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Gene: Plekhm2 (pleckstrin homology and RUN domain containing M2) Rattus norvegicus

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Symbol:

Plekhm2

Name:

pleckstrin homology and RUN domain containing M2

RGD ID:

1307005

Description:

Predicted to enable kinesin binding activity. Predicted to be involved in several processes, including Golgi organization; lysosome localization; and natural killer cell mediated cytotoxicity. Predicted to be located in lysosomal membrane. Predicted to be active in endosome membrane. Orthologous to human PLEKHM2 (pleckstrin homology and RUN domain containing M2); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; gentamycin.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC313667; pleckstrin homology domain containing, family M (with RUN domain) member 2; pleckstrin homology domain-containing family M member 2; regulatory solute carrier protein family 1 member 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	159,222,620 - 159,261,666 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	159,223,300 - 159,261,642 (-)	Ensembl				GRCr8
mRatBN7.2	5	153,939,582 - 153,978,625 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	153,940,262 - 153,978,689 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	156,625,416 - 156,663,648 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	158,398,694 - 158,436,930 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	158,387,856 - 158,426,085 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	160,182,556 - 160,219,770 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	160,182,251 - 160,219,812 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	163,897,199 - 163,934,413 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	160,527,710 - 160,565,407 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	152,296,410 - 152,333,474 (-)	NCBI		Celera
RGSC_v3.1	5	160,537,310 - 160,545,504 (-)	NCBI
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

dilated cardiomyopathy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

aristolochic acid A (ISO)

arsenous acid (ISO)

bisphenol A (ISO)

bortezomib (ISO)

butan-1-ol (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

CGP 52608 (ISO)

coumarin (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

epoxiconazole (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

fenthion (ISO)

FR900359 (ISO)

gentamycin (EXP)

maneb (ISO)

methamphetamine (ISO)

methidathion (ISO)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

PCB138 (EXP)

perfluorohexanesulfonic acid (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tamoxifen (ISO)

temozolomide (ISO)

tetrachloroethene (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Golgi organization (IBA,IEA,ISO)

lysosome localization (IBA,IEA,ISO)

natural killer cell mediated cytotoxicity (IEA,ISO)

regulation of protein localization (IBA,IEA,ISO)

Cellular Component

cytoplasm (IEA)

endosome membrane (IBA,IEA,ISO)

lysosomal membrane (IEA,ISO)

Molecular Function

kinesin binding (IBA,IEA,ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15905402	PMID:18787122	PMID:18996344	PMID:25898167

Genomics

Comparative Map Data

Plekhm2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	159,222,620 - 159,261,666 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	159,223,300 - 159,261,642 (-)	Ensembl				GRCr8
mRatBN7.2	5	153,939,582 - 153,978,625 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	153,940,262 - 153,978,689 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	156,625,416 - 156,663,648 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	158,398,694 - 158,436,930 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	158,387,856 - 158,426,085 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	160,182,556 - 160,219,770 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	160,182,251 - 160,219,812 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	163,897,199 - 163,934,413 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	160,527,710 - 160,565,407 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	152,296,410 - 152,333,474 (-)	NCBI		Celera
RGSC_v3.1	5	160,537,310 - 160,545,504 (-)	NCBI
Cytogenetic Map	5	q36	NCBI

PLEKHM2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	15,681,506 - 15,734,769 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	15,681,461 - 15,734,769 (+)	Ensembl			hg38	GRCh38
GRCh37	1	16,010,815 - 16,061,264 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	15,880,613 - 15,933,851 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	1	14,493,710 - 14,544,281 (+)	NCBI		Celera
Cytogenetic Map	1	p36.21	NCBI
HuRef	1	14,530,042 - 14,580,241 (+)	NCBI		HuRef
CHM1_1	1	15,809,564 - 15,859,865 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	15,125,588 - 15,179,507 (+)	NCBI		T2T-CHM13v2.0

Plekhm2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	141,353,043 - 141,391,457 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	141,353,045 - 141,392,210 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	141,625,732 - 141,664,146 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	141,625,734 - 141,664,899 (-)	Ensembl			mm10	GRCm38
MGSCv37	4	141,181,649 - 141,220,030 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	140,897,810 - 140,944,739 (-)	NCBI		MGSCv36	mm8
Celera	4	143,449,113 - 143,487,570 (-)	NCBI		Celera
Cytogenetic Map	4	D3	NCBI
cM Map	4	74.64	NCBI

Plekhm2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955527	2,438,595 - 2,463,842 (-)	Ensembl
ChiLan1.0	NW_004955527	2,438,595 - 2,453,120 (-)	NCBI	ChiLan1.0	ChiLan1.0

PLEKHM2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	211,181,303 - 211,231,842 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	210,429,902 - 210,480,362 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	14,826,604 - 14,877,142 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	15,850,776 - 15,869,327 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	15,846,673 - 15,869,327 (+)	Ensembl			panPan2	panpan1.1

PLEKHM2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	81,864,958 - 81,902,682 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	81,865,640 - 81,880,363 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	78,402,921 - 78,440,948 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	82,513,537 - 82,551,925 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	82,513,540 - 82,551,938 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	79,266,903 - 79,305,041 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	80,284,931 - 80,323,248 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	81,350,810 - 81,389,227 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Plekhm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	37,523,883 - 37,541,272 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	3,348,487 - 3,365,226 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	3,348,661 - 3,366,054 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PLEKHM2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	74,864,968 - 74,907,766 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	74,865,116 - 74,907,769 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	69,396,273 - 69,435,738 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PLEKHM2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	116,569,780 - 116,612,906 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	116,570,613 - 116,612,880 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666054	20,103,616 - 20,149,211 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Plekhm2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	16,485,195 - 16,521,995 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Plekhm2
150 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	153
Count of miRNA genes:	120
Interacting mature miRNAs:	138
Transcripts:	ENSRNOT00000016333
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	130249266	172190305	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	116702075	161702075	Rat
1354583	Despr3	Despair related QTL3	4.98	0.0002	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	5	132930505	172190305	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	141212838	172190305	Rat
1300119	Bp180	Blood pressure QTL 180	3.82		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	149642129	171146538	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	99905133	172190305	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	133789363	172190305	Rat
1331803	Rf32	Renal function QTL 32	2.798		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	134369199	172190305	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	136631198	172190305	Rat
1354631	Swd2	Spike wave discharge measurement QTL 2	3.64	0.0002	brain electrophysiology trait (VT:0010557)	brain total spike-and-wave discharge duration (CMO:0001740)	5	156396728	172190305	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	133081618	172190305	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
631263	Cm24	Cardiac mass QTL 24	3.5		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	149805999	162987697	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	138002522	170842766	Rat
1581505	Rf54	Renal function QTL 54			kidney physiology trait (VT:0002136)	kidney 20-HETE level (CMO:0001854)	5	133270647	172190305	Rat
2317753	Glom24	Glomerulus QTL 24	3.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	5	141764300	172190305	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	133789363	172190305	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	148093485	172129029	Rat
1581510	Cm54	Cardiac mass QTL 54	3.4	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	125969677	172190305	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
631272	Lanf1	Left ventricular atrial natriuretic factor QTL 1	12		heart left ventricle natriuretic peptide A amount (VT:0010596)	heart left ventricle natriuretic peptide A level (CMO:0002165)	5	156396728	167181764	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	131708216	172190305	Rat
2313096	Bmd78	Bone mineral density QTL 78	3.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	5	149661912	166600247	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	116702075	161702075	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	116702075	161702075	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	116702075	161702075	Rat
1298090	Bp155	Blood pressure QTL 155	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	156289283	171137955	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	133081618	172190305	Rat

Markers in Region

RH131979

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	153,994,571 - 153,994,764 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	160,235,934 - 160,236,126	NCBI	Rnor6.0
Rnor_5.0	5	163,950,334 - 163,950,526	UniSTS	Rnor5.0
RGSC_v3.4	5	160,581,298 - 160,581,490	UniSTS	RGSC3.4
Celera	5	152,348,259 - 152,348,451	UniSTS
RH 3.4 Map	5	1057.3	UniSTS
Cytogenetic Map	5	q36	UniSTS

AU040698

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	153,995,867 - 153,995,964 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	160,237,230 - 160,237,326	NCBI	Rnor6.0
Rnor_5.0	5	163,951,630 - 163,951,726	UniSTS	Rnor5.0
RGSC_v3.4	5	160,582,594 - 160,582,690	UniSTS	RGSC3.4
Celera	5	152,349,555 - 152,349,651	UniSTS
Cytogenetic Map	5	q36	UniSTS

RH134786

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	153,989,799 - 153,990,015 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	160,231,162 - 160,231,377	NCBI	Rnor6.0
Rnor_5.0	5	163,945,562 - 163,945,777	UniSTS	Rnor5.0
RGSC_v3.4	5	160,576,526 - 160,576,741	UniSTS	RGSC3.4
Celera	5	152,343,487 - 152,343,702	UniSTS
RH 3.4 Map	5	1057.3	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	92	59	6	356	192	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001191767	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039110081	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000016333 ⟹ ENSRNOP00000016333

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	159,223,300 - 159,261,642 (-)	Ensembl
mRatBN7.2 Ensembl	5	153,940,262 - 153,978,689 (-)	Ensembl
Rnor_6.0 Ensembl	5	160,182,251 - 160,219,812 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096039 ⟹ ENSRNOP00000087716

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	159,223,300 - 159,261,642 (-)	Ensembl
mRatBN7.2 Ensembl	5	153,940,262 - 153,978,689 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102733 ⟹ ENSRNOP00000089483

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	159,223,300 - 159,261,642 (-)	Ensembl
mRatBN7.2 Ensembl	5	153,940,262 - 153,978,689 (-)	Ensembl

RefSeq Acc Id:

NM_001191767 ⟹ NP_001178696

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	159,223,300 - 159,261,443 (-)	NCBI
mRatBN7.2	5	153,940,262 - 153,978,406 (-)	NCBI
Rnor_6.0	5	160,182,556 - 160,219,770 (-)	NCBI
Rnor_5.0	5	163,897,199 - 163,934,413 (-)	NCBI
Celera	5	152,296,410 - 152,333,474 (-)	NCBI

Sequence:

show sequence

ATGGAGCCTCGGGAGGTGAAGGACCGAATCCTGGAGAACATCTCGCTGTCGGTGAAGAAGCTGC
AGAGCTACTTCGCAGCATGCGAGGACGAGACCCCTGCCATCCGGAACCACGACAAGGTCCTGCA
GCGCCTGTGTGAGCACTTGGACCACGCCCTGTTGTACGGATTGCAAGACCTGTCCTCTGGCTAC
TGGGTGGTCGTGGTCCATTTCACCCGCAGAGAGGCCATCAGGCAAATTGAAGTGCTACAGCATG
TGGCCACCAACCTGGGGCGAAGCCGCGCCTGGCTCTACCTGGCTCTCAATGAGAATTCCTTGGA
GAGCTACCTTCGCCTGTTCCAGGAGAACCTGGGTCTGTTACAGAAGTACTATGTCAGGAATGCC
CTGGTCTGCAGCCACGATCACTTGACTCTCTTCCTGACCTTGGTGTCTGGGTTGGAGTTTATTC
GGTTCGACCTGGATCTGGATGCCCCGTACTTAGACCTGGCCCCATATATGCCTGACTACTATAA
ACCTCAGTACCTGCTGGACTTTGAAGACCGCCTTCCCAGCTCAGTCCACGGCTCAGACAGCCTG
TCCCTGAACTCCTTCAACTCTGTCACCTCCACCAACCTGGAATGGGATGACAGCGCAATTGCCC
CATCTAGTGAGGATTATGATTTTGGAGATGTGTTTCCAGCAGTGCCGTCTGTACCCAGCACAGA
CTGGGAAGATGGAGACCTCACAGATACCATCAGTGGTCCCCGCTCTACTGCTTCAGACCTGACC
AGTAGCAAGGCATCCACCAAGAGCCCCACCCAGCGCCACAACCCCTTCAACGAGGAGCAGGCGG
AGAGCGCGTCATCTGAGACCACCCCCGTGCACACTACCTCTCAGGAGAAGGAAGAGGCCCAGGC
CCCAGACCAGCCAGATGCTTGTACAGAGCTTGAAGTTATCAGGGTCACCAAGAAGAAGAAGATT
GGCAAGAAGAAAAAGACCAAGCTGGATGAGGAAGCAAGCCCACTGCACCCCAACTGTAGCCAGC
AGAAGTGCGGTCGGCAGGGGGACGGTGACGGACTTGTGGGCACCCCAGGCCTGGCGCGGAACTG
TTCGGACACCATACTTGCCTCTCCACAGGAGCAAGGGGAAGGGCCCGGCAGTACCGCCGGGAGC
TGTGAGCACTCAGAGCTCAGCCAGATGGGTTTGCTGATCCCCGAGATGAAGGACACCTCCATGG
AGTGCCTAGGACAGCCCCTGAGCAAGGTCATCGACCAGCTTCATGGCCAGCTGGACCCTAGCAC
CTGGTGCTCCCGTGTCGAGCCCCCGGATCAGTCCTTTCGGACCGGCTCTCCCGGGGAGGCCCCG
GAGAAACCGCCATTTTGCGACTTTAGTGAGGGGCTTCCAGCCCCCATGGACTTCTACCGGTTTA
CAGTCGAGAGTCCAAGTACTGTTGCACCAGGTGGCGGCCACCATGACCCTCCAGGGTCTAGCCA
ACCGCTGCATGTTCCTGGTAGCCCTGCGCCTGCTCTCCAAGAAGAAGAGGGAGGAAGAGGAGAG
GGACAGACATCTCAGCCCCTAGAGGACCAGCAAGGGAAGGAGATTCAGGAGCCAGAGCCTCAGG
AACCAGACAGCCAGTTGCCGCTGGTCAGCCAGGAGCCTGGGCCTGAACCTGTGTCCCAGCCTGA
ACCTGGAACCCAGGAAACTCTTTGCAAGCTCAAGGGAGACCAGCCCAGTCCTTGTCTGAGCAGT
GCTGAGGACTCCGGGGTAGACGAGGGCCAGGGTAGCCCCTCAGAGATGACGCACCCCTCAGAGT
TCAGAGTAGACAACAACCACTTGCTCCTACTCATGATTCACGTCTTTCGAGAAAATGAAGAACA
GTTGTTCAAAATGATCCGGATGAGCACAGGGCACATGGAGGGTAACCTACAGCTGCTCTACGTG
CTACTCACAGACTGCTATGTCTACCTGCTTCGGAAAGGGGCCACAGAAAAGCCATACCTGGTGG
AAGAGGCTGTTTCTTACAATGAACTTGACTATGTGTCGGTTGGCCTGGACCAACAGACTGTCAA
GCTGGTGTGCACCAACCGCAGGAAGCAGTTTCTGCTGGACACGGCCGACGTGGCCCTGGCTGAG
CTGTTCTTGGCGTCTCTGAAGTCAGCCATGATCAAAGGTTGCCGGGAACCACCCTACCCCAGCG
TCTTGACTGATGCCACCATGGAGAGGCTGGCGCTGGCAAAATTTGTCGCCCAGGAATCCAAATG
TGAGGCATCCACTGTGACCGTGCACTTCTACGGACTTGTACACTGGGAGGACCCCATGGAAGAG
GCCCTGGGCCCTGTTCCTTGCCAGTGCTCACCCGCTGAGGGCACGATCACCAAAGAAGGCATGC
TCCACTATAAGGCCAGCACCTCCTACCTGGGCAAAGAGCACTGGAAGGCCTGCTTCGTGGTGCT
CAGCAATGGGATCCTCTACCAGTATCCTGATCGCACTGACGTCATCCCCCTGCTCTCCGTGAAC
ATGGGTGGGGAGCAGTGCGGTGGCTGCCGGAGATCCAACACCACGGATCGGCCCCACGCCTTCC
AGGTCATTCTGGCTGACCGGCCTTGCCTGGAGCTAAGCGCCGACAGTGAGGCCGAGATGGCAGA
CTGGATGCAACATCTTTGCCAGGCCGTATCCAAAGGAGTCATACCCCAGGGCATAGCTCCCAGC
CCCTGTATCCCTTGCTGTCTGGTGATCACGGAGGACCGCCTCTTCACATGCCACGAAGATTGCC
AAACCAGCTTCTTCCGCTCCCTGGGCACAGCCAGACTGGCGGACATCACTGCTATCTCCACTGA
GTTAGGCAAGGAGTACTGTGTCCTGGAGTTCTCCCAGGATAGCCCCCAGCTGCCGAAGCCCTGG
GTCATCTACATGAGCTGCACTTCCGAGTTGGACCGGTTCCTGACCGCCCTGAGCTCTGGGTGGA
AAGCCATCTACCAGGTAGACCTTCCTCACAAGGCAATCCATGAAGCTTCCATCAAGCAGAAATT
TGAAGATGCCCTGAGCCTCATCCACAGCGCCTGGCAGCGGAGCGACAGCCTCTGCCGCGGCAGG
GCCTCCCGGGACCCCTGGTGCTGAGGCTGGGCAACCCTGTGGGCAGGCGGGAAGGAGGTGTGCT
GACCAGCCTCTGCACTGTGGTGTGCCGCCATGGCGTTTCAGAGCCAGGGGCCAACAACCCACTC
CTGCCTTGGGGTGGCAGAACCACTTAGTGTGGCTGGCGTGAGAGAGGAATTCAGTCAGTGCCTG
GCAC

hide sequence

RefSeq Acc Id:

XM_039110081 ⟹ XP_038966009

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	159,222,620 - 159,261,666 (-)	NCBI
mRatBN7.2	5	153,939,582 - 153,978,625 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001178696	(Get FASTA)	NCBI Sequence Viewer
	XP_038966009	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000016333
	ENSRNOP00000016333.5
	ENSRNOP00000087716
	ENSRNOP00000087716.1
	ENSRNOP00000089483.1

RefSeq Acc Id:

NP_001178696 ⟸ NM_001191767

- UniProtKB:

D4A932 (UniProtKB/TrEMBL), A0A8I6GI53 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEPREVKDRILENISLSVKKLQSYFAACEDETPAIRNHDKVLQRLCEHLDHALLYGLQDLSSGY
WVVVVHFTRREAIRQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLQKYYVRNA
LVCSHDHLTLFLTLVSGLEFIRFDLDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSL
SLNSFNSVTSTNLEWDDSAIAPSSEDYDFGDVFPAVPSVPSTDWEDGDLTDTISGPRSTASDLT
SSKASTKSPTQRHNPFNEEQAESASSETTPVHTTSQEKEEAQAPDQPDACTELEVIRVTKKKKI
GKKKKTKLDEEASPLHPNCSQQKCGRQGDGDGLVGTPGLARNCSDTILASPQEQGEGPGSTAGS
CEHSELSQMGLLIPEMKDTSMECLGQPLSKVIDQLHGQLDPSTWCSRVEPPDQSFRTGSPGEAP
EKPPFCDFSEGLPAPMDFYRFTVESPSTVAPGGGHHDPPGSSQPLHVPGSPAPALQEEEGGRGE
GQTSQPLEDQQGKEIQEPEPQEPDSQLPLVSQEPGPEPVSQPEPGTQETLCKLKGDQPSPCLSS
AEDSGVDEGQGSPSEMTHPSEFRVDNNHLLLLMIHVFRENEEQLFKMIRMSTGHMEGNLQLLYV
LLTDCYVYLLRKGATEKPYLVEEAVSYNELDYVSVGLDQQTVKLVCTNRRKQFLLDTADVALAE
LFLASLKSAMIKGCREPPYPSVLTDATMERLALAKFVAQESKCEASTVTVHFYGLVHWEDPMEE
ALGPVPCQCSPAEGTITKEGMLHYKASTSYLGKEHWKACFVVLSNGILYQYPDRTDVIPLLSVN
MGGEQCGGCRRSNTTDRPHAFQVILADRPCLELSADSEAEMADWMQHLCQAVSKGVIPQGIAPS
PCIPCCLVITEDRLFTCHEDCQTSFFRSLGTARLADITAISTELGKEYCVLEFSQDSPQLPKPW
VIYMSCTSELDRFLTALSSGWKAIYQVDLPHKAIHEASIKQKFEDALSLIHSAWQRSDSLCRGR
ASRDPWC

hide sequence

Ensembl Acc Id:

ENSRNOP00000016333 ⟸ ENSRNOT00000016333

RefSeq Acc Id:	XP_038966009 ⟸ XM_039110081
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A4P1 (UniProtKB/TrEMBL), A0A8I6GI53 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000087716 ⟸ ENSRNOT00000096039

Ensembl Acc Id:

ENSRNOP00000089483 ⟸ ENSRNOT00000102733

Protein Domains

PH RUN

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A932-F1-model_v2	AlphaFold	D4A932	1-1031	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307005	AgrOrtholog
BioCyc Gene	G2FUF-39335	BioCyc
Ensembl Genes	ENSRNOG00000012163	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000016333	ENTREZGENE
	ENSRNOT00000016333.9	UniProtKB/TrEMBL
	ENSRNOT00000096039	ENTREZGENE
	ENSRNOT00000096039.2	UniProtKB/TrEMBL
	ENSRNOT00000102733.2	UniProtKB/TrEMBL
Gene3D-CATH	1.20.58.900	UniProtKB/TrEMBL
	2.30.29.30	UniProtKB/TrEMBL
InterPro	PH_domain-containing_M2	UniProtKB/TrEMBL
	PH_PLEKHM2	UniProtKB/TrEMBL
	PH_type	UniProtKB/TrEMBL
	Pleckstrin_homology	UniProtKB/TrEMBL
	Run	UniProtKB/TrEMBL
	Run_dom_sf	UniProtKB/TrEMBL
	RUN_PLEKHM2	UniProtKB/TrEMBL
KEGG Report	rno:313667	UniProtKB/TrEMBL
NCBI Gene	313667	ENTREZGENE
PANTHER	PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 2	UniProtKB/TrEMBL
	PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 2	UniProtKB/TrEMBL
Pfam	PF00169	UniProtKB/TrEMBL
	PH_PLEKHM2	UniProtKB/TrEMBL
	RUN	UniProtKB/TrEMBL
PhenoGen	Plekhm2	PhenoGen
PROSITE	PH_DOMAIN	UniProtKB/TrEMBL
	RUN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000012163	RatGTEx
SMART	RUN	UniProtKB/TrEMBL
	SM00233	UniProtKB/TrEMBL
Superfamily-SCOP	PH domain-like	UniProtKB/TrEMBL
	SSF140741	UniProtKB/TrEMBL
UniProt	A0A8I6A4P1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GI53	ENTREZGENE, UniProtKB/TrEMBL
	D4A932	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-11-30	Plekhm2	pleckstrin homology and RUN domain containing M2	Plekhm2	pleckstrin homology domain containing, family M (with RUN domain) member 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Plekhm2	pleckstrin homology domain containing, family M (with RUN domain) member 2	Plekhm2_predicted	pleckstrin homology domain containing, family M (with RUN domain) member 2 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Plekhm2_predicted	pleckstrin homology domain containing, family M (with RUN domain) member 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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