Tfb2m (transcription factor B2, mitochondrial)

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Gene: Tfb2m (transcription factor B2, mitochondrial) Rattus norvegicus

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Symbol:

Tfb2m

Name:

transcription factor B2, mitochondrial

RGD ID:

1307091

Description:

Predicted to enable mitochondrial transcription factor activity and rRNA (adenine-N6,N6-)-dimethyltransferase activity. Predicted to be involved in rRNA methylation and transcription initiation at mitochondrial promoter. Predicted to be located in mitochondrial nucleoid. Predicted to be active in mitochondrial matrix. Orthologous to human TFB2M (transcription factor B2, mitochondrial); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

dimethyladenosine transferase 2, mitochondrial; dimethyladenosine transferase 2, mitochondrial-like; LOC108348143; LOC289307; mitochondrial 12S rRNA dimethylase 2; mitochondrial transcription factor B2; mtTFB2; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	93,810,859 - 93,828,678 (-)	NCBI		GRCr8
mRatBN7.2	13	91,278,889 - 91,296,709 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	91,278,898 - 91,296,657 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	93,784,087 - 93,801,822 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	95,184,250 - 95,201,981 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	92,358,929 - 92,376,664 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	97,820,493 - 97,838,275 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	97,613,991 - 97,628,059 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	13	97,820,493 - 97,838,228 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	102,830,291 - 102,848,026 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	13	102,630,835 - 102,643,959 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	95,228,520 - 95,246,255 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	95,417,455 - 95,435,191 (-)	NCBI
Celera	13	90,831,066 - 90,847,804 (-)	NCBI		Celera
Cytogenetic Map	13	q26	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

developmental and epileptic encephalopathy 54 (ISO)

gastrointestinal stromal tumor (ISO)

parathyroid carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

acetamide (EXP)

aldehydo-D-glucose (EXP)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

arsenous acid (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

Cinobufagin (ISO)

cisplatin (ISO)

cobalt dichloride (EXP)

copper(II) sulfate (ISO)

D-glucose (EXP)

DDE (ISO)

diarsenic trioxide (ISO)

dicrotophos (ISO)

dimethyl fumarate (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

enniatin (EXP)

ethyl methanesulfonate (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

formononetin (EXP)

gamma-hexachlorocyclohexane (ISO)

gentamycin (EXP)

glucose (EXP)

hydrogen peroxide (ISO)

ivermectin (ISO)

lead(0) (ISO)

leflunomide (ISO)

lipopolysaccharide (ISO)

nefazodone (EXP)

nimesulide (EXP)

paracetamol (ISO)

perfluorooctanoic acid (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

T-2 toxin (EXP)

tetrachloromethane (EXP)

titanium dioxide (ISO)

Triptolide (ISO)

triptonide (ISO)

tungsten (ISO)

valproic acid (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mitochondrial transcription (ISO)

rRNA methylation (IBA,IEA)

transcription initiation at mitochondrial promoter (IBA,ISO,ISS)

Cellular Component

mitochondrial matrix (IBA,ISO)

mitochondrial nucleoid (ISO)

mitochondrion (IEA,ISO)

Molecular Function

mitochondrial transcription factor activity (IBA,ISO,ISS)

RNA binding (IEA)

rRNA (adenine-N6,N6-)-dimethyltransferase activity (IBA,IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12068295	PMID:12477932	PMID:15489334	PMID:18063578	PMID:18614015	PMID:20410300	PMID:21113058	PMID:22681889	PMID:29149603

Genomics

Comparative Map Data

Tfb2m
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	93,810,859 - 93,828,678 (-)	NCBI		GRCr8
mRatBN7.2	13	91,278,889 - 91,296,709 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	91,278,898 - 91,296,657 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	93,784,087 - 93,801,822 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	95,184,250 - 95,201,981 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	92,358,929 - 92,376,664 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	97,820,493 - 97,838,275 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	97,613,991 - 97,628,059 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	13	97,820,493 - 97,838,228 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	102,830,291 - 102,848,026 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	13	102,630,835 - 102,643,959 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	95,228,520 - 95,246,255 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	95,417,455 - 95,435,191 (-)	NCBI
Celera	13	90,831,066 - 90,847,804 (-)	NCBI		Celera
Cytogenetic Map	13	q26	NCBI

TFB2M
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	246,540,561 - 246,566,261 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	246,540,561 - 246,566,261 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	246,703,863 - 246,729,563 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	244,770,489 - 244,796,186 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	243,029,908 - 243,055,604	NCBI
Celera	1	219,991,213 - 220,016,913 (-)	NCBI		Celera
Cytogenetic Map	1	q44	NCBI
HuRef	1	217,089,659 - 217,115,356 (-)	NCBI		HuRef
CHM1_1	1	247,976,165 - 248,001,862 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	245,961,432 - 245,987,151 (-)	NCBI		T2T-CHM13v2.0

Tfb2m
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	179,355,617 - 179,373,870 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	179,355,620 - 179,373,832 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	179,528,052 - 179,546,305 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	179,528,055 - 179,546,267 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	181,458,187 - 181,476,398 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	181,364,731 - 181,382,942 (-)	NCBI		MGSCv36	mm8
Celera	1	186,598,996 - 186,617,245 (-)	NCBI		Celera
Cytogenetic Map	1	H4	NCBI
cM Map	1	83.56	NCBI

Tfb2m
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	9,421,957 - 9,441,091 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	9,424,329 - 9,441,212 (-)	NCBI	ChiLan1.0	ChiLan1.0

TFB2M
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	2,566,012 - 2,591,941 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	2,782,783 - 2,808,906 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	222,157,251 - 222,184,186 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	227,512,367 - 227,538,060 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	227,512,367 - 227,538,060 (-)	Ensembl	panpan1.1		panPan2

TFB2M
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	37,259,671 - 37,278,397 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	37,250,601 - 37,278,366 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	36,742,133 - 36,760,850 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	37,091,933 - 37,110,662 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	37,085,571 - 37,110,687 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	36,932,190 - 36,950,900 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	36,940,202 - 36,958,896 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	37,209,120 - 37,227,834 (-)	NCBI		UU_Cfam_GSD_1.0

Tfb2m
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	50,226,674 - 50,249,990 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936526	4,497,507 - 4,520,048 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936526	4,497,396 - 4,520,650 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TFB2M
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	19,028,820 - 19,046,327 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	19,028,813 - 19,046,343 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	21,380,800 - 21,391,917 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TFB2M
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	83,564,405 - 83,591,980 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	83,564,432 - 83,591,930 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	85,842,481 - 85,869,767 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tfb2m
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624771	13,115,227 - 13,132,841 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tfb2m
136 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	115
Count of miRNA genes:	90
Interacting mature miRNAs:	110
Transcripts:	ENSRNOT00000003618
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	20605871	101339738	Rat
7387280	Uae43	Urinary albumin excretion QTL 43	5.69	0.4174	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	66451204	106807694	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	31241331	93395974	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	65103704	106807694	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	30395351	101056920	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	56056920	101056920	Rat
4889606	Gluco63	Glucose level QTL 63	2.86	0.003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	80753256	106807694	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	74023918	97213863	Rat
1641901	Alcrsp6	Alcohol response QTL 6			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	13	52362171	97362171	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	65103704	106807694	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	61825626	106807694	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	8897350	101631289	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	101056920	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	74862117	101339893	Rat

Markers in Region

RH129620

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	91,278,894 - 91,279,089 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	97,820,496 - 97,820,690	NCBI	Rnor6.0
Rnor_5.0	13	102,830,294 - 102,830,488	UniSTS	Rnor5.0
RGSC_v3.4	13	95,228,523 - 95,228,717	UniSTS	RGSC3.4
Celera	13	90,831,069 - 90,831,263	UniSTS
RH 3.4 Map	13	609.5	UniSTS
Cytogenetic Map	13	q26	UniSTS

RH131657

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	91,279,470 - 91,279,659 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	97,821,072 - 97,821,260	NCBI	Rnor6.0
Rnor_5.0	13	102,830,870 - 102,831,058	UniSTS	Rnor5.0
RGSC_v3.4	13	95,229,099 - 95,229,287	UniSTS	RGSC3.4
Celera	13	90,831,645 - 90,831,833	UniSTS
RH 3.4 Map	13	609.7	UniSTS
Cytogenetic Map	13	q26	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001008293	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008769817	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090552	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090553	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272164	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272165	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC115369	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC085870	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000003618 ⟹ ENSRNOP00000003618

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	91,278,898 - 91,296,657 (-)	Ensembl
Rnor_6.0 Ensembl	13	97,820,493 - 97,838,228 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000086734

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	91,279,444 - 91,296,657 (-)	Ensembl
Rnor_6.0 Ensembl	13	97,613,991 - 97,628,059 (-)	Ensembl

RefSeq Acc Id:

NM_001008293 ⟹ NP_001008294

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	93,810,859 - 93,828,594 (-)	NCBI
mRatBN7.2	13	91,278,892 - 91,296,623 (-)	NCBI
Rnor_6.0	13	97,820,493 - 97,838,228 (-)	NCBI
Rnor_5.0	13	102,830,291 - 102,848,026 (-)	NCBI
RGSC_v3.4	13	95,228,520 - 95,246,255 (-)	RGD
Celera	13	90,831,066 - 90,847,804 (-)	NCBI

Sequence:

show sequence

CGTGAAGTATGTGCACGTGTGATGTGGTGCTCCGTGTTCTTCGCAGAGGCTACACTGTTAACTG
GTGATTGGGGTGGACATTAGAGGAGGATGAGGGGACTGGCGATGAGGCTGCCCCCGCGGCTGGC
GCTGTCAGTGTTGGCGGGCCGCGGCCCGTCTTGCATTCTGGGGTCCGGAGCGGCGACGCGGAAG
GACTGGCAAGAGAGGAACCGGCGTAGCTTCTCTGACCTCTACACTCAACCGTTGCCTGATTGTG
ATTTCGAGGAGTCGTCCTCGTGGACACACAAGAGTCGATCAGAGCCTACGCGTCACATAGCATG
TAAGAAATCGGCCAGGAACCTGGTACGAGACCTGCTGGAGCACCAAAACCCATCCCATCAACTT
ATACTAGAGTGCAATCCAGGTCCAGGAATCCTGACTGGGGCATTACTTAAAGCTGGTGCCAGAG
TGGTTGCCTTTGAAAGTGAAAAGATGTTTATTCCACATTTGGAGTCCTTAAGGAAGAATGCGGA
TGGAGAGTTACAAGTGGTTCACTGTGACTTCTTTAAAATAGATCCTAGGTATCAGGAGCTAGTA
CGACCGGATGTGAATTCACACACAATTTTTCAGAACCTGGGAATAAAAGCAGTTCCTTGGTCAG
CAGGTGTTCCTATAAAAGTATTTGGAATTCTACCAAATAAACATGAAAGACGATTGCTTTGGAA
AATCCTGTTTGATCTGTACTCCTGCGAATCTATATACAGATATGGACGAGTAGAACTGAATATG
TTCATTAGTGAAAAAGAATTCCGGAAACTAATAGCAACTCCTAAAAGGCCAGATTTATATCAAG
TATTGGGTGTGCTTTGGCAAGTGGCTTGTGAAATTAAGTTTCTGCACATGGAGCCTTGGTCGTC
ATTTAGTGTGCATGCCGAAAATGGGCACTTGGAAAAGTCAAAGCACTCGGAATCATTAAATTTA
CTGAAACAAAACCTATATCTTGTTCGAATGACTCCTCGTAGGACATTATTTACAGAAAACCTAA
GTCCTTTGAACTATGATATGTTTTTCCACTTGGTAAAGCACTGCTTTGGGAAACGCAATGCCCC
AATAATACACCATTTACGTTCCCTGAGTACGGTTGACCCCATTAATATACTAAGGCAGATAAGG
AAAAGACCTGGAGACACGGCTGCTAAAATGTATCCTCACGACTTCAAAAGACTTTTTGAAACTA
TAGAACGTTCAGAAGACTCTGTCTTTAAATGGATCTATGACTACTGCTCGGACGACAGTGAGCT
CTAGGGAAAACGTCTACAAGCCATGAATGAGCTGTTTGTCTATTAATTTTGAAATTATGTGATG
AATGAAAACTGAATTTCAAGATGTTCATATCCTTTTAGCAGAAGAGAAACTATCCTTGTTTGGC
ACAGATGAAGCGAATAATTTCCTCTTAAGTTGATACCTTTGATACACAGGAAAAACCATGGCTG
CAGGTTTATTCAAAGTTAAATAAAACAAAAACTTGTCAGTTCAGTAAGATCAAATGTGCTTTGT
TTTAAATTACTTCTGCTGTAGATCAGTGGTAGAACATGAGCCTAGGTGTCCAAGGTTCTGGTTT
TGCTTTCCAGTACAGGAAATTTTAAGAAATTTCTCTTCACTGCAAAGGCCCATAGGTGTGGAAC
ATTTCCTATGGGAATTTATTTACTTTAGAAATGGAAACCTTTGGGCCAAACATCTTTCAATATG
CACTTTTCACCACTGCCAATGGCTTGACTCTCCCTCCAGTTTCAATACTGTTACACTTAGAATG
TGCATTGATTTGGGCAGACGTGGTGGTGCAAGTCCCAGGACTCGTGAGGTAGAGGGCCCACCAG
TTCAATGCCAGTTCAACTGTGGAATTGAGTGTGAGGCCAGTTTGGGCTAAGAAAAGACCTGGTC
AAAACAAGACAAAACAATAAAAACTTATTTCAGAAAGTGATTAGATTATCTTTTATGTTGAAGT
GGATTATCAGGTACTATGCAATCCAATTGTTTAAATTCTAGTATGTTTTAAAATTTTTTGAGAA
ATAAAGAATTTGCACATTTAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_008769817 ⟹ XP_008768039

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	93,810,859 - 93,828,664 (-)	NCBI
mRatBN7.2	13	91,278,889 - 91,296,709 (-)	NCBI
Rnor_6.0	13	97,820,493 - 97,838,275 (-)	NCBI

Sequence:

show sequence

TCGCATGCGCCATTCGTAATGTTTACTTCCGCCCGGCCTAGTGAGGCCGTGAAGTATGTGCACG
TGTGATGTGGTGCTCCGTGTTCTTCGCAGAGGCTACACTGTTAACTGGTGATTGGGGTGGACAT
TAGAGGAGGATGAGGGGACTGGCGATGAGGCTGCCCCCGCGGCTGGCGCTGTCAGTGTTGGCGG
GCCGCGGCCCGTCTTGCATTCTGGGGTCCGGAGCGGCGACGCGGAAGGACTGGCAAGAGAGGAA
CCGGCGTAGCTTCTCTGACCTCTACACTCAACCGTTGCCTGATTGTGATTTCGAGGAGTCGTCC
TCGTGGACACACAAGAGTCGATCAGAGCCTACGCGTCACATAGCATGTAAGAAATCGGCCAGGA
ACCTGGTACGAGACCTGCTGGAGCACCAAAACCCATCCCATCAACTTATACTAGAGTGCAATCC
AGGTCCAGGAATCCTGACTGGGGCATTACTTAAAGCTGGTGCCAGAGTGGTTGCCTTTGAAAGT
GAAAAGATGTTTATTCCACATTTGGAGTCCTTAAGGAAGAATGCGGATGGAGAGTTACAAGTGG
TTCACTGTGACTTCTTTAAAATAGATCCTAGGTATCAGGAGCTAGTACGACCGGATGTGAATTC
ACACACAATTTTTCAGAACCTGGGAATAAAAGCAGTTCCTTGGTCAGCAGGTGTTCCTATAAAA
GTATTTGGAATTCTACCAAATAAACATGAAAGACGATTGCTTTGGAAAATCCTGTTTGATCTGT
ACTCCTGCGAATCTATATACAGATATGGACGAGTAGAACTGAATATGTTCATTAGTGAAAAAGA
ATTCCGGAAACTAATAGCAACTCCTAAAAGGCCAGATTTATATCAAGTATTGGGTGTGCTTTGG
CAAGTGGCTTGTGAAATTAAGTTTCTGCACATGGTGAGTGAAGTTTTAATGCCAGAAGAACTAT
GTTACTCAGGTTGGAGCCTTGGTCGTCATTTAGTGTGCATGCCGAAAATGGGCACTTGGAAAAG
TCAAAGCACTCGTTCCCTGAGTACGGTTGACCCCATTAATATACTAAGGCAGATAAGGAAAAGA
CCTGGAGACACGGCTGCTAAAATGTATCCTCACGACTTCAAAAGACTTTTTGAAACTATAGAAC
GTTCAGAAGACTCTGTCTTTAAATGGATCTATGACTACTGCTCGGACGACAGTGAGCTCTAGGG
AAAACGTCTACAAGCCATGAATGAGCTGTTTGTCTATTAATTTTGAAATTATGTGATGAATGAA
AACTGAATTTCAAGATGTTCATATCCTTTTAGCAGAAGAGAAACTATCCTTGTTTGGCACAGAT
GAAGCGAATAATTTCCTCTTAAGTTGATACCTTTGATACACAGGAAAAACCATGGCTGCAGGTT
TATTCAAAGTTAAATAAAACAAAAACTTGTCAGTTCAGTAAGATCAAATGTGCTTTGTTTTAAA
TTACTTCTGCTGTAGATCAGTGGTAGAACATGAGCCTAGGTGTCCAAGGTTCTGGTTTTGCTTT
CCAGTACAGGAAATTTTAAGAAATTTCTCTTCACTGCAAAGGCCCATAGGTGTGGAACATTTCC
TATGGGAATTTATTTACTTTAGAAATGGAAACCTTTGGGCCAAACATCTTTCAATATGCACTTT
TCACCACTGCCAATGGCTTGACTCTCCCTCCAGTTTCAATACTGTTACACTTAGAATGTGCATT
GATTTGGGCAGACGTGGTGGTGCAAGTCCCAGGACTCGTGAGGTAGAGGGCCCACCAGTTCAAT
GCCAGTTCAACTGTGGAATTGAGTGTGAGGCCAGTTTGGGCTAAGAAAAGACCTGGTCAAAACA
AGACAAAACAATAAAAACTTATTTCAGAAAGTGATTAGATTATCTTTTATGTTGAAGTGGATTA
TCAGGTACTATGCAATCCAATTGTTTAAATTCTAGTATGTTTTAAAATTTTTTGAGAAATAAAG
AATTTGCACATTT

hide sequence

RefSeq Acc Id:

XM_039090552 ⟹ XP_038946480

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	93,810,859 - 93,828,678 (-)	NCBI
mRatBN7.2	13	91,278,889 - 91,296,706 (-)	NCBI

RefSeq Acc Id:

XM_039090553 ⟹ XP_038946481

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	93,811,783 - 93,828,661 (-)	NCBI
mRatBN7.2	13	91,279,714 - 91,296,707 (-)	NCBI

RefSeq Acc Id:

XM_063272164 ⟹ XP_063128234

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	93,810,859 - 93,828,661 (-)	NCBI

RefSeq Acc Id:

XM_063272165 ⟹ XP_063128235

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	93,813,673 - 93,828,661 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001008294	(Get FASTA)	NCBI Sequence Viewer
	XP_008768039	(Get FASTA)	NCBI Sequence Viewer
	XP_038946480	(Get FASTA)	NCBI Sequence Viewer
	XP_038946481	(Get FASTA)	NCBI Sequence Viewer
	XP_063128234	(Get FASTA)	NCBI Sequence Viewer
	XP_063128235	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH85870	(Get FASTA)	NCBI Sequence Viewer
	EDL94810	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000003618.3
	ENSRNOP00000084899.1
	ENSRNOP00055016506
	ENSRNOP00060008105
	ENSRNOP00065030749
GenBank Protein	Q5U2T7	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001008294 ⟸ NM_001008293

- UniProtKB:

Q5U2T7 (UniProtKB/Swiss-Prot), A6JGF4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRGLAMRLPPRLALSVLAGRGPSCILGSGAATRKDWQERNRRSFSDLYTQPLPDCDFEESSSWT
HKSRSEPTRHIACKKSARNLVRDLLEHQNPSHQLILECNPGPGILTGALLKAGARVVAFESEKM
FIPHLESLRKNADGELQVVHCDFFKIDPRYQELVRPDVNSHTIFQNLGIKAVPWSAGVPIKVFG
ILPNKHERRLLWKILFDLYSCESIYRYGRVELNMFISEKEFRKLIATPKRPDLYQVLGVLWQVA
CEIKFLHMEPWSSFSVHAENGHLEKSKHSESLNLLKQNLYLVRMTPRRTLFTENLSPLNYDMFF
HLVKHCFGKRNAPIIHHLRSLSTVDPINILRQIRKRPGDTAAKMYPHDFKRLFETIERSEDSVF
KWIYDYCSDDSEL

hide sequence

RefSeq Acc Id:	XP_008768039 ⟸ XM_008769817
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZY51 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRGLAMRLPPRLALSVLAGRGPSCILGSGAATRKDWQERNRRSFSDLYTQPLPDCDFEESSSWT HKSRSEPTRHIACKKSARNLVRDLLEHQNPSHQLILECNPGPGILTGALLKAGARVVAFESEKM FIPHLESLRKNADGELQVVHCDFFKIDPRYQELVRPDVNSHTIFQNLGIKAVPWSAGVPIKVFG ILPNKHERRLLWKILFDLYSCESIYRYGRVELNMFISEKEFRKLIATPKRPDLYQVLGVLWQVA CEIKFLHMVSEVLMPEELCYSGWSLGRHLVCMPKMGTWKSQSTRSLSTVDPINILRQIRKRPGD TAAKMYPHDFKRLFETIERSEDSVFKWIYDYCSDDSEL hide sequence

Ensembl Acc Id:

ENSRNOP00000003618 ⟸ ENSRNOT00000003618

RefSeq Acc Id:	XP_038946480 ⟸ XM_039090552
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038946481 ⟸ XM_039090553
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_063128234 ⟸ XM_063272164
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063128235 ⟸ XM_063272165
- Peptide Label:	isoform X4

Protein Domains

Ribosomal RNA adenine methylase transferase N-

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5U2T7-F1-model_v2	AlphaFold	Q5U2T7	1-397	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699052

Promoter ID:

EPDNEW_R9577

Type:

multiple initiation site

Name:

Tfb2m_1

Description:

transcription factor B2, mitochondrial

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	97,838,260 - 97,838,320	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307091	AgrOrtholog
BioCyc Gene	G2FUF-17146	BioCyc
Ensembl Genes	ENSRNOG00000002695	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00000058321	Ensembl
	ENSRNOG00055012066	UniProtKB/Swiss-Prot
	ENSRNOG00060006647	UniProtKB/Swiss-Prot
	ENSRNOG00065022298	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000003618.4	UniProtKB/Swiss-Prot
	ENSRNOT00000086734.2	UniProtKB/TrEMBL
	ENSRNOT00055020504	UniProtKB/Swiss-Prot
	ENSRNOT00060010893	UniProtKB/Swiss-Prot
	ENSRNOT00065037996	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.50.150	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7191198	IMAGE-MGC_LOAD
InterPro	KsgA/Erm	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	rRNA_Ade_methylase_Trfase_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SAM-dependent_MTases	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:289307	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94625	IMAGE-MGC_LOAD
NCBI Gene	289307	ENTREZGENE
PANTHER	PTHR11727	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11727:SF13	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	RrnaAD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Tfb2m	PhenoGen
PIRSF	MtTFB2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	SAM_RNA_A_N6_MT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000002695	RatGTEx
	ENSRNOG00000058321	RatGTEx
	ENSRNOG00055012066	RatGTEx
	ENSRNOG00060006647	RatGTEx
	ENSRNOG00065022298	RatGTEx
SMART	rADc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF53335	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5ZY51	ENTREZGENE, UniProtKB/TrEMBL
	A6JGF4	ENTREZGENE, UniProtKB/TrEMBL
	Q5U2T7	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Tfb2m	transcription factor B2, mitochondrial	LOC108348143	dimethyladenosine transferase 2, mitochondrial-like	Data merged from RGD:11397271	737654	PROVISIONAL
2016-08-02	LOC108348143	dimethyladenosine transferase 2, mitochondrial-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-12-06	Tfb2m	transcription factor B2, mitochondrial	Tfb2m_predicted	transcription factor B2, mitochondrial (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Tfb2m_predicted	transcription factor B2, mitochondrial (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar