Igtp (interferon gamma induced GTPase) - Rat Genome Database

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Gene: Igtp (interferon gamma induced GTPase) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Igtp
Name: interferon gamma induced GTPase
RGD ID: 1306896
Description: Predicted to enable GTPase activity. Predicted to be involved in autophagosome assembly; cellular response to interferon-beta; and innate immune response. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M); PARTICIPATES IN toxoplasmosis pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ac2-233; LOC303163
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81042,875,047 - 42,882,866 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1042,876,790 - 42,882,858 (+)EnsemblGRCr8
mRatBN7.21042,374,590 - 42,382,410 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1042,357,400 - 42,408,247 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1047,039,739 - 47,047,630 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01046,530,007 - 46,537,900 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01042,033,668 - 42,041,559 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01043,631,089 - 43,639,044 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1043,613,931 - 43,653,390 (+)Ensemblrn6Rnor6.0
Rnor_5.01043,424,585 - 43,432,536 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41043,829,273 - 43,837,092 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1041,664,012 - 41,671,823 (+)NCBICelera
RGSC_v3.11043,842,896 - 43,866,669 (+)NCBI
Cytogenetic Map10q22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:26242173  


Genomics

Variants

.
Variants in Igtp
70 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:23
Count of miRNA genes:23
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000039335
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH136641  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21042,355,542 - 42,355,723 (+)MAPPERmRatBN7.2
Rnor_6.01043,611,883 - 43,612,063NCBIRnor6.0
Rnor_5.01043,405,639 - 43,405,819UniSTSRnor5.0
RGSC_v3.41043,809,090 - 43,809,270UniSTSRGSC3.4
Celera1041,645,349 - 41,645,529UniSTS
RH 3.4 Map10524.58UniSTS
Cytogenetic Map10q22UniSTS
AI175782  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21042,382,130 - 42,382,323 (+)MAPPERmRatBN7.2
Rnor_6.01043,638,730 - 43,638,922NCBIRnor6.0
Rnor_5.01043,432,222 - 43,432,414UniSTSRnor5.0
RGSC_v3.41043,836,813 - 43,837,005UniSTSRGSC3.4
Celera1041,671,544 - 41,671,736UniSTS
RH 3.4 Map71125.52UniSTS
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000039335   ⟹   ENSRNOP00000034525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1042,357,400 - 42,408,247 (+)Ensembl
Rnor_6.0 Ensembl1043,613,931 - 43,653,390 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077764   ⟹   ENSRNOP00000072930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1042,876,790 - 42,882,858 (+)Ensembl
mRatBN7.2 Ensembl1042,374,570 - 42,382,079 (+)Ensembl
Rnor_6.0 Ensembl1043,633,035 - 43,638,594 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109169   ⟹   ENSRNOP00000082763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1042,374,585 - 42,381,021 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117553   ⟹   ENSRNOP00000081750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1042,880,846 - 42,882,858 (+)Ensembl
mRatBN7.2 Ensembl1042,360,790 - 42,397,547 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118495   ⟹   ENSRNOP00000089920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1042,876,790 - 42,882,832 (+)Ensembl
mRatBN7.2 Ensembl1042,374,585 - 42,382,445 (+)Ensembl
RefSeq Acc Id: NM_001008765   ⟹   NP_001008765
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81042,875,047 - 42,882,866 (+)NCBI
mRatBN7.21042,374,590 - 42,382,410 (+)NCBI
Rnor_6.01043,631,105 - 43,639,009 (+)NCBI
Rnor_5.01043,424,585 - 43,432,536 (+)NCBI
RGSC_v3.41043,829,273 - 43,837,092 (+)RGD
Celera1041,664,012 - 41,671,823 (+)RGD
Sequence:
RefSeq Acc Id: NP_001008765   ⟸   NM_001008765
- UniProtKB: A1L1K2 (UniProtKB/TrEMBL),   A6HER8 (UniProtKB/TrEMBL),   B2GV84 (UniProtKB/TrEMBL),   A0A8I6GHS3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072930   ⟸   ENSRNOT00000077764
Ensembl Acc Id: ENSRNOP00000034525   ⟸   ENSRNOT00000039335
Ensembl Acc Id: ENSRNOP00000082763   ⟸   ENSRNOT00000109169
Ensembl Acc Id: ENSRNOP00000081750   ⟸   ENSRNOT00000117553
Ensembl Acc Id: ENSRNOP00000089920   ⟸   ENSRNOT00000118495
Protein Domains
IRG-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7F469-F1-model_v2 AlphaFold F7F469 1-1388 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306896 AgrOrtholog
BioCyc Gene G2FUF-25005 BioCyc
Ensembl Genes ENSRNOG00000027008 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000077764.3 UniProtKB/TrEMBL
  ENSRNOT00000117553.2 UniProtKB/TrEMBL
  ENSRNOT00000118495 ENTREZGENE
  ENSRNOT00000118495.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7319275 IMAGE-MGC_LOAD
InterPro G_IRG_dom UniProtKB/TrEMBL
  Interferon-inducible_GTPase UniProtKB/TrEMBL
  IRG UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:303163 UniProtKB/TrEMBL
MGC_CLONE MGC:188200 IMAGE-MGC_LOAD
NCBI Gene 303163 ENTREZGENE
PANTHER IMMUNITY-RELATED GTPASE FAMILY M PROTEIN 2-RELATED UniProtKB/TrEMBL
  INTERFERON-INDUCIBLE GTPASE UniProtKB/TrEMBL
Pfam IIGP UniProtKB/TrEMBL
PhenoGen Igtp PhenoGen
PROSITE G_IRG UniProtKB/TrEMBL
RatGTEx ENSRNOG00000027008 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2K471_RAT UniProtKB/TrEMBL
  A0A8I5ZSB0_RAT UniProtKB/TrEMBL
  A0A8I6GHS3 ENTREZGENE, UniProtKB/TrEMBL
  A1L1K2 ENTREZGENE
  A6HER8 ENTREZGENE, UniProtKB/TrEMBL
  B2GV84 ENTREZGENE, UniProtKB/TrEMBL
  Q7TPJ1_RAT UniProtKB/TrEMBL
UniProt Secondary A1L1K2 UniProtKB/TrEMBL
  F7F469 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Igtp  interferon gamma induced GTPase  Igtp_predicted  interferon gamma induced GTPase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Igtp_predicted  interferon gamma induced GTPase (predicted)      Symbol and Name status set to approved 70820 APPROVED