Igtp (interferon gamma induced GTPase) - Rat Genome Database

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Pathways
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Gene: Igtp (interferon gamma induced GTPase) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Igtp
Name: interferon gamma induced GTPase
RGD ID: 1306896
Description: Predicted to enable GTPase activity. Predicted to be involved in cellular response to interferon-beta and defense response. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M); PARTICIPATES IN toxoplasmosis pathway.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ac2-233; LOC303163
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81042,875,047 - 42,882,866 (+)NCBIGRCr8
mRatBN7.21042,374,590 - 42,382,410 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1042,357,400 - 42,408,247 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1047,039,739 - 47,047,630 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01046,530,007 - 46,537,900 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01042,033,668 - 42,041,559 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01043,631,089 - 43,639,044 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1043,613,931 - 43,653,390 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01043,424,585 - 43,432,536 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41043,829,273 - 43,837,092 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11043,842,896 - 43,866,669 (+)NCBI
Celera1041,664,012 - 41,671,823 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:26242173  


Genomics

Variants

.
Variants in Igtp
98 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:23
Count of miRNA genes:23
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000039335
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat

Markers in Region
RH136641  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21042,355,542 - 42,355,723 (+)MAPPERmRatBN7.2
Rnor_6.01043,611,883 - 43,612,063NCBIRnor6.0
Rnor_5.01043,405,639 - 43,405,819UniSTSRnor5.0
RGSC_v3.41043,809,090 - 43,809,270UniSTSRGSC3.4
Celera1041,645,349 - 41,645,529UniSTS
RH 3.4 Map10524.58UniSTS
Cytogenetic Map10q22UniSTS
AI175782  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21042,382,130 - 42,382,323 (+)MAPPERmRatBN7.2
Rnor_6.01043,638,730 - 43,638,922NCBIRnor6.0
Rnor_5.01043,432,222 - 43,432,414UniSTSRnor5.0
RGSC_v3.41043,836,813 - 43,837,005UniSTSRGSC3.4
Celera1041,671,544 - 41,671,736UniSTS
RH 3.4 Map71125.52UniSTS
Cytogenetic Map10q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 5 42 27 19 27 15 14 10
Low 1 38 15 14 14 8 11 56 20 27 1 8
Below cutoff 18

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000039335   ⟹   ENSRNOP00000034525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1042,357,400 - 42,408,247 (+)Ensembl
Rnor_6.0 Ensembl1043,613,931 - 43,653,390 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077764   ⟹   ENSRNOP00000072930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1042,374,570 - 42,382,079 (+)Ensembl
Rnor_6.0 Ensembl1043,633,035 - 43,638,594 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109169   ⟹   ENSRNOP00000082763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1042,374,585 - 42,381,021 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117553   ⟹   ENSRNOP00000081750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1042,360,790 - 42,397,547 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118495   ⟹   ENSRNOP00000089920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1042,374,585 - 42,382,445 (+)Ensembl
RefSeq Acc Id: NM_001008765   ⟹   NP_001008765
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81042,875,047 - 42,882,866 (+)NCBI
mRatBN7.21042,374,590 - 42,382,410 (+)NCBI
Rnor_6.01043,631,105 - 43,639,009 (+)NCBI
Rnor_5.01043,424,585 - 43,432,536 (+)NCBI
RGSC_v3.41043,829,273 - 43,837,092 (+)RGD
Celera1041,664,012 - 41,671,823 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001008765   ⟸   NM_001008765
- UniProtKB: A1L1K2 (UniProtKB/TrEMBL),   A6HER8 (UniProtKB/TrEMBL),   B2GV84 (UniProtKB/TrEMBL),   A0A8I6GHS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072930   ⟸   ENSRNOT00000077764
RefSeq Acc Id: ENSRNOP00000034525   ⟸   ENSRNOT00000039335
RefSeq Acc Id: ENSRNOP00000082763   ⟸   ENSRNOT00000109169
RefSeq Acc Id: ENSRNOP00000081750   ⟸   ENSRNOT00000117553
RefSeq Acc Id: ENSRNOP00000089920   ⟸   ENSRNOT00000118495
Protein Domains
IRG-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7F469-F1-model_v2 AlphaFold F7F469 1-1388 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306896 AgrOrtholog
BioCyc Gene G2FUF-25005 BioCyc
Ensembl Genes ENSRNOG00000027008 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039335.6 UniProtKB/TrEMBL
  ENSRNOT00000077764.2 UniProtKB/TrEMBL
  ENSRNOT00000109169.1 UniProtKB/TrEMBL
  ENSRNOT00000117553.1 UniProtKB/TrEMBL
  ENSRNOT00000118495 ENTREZGENE
  ENSRNOT00000118495.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7319275 IMAGE-MGC_LOAD
InterPro G_IRG_dom UniProtKB/TrEMBL
  Interferon-inducible_GTPase UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:303163 UniProtKB/TrEMBL
MGC_CLONE MGC:188200 IMAGE-MGC_LOAD
NCBI Gene 303163 ENTREZGENE
PANTHER IMMUNITY-RELATED GTPASE FAMILY M PROTEIN UniProtKB/TrEMBL
  INTERFERON-INDUCIBLE GTPASE UniProtKB/TrEMBL
Pfam IIGP UniProtKB/TrEMBL
PhenoGen Igtp PhenoGen
PROSITE G_IRG UniProtKB/TrEMBL
RatGTEx ENSRNOG00000027008 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2K471_RAT UniProtKB/TrEMBL
  A0A8I5ZSB0_RAT UniProtKB/TrEMBL
  A0A8I5ZU46_RAT UniProtKB/TrEMBL
  A0A8I6GHS3 ENTREZGENE, UniProtKB/TrEMBL
  A1L1K2 ENTREZGENE
  A6HER8 ENTREZGENE, UniProtKB/TrEMBL
  B2GV84 ENTREZGENE, UniProtKB/TrEMBL
  Q7TPJ1_RAT UniProtKB/TrEMBL
UniProt Secondary A1L1K2 UniProtKB/TrEMBL
  F7F469 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Igtp  interferon gamma induced GTPase  Igtp_predicted  interferon gamma induced GTPase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Igtp_predicted  interferon gamma induced GTPase (predicted)      Symbol and Name status set to approved 70820 APPROVED