elastin	14	8267090	53267090	Rat
70195	Mcs8	Mammary carcinoma susceptibility QTL 8	4.28		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	14	3813074	24531477	Rat
2300183	Bmd60	Bone mineral density QTL 60	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11030622	95876975	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41131407	Rat
2300159	Bmd61	Bone mineral density QTL 61	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
70204	Niddm20	Non-insulin dependent diabetes mellitus QTL 20	5.1	0.000008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	1217606	16960180	Rat
2302045	Pia39	Pristane induced arthritis QTL 39	4.9	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G2a level (CMO:0002116)	14	8267090	53267090	Rat
1300140	Srn3	Serum renin concentration QTL 3	3.19		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	14	14875168	30883947	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001010967	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB162193	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC113621	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC105771	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474060	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000003102 ⟹ ENSRNOP00000003102

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	15,777,306 - 15,796,410 (+)	Ensembl
Rnor_6.0 Ensembl	14	17,283,124 - 17,302,366 (+)	Ensembl

RefSeq Acc Id:

NM_001010967 ⟹ NP_001010967

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	16,061,599 - 16,080,703 (+)	NCBI
mRatBN7.2	14	15,777,306 - 15,796,411 (+)	NCBI
Rnor_6.0	14	17,283,262 - 17,302,364 (+)	NCBI
Rnor_5.0	14	17,199,739 - 17,218,991 (+)	NCBI
RGSC_v3.4	14	17,338,759 - 17,358,274 (+)	RGD
Celera	14	15,171,712 - 15,190,788 (+)	RGD

Sequence:

show sequence

CCTCAGCAGCCCGAGCCATGGGGACCCCAGCCATCCGGGCCGCGTGCCATGGGGCACACCTGGC
GCTGGCTCTGTTGCTGCTGCTGTCGCTGTCGGATCCCTGGCTGTGGGCGACCGCCCCTGGCACT
CCGCCTCTCTTCAACGTCAGTCTGGACGCGGCCCCGGAGCTGCGCTGGCTGCCGATGCTGCAGC
ACTACGACCCAGACTTCGTGCGCGCCGCGGTGGCGCAGGTTATTGGAGACAGGGTTCCCCAGTG
GATACTAGAGATGATCGGAGAAATCGTGCAGAAGGTGGAGAGCTTCCTGCCTCAGCCCTTCACC
TCCGAGATCCGCGGCATATGTGACTACCTCAACCTCAGCCTGGCAGAGGGTGTCTTGGTCAACT
TGGCCTATGAGGCTTCCGCATTCTGCACCAGTATTGTGGCCCAAGACTCCCAAGGCCGTATTTA
CCATGGCCGGAACCTGGACTATCCTTTTGGAAATGCCTTACGAAAGCTGACAGCAGACGTGCAG
TTTGTAAAGAACGGGCAGATTGTATTCACAGCGACCACTTTTGTTGGCTATGTAGGACTGTGGA
CAGGTCAAAGTCCCCACAAGTTTACAATTTCTGGTGATGAACGAGACAAAGGCTGGTGGTGGGA
GAACATGATTGCTGCGCTTTCCTTGGGACACTCGCCCATCAGCTGGCTTATCCGCAAAACCCTG
ACTGAGTCCGAAGACTTCGAAGCGGCCGTTTACACGCTGGCCAAGACTCCCCTCATTGCTGATG
TGTATTACATCGTTGGGGGTACATCGCCCCAGGAGGGAGTAGTCATCACCAGGGACAGAGGTGG
CCCCGCGGACATTTGGCCTCTTGACCCTCTGAATGGAGCGTGGTTCCGAGTCGAGACCAATTAT
GACCACTGGGAGCCTGTGCCCAAGAGGGATGACCGAAGGACACCAGCCATCAAAGCCCTAAATG
CCACAGGGCAAGCTCACCTCAGTCTGGAGACCCTCTTCCAGGTTTTATCCGTGTTTCCTGTTTA
TAACAACTACACAATTTATACCACAGTGATGAGCGCTGCTGAGCCCGACAAGTACATGACCATG
ATCAGAAACCCAAGCTGAAGATGATTTATTGTCAAAGAGCTGCATTTGGAAGACTAAGACTGGA
AGTATTGTACGGTTTCCTGAGCAACGCAGGCTCCCTCTTCAGAAAGCCTTTCTGCCTTGTGGAA
GGGGTAGATCTCTTGGCACACATCTGGAGGAAGAGGAGTGTATTCTGCTGTCTTGCATCCTCCT
GATGTCCTGGTCCCCTTGAGCTTCATTAACAACCCACCCTGGCTTGAACAACTCAGATAACTGA
TCTCGGAGGTCAGGCTGCACCTGACTAGTCACAGGTTTCCTGTGATTCTGTGTCCACGCCCCTG
CTTTTCCACTGAAGAAGGGAACAGACAAGATAGCTGTCGTGTGGAGGGAGGCCTTGTGGACAAC
CCCCCAGGAGAAAATTTCCCCTAAGGCTGGGGTGAGGCTCAGTAGCAGAATTTGCACCACTAAG
TAAATAGTAAATAGATAAACGAACAAAAGTTTTCTCTCAGGAGTGGAAACCTCTAATCTGAGTA
GAATTTGCTTGAAGATATGTTCCTCTGACCTTTGATTTCATGTTTCTATATAGTGGAAATTCAC
TTTTTATAAACTTCTAATGTATTGTTTTAACGTGGGCCTTATTAAAAATAAAGCTAATTTCTTA
GTGCTTTTGAAAATTATGTGACAACAAATAATTTCCTGTCATTCTTTATCGTTTGTTAATAAAA
TGTCAAAAAATGCTAGCTGCAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001010967	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI05772	(Get FASTA)	NCBI Sequence Viewer
	BAD88529	(Get FASTA)	NCBI Sequence Viewer
	EDL88611	(Get FASTA)	NCBI Sequence Viewer
	EDL88612	(Get FASTA)	NCBI Sequence Viewer
	EDL88613	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000003102.5
	ENSRNOP00055007979
	ENSRNOP00060026603
	ENSRNOP00065024565
GenBank Protein	Q5KTC7	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001010967 ⟸ NM_001010967
- Peptide Label:	precursor
- UniProtKB:	Q5KTC7 (UniProtKB/Swiss-Prot), Q3KRD3 (UniProtKB/Swiss-Prot), A6KK97 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGTPAIRAACHGAHLALALLLLLSLSDPWLWATAPGTPPLFNVSLDAAPELRWLPMLQHYDPDF VRAAVAQVIGDRVPQWILEMIGEIVQKVESFLPQPFTSEIRGICDYLNLSLAEGVLVNLAYEAS AFCTSIVAQDSQGRIYHGRNLDYPFGNALRKLTADVQFVKNGQIVFTATTFVGYVGLWTGQSPH KFTISGDERDKGWWWENMIAALSLGHSPISWLIRKTLTESEDFEAAVYTLAKTPLIADVYYIVG GTSPQEGVVITRDRGGPADIWPLDPLNGAWFRVETNYDHWEPVPKRDDRRTPAIKALNATGQAH LSLETLFQVLSVFPVYNNYTIYTTVMSAAEPDKYMTMIRNPS hide sequence

Ensembl Acc Id:

ENSRNOP00000003102 ⟸ ENSRNOT00000003102

Protein Domains

Acid ceramidase N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5KTC7-F1-model_v2	AlphaFold	Q5KTC7	1-362	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699215

Promoter ID:

EPDNEW_R9740

Type:

multiple initiation site

Name:

Naaa_1

Description:

N-acylethanolamine acid amidase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	17,283,266 - 17,283,326	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307267	AgrOrtholog
BioCyc Gene	G2FUF-16256	BioCyc
Ensembl Genes	ENSRNOG00000002273	Ensembl, UniProtKB/Swiss-Prot
	ENSRNOG00055006332	UniProtKB/Swiss-Prot
	ENSRNOG00060018886	UniProtKB/Swiss-Prot
	ENSRNOG00065018387	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000003102.7	UniProtKB/Swiss-Prot
	ENSRNOT00055010296	UniProtKB/Swiss-Prot
	ENSRNOT00060032600	UniProtKB/Swiss-Prot
	ENSRNOT00065030855	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7930474	IMAGE-MGC_LOAD
InterPro	Acid_ceramidase-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Acid_ceramidase_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:497009	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:124515	IMAGE-MGC_LOAD
NCBI Gene	Naaa	ENTREZGENE
PANTHER	ACID AMIDASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	N-ACYLETHANOLAMINE-HYDROLYZING ACID AMIDASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	NAAA-beta	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Naaa	PhenoGen
PIRSF	Acid_ceramidase-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000002273	RatGTEx
	ENSRNOG00055006332	RatGTEx
	ENSRNOG00060018886	RatGTEx
	ENSRNOG00065018387	RatGTEx
UniProt	A6KK97	ENTREZGENE, UniProtKB/TrEMBL
	NAAA_RAT	UniProtKB/Swiss-Prot
	Q3KRD3	ENTREZGENE
	Q5KTC7	ENTREZGENE
UniProt Secondary	Q3KRD3	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-06-27			Naaa	N-acylethanolamine acid amidase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-05-15	Naaa	N-acylethanolamine acid amidase	Asahl	N-acylsphingosine amidohydrolase (acid ceramidase)-like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Asahl	N-acylsphingosine amidohydrolase (acid ceramidase)-like	Asahl_predicted	N-acylsphingosine amidohydrolase (acid ceramidase)-like (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Asahl_predicted	N-acylsphingosine amidohydrolase (acid ceramidase)-like (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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