Rad18 (RAD18 E3 ubiquitin protein ligase) - Rat Genome Database

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Gene: Rad18 (RAD18 E3 ubiquitin protein ligase) Rattus norvegicus
Analyze
Symbol: Rad18
Name: RAD18 E3 ubiquitin protein ligase
RGD ID: 1306993
Description: Predicted to enable several functions, including DNA binding activity; ubiquitin binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in positive regulation of chromosome segregation; postreplication repair; and protein monoubiquitination. Predicted to act upstream of or within several processes, including negative regulation of DNA recombination; protein autoubiquitination; and response to UV. Predicted to be located in centrosome; chromosome; and nucleus. Predicted to be part of Rad6-Rad18 complex. Predicted to be active in nucleus. Orthologous to human RAD18 (RAD18 E3 ubiquitin protein ligase); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: E3 ubiquitin-protein ligase RAD18; LOC362412; MGC156682; RAD18 homolog; RAD18 homolog (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84147,291,463 - 147,376,904 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4147,291,276 - 147,376,869 (-)EnsemblGRCr8
mRatBN7.24145,735,654 - 145,821,102 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4145,735,654 - 145,821,069 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4151,128,531 - 151,213,335 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04146,909,335 - 146,994,147 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04145,530,588 - 145,615,388 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04144,537,329 - 144,620,606 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4144,536,729 - 144,620,731 (-)Ensemblrn6Rnor6.0
Rnor_5.04207,837,216 - 207,920,089 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44148,452,664 - 148,543,743 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4134,304,974 - 134,388,922 (-)NCBICelera
RGSC_v3.14148,697,688 - 148,788,534 (-)NCBI
Cytogenetic Map4q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dibromoethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-nitrotoluene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
avobenzone  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
biphenyl-4-amine  (ISO)
bisphenol A  (EXP,ISO)
Brevetoxin B  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chlordecone  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clotrimazole  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
DDE  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
doxorubicin  (EXP,ISO)
fenthion  (ISO)
flumequine  (ISO)
FR900359  (ISO)
furan  (EXP)
gentamycin  (EXP)
hexadecanoic acid  (ISO)
indole-3-methanol  (EXP)
lead(0)  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
MeIQx  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (ISO)
methimazole  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
succimer  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IEA,ISO)
chromatin  (ISO)
chromosome  (IEA)
nuclear body  (IEA,ISO)
nuclear inclusion body  (IEA,ISO)
nuclear speck  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
Rad6-Rad18 complex  (IBA)
replication fork  (IEA,ISO)
site of double-strand break  (IEA,ISO)
XY body  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. Formation of D-serine from L-phosphoserine in brain synaptosomes. Wood PL, etal., J Neurochem. 1996 Oct;67(4):1485-90.
Additional References at PubMed
PMID:10908344   PMID:11013078   PMID:12477932   PMID:12509447   PMID:15383616   PMID:15632077   PMID:15657431   PMID:17970741   PMID:18363965   PMID:19068231   PMID:22036607   PMID:22742833  
PMID:25023518   PMID:25931565  


Genomics

Comparative Map Data
Rad18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84147,291,463 - 147,376,904 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4147,291,276 - 147,376,869 (-)EnsemblGRCr8
mRatBN7.24145,735,654 - 145,821,102 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4145,735,654 - 145,821,069 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4151,128,531 - 151,213,335 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04146,909,335 - 146,994,147 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04145,530,588 - 145,615,388 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04144,537,329 - 144,620,606 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4144,536,729 - 144,620,731 (-)Ensemblrn6Rnor6.0
Rnor_5.04207,837,216 - 207,920,089 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44148,452,664 - 148,543,743 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4134,304,974 - 134,388,922 (-)NCBICelera
RGSC_v3.14148,697,688 - 148,788,534 (-)NCBI
Cytogenetic Map4q42NCBI
RAD18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3838,877,075 - 8,963,472 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl38,775,402 - 8,963,773 (-)Ensemblhg38GRCh38
GRCh3738,918,759 - 9,005,156 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3638,896,560 - 8,980,146 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3438,896,560 - 8,980,146NCBI
Celera38,853,629 - 8,939,882 (-)NCBICelera
Cytogenetic Map3p25.3NCBI
HuRef38,853,076 - 8,939,344 (-)NCBIHuRef
CHM1_138,869,168 - 8,955,418 (-)NCBICHM1_1
T2T-CHM13v2.038,868,283 - 8,960,543 (-)NCBIT2T-CHM13v2.0
Rad18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396112,596,812 - 112,673,650 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6112,596,811 - 112,673,647 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm386112,619,851 - 112,696,691 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6112,619,850 - 112,696,686 (-)Ensemblmm10GRCm38
MGSCv376112,569,845 - 112,646,664 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366112,586,582 - 112,662,371 (-)NCBIMGSCv36mm8
Celera6114,452,215 - 114,522,098 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map652.42NCBI
Rad18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955561464,343 - 599,789 (-)Ensembl
ChiLan1.0NW_004955561463,586 - 602,354 (-)NCBIChiLan1.0ChiLan1.0
RAD18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v228,891,471 - 8,977,466 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan138,896,229 - 8,982,224 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v038,832,910 - 8,918,067 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.139,076,500 - 9,161,585 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl39,076,500 - 9,161,585 (-)EnsemblpanPan2panpan1.1
RAD18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1209,163,322 - 9,271,224 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl209,163,428 - 9,263,730 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha209,195,146 - 9,302,722 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0209,192,202 - 9,299,425 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl209,191,837 - 9,291,927 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1208,913,303 - 9,020,670 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0209,259,143 - 9,366,272 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0209,232,350 - 9,339,667 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rad18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494214,776,226 - 14,879,342 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366024,030,459 - 4,081,931 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366024,030,353 - 4,134,119 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAD18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1365,253,424 - 65,359,174 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11365,253,416 - 65,359,506 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RAD18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12244,878,015 - 44,960,610 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2244,875,292 - 44,960,089 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041121,606,379 - 121,689,362 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rad18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247313,597,779 - 3,697,138 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247313,510,430 - 3,698,859 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Rad18
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1633,842,107 - 33,919,312 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rad18
626 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:576
Count of miRNA genes:253
Interacting mature miRNAs:322
Transcripts:ENSRNOT00000066468
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4117737142152833657Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4108206096153206096Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4103834277148834277Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4107346299152346299Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4113634167149763391Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4121020385148834277Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat

Markers in Region
AA800878  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24145,735,817 - 145,736,047 (+)MAPPERmRatBN7.2
Rnor_6.04144,536,864 - 144,537,093NCBIRnor6.0
Rnor_5.04207,836,751 - 207,836,980UniSTSRnor5.0
RGSC_v3.44148,452,198 - 148,452,427UniSTSRGSC3.4
Celera4134,304,508 - 134,304,737UniSTS
RH 3.4 Map4937.2UniSTS
Cytogenetic Map4q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 354 192 11 144 79 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000066468   ⟹   ENSRNOP00000063400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4147,291,524 - 147,376,839 (-)Ensembl
mRatBN7.2 Ensembl4145,735,654 - 145,821,069 (-)Ensembl
Rnor_6.0 Ensembl4144,536,729 - 144,620,731 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099439   ⟹   ENSRNOP00000076533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4147,291,276 - 147,376,869 (-)Ensembl
mRatBN7.2 Ensembl4145,735,654 - 145,821,069 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115978   ⟹   ENSRNOP00000094440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4147,291,276 - 147,376,869 (-)Ensembl
mRatBN7.2 Ensembl4145,735,676 - 145,821,067 (-)Ensembl
RefSeq Acc Id: NM_001077673   ⟹   NP_001071141
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84147,292,093 - 147,376,869 (-)NCBI
mRatBN7.24145,736,284 - 145,821,065 (-)NCBI
Rnor_6.04144,537,330 - 144,620,584 (-)NCBI
Rnor_5.04207,837,216 - 207,920,089 (-)NCBI
RGSC_v3.44148,452,664 - 148,543,743 (-)RGD
Celera4134,304,974 - 134,388,922 (-)RGD
Sequence:
RefSeq Acc Id: XM_006237036   ⟹   XP_006237098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84147,291,463 - 147,376,904 (-)NCBI
mRatBN7.24145,735,654 - 145,821,102 (-)NCBI
Rnor_6.04144,537,329 - 144,620,606 (-)NCBI
Rnor_5.04207,837,216 - 207,920,089 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006237037   ⟹   XP_006237099
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84147,291,463 - 147,376,904 (-)NCBI
mRatBN7.24145,735,654 - 145,821,102 (-)NCBI
Rnor_6.04144,537,339 - 144,620,606 (-)NCBI
Rnor_5.04207,837,216 - 207,920,089 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063286290   ⟹   XP_063142360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84147,291,463 - 147,376,904 (-)NCBI
RefSeq Acc Id: NP_001071141   ⟸   NM_001077673
- UniProtKB: A0JPN0 (UniProtKB/TrEMBL),   A0A8I5YBD2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237098   ⟸   XM_006237036
- Peptide Label: isoform X1
- UniProtKB: A0A8I5YBD2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237099   ⟸   XM_006237037
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GKR5 (UniProtKB/TrEMBL),   A6IBN3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063400   ⟸   ENSRNOT00000066468
Ensembl Acc Id: ENSRNOP00000076533   ⟸   ENSRNOT00000099439
Ensembl Acc Id: ENSRNOP00000094440   ⟸   ENSRNOT00000115978
RefSeq Acc Id: XP_063142360   ⟸   XM_063286290
- Peptide Label: isoform X3
- UniProtKB: A6IBN3 (UniProtKB/TrEMBL)
Protein Domains
RING-type   SAP   UBZ4-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0JPN0-F1-model_v2 AlphaFold A0JPN0 1-494 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306993 AgrOrtholog
BioCyc Gene G2FUF-43418 BioCyc
Ensembl Genes ENSRNOG00000005907 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066468 ENTREZGENE
  ENSRNOT00000066468.4 UniProtKB/TrEMBL
  ENSRNOT00000099439 ENTREZGENE
  ENSRNOT00000099439.2 UniProtKB/TrEMBL
  ENSRNOT00000115978 ENTREZGENE
  ENSRNOT00000115978.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.720.30 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8366167 IMAGE-MGC_LOAD
InterPro Rad18 UniProtKB/TrEMBL
  SAP_DNA-bd UniProtKB/TrEMBL
  SAP_dom_sf UniProtKB/TrEMBL
  Znf_Rad18_put UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
KEGG Report rno:362412 UniProtKB/TrEMBL
MGC_CLONE MGC:156682 IMAGE-MGC_LOAD
NCBI Gene 362412 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE RAD18 UniProtKB/TrEMBL
  PTHR14134 UniProtKB/TrEMBL
Pfam SAP UniProtKB/TrEMBL
  zf-C3HC4_2 UniProtKB/TrEMBL
PhenoGen Rad18 PhenoGen
PROSITE SAP UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
  ZF_UBZ4 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005907 RatGTEx
SMART RING UniProtKB/TrEMBL
  SAP UniProtKB/TrEMBL
  ZnF_Rad18 UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt A0A8I5YBD2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GKR5 ENTREZGENE, UniProtKB/TrEMBL
  A0JPN0 ENTREZGENE, UniProtKB/TrEMBL
  A6IBN3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-08-06 Rad18  RAD18 E3 ubiquitin protein ligase  Rad18  RAD18 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Rad18  RAD18 homolog (S. cerevisiae)   Rad18_predicted  RAD18 homolog (S. cerevisiae) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Rad18_predicted  RAD18 homolog (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED