Ppef2 (protein phosphatase with EF-hand domain 2) - Rat Genome Database

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Gene: Ppef2 (protein phosphatase with EF-hand domain 2) Rattus norvegicus
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Symbol: Ppef2
Name: protein phosphatase with EF-hand domain 2
RGD ID: 1307093
Description: Predicted to enable several functions, including heat shock protein binding activity; mitogen-activated protein kinase kinase kinase binding activity; and protein serine/threonine kinase inhibitor activity. Predicted to be involved in cellular response to hydrogen peroxide; negative regulation of MAPK cascade; and negative regulation of apoptotic signaling pathway. Predicted to be active in cytosol and nucleus. Orthologous to human PPEF2 (protein phosphatase with EF-hand domain 2); INTERACTS WITH 1,2-dimethylhydrazine; 3,3',4,4',5-pentachlorobiphenyl; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC305246; protein phosphatase, EF hand calcium-binding domain 2; serine/threonine-protein phosphatase with EF-hands 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81416,081,706 - 16,115,903 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1416,081,706 - 16,115,903 (+)EnsemblGRCr8
mRatBN7.21415,797,414 - 15,831,620 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1415,797,435 - 15,831,491 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1415,806,128 - 15,840,041 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01417,124,981 - 17,158,888 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01415,820,423 - 15,854,336 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01417,306,825 - 17,333,588 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1417,306,825 - 17,333,588 (-)Ensemblrn6Rnor6.0
Rnor_5.01417,220,015 - 17,254,101 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41417,359,298 - 17,392,820 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1415,191,812 - 15,226,681 (+)NCBICelera
RGSC_v3.11417,366,155 - 17,392,304 (+)NCBI
Cytogenetic Map14p22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA)
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20674765  


Genomics

Comparative Map Data
Ppef2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81416,081,706 - 16,115,903 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1416,081,706 - 16,115,903 (+)EnsemblGRCr8
mRatBN7.21415,797,414 - 15,831,620 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1415,797,435 - 15,831,491 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1415,806,128 - 15,840,041 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01417,124,981 - 17,158,888 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01415,820,423 - 15,854,336 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01417,306,825 - 17,333,588 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1417,306,825 - 17,333,588 (-)Ensemblrn6Rnor6.0
Rnor_5.01417,220,015 - 17,254,101 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41417,359,298 - 17,392,820 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1415,191,812 - 15,226,681 (+)NCBICelera
RGSC_v3.11417,366,155 - 17,392,304 (+)NCBI
Cytogenetic Map14p22NCBI
PPEF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38475,859,867 - 75,902,452 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl475,859,864 - 75,902,571 (-)Ensemblhg38GRCh38
GRCh37476,781,020 - 76,823,605 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36477,000,049 - 77,042,705 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34477,138,206 - 77,180,860NCBI
Celera474,081,428 - 74,124,167 (-)NCBICelera
Cytogenetic Map4q21.1NCBI
HuRef472,533,638 - 72,576,290 (-)NCBIHuRef
CHM1_1476,757,660 - 76,800,341 (-)NCBICHM1_1
T2T-CHM13v2.0479,199,974 - 79,242,943 (-)NCBIT2T-CHM13v2.0
Ppef2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39592,374,109 - 92,404,759 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl592,374,538 - 92,404,137 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38592,226,679 - 92,256,278 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl592,226,679 - 92,256,278 (-)Ensemblmm10GRCm38
MGSCv37592,656,000 - 92,682,185 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36593,301,879 - 93,331,478 (-)NCBIMGSCv36mm8
Celera590,370,721 - 90,397,012 (-)NCBICelera
Cytogenetic Map5E2NCBI
cM Map546.28NCBI
Ppef2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554741,758,988 - 1,770,427 (+)NCBIChiLan1.0ChiLan1.0
PPEF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2354,175,626 - 54,214,835 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1454,365,444 - 54,404,651 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0448,308,761 - 48,345,861 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1454,141,778 - 54,184,351 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl454,141,778 - 54,184,351 (+)EnsemblpanPan2panpan1.1
PPEF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.132443,495 - 467,929 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3241,413,982 - 41,438,265 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.032468,224 - 493,100 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl32468,209 - 492,816 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.132468,945 - 492,944 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.032420,736 - 445,091 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03239,723,367 - 39,747,609 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ppef2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528511,613,000 - 11,650,316 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493659864,997 - 106,208 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493659865,009 - 102,349 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPEF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl871,519,274 - 71,573,563 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1871,519,873 - 71,555,977 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2875,655,670 - 75,700,481 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPEF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1724,371,242 - 24,407,311 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl724,371,587 - 24,406,695 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660372,713,831 - 2,754,856 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppef2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248724,726,647 - 4,747,516 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248724,726,169 - 4,805,021 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ppef2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1115,072,798 - 5,098,579 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ppef2
281 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:38
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000003122
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14395787821572472Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14395787818558812Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141133490630674469Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141133471628389666Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14117877928Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141513759431238250Rat

Markers in Region
stSG607015  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21415,797,055 - 15,798,143 (+)MAPPERmRatBN7.2
mRatBN7.2135,548,790 - 5,549,884 (+)MAPPERmRatBN7.2
Rnor_6.01417,303,009 - 17,304,096NCBIRnor6.0
Rnor_6.0138,574,590 - 8,575,683NCBIRnor6.0
Rnor_5.01417,219,636 - 17,220,723UniSTSRnor5.0
Rnor_5.01313,839,936 - 13,841,029UniSTSRnor5.0
Cytogenetic Map14p22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 12 62 146 73 72 41 30 41 6 242 119 5 123 64 89 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000077636   ⟹   ENSRNOP00000075449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1416,081,706 - 16,115,903 (+)Ensembl
mRatBN7.2 Ensembl1415,797,435 - 15,831,491 (+)Ensembl
Rnor_6.0 Ensembl1417,306,825 - 17,333,588 (-)Ensembl
RefSeq Acc Id: NM_001107210   ⟹   NP_001100680
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81416,081,706 - 16,115,903 (+)NCBI
mRatBN7.21415,797,414 - 15,831,620 (+)NCBI
Rnor_6.01417,306,825 - 17,333,588 (-)NCBI
Rnor_5.01417,220,015 - 17,254,101 (+)NCBI
RGSC_v3.41417,359,298 - 17,392,820 (+)RGD
Celera1415,191,812 - 15,226,681 (+)RGD
Sequence:
RefSeq Acc Id: XM_039091867   ⟹   XP_038947795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81416,089,055 - 16,115,773 (+)NCBI
mRatBN7.21415,804,770 - 15,831,614 (+)NCBI
RefSeq Acc Id: XM_039091868   ⟹   XP_038947796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81416,096,636 - 16,115,773 (+)NCBI
mRatBN7.21415,812,345 - 15,831,614 (+)NCBI
RefSeq Acc Id: NP_001100680   ⟸   NM_001107210
- UniProtKB: D3ZN69 (UniProtKB/TrEMBL),   A6KKA0 (UniProtKB/TrEMBL),   A6KKA1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075449   ⟸   ENSRNOT00000077636
RefSeq Acc Id: XP_038947795   ⟸   XM_039091867
- Peptide Label: isoform X1
- UniProtKB: A6KKA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038947796   ⟸   XM_039091868
- Peptide Label: isoform X2
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZN69-F1-model_v2 AlphaFold D3ZN69 1-754 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307093 AgrOrtholog
BioCyc Gene G2FUF-16255 BioCyc
Ensembl Genes ENSRNOG00000052061 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000077636 ENTREZGENE
  ENSRNOT00000077636.3 UniProtKB/TrEMBL
Gene3D-CATH 3.60.21.10 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
InterPro EF-hand-like_dom UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_Ca-bd UniProtKB/TrEMBL
  M-pesterase UniProtKB/TrEMBL
  Metallo-depent_PP-like UniProtKB/TrEMBL
  PPP5 UniProtKB/TrEMBL
  PPP_phosphatase UniProtKB/TrEMBL
  Ser/Thr-Pase_EF-hand_contain UniProtKB/TrEMBL
  Ser/Thr-sp_prot-phosphatase UniProtKB/TrEMBL
KEGG Report rno:305246 UniProtKB/TrEMBL
NCBI Gene 305246 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN PHOSPHATASE WITH EF-HANDS 2 UniProtKB/TrEMBL
Pfam EF_hand_5 UniProtKB/TrEMBL
  Metallophos UniProtKB/TrEMBL
  PPP5 UniProtKB/TrEMBL
PhenoGen Ppef2 PhenoGen
PIRSF PPEF UniProtKB/TrEMBL
PRINTS STPHPHTASE UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  PS50096 UniProtKB/TrEMBL
  SER_THR_PHOSPHATASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000052061 RatGTEx
SMART EFh UniProtKB/TrEMBL
  PP2Ac UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
  SSF56300 UniProtKB/TrEMBL
UniProt A6KKA0 ENTREZGENE, UniProtKB/TrEMBL
  A6KKA1 ENTREZGENE, UniProtKB/TrEMBL
  D3ZN69 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Ppef2  protein phosphatase with EF-hand domain 2  Ppef2  protein phosphatase, EF hand calcium-binding domain 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ppef2  protein phosphatase, EF hand calcium-binding domain 2   Ppef2_predicted  protein phosphatase, EF hand calcium-binding domain 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ppef2_predicted  protein phosphatase, EF hand calcium-binding domain 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED