Tmprss6 (transmembrane serine protease 6) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tmprss6 (transmembrane serine protease 6) Rattus norvegicus
Analyze
Symbol: Tmprss6
Name: transmembrane serine protease 6
RGD ID: 1307138
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including membrane protein proteolysis; regulation of transcription by RNA polymerase II; and self proteolysis. Predicted to act upstream of or within multicellular organismal-level iron ion homeostasis and negative regulation of BMP signaling pathway. Predicted to be located in extracellular space. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in microcytic anemia. Orthologous to human TMPRSS6 (transmembrane serine protease 6); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC315388; transmembrane protease serine 6; transmembrane protease, serine 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87111,871,504 - 111,902,127 (-)NCBIGRCr8
mRatBN7.27109,991,008 - 110,021,626 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7109,985,931 - 110,021,624 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7111,741,252 - 111,771,803 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07113,964,790 - 113,995,347 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07113,932,869 - 113,963,426 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07119,659,323 - 119,689,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7119,659,324 - 119,689,938 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07119,649,831 - 119,680,259 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47116,391,730 - 116,419,671 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17116,425,992 - 116,456,922 (-)NCBI
Celera7106,329,190 - 106,359,893 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12744720   PMID:17981570   PMID:18408718   PMID:19357398   PMID:19751239   PMID:20937842   PMID:25156943   PMID:25860887   PMID:28282554  


Genomics

Comparative Map Data
Tmprss6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87111,871,504 - 111,902,127 (-)NCBIGRCr8
mRatBN7.27109,991,008 - 110,021,626 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7109,985,931 - 110,021,624 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7111,741,252 - 111,771,803 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07113,964,790 - 113,995,347 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07113,932,869 - 113,963,426 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07119,659,323 - 119,689,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7119,659,324 - 119,689,938 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07119,649,831 - 119,680,259 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47116,391,730 - 116,419,671 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17116,425,992 - 116,456,922 (-)NCBI
Celera7106,329,190 - 106,359,893 (-)NCBICelera
Cytogenetic Map7q34NCBI
TMPRSS6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382237,065,436 - 37,110,536 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2237,065,436 - 37,109,713 (-)EnsemblGRCh38hg38GRCh38
GRCh372237,461,476 - 37,505,753 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362235,791,425 - 35,829,639 (-)NCBINCBI36Build 36hg18NCBI36
Build 342235,785,978 - 35,824,193NCBI
Celera2221,262,809 - 21,300,772 (-)NCBICelera
Cytogenetic Map22q12.3NCBI
HuRef2220,426,706 - 20,464,791 (-)NCBIHuRef
CHM1_12237,420,983 - 37,458,920 (-)NCBICHM1_1
T2T-CHM13v2.02237,525,034 - 37,570,488 (-)NCBIT2T-CHM13v2.0
Tmprss6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391578,323,867 - 78,352,848 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1578,323,867 - 78,352,834 (-)EnsemblGRCm39 Ensembl
GRCm381578,439,667 - 78,468,648 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1578,439,667 - 78,468,634 (-)EnsemblGRCm38mm10GRCm38
MGSCv371578,270,097 - 78,299,064 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361578,266,931 - 78,295,735 (-)NCBIMGSCv36mm8
Celera1579,902,371 - 79,931,350 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.49NCBI
Tmprss6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541323,580,530 - 23,612,276 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541323,579,946 - 23,615,277 (-)NCBIChiLan1.0ChiLan1.0
TMPRSS6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22346,921,683 - 46,967,316 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12249,610,237 - 49,655,886 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02217,979,094 - 18,032,590 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12235,815,051 - 35,867,818 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2235,815,051 - 35,859,940 (-)Ensemblpanpan1.1panPan2
TMPRSS6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11027,393,650 - 27,435,893 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1027,397,123 - 27,435,908 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1027,353,491 - 27,390,639 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01028,190,798 - 28,228,167 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1028,190,967 - 28,228,124 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11027,912,441 - 27,949,753 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01028,221,179 - 28,258,351 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01028,399,083 - 28,436,250 (+)NCBIUU_Cfam_GSD_1.0
Tmprss6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494510,804,553 - 10,838,236 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364923,819,309 - 3,848,075 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364923,819,347 - 3,848,372 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMPRSS6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl510,663,635 - 10,705,471 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1510,663,491 - 10,704,583 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.258,263,703 - 8,304,970 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMPRSS6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11919,771,303 - 19,811,751 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1919,771,952 - 19,806,420 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045106,017,797 - 106,057,808 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmprss6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475210,693,634 - 10,727,269 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475210,693,895 - 10,727,269 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmprss6
217 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:66
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000000200
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
D3Rat170  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27110,020,888 - 110,021,016 (+)MAPPERmRatBN7.2
Rnor_6.07119,689,203 - 119,689,330NCBIRnor6.0
Rnor_5.07119,679,522 - 119,679,649UniSTSRnor5.0
Celera7106,359,157 - 106,359,285UniSTS
RH 3.4 Map7815.9RGD
RH 3.4 Map7815.9UniSTS
SHRSP x BN Map347.2998RGD
SHRSP x BN Map347.2998UniSTS
Cytogenetic Map7q34UniSTS
RH135327  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27110,008,637 - 110,008,839 (+)MAPPERmRatBN7.2
Rnor_6.07119,676,952 - 119,677,153NCBIRnor6.0
Rnor_5.07119,667,271 - 119,667,472UniSTSRnor5.0
RGSC_v3.47116,410,914 - 116,411,115UniSTSRGSC3.4
Celera7106,346,903 - 106,347,104UniSTS
RH 3.4 Map7816.5UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 38 83 91 90 59 25 59 6 199 85 63 38 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000000200   ⟹   ENSRNOP00000000200
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7109,991,009 - 110,017,384 (-)Ensembl
Rnor_6.0 Ensembl7119,659,324 - 119,689,938 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097438   ⟹   ENSRNOP00000080392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7109,990,993 - 110,021,624 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103139   ⟹   ENSRNOP00000095497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7109,985,931 - 110,021,624 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109455   ⟹   ENSRNOP00000095053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7109,993,755 - 110,017,384 (-)Ensembl
RefSeq Acc Id: NM_001130556   ⟹   NP_001124028
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87111,871,505 - 111,902,116 (-)NCBI
mRatBN7.27109,991,009 - 110,021,624 (-)NCBI
Rnor_6.07119,659,324 - 119,689,938 (-)NCBI
Rnor_5.07119,649,831 - 119,680,259 (-)NCBI
RGSC_v3.47116,391,730 - 116,419,671 (-)RGD
Celera7106,329,190 - 106,359,893 (-)RGD
Sequence:
RefSeq Acc Id: XM_006241995   ⟹   XP_006242057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87111,871,504 - 111,902,125 (-)NCBI
mRatBN7.27109,991,008 - 110,021,625 (-)NCBI
Rnor_6.07119,659,323 - 119,689,953 (-)NCBI
Rnor_5.07119,649,831 - 119,680,259 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241996   ⟹   XP_006242058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87111,871,504 - 111,902,127 (-)NCBI
mRatBN7.27109,991,536 - 110,021,626 (-)NCBI
Rnor_6.07119,659,323 - 119,689,953 (-)NCBI
Rnor_5.07119,649,831 - 119,680,259 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001124028   ⟸   NM_001130556
- UniProtKB: D3ZF49 (UniProtKB/TrEMBL),   A6HSK5 (UniProtKB/TrEMBL),   A0A8I6ANM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242058   ⟸   XM_006241996
- Peptide Label: isoform X2
- UniProtKB: A0A8I6G6J0 (UniProtKB/TrEMBL),   A0A8I6ANM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242057   ⟸   XM_006241995
- Peptide Label: isoform X1
- UniProtKB: A6HSK7 (UniProtKB/TrEMBL),   A0A8I6ANM9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000200   ⟸   ENSRNOT00000000200
Ensembl Acc Id: ENSRNOP00000095497   ⟸   ENSRNOT00000103139
Ensembl Acc Id: ENSRNOP00000080392   ⟸   ENSRNOT00000097438
Ensembl Acc Id: ENSRNOP00000095053   ⟸   ENSRNOT00000109455
Protein Domains
CUB   Peptidase S1   SEA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZF49-F1-model_v2 AlphaFold D3ZF49 1-772 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695462
Promoter ID:EPDNEW_R5987
Type:multiple initiation site
Name:Tmprss6_1
Description:transmembrane protease, serine 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07119,689,944 - 119,690,004EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307138 AgrOrtholog
BioCyc Gene G2FUF-32819 BioCyc
Ensembl Genes ENSRNOG00000000184 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000200.7 UniProtKB/TrEMBL
  ENSRNOT00000097438.1 UniProtKB/TrEMBL
  ENSRNOT00000103139.1 UniProtKB/TrEMBL
  ENSRNOT00000109455.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
  2.60.120.290 UniProtKB/TrEMBL
  3.30.70.960 UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/TrEMBL
InterPro CUB UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDLR_classA_rpt UniProtKB/TrEMBL
  Peptidase_S1 UniProtKB/TrEMBL
  Peptidase_S1_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  SEA UniProtKB/TrEMBL
  SEA_dom_sf UniProtKB/TrEMBL
  sperma_CUB_dom UniProtKB/TrEMBL
  Trypsin-like_Pept_dom UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:315388 UniProtKB/TrEMBL
NCBI Gene 315388 ENTREZGENE
PANTHER ACROSIN-RELATED UniProtKB/TrEMBL
  LOW QUALITY PROTEIN: TRANSMEMBRANE PROTEASE SERINE 6 UniProtKB/TrEMBL
  LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED UniProtKB/TrEMBL
  PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1-LIKE PROTEIN UniProtKB/TrEMBL
Pfam Ldl_recept_a UniProtKB/TrEMBL
  SEA UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
PhenoGen Tmprss6 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
  LDLRECEPTOR UniProtKB/TrEMBL
PROSITE CUB UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
  SEA UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000184 RatGTEx
SMART LDLa UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP CUB UniProtKB/TrEMBL
  LDL_rcpt_classA_cys-rich UniProtKB/TrEMBL
  Pept_Ser_Cys UniProtKB/TrEMBL
  SSF82671 UniProtKB/TrEMBL
UniProt A0A8I6AN63_RAT UniProtKB/TrEMBL
  A0A8I6ANM9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G6J0 ENTREZGENE, UniProtKB/TrEMBL
  A6HSK5 ENTREZGENE, UniProtKB/TrEMBL
  A6HSK7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZF49 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-26 Tmprss6  transmembrane serine protease 6  Tmprss6  transmembrane protease, serine 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-20 Tmprss6  transmembrane protease, serine 6  Tmprss6  transmembrane serine protease 6   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Tmprss6  transmembrane serine protease 6   Tmprss6_predicted  transmembrane serine protease 6 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tmprss6_predicted  transmembrane serine protease 6 (predicted)      Symbol and Name status set to approved 70820 APPROVED