Shc2 (SHC adaptor protein 2) - Rat Genome Database

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Gene: Shc2 (SHC adaptor protein 2) Rattus norvegicus
Analyze
Symbol: Shc2
Name: SHC adaptor protein 2
RGD ID: 1307137
Description: Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be active in plasma membrane. Orthologous to human SHC2 (SHC adaptor protein 2); PARTICIPATES IN chemokine mediated signaling pathway; chronic myeloid leukemia pathway; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC314612; protein Sck; SH2 domain protein C2; SHC (Src homology 2 domain containing) transforming protein 2; SHC-transforming protein 2; src homology 2 domain-containing transforming; src homology 2 domain-containing transforming protein C2; src homology 2 domain-containing-transforming protein C2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,717,320 - 10,739,539 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl710,717,320 - 10,739,539 (+)EnsemblGRCr8
mRatBN7.2710,066,705 - 10,088,926 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl710,066,705 - 10,088,926 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx712,948,071 - 12,970,304 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,826,155 - 14,848,390 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,685,795 - 12,708,193 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,948,952 - 12,971,174 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,948,952 - 12,971,174 (+)Ensemblrn6Rnor6.0
Rnor_5.0713,117,670 - 13,139,889 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4711,583,380 - 11,605,675 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera78,239,277 - 8,261,491 (+)NCBICelera
RGSC_v3.1711,582,082 - 11,604,162 (+)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Differential regulation of Shc adaptor proteins in skeletal muscle, spinal cord and forebrain of aged rats with sensorimotor impairment. Jiang X, etal., Aging Cell 2003 Feb;2(1):47-57.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Shc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,717,320 - 10,739,539 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl710,717,320 - 10,739,539 (+)EnsemblGRCr8
mRatBN7.2710,066,705 - 10,088,926 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl710,066,705 - 10,088,926 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx712,948,071 - 12,970,304 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,826,155 - 14,848,390 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,685,795 - 12,708,193 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,948,952 - 12,971,174 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,948,952 - 12,971,174 (+)Ensemblrn6Rnor6.0
Rnor_5.0713,117,670 - 13,139,889 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4711,583,380 - 11,605,675 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera78,239,277 - 8,261,491 (+)NCBICelera
RGSC_v3.1711,582,082 - 11,604,162 (+)NCBI
Cytogenetic Map7q11NCBI
SHC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819416,589 - 461,033 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19416,589 - 461,100 (-)Ensemblhg38GRCh38
GRCh3719416,589 - 461,033 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3619367,583 - 411,832 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3419411,901 - 411,957NCBI
Cytogenetic Map19p13.3NCBI
HuRef19185,638 - 230,388 (-)NCBIHuRef
CHM1_119413,915 - 460,585 (-)NCBICHM1_1
T2T-CHM13v2.019364,869 - 412,538 (-)NCBIT2T-CHM13v2.0
Shc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,453,768 - 79,473,752 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,453,885 - 79,473,752 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381079,617,934 - 79,637,918 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,618,051 - 79,637,918 (-)Ensemblmm10GRCm38
MGSCv371079,080,679 - 79,100,663 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361079,021,033 - 79,040,990 (-)NCBIMGSCv36mm8
Celera1080,631,300 - 80,651,284 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Shc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554957,210,577 - 7,236,056 (+)Ensembl
ChiLan1.0NW_0049554957,216,806 - 7,236,056 (+)NCBIChiLan1.0ChiLan1.0
SHC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2204,723,555 - 4,787,947 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1193,967,330 - 4,025,675 (-)NCBINHGRI_mPanPan1
PanPan1.119367,348 - 405,054 (-)NCBIPanPan1.1PanPan1.1panPan2
SHC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12058,001,442 - 58,023,201 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,804,227 - 57,825,834 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02058,744,465 - 58,766,097 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,743,210 - 58,766,090 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,798,377 - 57,819,985 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02058,278,093 - 58,299,887 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,481,722 - 58,503,345 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Shc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,725,930 - 217,743,083 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493658890,810 - 108,341 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493658891,700 - 109,784 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SHC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1277,812,379 - 77,844,032 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SHC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16151,955 - 193,626 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660818,929,577 - 8,971,785 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Shc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248287,978,031 - 7,996,448 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Shc2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11155,234,838 - 155,256,235 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Shc2
388 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:189
Count of miRNA genes:139
Interacting mature miRNAs:155
Transcripts:ENSRNOT00000010714
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 154 91 90 59 72 59 6 331 172 11 133 76 92 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000010714   ⟹   ENSRNOP00000010714
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl710,717,320 - 10,739,539 (+)Ensembl
mRatBN7.2 Ensembl710,066,705 - 10,088,926 (+)Ensembl
Rnor_6.0 Ensembl712,948,952 - 12,971,174 (+)Ensembl
RefSeq Acc Id: NM_001108065   ⟹   NP_001101535
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,717,320 - 10,739,539 (+)NCBI
mRatBN7.2710,066,705 - 10,088,926 (+)NCBI
Rnor_6.0712,948,952 - 12,971,174 (+)NCBI
Rnor_5.0713,117,670 - 13,139,889 (+)NCBI
RGSC_v3.4711,583,380 - 11,605,675 (+)RGD
Celera78,239,277 - 8,261,491 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101535 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL89416 (Get FASTA)   NCBI Sequence Viewer  
  EDL89417 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010714
  ENSRNOP00000010714.5
GenBank Protein O70142 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001101535   ⟸   NM_001108065
- UniProtKB: O70142 (UniProtKB/Swiss-Prot),   A6K8Z6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010714   ⟸   ENSRNOT00000010714
Protein Domains
PID   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70142-F1-model_v2 AlphaFold O70142 1-573 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695057
Promoter ID:EPDNEW_R5581
Type:initiation region
Name:Shc2_1
Description:SHC adaptor protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,948,998 - 12,949,058EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307137 AgrOrtholog
BioCyc Gene G2FUF-34876 BioCyc
Ensembl Genes ENSRNOG00000008030 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010714 ENTREZGENE
  ENSRNOT00000010714.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
  3.30.505.10 UniProtKB/Swiss-Prot
InterPro CEP152/SHC-Transforming UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PID_Shc-like UniProtKB/Swiss-Prot
  PTB/PI_dom UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SHC_SH2 UniProtKB/Swiss-Prot
KEGG Report rno:314612 UniProtKB/Swiss-Prot
NCBI Gene 314612 ENTREZGENE
PANTHER PTHR10337:SF5 UniProtKB/Swiss-Prot
  SHC TRANSFORMING PROTEIN UniProtKB/Swiss-Prot
Pfam PID UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
PhenoGen Shc2 PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot
  SHCPIDOMAIN UniProtKB/Swiss-Prot
PROSITE PID UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008030 RatGTEx
SMART PTB UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
UniProt A6K8Z6 ENTREZGENE, UniProtKB/TrEMBL
  O70142 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-20 Shc2  SHC adaptor protein 2  Shc2  SHC (Src homology 2 domain containing) transforming protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-04 Shc2  SHC (Src homology 2 domain containing) transforming protein 2  Shc2  src homology 2 domain-containing transforming protein C2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Shc2  src homology 2 domain-containing transforming protein C2   Shc2_predicted  src homology 2 domain-containing transforming protein C2 (predicted)  'predicted' is removed 2292626 APPROVED
2007-04-24 Shc2_predicted  src homology 2 domain-containing transforming protein C2 (predicted)  Shc2  src homology 2 domain-containing transforming protein C2  Data merged from RGD:69347 737654 APPROVED
2005-01-12 Shc2_predicted  src homology 2 domain-containing transforming protein C2 (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-06-10 Shc2  src homology 2 domain-containing transforming protein C2      Name updated 70584 APPROVED