Aspm (assembly factor for spindle microtubules) - Rat Genome Database

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Gene: Aspm (assembly factor for spindle microtubules) Rattus norvegicus
Analyze
Symbol: Aspm
Name: assembly factor for spindle microtubules
RGD ID: 1307111
Description: Predicted to enable calmodulin binding activity. Predicted to be involved in regulation of meiotic cell cycle; spindle localization; and spindle organization. Predicted to act upstream of or within several processes, including maintenance of centrosome location; nervous system development; and neuronal stem cell population maintenance. Located in apical plasma membrane; microtubule cytoskeleton; and midbody. Human ortholog(s) of this gene implicated in microcephaly; primary autosomal recessive microcephaly; primary autosomal recessive microcephaly 5; and visual epilepsy. Orthologous to human ASPM (assembly factor for spindle microtubules); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: abnormal spindle microtubule assembly; asp (abnormal spindle) homolog, microcephaly associated; asp (abnormal spindle) homolog, microcephaly associated (Drosophila); asp (abnormal spindle)-like, microcephaly associated; asp (abnormal spindle)-like, microcephaly associated (Drosophila) ; Calmbp1; calmodulin binding protein 1; LOC289054
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81353,625,584 - 53,674,489 (+)NCBIGRCr8
mRatBN7.21351,074,849 - 51,123,755 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1351,074,849 - 51,123,755 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1353,674,430 - 53,723,339 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01354,962,363 - 55,011,271 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01352,237,670 - 52,286,704 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01356,546,021 - 56,591,793 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1356,546,021 - 56,591,793 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01361,564,059 - 61,609,831 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41352,811,658 - 52,860,925 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11352,825,867 - 52,874,707 (+)NCBI
Celera1351,338,709 - 51,386,444 (+)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-palmitoylglycerol  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-Hydroxybenzo[a]pyrene  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
boron nitride  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chromium(3+) trichloride  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
erythromycin estolate  (EXP)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (EXP)
gamma-tocopherol  (ISO)
geldanamycin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
leflunomide  (ISO)
lidocaine  (EXP)
lucanthone  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methylmercury chloride  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nicotine  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phytoestrogen  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
riboflavin  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP)
tocopherol  (ISO)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Deregulation of microcephalin and ASPM expression are correlated with epithelial ovarian cancer progression. Alsiary R, etal., PLoS One. 2014 May 15;9(5):e97059. doi: 10.1371/journal.pone.0097059. eCollection 2014.
2. ASPM-associated stem cell proliferation is involved in malignant progression of gliomas and constitutes an attractive therapeutic target. Bikeye SN, etal., Cancer Cell Int. 2010 Jan 11;10:1. doi: 10.1186/1475-2867-10-1.
3. Primary microcephaly with ASPM mutation shows simplified cortical gyration with antero-posterior gradient pre- and post-natally. Desir J, etal., Am J Med Genet A. 2008 Jun 1;146A(11):1439-43. doi: 10.1002/ajmg.a.32312.
4. Expression analysis of the autosomal recessive primary microcephaly genes MCPH1 (microcephalin) and MCPH5 (ASPM, abnormal spindle-like, microcephaly associated) in human malignant gliomas. Hagemann C, etal., Oncol Rep. 2008 Aug;20(2):301-8.
5. Mutation analysis of the ASPM gene in 18 Pakistani families with autosomal recessive primary microcephaly. Kousar R, etal., J Child Neurol. 2010 Jun;25(6):715-20. doi: 10.1177/0883073809346850. Epub 2009 Oct 6.
6. ASPM is a novel marker for vascular invasion, early recurrence, and poor prognosis of hepatocellular carcinoma. Lin SY, etal., Clin Cancer Res. 2008 Aug 1;14(15):4814-20. doi: 10.1158/1078-0432.CCR-07-5262.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. ASPM and citron kinase co-localize to the midbody ring during cytokinesis. Paramasivam M, etal., Cell Cycle. 2007 Jul 1;6(13):1605-12. Epub 2007 Apr 27.
9. Expanding the clinical and neuroradiologic phenotype of primary microcephaly due to ASPM mutations. Passemard S, etal., Neurology. 2009 Sep 22;73(12):962-9. doi: 10.1212/WNL.0b013e3181b8799a.
10. Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline. Pulvers JN, etal., Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16595-600. doi: 10.1073/pnas.1010494107. Epub 2010 Sep 7.
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. ASPM mutations identified in patients with primary microcephaly and seizures. Shen J, etal., J Med Genet. 2005 Sep;42(9):725-9.
15. Genome-wide analysis of the oxyntic proliferative isthmus zone reveals ASPM as a possible gastric stem/progenitor cell marker over-expressed in cancer. Vange P, etal., J Pathol. 2015 Dec;237(4):447-59. doi: 10.1002/path.4591. Epub 2015 Aug 26.
Additional References at PubMed
PMID:15972725   PMID:16798874   PMID:19896444   PMID:21044324   PMID:21937711   PMID:22031545   PMID:23152892   PMID:24220505  


Genomics

Comparative Map Data
Aspm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81353,625,584 - 53,674,489 (+)NCBIGRCr8
mRatBN7.21351,074,849 - 51,123,755 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1351,074,849 - 51,123,755 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1353,674,430 - 53,723,339 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01354,962,363 - 55,011,271 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01352,237,670 - 52,286,704 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01356,546,021 - 56,591,793 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1356,546,021 - 56,591,793 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01361,564,059 - 61,609,831 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41352,811,658 - 52,860,925 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11352,825,867 - 52,874,707 (+)NCBI
Celera1351,338,709 - 51,386,444 (+)NCBICelera
Cytogenetic Map13q13NCBI
ASPM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381197,084,127 - 197,146,669 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1197,084,121 - 197,146,694 (-)EnsemblGRCh38hg38GRCh38
GRCh371197,053,257 - 197,115,799 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361195,319,997 - 195,382,287 (-)NCBINCBI36Build 36hg18NCBI36
Build 341193,785,110 - 193,847,224NCBI
Celera1170,178,726 - 170,241,291 (-)NCBICelera
Cytogenetic Map1q31.3NCBI
HuRef1168,210,775 - 168,273,332 (-)NCBIHuRef
CHM1_11198,475,715 - 198,538,290 (-)NCBICHM1_1
T2T-CHM13v2.01196,345,951 - 196,408,493 (-)NCBIT2T-CHM13v2.0
Aspm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391139,381,450 - 139,421,826 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1139,382,510 - 139,421,829 (+)EnsemblGRCm39 Ensembl
GRCm381139,454,188 - 139,494,088 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1139,454,772 - 139,494,091 (+)EnsemblGRCm38mm10GRCm38
MGSCv371141,351,350 - 141,390,665 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361141,271,184 - 141,310,501 (+)NCBIMGSCv36mm8
Celera1142,091,996 - 142,131,299 (+)NCBICelera
Cytogenetic Map1FNCBI
cM Map161.45NCBI
Aspm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540633,661,322 - 33,720,259 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540633,665,675 - 33,720,468 (-)NCBIChiLan1.0ChiLan1.0
ASPM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2152,234,381 - 52,296,951 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1152,203,536 - 52,265,974 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01172,674,890 - 172,737,426 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11176,988,297 - 177,050,810 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1176,988,297 - 177,050,810 (-)Ensemblpanpan1.1panPan2
ASPM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.175,591,530 - 5,663,673 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl75,590,957 - 5,660,919 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha75,214,490 - 5,283,621 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.075,281,249 - 5,357,084 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl75,281,133 - 5,357,008 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.175,223,076 - 5,291,758 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.075,324,076 - 5,392,760 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.075,356,703 - 5,425,864 (+)NCBIUU_Cfam_GSD_1.0
Aspm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934477,418,215 - 77,467,185 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365676,653,728 - 6,701,752 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365676,653,382 - 6,701,856 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASPM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1019,975,192 - 20,039,623 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11019,971,516 - 20,039,680 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21024,612,797 - 24,657,404 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ASPM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12532,269,518 - 32,334,617 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2532,281,424 - 32,334,977 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605533,177,890 - 33,242,078 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aspm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247983,165,393 - 3,225,181 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247983,164,145 - 3,223,810 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aspm
355 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:247
Count of miRNA genes:169
Interacting mature miRNAs:188
Transcripts:ENSRNOT00000016797
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134372077062022792Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat

Markers in Region
RH144463  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,257,063 - 76,257,271 (+)MAPPERmRatBN7.2
Rnor_6.0981,960,727 - 81,960,934NCBIRnor6.0
Rnor_5.0981,723,109 - 81,723,316UniSTSRnor5.0
RGSC_v3.4974,031,162 - 74,031,369UniSTSRGSC3.4
Celera973,829,516 - 73,829,723UniSTS
RH 3.4 Map9712.2UniSTS
Cytogenetic Map13q13UniSTS
Aspm  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21351,110,544 - 51,111,542 (+)MAPPERmRatBN7.2
Rnor_6.01356,578,583 - 56,579,580NCBIRnor6.0
Rnor_5.01361,596,621 - 61,597,618UniSTSRnor5.0
Celera1351,373,234 - 51,374,231UniSTS
Cytogenetic Map13q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 22 25 18 14 18 33 16 32
Low 3 17 28 19 5 19 4 4 41 18 9 11 4
Below cutoff 4 4 4 4 4 7 1 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016797   ⟹   ENSRNOP00000016797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1351,074,849 - 51,123,755 (+)Ensembl
Rnor_6.0 Ensembl1356,546,021 - 56,591,793 (+)Ensembl
RefSeq Acc Id: NM_001105955   ⟹   NP_001099425
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81353,625,584 - 53,674,489 (+)NCBI
mRatBN7.21351,074,849 - 51,123,755 (+)NCBI
Rnor_6.01356,546,021 - 56,591,793 (+)NCBI
Rnor_5.01361,564,059 - 61,609,831 (+)NCBI
RGSC_v3.41352,811,658 - 52,860,925 (+)RGD
Celera1351,338,709 - 51,386,444 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001099425 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM09621 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016797
  ENSRNOP00000016797.7
Reference Protein Sequences
RefSeq Acc Id: NP_001099425   ⟸   NM_001105955
- UniProtKB: D3ZZQ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016797   ⟸   ENSRNOT00000016797
Protein Domains
Calponin-homology (CH)

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698864
Promoter ID:EPDNEW_R9389
Type:initiation region
Name:Aspm_1
Description:abnormal spindle microtubule assembly
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01356,546,075 - 56,546,135EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307111 AgrOrtholog
BioCyc Gene G2FUF-18075 BioCyc
Ensembl Genes ENSRNOG00000012318 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016797 ENTREZGENE
  ENSRNOT00000016797.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  1.20.5.190 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  Calponin-like_dom_sf UniProtKB/TrEMBL
  Calponin_act-bd UniProtKB/TrEMBL
  IQ_CaM-bd_region UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene 289054 ENTREZGENE
PANTHER SPERMATOGENESIS-ASSOCIATED PROTEIN 17 UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/TrEMBL
Pfam PF00307 UniProtKB/TrEMBL
  PF00612 UniProtKB/TrEMBL
PhenoGen Aspm PhenoGen
PROSITE PS50021 UniProtKB/TrEMBL
  PS50096 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012318 RatGTEx
SMART SM00015 UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
Superfamily-SCOP Calponin-homology UniProtKB/TrEMBL
  SSF48371 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt D3ZZQ1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-01-09 Aspm  assembly factor for spindle microtubules  Aspm  abnormal spindle microtubule assembly  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-08-27 Aspm  abnormal spindle microtubule assembly  Aspm  asp (abnormal spindle) homolog, microcephaly associated (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Aspm  asp (abnormal spindle) homolog, microcephaly associated (Drosophila)  Aspm  asp (abnormal spindle)-like, microcephaly associated (Drosophila)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Aspm  asp (abnormal spindle)-like, microcephaly associated (Drosophila)   Aspm_predicted  asp (abnormal spindle)-like, microcephaly associated (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Aspm_predicted  asp (abnormal spindle)-like, microcephaly associated (Drosophila) (predicted)  Calmbp1_predicted  calmodulin binding protein 1 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Calmbp1_predicted  calmodulin binding protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED