Ahsa2 (activator of HSP90 ATPase homolog 2) - Rat Genome Database

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Gene: Ahsa2 (activator of HSP90 ATPase homolog 2) Rattus norvegicus
Analyze
Symbol: Ahsa2
Name: activator of HSP90 ATPase homolog 2
RGD ID: 1307171
Description: Predicted to enable ATPase activator activity and protein-folding chaperone binding activity. Orthologous to human AHSA2P (activator of HSP90 ATPase homolog 2, pseudogene); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: activator of 90 kDa heat shock protein ATPase homolog 2; activator of heat shock protein ATPase homolog 2; activator of heat shock protein ATPase homolog 2 (yeast); AHA1, activator of heat shock protein ATPase 2; AHA1, activator of heat shock protein ATPase homolog 2; AHA1, activator of heat shock protein ATPase homolog 2 (yeast); LOC305577
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814101,677,447 - 101,688,706 (-)NCBIGRCr8
mRatBN7.21497,476,304 - 97,485,725 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1497,476,817 - 97,485,657 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14101,808,480 - 101,817,783 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014103,052,841 - 103,062,144 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01499,524,406 - 99,533,710 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014108,262,795 - 108,274,000 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14108,265,207 - 108,273,938 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014105,098,652 - 105,111,031 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414104,424,340 - 104,435,511 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.114104,445,383 - 104,454,723 (-)NCBI
Celera1496,451,164 - 96,462,335 (-)NCBICelera
Cytogenetic Map14q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
protein folding  (IBA,IEA)

Cellular Component
cytosol  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Ahsa2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814101,677,447 - 101,688,706 (-)NCBIGRCr8
mRatBN7.21497,476,304 - 97,485,725 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1497,476,817 - 97,485,657 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14101,808,480 - 101,817,783 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014103,052,841 - 103,062,144 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01499,524,406 - 99,533,710 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014108,262,795 - 108,274,000 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14108,265,207 - 108,273,938 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014105,098,652 - 105,111,031 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414104,424,340 - 104,435,511 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.114104,445,383 - 104,454,723 (-)NCBI
Celera1496,451,164 - 96,462,335 (-)NCBICelera
Cytogenetic Map14q22NCBI
AHSA2P
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38261,177,418 - 61,188,925 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl261,177,418 - 61,191,203 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl261,177,539 - 61,186,786 (+)EnsemblGRCh38hg38GRCh38
GRCh37261,404,553 - 61,416,060 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36261,258,325 - 61,267,562 (+)NCBINCBI36Build 36hg18NCBI36
Build 34261,316,471 - 61,325,709NCBI
Celera261,249,018 - 61,259,145 (+)NCBICelera
Cytogenetic Map2p15NCBI
HuRef261,145,293 - 61,155,415 (+)NCBIHuRef
CHM1_1261,335,057 - 61,345,168 (+)NCBICHM1_1
T2T-CHM13v2.0261,183,270 - 61,194,773 (+)NCBIT2T-CHM13v2.0
Ahsa2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391123,437,882 - 23,448,045 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1123,437,882 - 23,448,030 (-)EnsemblGRCm39 Ensembl
GRCm381123,487,882 - 23,498,045 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1123,487,882 - 23,498,030 (-)EnsemblGRCm38mm10GRCm38
MGSCv371123,387,882 - 23,397,946 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361123,387,882 - 23,397,946 (-)NCBIMGSCv36mm8
Celera1125,615,778 - 25,625,842 (-)NCBICelera
Cytogenetic Map11A3.2NCBI
cM Map1114.32NCBI
Ahsa2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542422,688,824 - 22,700,820 (-)NCBIChiLan1.0ChiLan1.0
AHSA2P
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21265,192,622 - 65,207,909 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A65,200,188 - 65,211,860 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A61,260,821 - 61,272,041 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A62,399,595 - 62,410,786 (+)NCBIpanpan1.1PanPan1.1panPan2
AHSA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11061,263,722 - 61,266,435 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1061,154,608 - 61,156,671 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01062,273,702 - 62,275,768 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11061,976,438 - 61,978,503 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01062,261,179 - 62,263,246 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01062,556,347 - 62,558,413 (+)NCBIUU_Cfam_GSD_1.0
LOC101971192
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629221,890,890 - 21,903,777 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364916,668,404 - 6,679,817 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AHSA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1380,587,756 - 80,598,089 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
AHSA2P
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11445,798,972 - 45,809,431 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604565,992,194 - 66,002,602 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ahsa2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624833719,909 - 732,251 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ahsa2
26 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:369
Count of miRNA genes:208
Interacting mature miRNAs:264
Transcripts:ENSRNOT00000056855
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat

Markers in Region
AI450991  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21497,476,027 - 97,476,238 (+)MAPPERmRatBN7.2
Rnor_6.014108,264,358 - 108,264,568NCBIRnor6.0
Rnor_5.014105,100,215 - 105,100,425UniSTSRnor5.0
RGSC_v3.414104,425,903 - 104,426,113UniSTSRGSC3.4
Celera1496,452,727 - 96,452,937UniSTS
Cytogenetic Map14q22UniSTS
BE107036  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21497,476,326 - 97,476,511 (+)MAPPERmRatBN7.2
Rnor_6.014108,264,657 - 108,264,841NCBIRnor6.0
Rnor_5.014105,100,514 - 105,100,698UniSTSRnor5.0
RGSC_v3.414104,426,202 - 104,426,386UniSTSRGSC3.4
Celera1496,453,026 - 96,453,210UniSTS
RH 3.4 Map14778.7UniSTS
Cytogenetic Map14q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 51 35 19 35 6 8 74 35 38 11 6
Low 2 6 6 6 2 3 3 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000084642   ⟹   ENSRNOP00000074374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1497,476,817 - 97,485,657 (-)Ensembl
Rnor_6.0 Ensembl14108,265,207 - 108,273,938 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095424   ⟹   ENSRNOP00000091962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1497,476,817 - 97,485,419 (-)Ensembl
RefSeq Acc Id: NM_001401431   ⟹   NP_001388360
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814101,677,447 - 101,686,750 (-)NCBI
mRatBN7.21497,476,304 - 97,485,608 (-)NCBI
RefSeq Acc Id: XM_006251539   ⟹   XP_006251601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814101,677,960 - 101,688,706 (-)NCBI
mRatBN7.21497,476,306 - 97,485,716 (-)NCBI
Rnor_6.014108,264,639 - 108,274,000 (-)NCBI
Rnor_5.014105,098,652 - 105,111,031 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251541   ⟹   XP_006251603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814101,677,960 - 101,688,706 (-)NCBI
mRatBN7.21497,476,306 - 97,485,703 (-)NCBI
Rnor_6.014108,264,639 - 108,273,997 (-)NCBI
Rnor_5.014105,098,652 - 105,111,031 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251542   ⟹   XP_006251604
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814101,677,960 - 101,686,487 (-)NCBI
mRatBN7.21497,476,306 - 97,485,340 (-)NCBI
Rnor_6.014108,264,639 - 108,273,644 (-)NCBI
Rnor_5.014105,098,652 - 105,111,031 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063273267   ⟹   XP_063129337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814101,677,960 - 101,687,443 (-)NCBI
RefSeq Acc Id: XR_005492978
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814101,679,346 - 101,687,443 (-)NCBI
mRatBN7.21497,478,201 - 97,485,725 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_006251601   ⟸   XM_006251539
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ACS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251603   ⟸   XM_006251541
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ACS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251604   ⟸   XM_006251542
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ACS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074374   ⟸   ENSRNOT00000084642
RefSeq Acc Id: ENSRNOP00000091962   ⟸   ENSRNOT00000095424
RefSeq Acc Id: NP_001388360   ⟸   NM_001401431
- UniProtKB: A0A0G2K7W5 (UniProtKB/TrEMBL),   A0A8I6ACS3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129337   ⟸   XM_063273267
- Peptide Label: isoform X2
Protein Domains
Activator of Hsp90 ATPase AHSA1-like N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K7W5-F1-model_v2 AlphaFold A0A0G2K7W5 1-331 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699521
Promoter ID:EPDNEW_R10045
Type:initiation region
Name:Ahsa2_1
Description:activator of HSP90 ATPase homolog 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.014108,273,937 - 108,273,997EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307171 AgrOrtholog
BioCyc Gene G2FUF-14773 BioCyc
Ensembl Genes ENSRNOG00000052142 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000084642 ENTREZGENE
  ENSRNOT00000084642.2 UniProtKB/TrEMBL
  ENSRNOT00000095424.1 UniProtKB/TrEMBL
Gene3D-CATH 3.15.10.20 UniProtKB/TrEMBL
  3.30.530.20 UniProtKB/TrEMBL
InterPro Activator_of_Hsp90_ATPase UniProtKB/TrEMBL
  Aha1 UniProtKB/TrEMBL
  AHSA1_N UniProtKB/TrEMBL
  START-like_dom UniProtKB/TrEMBL
NCBI Gene 305577 ENTREZGENE
PANTHER ACTIVATOR OF 90 KDA HEAT SHOCK PROTEIN ATPASE HOMOLOG 2-RELATED UniProtKB/TrEMBL
  PTHR13009 UniProtKB/TrEMBL
Pfam Aha1_N UniProtKB/TrEMBL
  AHSA1 UniProtKB/TrEMBL
PhenoGen Ahsa2 PhenoGen
RatGTEx ENSRNOG00000052142 RatGTEx
SMART Aha1_N UniProtKB/TrEMBL
Superfamily-SCOP Bet v1-like UniProtKB/TrEMBL
  SSF103111 UniProtKB/TrEMBL
UniProt A0A0G2K7W5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ACS3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-18 Ahsa2  activator of HSP90 ATPase homolog 2  Ahsa2  AHA1, activator of heat shock protein ATPase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-13 Ahsa2  AHA1, activator of heat shock protein ATPase 2  Ahsa2  AHA1, activator of heat shock protein ATPase homolog 2 (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-26 Ahsa2  AHA1, activator of heat shock protein ATPase homolog 2 (yeast)  Ahsa2_predicted  activator of heat shock protein ATPase homolog 2 (yeast) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Ahsa2_predicted  activator of heat shock protein ATPase homolog 2 (yeast) (predicted)      Symbol and Name status set to approved 70820 APPROVED