Kcnrg (potassium channel regulator) - Rat Genome Database

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Gene: Kcnrg (potassium channel regulator) Rattus norvegicus
Analyze
Symbol: Kcnrg
Name: potassium channel regulator
RGD ID: 1307199
Description: Predicted to enable identical protein binding activity. Predicted to be involved in protein homooligomerization. Predicted to be active in endoplasmic reticulum. Orthologous to human KCNRG (potassium channel regulator); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrolein.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC305947; putative potassium channel regulatory protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81539,948,920 - 40,020,937 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.21535,774,456 - 35,779,409 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1535,774,326 - 35,779,415 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1537,639,239 - 37,643,557 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01538,789,863 - 38,794,181 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01537,235,171 - 37,239,497 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01541,937,880 - 41,942,205 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1541,937,880 - 41,942,205 (+)Ensemblrn6Rnor6.0
Rnor_5.01545,738,076 - 45,742,401 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41540,754,299 - 40,758,625 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1535,469,851 - 35,474,175 (+)NCBICelera
RGSC_v3.11540,769,998 - 40,852,621 (+)NCBI
Cytogenetic Map15p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16189514   PMID:19447967   PMID:19968958   PMID:25416956  


Genomics

Comparative Map Data
Kcnrg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81539,948,920 - 40,020,937 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.21535,774,456 - 35,779,409 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1535,774,326 - 35,779,415 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1537,639,239 - 37,643,557 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01538,789,863 - 38,794,181 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01537,235,171 - 37,239,497 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01541,937,880 - 41,942,205 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1541,937,880 - 41,942,205 (+)Ensemblrn6Rnor6.0
Rnor_5.01545,738,076 - 45,742,401 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41540,754,299 - 40,758,625 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1535,469,851 - 35,474,175 (+)NCBICelera
RGSC_v3.11540,769,998 - 40,852,621 (+)NCBI
Cytogenetic Map15p12NCBI
KCNRG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381350,015,444 - 50,020,922 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1350,015,254 - 50,020,922 (+)Ensemblhg38GRCh38
GRCh371350,589,580 - 50,595,058 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361349,487,391 - 49,493,059 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341349,487,390 - 49,493,059NCBI
Celera1331,644,032 - 31,649,698 (+)NCBICelera
Cytogenetic Map13q14.2NCBI
HuRef1331,384,465 - 31,390,131 (+)NCBIHuRef
CHM1_11350,557,221 - 50,562,888 (+)NCBICHM1_1
T2T-CHM13v2.01349,236,038 - 49,241,514 (+)NCBIT2T-CHM13v2.0
Kcnrg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391461,844,905 - 61,850,282 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1461,844,906 - 61,850,275 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381461,607,457 - 61,612,833 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1461,607,457 - 61,612,826 (+)Ensemblmm10GRCm38
MGSCv371462,226,294 - 62,231,670 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361460,561,567 - 60,566,943 (+)NCBIMGSCv36mm8
Celera1459,374,897 - 59,380,323 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.16NCBI
Kcnrg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554313,395,920 - 3,402,494 (+)NCBIChiLan1.0ChiLan1.0
KCNRG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21451,456,693 - 51,466,759 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11350,108,076 - 50,121,574 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01331,154,531 - 31,161,081 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11349,901,696 - 49,908,169 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1349,901,696 - 49,908,169 (+)EnsemblpanPan2panpan1.1
KCNRG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1221,870,964 - 1,875,849 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha221,897,328 - 1,905,449 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0221,857,800 - 1,865,935 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1221,767,852 - 1,775,966 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0221,816,987 - 1,825,094 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0221,835,448 - 1,843,572 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kcnrg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945159,507,452 - 159,514,004 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365652,991,410 - 2,997,557 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365652,991,568 - 2,997,592 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNRG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1117,784,998 - 17,794,710 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11117,784,243 - 17,796,826 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KCNRG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1327,926,469 - 27,932,895 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605715,942,335 - 15,947,803 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnrg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247484,674,722 - 4,683,255 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Kcnrg
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11262,809,559 - 62,826,049 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kcnrg
372 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:289
Count of miRNA genes:187
Interacting mature miRNAs:198
Transcripts:ENSRNOT00000032514
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
BF386087  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21535,777,057 - 35,777,237 (+)MAPPERmRatBN7.2
Rnor_6.01541,940,445 - 41,940,624NCBIRnor6.0
Rnor_5.01545,740,641 - 45,740,820UniSTSRnor5.0
RGSC_v3.41540,756,865 - 40,757,044UniSTSRGSC3.4
Celera1535,472,415 - 35,472,594UniSTS
RH 3.4 Map15216.6UniSTS
Cytogenetic Map15p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 164 91 90 59 74 59 6 333 172 10 144 78 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000032514   ⟹   ENSRNOP00000037710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1535,774,326 - 35,779,415 (+)Ensembl
Rnor_6.0 Ensembl1541,937,880 - 41,942,205 (+)Ensembl
RefSeq Acc Id: NM_001191687   ⟹   NP_001178616
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,950,502 - 39,955,455 (+)NCBI
mRatBN7.21535,774,456 - 35,779,409 (+)NCBI
Rnor_6.01541,937,880 - 41,942,205 (+)NCBI
Rnor_5.01545,738,076 - 45,742,401 (+)NCBI
Celera1535,469,851 - 35,474,175 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063274279   ⟹   XP_063130349
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,948,920 - 40,020,937 (+)NCBI
RefSeq Acc Id: XR_005494005
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,961,323 - 40,020,937 (+)NCBI
RefSeq Acc Id: XR_005494006
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,961,361 - 40,020,937 (+)NCBI
RefSeq Acc Id: XR_005494007
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,995,716 - 40,020,937 (+)NCBI
RefSeq Acc Id: XR_005494010
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,961,350 - 40,020,937 (+)NCBI
RefSeq Acc Id: XR_005494011
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,995,732 - 40,020,937 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001178616 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130349 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001178616   ⟸   NM_001191687
- UniProtKB: D3ZIP1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000037710   ⟸   ENSRNOT00000032514
RefSeq Acc Id: XP_063130349   ⟸   XM_063274279
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZIP1-F1-model_v2 AlphaFold D3ZIP1 1-268 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307199 AgrOrtholog
BioCyc Gene G2FUF-13495 BioCyc
Ensembl Genes ENSRNOG00000021831 Ensembl
  ENSRNOG00000071559 ENTREZGENE
Ensembl Transcript ENSRNOT00000173763 ENTREZGENE
NCBI Gene 305947 ENTREZGENE
PhenoGen Kcnrg PhenoGen
RatGTEx ENSRNOG00000021831 RatGTEx
  ENSRNOG00000071559 RatGTEx
UniProt D3ZIP1 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Kcnrg  potassium channel regulator   Kcnrg_predicted  potassium channel regulator (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Kcnrg_predicted  potassium channel regulator (predicted)      Symbol and Name status set to approved 70820 APPROVED