Actl9 (actin-like 9) - Rat Genome Database

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Gene: Actl9 (actin-like 9) Rattus norvegicus
Analyze
Symbol: Actl9
Name: actin-like 9
RGD ID: 1306886
Description: Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in acrosome assembly and fertilization. Predicted to be located in acrosomal vesicle; perinuclear theca; and sperm head. Predicted to be active in actin cytoskeleton. Human ortholog(s) of this gene implicated in spermatogenic failure 53. Orthologous to human ACTL9 (actin like 9); INTERACTS WITH bisphenol A; cadmium dichloride; 17alpha-ethynylestradiol (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: actin-like 9A; actin-like protein 9; Actl9a; LOC314659; RGD1306886; similar to actin-like 7-alpha-like protein
RGD Orthologs
Human
Mouse
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8714,936,690 - 14,938,067 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl714,935,601 - 15,006,102 (+)EnsemblGRCr8
mRatBN7.2714,234,504 - 14,235,881 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl714,234,504 - 14,235,881 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx717,237,799 - 17,239,176 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0719,108,924 - 19,110,301 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0716,989,328 - 16,990,705 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd717,775,632 - 17,777,009 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive717,938,977 - 17,940,354 (+)NCBILyon_Normotensive
Lyon_Hypertensive718,014,494 - 18,015,871 (+)NCBILyon_Hypertensive
F344_StmMcwi716,377,791 - 16,379,168 (+)NCBIF344_StmMcwi
Rnor_6.0718,310,624 - 18,312,001 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl718,310,624 - 18,312,001 (+)Ensemblrn6Rnor6.0
Rnor_5.0718,488,144 - 18,489,521 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4715,944,094 - 15,945,471 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera713,134,241 - 13,135,618 (+)NCBICelera
RGSC_v3.1715,944,166 - 15,945,467 (+)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Actl9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8714,936,690 - 14,938,067 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl714,935,601 - 15,006,102 (+)EnsemblGRCr8
mRatBN7.2714,234,504 - 14,235,881 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl714,234,504 - 14,235,881 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx717,237,799 - 17,239,176 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0719,108,924 - 19,110,301 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0716,989,328 - 16,990,705 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd717,775,632 - 17,777,009 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive717,938,977 - 17,940,354 (+)NCBILyon_Normotensive
Lyon_Hypertensive718,014,494 - 18,015,871 (+)NCBILyon_Hypertensive
F344_StmMcwi716,377,791 - 16,379,168 (+)NCBIF344_StmMcwi
Rnor_6.0718,310,624 - 18,312,001 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl718,310,624 - 18,312,001 (+)Ensemblrn6Rnor6.0
Rnor_5.0718,488,144 - 18,489,521 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4715,944,094 - 15,945,471 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera713,134,241 - 13,135,618 (+)NCBICelera
RGSC_v3.1715,944,166 - 15,945,467 (+)NCBI
Cytogenetic Map7q11NCBI
ACTL9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38198,697,400 - 8,698,795 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl198,697,400 - 8,698,795 (-)Ensemblhg38GRCh38
GRCh37198,807,750 - 8,809,145 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36198,668,753 - 8,670,172 (-)NCBIBuild 36Build 36hg18NCBI36
Celera198,627,110 - 8,628,531 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef198,423,908 - 8,425,329 (-)NCBIHuRef
CHM1_1198,807,253 - 8,808,674 (-)NCBICHM1_1
T2T-CHM13v2.0198,692,998 - 8,694,393 (-)NCBIT2T-CHM13v2.0
Actl9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391733,651,873 - 33,653,242 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1733,651,870 - 33,653,242 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381733,432,899 - 33,434,268 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1733,432,896 - 33,434,268 (+)Ensemblmm10GRCm38
MGSCv371733,569,844 - 33,571,213 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361733,035,344 - 33,036,713 (+)NCBIMGSCv36mm8
Celera1736,194,369 - 36,195,738 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
ACTL9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl270,658,247 - 70,659,497 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1270,658,141 - 70,659,497 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2271,026,249 - 71,027,727 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACTL9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.168,045,858 - 8,047,510 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl68,045,910 - 8,047,160 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607412,181,584 - 12,183,167 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Actl9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248281,379,751 - 1,380,965 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248281,379,709 - 1,381,237 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Actl9
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11158,963,288 - 158,964,647 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Actl9
21 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:43
Interacting mature miRNAs:45
Transcripts:ENSRNOT00000075258
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
2 4 2 9 13 15 7 9 7 30 13 9 6 24 8

Sequence


Ensembl Acc Id: ENSRNOT00000075258   ⟹   ENSRNOP00000067593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl714,935,601 - 15,006,102 (+)Ensembl
mRatBN7.2 Ensembl714,234,504 - 14,235,881 (+)Ensembl
Rnor_6.0 Ensembl718,310,624 - 18,312,001 (+)Ensembl
RefSeq Acc Id: NM_001108077   ⟹   NP_001101547
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8714,936,690 - 14,938,067 (+)NCBI
mRatBN7.2714,234,504 - 14,235,881 (+)NCBI
Dahl_SR_JrHsd717,775,632 - 17,777,009 (+)NCBI
Lyon_Normotensive717,938,977 - 17,940,354 (+)NCBI
Lyon_Hypertensive718,014,494 - 18,015,871 (+)NCBI
F344_StmMcwi716,377,791 - 16,379,168 (+)NCBI
Rnor_6.0718,310,624 - 18,312,001 (+)NCBI
Rnor_5.0718,488,144 - 18,489,521 (+)NCBI
RGSC_v3.4715,944,094 - 15,945,471 (+)RGD
Celera713,134,241 - 13,135,618 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101547 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI67767 (Get FASTA)   NCBI Sequence Viewer  
  EDL86637 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067593.2
RefSeq Acc Id: NP_001101547   ⟸   NM_001108077
- UniProtKB: B3DMA6 (UniProtKB/TrEMBL),   M0RD96 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067593   ⟸   ENSRNOT00000075258

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B3DMA6-F1-model_v2 AlphaFold B3DMA6 1-415 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695078
Promoter ID:EPDNEW_R5603
Type:multiple initiation site
Name:Actl9_1
Description:actin-like 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0718,310,628 - 18,310,688EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306886 AgrOrtholog
BioCyc Gene G2FUF-34725 BioCyc
Ensembl Genes ENSRNOG00000049571 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075258.4 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.40 UniProtKB/TrEMBL
  Actin, Chain A, domain 4 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7456143 IMAGE-MGC_LOAD
InterPro Actin-like UniProtKB/TrEMBL
  ATPase_NBD UniProtKB/TrEMBL
KEGG Report rno:314659 UniProtKB/TrEMBL
MGC_CLONE MGC:187540 IMAGE-MGC_LOAD
NCBI Gene 314659 ENTREZGENE
PANTHER Actin_like UniProtKB/TrEMBL
Pfam Actin UniProtKB/TrEMBL
PhenoGen Actl9 PhenoGen
PRINTS ACTIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049571 RatGTEx
SMART ACTIN UniProtKB/TrEMBL
Superfamily-SCOP SSF53067 UniProtKB/TrEMBL
UniProt B3DMA6 ENTREZGENE, UniProtKB/TrEMBL
  M0RD96 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-06-12 Actl9  actin-like 9  RGD1306886  similar to actin-like 7-alpha-like protein   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1306886  similar to actin-like 7-alpha-like protein   RGD1306886_predicted  similar to actin-like 7-alpha-like protein (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1306886_predicted  similar to actin-like 7-alpha-like protein (predicted)  LOC314659_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC314659_predicted  similar to actin-like 7-alpha-like protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL