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Gene: Mpzl2 (myelin protein zero-like 2) Rattus norvegicus

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Symbol:

Mpzl2

Name:

myelin protein zero-like 2

RGD ID:

1307196

Description:

Predicted to be involved in cell-cell adhesion. Predicted to act upstream of or within T cell differentiation in thymus. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 111. Orthologous to human MPZL2 (myelin protein zero like 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; alpha-Zearalanol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

epithelial V-like antigen; epithelial V-like antigen 1; Eva; Eva1; LOC300679; myelin protein zero-like protein 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MPZL2 (myelin protein zero like 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Mpzl2 (myelin protein zero-like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mpzl2 (myelin protein zero like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MPZL2 (myelin protein zero like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MPZL2 (myelin protein zero like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mpzl2 (myelin protein zero like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MPZL2 (myelin protein zero like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MPZL2 (myelin protein zero like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mpzl2 (myelin protein zero like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Mpzl2 (myelin protein zero like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	MPZL2 (myelin protein zero like 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mpzl2 (myelin protein zero-like 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mpzl2b (myelin protein zero-like 2b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mpzl2b (myelin protein zero-like 2b)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mpzl2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mpzl2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	54,244,920 - 54,256,064 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	54,243,556 - 54,256,074 (+)	Ensembl				GRCr8
mRatBN7.2	8	45,348,285 - 45,359,298 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	45,348,285 - 45,359,298 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	50,843,848 - 50,854,747 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	49,122,587 - 49,133,486 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	46,993,141 - 47,004,040 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	49,342,067 - 49,353,080 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	49,342,067 - 49,353,080 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	47,959,127 - 47,980,096 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	47,991,599 - 48,003,100 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	44,934,312 - 44,945,501 (+)	NCBI		Celera
RGSC_v3.1	8	48,000,623 - 48,010,534 (+)	NCBI
Cytogenetic Map	8	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal recessive nonsyndromic deafness (ISO)

autosomal recessive nonsyndromic deafness 111 (ISO,ISS)

genetic disease (ISO)

Hearing Loss (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',4,4'-tetrachlorobiphenyl (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

amitrole (EXP)

amphetamine (EXP)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bilirubin IXalpha (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butan-1-ol (ISO)

Butylbenzyl phthalate (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

carnosic acid (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

chloroprene (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

ciglitazone (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (EXP,ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

diethyl phthalate (ISO)

diisobutyl phthalate (ISO)

diisononyl phthalate (ISO)

dioxygen (EXP)

dorsomorphin (ISO)

epoxiconazole (ISO)

ethanol (ISO)

furan (EXP)

gentamycin (EXP)

glyphosate (EXP)

isobutanol (ISO)

leflunomide (ISO)

lipopolysaccharide (ISO)

mercury dibromide (ISO)

methimazole (EXP)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

nickel atom (ISO)

oxaliplatin (EXP)

ozone (ISO)

paclitaxel (EXP,ISO)

paracetamol (EXP,ISO)

perfluorononanoic acid (ISO)

perfluorooctanoic acid (EXP)

phenethyl isothiocyanate (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

progesterone (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sotorasib (ISO)

sulforaphane (ISO)

tamoxifen (ISO)

tetrachloromethane (ISO)

Theaflavin 3,3'-digallate (ISO)

thiram (ISO)

titanium dioxide (ISO)

topotecan (EXP,ISO)

trametinib (ISO)

trichostatin A (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

tris(2-butoxyethyl) phosphate (ISO)

valproic acid (EXP,ISO)

vinclozolin (EXP)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell-cell adhesion (IBA,ISO)

T cell differentiation in thymus (ISO)

Cellular Component

membrane (IEA)

plasma membrane (IBA,ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9585423	PMID:19851463

Genomics

Comparative Map Data

Mpzl2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	54,244,920 - 54,256,064 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	54,243,556 - 54,256,074 (+)	Ensembl				GRCr8
mRatBN7.2	8	45,348,285 - 45,359,298 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	45,348,285 - 45,359,298 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	50,843,848 - 50,854,747 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	49,122,587 - 49,133,486 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	46,993,141 - 47,004,040 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	49,342,067 - 49,353,080 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	49,342,067 - 49,353,080 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	47,959,127 - 47,980,096 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	47,991,599 - 48,003,100 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	44,934,312 - 44,945,501 (+)	NCBI		Celera
RGSC_v3.1	8	48,000,623 - 48,010,534 (+)	NCBI
Cytogenetic Map	8	q22	NCBI

MPZL2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	118,253,416 - 118,264,297 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	118,253,416 - 118,264,536 (-)	Ensembl			hg38	GRCh38
GRCh37	11	118,124,131 - 118,135,012 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	117,629,344 - 117,640,219 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	11	117,632,836 - 117,640,219	NCBI
Celera	11	115,282,009 - 115,293,130 (-)	NCBI		Celera
Cytogenetic Map	11	q23.3	NCBI
HuRef	11	114,057,725 - 114,068,846 (-)	NCBI		HuRef
CHM1_1	11	118,010,121 - 118,021,238 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	118,269,772 - 118,280,653 (-)	NCBI		T2T-CHM13v2.0

Mpzl2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	44,951,595 - 44,965,341 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	44,951,097 - 44,965,313 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	45,042,344 - 45,054,043 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	45,039,799 - 45,054,015 (+)	Ensembl			mm10	GRCm38
MGSCv37	9	44,850,427 - 44,862,126 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	44,793,552 - 44,805,007 (+)	NCBI		MGSCv36	mm8
Celera	9	42,317,403 - 42,329,166 (+)	NCBI		Celera
Cytogenetic Map	9	A5.2	NCBI
cM Map	9	24.84	NCBI

Mpzl2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	19,422,537 - 19,434,596 (-)	Ensembl
ChiLan1.0	NW_004955412	19,422,532 - 19,434,596 (-)	NCBI	ChiLan1.0	ChiLan1.0

MPZL2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	118,957,497 - 118,968,498 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	120,062,474 - 120,073,480 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	113,063,961 - 113,102,097 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	117,023,102 - 117,034,209 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	117,023,102 - 117,034,209 (-)	Ensembl			panPan2	panpan1.1

MPZL2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	15,446,803 - 15,458,667 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	15,447,104 - 15,458,515 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	15,497,525 - 15,510,264 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	15,388,932 - 15,401,457 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	15,389,046 - 15,401,457 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	15,527,149 - 15,539,697 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	15,430,679 - 15,443,207 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	15,471,780 - 15,484,528 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Mpzl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	100,412,421 - 100,423,313 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936542	3,333,830 - 3,343,852 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936542	3,332,822 - 3,344,663 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MPZL2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	45,565,513 - 45,578,185 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	45,566,365 - 45,578,168 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	50,607,407 - 50,619,210 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MPZL2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	109,635,053 - 109,645,142 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	109,633,493 - 109,645,145 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666043	16,387,120 - 16,397,553 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mpzl2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624784	13,672,672 - 13,684,612 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Mpzl2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	39,574,247 - 39,585,157 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Mpzl2
146 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	851
Count of miRNA genes:	304
Interacting mature miRNAs:	393
Transcripts:	ENSRNOT00000021693
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298065	Scl16	Serum cholesterol level QTL 16	3.8		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39752803	84752803	Rat
2313057	Bss76	Bone structure and strength QTL 76	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	8	39106258	91341052	Rat
2317030	Wbc5	White blood cell count QTL 5	3.21	0.005	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	8	16994642	61994642	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	49849908	118871671	Rat
2313067	Bss77	Bone structure and strength QTL 77	3.1	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	8	39106258	91341052	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	39106363	103375781	Rat
2301416	Bp315	Blood pressure QTL 315		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	15952279	60952279	Rat
2317032	Ginf2	Gastrointestinal inflammation QTL 2	3.21	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	8	12964165	57964165	Rat
1298079	Activ2	Activity QTL 2	9.5	0.000001	voluntary movement trait (VT:0003491)	rearing measurement (CMO:0001515)	8	50763951	95763951	Rat
11556286	Cm81	Cardiac mass QTL 81		0.01	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	39106258	84106258	Rat
2317036	Livw3	Liver weight QTL 3	2.43	0.01	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	8	12964165	57964165	Rat
70161	Bp62	Blood pressure QTL 62	2.9	0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	51589699	99045312	Rat
12880023	Bw184	Body weight QTL 184		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	10382540	55382540	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	39106363	103375781	Rat
5684993	Bmd84	Bone mineral density QTL 84	4.1		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	8	51589699	58991895	Rat
61464	Niddm11	Non-insulin dependent diabetes mellitus QTL 11	3.1	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	44477926	89477926	Rat
2317051	Aia18	Adjuvant induced arthritis QTL 18	2.42		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	8	16994642	61994642	Rat
12880028	Cm103	Cardiac mass QTL 103		0.02	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	10382540	55382540	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	39106258	103375958	Rat
2317048	Ginf1	Gastrointestinal inflammation QTL 1	3.52	0.005	cecum mucosa thickness (VT:0010234)	enterocolitis severity score (CMO:0002138)	8	12964165	57964165	Rat
12880025	Cm102	Cardiac mass QTL 102		0.044	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	8	10382540	55382540	Rat
2313088	Bss75	Bone structure and strength QTL 75	3.1	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	8	39106258	91341052	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	35464071	107982864	Rat
731182	Uae24	Urinary albumin excretion QTL 24	6.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	47541419	92541419	Rat
2302278	Gluco36	Glucose level QTL 36	4.2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	37760859	58991895	Rat
12880044	Am9	Aortic mass QTL 9		0.007	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	10382540	55382540	Rat
724514	Uae15	Urinary albumin excretion QTL 15	2.9		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	37760859	61459705	Rat
631648	Stl5	Serum triglyceride level QTL 5	4	0.0003	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	35464071	71842899	Rat
61353	Bp35	Blood pressure QTL 35		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	8	39106258	84106258	Rat
737824	Hcar10	Hepatocarcinoma resistance QTL 10	2.9		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	8	49610204	68373388	Rat
631842	Inf1	Infertility severity QTL 1	4.1	0.001	seminal gland mass (VT:0010524)	seminal vesicle wet weight (CMO:0001603)	8	31543661	76543661	Rat
1331769	Rf39	Renal function QTL 39	3.871		urine output (VT:0003620)	timed urine volume (CMO:0000260)	8	50763951	107970527	Rat
1359033	Bp273	Blood pressure QTL 273			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	39106258	84106258	Rat
1358906	Bp253	Blood pressure QTL 253	4	0.0004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	49610204	94610204	Rat
61358	Bp39	Blood pressure QTL 39	2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	44447837	89447837	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	35464071	107982864	Rat
1598824	Memor4	Memory QTL 4	2.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	8	17993862	62252873	Rat
1331744	Bp217	Blood pressure QTL 217	3.398		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	39106258	67378345	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39106363	114525825	Rat
2313046	Bss78	Bone structure and strength QTL 78	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	8	39106258	91341052	Rat
1582254	Kidm31	Kidney mass QTL 31	3		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	8	49245178	94245178	Rat
724540	Uae8	Urinary albumin excretion QTL 8	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	8	39106258	103375958	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	35464071	107982864	Rat
631216	Stl9	Serum triglyceride level QTL 9	4.71	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	8	50763951	67219641	Rat
1359021	Bp271	Blood pressure QTL 271	1.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	34125902	55607752	Rat
1582243	Bw66	Body weight QTL 66	3.4	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	8	49245178	94245178	Rat
61373	Mcs4	Mammary carcinoma susceptibility QTL 4	1.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	8	44475043	89475043	Rat

Markers in Region

BI282616

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	45,358,977 - 45,359,182 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	49,352,760 - 49,352,964	NCBI	Rnor6.0
Rnor_5.0	8	47,979,776 - 47,979,980	UniSTS	Rnor5.0
RGSC_v3.4	8	48,002,780 - 48,002,984	UniSTS	RGSC3.4
Celera	8	44,945,181 - 44,945,385	UniSTS
RH 3.4 Map	8	451.6	UniSTS
Cytogenetic Map	8	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	65	150	91	90	59	83	59	6	345	181	11	129	81	92	31	7	7

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106818	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063265111	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010053944	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC094331	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000021693 ⟹ ENSRNOP00000021693

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	54,245,045 - 54,256,058 (+)	Ensembl
mRatBN7.2 Ensembl	8	45,348,285 - 45,359,298 (+)	Ensembl
Rnor_6.0 Ensembl	8	49,342,067 - 49,353,080 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000101830 ⟹ ENSRNOP00000094766

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	54,243,556 - 54,256,074 (+)	Ensembl

RefSeq Acc Id:

NM_001106818 ⟹ NP_001100288

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	54,245,045 - 54,256,058 (+)	NCBI
mRatBN7.2	8	45,348,285 - 45,359,298 (+)	NCBI
Rnor_6.0	8	49,342,067 - 49,353,080 (+)	NCBI
Rnor_5.0	8	47,959,127 - 47,980,096 (+)	NCBI
RGSC_v3.4	8	47,991,599 - 48,003,100 (+)	RGD
Celera	8	44,934,312 - 44,945,501 (+)	RGD

Sequence:

show sequence

AGCAGCCTGGGACATTTCAAACTGGCACCACCTCCTTCTGGCTGTCTCTGAGGCCATCCGGAGG
CCAGGGCTCAGTCAGTTGAACGGAAAAACTAAGGAGAGGACTGCAGAGTCTGAGACCTTTGCGC
AGAAGGCTGGAGTGTGGAGGAAGGCGGGAGGGAGAATCAGGAGGAGGGCGCTGGGTGCGGAGGC
CCCACCTTTCATTCCAGAGCTGTACCGGCCCGGGCGGGATGAGTCAAGACCCGCTGGGTCTGCT
GTGCACCTTCCCATAGGTGAGGGAGTCGACCTCTCTGGGGAAAAACTGCAGCGCCTGCTAGTCC
TAGCCTTGGCCTTGGCTGGGTGCTGGAGTCTTGGGTCTGCCGAGTCTGGCCTCTGGGGCCACGG
CTGGCTTTCCCTGATGTATGGCAAGAGCCTCGCTCGTGTGCTTCCATTTCTCCTGAGCTTACAG
CTCACAGTCTTTTATCCTACAACAGCAGTGGAAATTTACACCTCCGGAGCCCTGGAGGCAGTTA
ACGGGACAGATATTCGGTTAAAATGCACTTTCTCCAGCTTTGCCCCTGTGGGAGATGCGCTAAC
CGTGACGTGGAATTTCCGACCTCGAGATGGGGGTCGTGAGCAGTTTGTATTCTATTACCACATG
GATCCCTTCAGACCCATGAGCGGACGGTTCAAAGACCGGGTGGTCTGGGATGGAAACCCCGAGC
GGTATGATGTCTCCATCATGCTATGGAAGCTGCAGTTTGACGACAACGGGACATACACCTGCCA
GGTGAAGAATCCACCGGATGTTGATGGTCTGATCGGGACGATCCGGCTCAGCGTTGTGCACACT
GTGCCCTTCTCCGAGATCTACTTCCTGGCCGTGGCCATTGGCTCTGCTTGTGCACTGATGATCA
TCATAGTGATCGTGGTGGTCCTCTTCCAACACTTCCGGAAAAAGCGATGGGCAGAAAGGGCGGA
TAAATCTGAGGGGACAAAATCAAAAGAAGAGGAGAAACTCAATCAAGGGACTAAAGTCTCTGTT
TATGTGGAAGATACAGACTAACACTGTGGGAAGCTGAGGATTTTCGAGGACAGCATCAGCACTC
CTTGACATCAATGGAAACATTTCCAGCGATGACCTGTCGTCCTACAGGTTCTGCAGCACAAACC
TGCCTAGATGAGCAATGCCCCTGACCGGCAGCTTAGGGTTCTGCCTGAGCCACTAGCCTCAGGC
TTACCTTCATTACTAGGGTCCTGTCTAATTCCAGAGCGCAATTGTGTGTTAGCTTTTGTAAACT
GCGAGGTTACATATTTGTCCTTCCACATTCTTACAATGTATGACTCCTATACTCCTGTGTATAC
TGGCATCAGAGGGATATGAAGCCAGCCAGCTTGTCTGCCAGGGCATACCTTCTCACATTTCAGT
TTTAGAACAGCGCACAGGAGTGCTAAGGGGTCTGGAGAGATGGCTAAACTCTTGTTCTTGCAGA
AGAACCCAGTTCAGTTCTCAGCACCCATTTGGTGGCTCACAGCTATCAGTATCCAGTTCTAGGG
GATGTGACACCGTCATCTGGTGTCTGTAGGTACTGCATGCACATGGTATGTGCAGGCCGTCCAC
CTCCCCTCCCCCATAAGATGAATACATTAAATCATTAAAAGACTAGCTAAACCATCCAGCCATT
ATTTTTTTTTATTAAAACCAAACCCCAAATTTACACTGGAAGTTTGATTTTCATGACTGTCTTT
AAATGGAAATATCCTGATTTTTTAGATTTTTTACTGATTTTTTTTAAGTGTTCTAGATTTATCG
TTTTGTCAATTACTCCAAGGTTTCTAGGTGACAGCGCAAGTCTAAGCACAGTAACTATAAAAGG
TCACAGAAGCACCAGGACACCAGCAAGTGCCACCAGGATGAATCGCTCAGCACCACTTTTGTAT
TTATTTATTTATTTTTAGACAGGTTCTCACTATGTAGTGCTGGCTGGTCTAGAGCTGACTATGC
CGACAGAGTTGGCCTCAAACCTAGAGACCCCCTGCCTCAGCTCTCGAGTGCTTTGATAAAGTAT
GCATCACCACATCCTGCCCAACTGTAGGTTTGTAATGAGCATAGACAGATTGCTTGCTCTGCGC
TCCCTTTCACCCCCACCTTGGAAGACTCTGCTCATTCGCAGACTGGAGTCATGAAGCAGTTTAT
TAGAAGACTTTGTGACAGACTACAACTTAAAAAAAAAATCAGACTCGTGCCAACCCAAAGCAAA
TGGCCTCTTTTTTTTTTGTTTTTTGTTTTTTGTTTTTGTTTTTTAAGTCTTGTGTGTGAGAACT
AGAAGAGATTATTTAAAGTTCTTTTGGTTTTGGTTCGCCTTGTTTTAAGGAGAATTTGCTGTGG
ACCAAAGAAATAACAAAACTACCTAAAAGGAATGAACCAATTTTATTTTTCCCTTTATTGAGTA
CAAAGCAAAGTTTTTTTTAAGTGGCCTGTGGAAAGAGGAGGGATGGCTTTCTTCTCTGAGTCTA
GTGACCCGGTCTGTGCGCACCAGCACTGTTTGGAGAACAGAGAACATCTAAAGGTTCAGGTCTG
GAGTGAATCTTCACAATGCAATTCTTCACTGACTGAGTCGCACAGATTGTTTCTTCTTAACAAA
CTGGAAATTTCCAAAAGATTCAATTTTTACATATTGGATCTTGATATTTTACCCAGTCTTTAAA
AAAAATAAATTAGCATAATTTACATATACATTTTGGTCTTGAAATCCATTCTATATCTCTTGTT
CTGCTTTTTATAATGCCTGAAAAAAAAAGGTTTTGTTCTTATTTCTCTCCCTCTCTCCCTCTTT
CTCTCTTAAAAATTAAGAAAGGGTCTCACTAAATTGCTCTGGCTGTCCTGAAACTCACTTTGTA
GATCAGGCTGGCCTTGATCTCAGAGATCCCACTGCCTCTGCCTCACCCGTGCTAGAAGTAAGGG
ATTGCTCCTCCATACCCTGGCCTAAAGTTTTGATACCTAGTTTTGAAGCTACAAGCTAGACCTG
TATATTCTCTTGTGAACATAGCGACTGGATATTTCTTTAAACAGATGGCCTGTGTATGTTTCAT
ACTTGTAATGAAGTAGTTAAAAACCCCACAGGGACTGTCTCCAGCGAACTTGCAGCTTGTGTCC
TGTCTGAATATTCATGGGGTACCACATTCTTGGTCAGTATCTCCTTCCTAAGAGTACCTTTGTA
CTGTAACTTATTTTTTATTATGCCTGAAGCACTGTGTAAATAAACCCTTAGTAAT

hide sequence

RefSeq Acc Id:

XM_063265111 ⟹ XP_063121181

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	54,246,082 - 54,256,064 (+)	NCBI

RefSeq Acc Id:

XR_010053944

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	54,244,920 - 54,250,031 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100288	(Get FASTA)	NCBI Sequence Viewer
	XP_063121181	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL95347	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000021693
	ENSRNOP00000021693.5

RefSeq Acc Id:	NP_001100288 ⟸ NM_001106818
- Peptide Label:	precursor
- UniProtKB:	D4AAE2 (UniProtKB/TrEMBL), A6J424 (UniProtKB/TrEMBL)
- Sequence:	show sequence MYGKSLARVLPFLLSLQLTVFYPTTAVEIYTSGALEAVNGTDIRLKCTFSSFAPVGDALTVTWN FRPRDGGREQFVFYYHMDPFRPMSGRFKDRVVWDGNPERYDVSIMLWKLQFDDNGTYTCQVKNP PDVDGLIGTIRLSVVHTVPFSEIYFLAVAIGSACALMIIIVIVVVLFQHFRKKRWAERADKSEG TKSKEEEKLNQGTKVSVYVEDTD hide sequence

Ensembl Acc Id:

ENSRNOP00000021693 ⟸ ENSRNOT00000021693

RefSeq Acc Id:	XP_063121181 ⟸ XM_063265111
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000094766 ⟸ ENSRNOT00000101830

Protein Domains

Ig-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4AAE2-F1-model_v2	AlphaFold	D4AAE2	1-215	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695909

Promoter ID:

EPDNEW_R6434

Type:

initiation region

Name:

Mpzl2_1

Description:

myelin protein zero-like 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	49,342,274 - 49,342,334	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307196	AgrOrtholog
BioCyc Gene	G2FUF-30687	BioCyc
Ensembl Genes	ENSRNOG00000016085	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000021693	ENTREZGENE
	ENSRNOT00000021693.7	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
InterPro	Ig-like	UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	Ig_sub	UniProtKB/TrEMBL
	Ig_V-set	UniProtKB/TrEMBL
	MPZL2	UniProtKB/TrEMBL
	Myelin_P0	UniProtKB/TrEMBL
KEGG Report	rno:300679	UniProtKB/TrEMBL
NCBI Gene	300679	ENTREZGENE
PANTHER	PTHR13869	UniProtKB/TrEMBL
	PTHR13869:SF21	UniProtKB/TrEMBL
Pfam	V-set	UniProtKB/TrEMBL
PhenoGen	Mpzl2	PhenoGen
PRINTS	MYELINP0	UniProtKB/TrEMBL
PROSITE	IG_LIKE	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000016085	RatGTEx
SMART	IGv	UniProtKB/TrEMBL
	SM00409	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48726	UniProtKB/TrEMBL
UniProt	A6J424	ENTREZGENE, UniProtKB/TrEMBL
	D4AAE2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-04	Mpzl2	myelin protein zero-like 2	Eva1_predicted	epithelial V-like antigen 1 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Eva1_predicted	epithelial V-like antigen 1 (predicted)	Eva_predicted	epithelial V-like antigen (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-12	Eva_predicted	epithelial V-like antigen (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

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