Thumpd2 (THUMP domain 2 tRNA and snRNA guanosine methyltransferase) - Rat Genome Database

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Gene: Thumpd2 (THUMP domain 2 tRNA and snRNA guanosine methyltransferase) Rattus norvegicus
Analyze
Symbol: Thumpd2
Name: THUMP domain 2 tRNA and snRNA guanosine methyltransferase (Ensembl:THUMP domain containing 2)
RGD ID: 1306878
Description: Predicted to enable U6 snRNA (guanine-N(2))-methyltransferase activity and tRNA (guanine) methyltransferase activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome and tRNA methylation. Predicted to be part of tRNA methyltransferase complex. Predicted to be active in nucleus. Orthologous to human THUMPD2 (THUMP domain containing 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC313851; MGC108999; THUMP domain containing 2; THUMP domain-containing protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8619,677,039 - 19,728,947 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl619,677,025 - 19,739,317 (+)EnsemblGRCr8
mRatBN7.2613,924,742 - 13,976,657 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl613,924,765 - 13,976,657 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx614,228,394 - 14,280,284 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0614,551,389 - 14,596,793 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0614,041,656 - 14,093,548 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.063,743,080 - 3,794,512 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl63,743,074 - 3,794,501 (-)Ensemblrn6Rnor6.0
Rnor_5.063,710,777 - 3,762,198 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.463,974,995 - 4,026,884 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera613,611,109 - 13,658,637 (+)NCBICelera
RGSC_v3.163,974,998 - 4,026,884 (-)NCBI
Cytogenetic Map6q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Thumpd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8619,677,039 - 19,728,947 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl619,677,025 - 19,739,317 (+)EnsemblGRCr8
mRatBN7.2613,924,742 - 13,976,657 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl613,924,765 - 13,976,657 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx614,228,394 - 14,280,284 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0614,551,389 - 14,596,793 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0614,041,656 - 14,093,548 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.063,743,080 - 3,794,512 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl63,743,074 - 3,794,501 (-)Ensemblrn6Rnor6.0
Rnor_5.063,710,777 - 3,762,198 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.463,974,995 - 4,026,884 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera613,611,109 - 13,658,637 (+)NCBICelera
RGSC_v3.163,974,998 - 4,026,884 (-)NCBI
Cytogenetic Map6q12NCBI
THUMPD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38239,736,060 - 39,779,276 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl239,736,060 - 39,779,276 (-)Ensemblhg38GRCh38
GRCh37239,963,200 - 40,006,416 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36239,816,949 - 39,859,881 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34239,875,095 - 39,918,028NCBI
Celera239,804,157 - 39,847,379 (-)NCBICelera
Cytogenetic Map2p22.1NCBI
HuRef239,702,624 - 39,745,816 (-)NCBIHuRef
CHM1_1239,893,491 - 39,936,707 (-)NCBICHM1_1
T2T-CHM13v2.0239,745,056 - 39,788,273 (-)NCBIT2T-CHM13v2.0
Thumpd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391781,331,676 - 81,372,542 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1781,333,761 - 81,372,511 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381781,024,247 - 81,065,113 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1781,026,332 - 81,065,082 (-)Ensemblmm10GRCm38
MGSCv371781,425,667 - 81,464,425 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361780,934,653 - 80,973,411 (-)NCBIMGSCv36mm8
Celera1785,358,226 - 85,398,858 (-)NCBICelera
Cytogenetic Map17E3NCBI
cM Map1751.04NCBI
Thumpd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554417,329,093 - 7,369,782 (-)Ensembl
ChiLan1.0NW_0049554417,329,468 - 7,369,957 (-)NCBIChiLan1.0ChiLan1.0
THUMPD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21286,690,167 - 86,732,755 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A86,694,147 - 86,737,375 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A39,768,913 - 39,816,471 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A40,526,774 - 40,569,226 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A40,526,774 - 40,571,909 (-)EnsemblpanPan2panpan1.1
THUMPD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11731,701,025 - 31,738,451 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1731,701,475 - 31,738,478 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1731,460,906 - 31,498,263 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01732,359,635 - 32,397,274 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1732,359,660 - 32,397,265 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11731,580,931 - 31,618,257 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01731,650,259 - 31,687,785 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01731,864,590 - 31,902,483 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Thumpd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629240,140,558 - 40,182,653 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650811,569,170 - 11,611,609 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650811,569,195 - 11,611,264 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THUMPD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3100,557,016 - 100,597,671 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.13100,557,168 - 100,597,664 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23106,694,190 - 106,734,643 (-)NCBISscrofa10.2Sscrofa10.2susScr3
THUMPD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11467,589,985 - 67,632,144 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604544,305,947 - 44,375,406 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Thumpd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473821,237,709 - 21,287,551 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473821,238,535 - 21,287,491 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Thumpd2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1711,984,671 - 12,023,010 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Thumpd2
418 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:147
Count of miRNA genes:118
Interacting mature miRNAs:126
Transcripts:ENSRNOT00000011000
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
8693699Alc37Alcohol consumption QTL 372.60.224drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)61371716927053860Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6125740059Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6120510098Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat
8693690Alc35Alcohol consumption QTL 352.20.606drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)61371716927053860Rat

Markers in Region
RH130889  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2613,947,264 - 13,947,448 (-)MAPPERmRatBN7.2
Rnor_6.063,771,818 - 3,772,001NCBIRnor6.0
Rnor_5.063,739,515 - 3,739,698UniSTSRnor5.0
RGSC_v3.464,004,199 - 4,004,382UniSTSRGSC3.4
Celera613,633,564 - 13,633,747UniSTS
Cytogenetic Map6q12UniSTS
RH132120  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2613,976,412 - 13,976,562 (-)MAPPERmRatBN7.2
Rnor_6.063,743,175 - 3,743,324NCBIRnor6.0
Rnor_5.063,710,872 - 3,711,021UniSTSRnor5.0
RGSC_v3.463,975,090 - 3,975,239UniSTSRGSC3.4
Celera613,658,393 - 13,658,542UniSTS
Cytogenetic Map6q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000011000   ⟹   ENSRNOP00000011000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl619,677,046 - 19,728,942 (+)Ensembl
mRatBN7.2 Ensembl613,924,765 - 13,976,657 (+)Ensembl
Rnor_6.0 Ensembl63,743,080 - 3,794,501 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084499   ⟹   ENSRNOP00000071513
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl619,677,046 - 19,728,942 (+)Ensembl
mRatBN7.2 Ensembl613,924,765 - 13,976,653 (+)Ensembl
Rnor_6.0 Ensembl63,743,084 - 3,794,501 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087891   ⟹   ENSRNOP00000075202
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl619,677,025 - 19,728,942 (+)Ensembl
mRatBN7.2 Ensembl613,924,765 - 13,976,653 (+)Ensembl
Rnor_6.0 Ensembl63,743,074 - 3,794,489 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100728   ⟹   ENSRNOP00000086376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl619,677,046 - 19,739,317 (+)Ensembl
mRatBN7.2 Ensembl613,934,280 - 13,974,854 (+)Ensembl
RefSeq Acc Id: NM_001012108   ⟹   NP_001012108
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8619,677,060 - 19,728,944 (+)NCBI
mRatBN7.2613,924,765 - 13,976,654 (+)NCBI
Rnor_6.063,743,083 - 3,794,501 (-)NCBI
Rnor_5.063,710,777 - 3,762,198 (-)NCBI
RGSC_v3.463,974,995 - 4,026,884 (-)RGD
Celera613,611,109 - 13,658,634 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001163506   ⟹   NP_001156978
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8619,677,060 - 19,728,947 (+)NCBI
mRatBN7.2613,924,765 - 13,976,657 (+)NCBI
Rnor_6.063,743,080 - 3,794,501 (-)NCBI
Rnor_5.063,710,777 - 3,762,198 (-)NCBI
RGSC_v3.463,974,995 - 4,026,884 (-)RGD
Celera613,611,109 - 13,658,637 (+)RGD
Sequence:
RefSeq Acc Id: NM_001410276   ⟹   NP_001397205
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8619,677,060 - 19,728,944 (+)NCBI
mRatBN7.2613,924,765 - 13,976,654 (+)NCBI
RefSeq Acc Id: XM_006239673   ⟹   XP_006239735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8619,677,045 - 19,728,944 (+)NCBI
mRatBN7.2613,924,742 - 13,976,654 (+)NCBI
Rnor_6.063,743,083 - 3,794,512 (-)NCBI
Rnor_5.063,710,777 - 3,762,198 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006239675   ⟹   XP_006239737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8619,677,045 - 19,728,944 (+)NCBI
mRatBN7.2613,924,742 - 13,976,173 (+)NCBI
Rnor_6.063,743,612 - 3,794,512 (-)NCBI
Rnor_5.063,710,777 - 3,762,198 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006239677   ⟹   XP_006239739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8619,677,045 - 19,728,944 (+)NCBI
mRatBN7.2613,924,742 - 13,976,173 (+)NCBI
Rnor_6.063,743,612 - 3,794,512 (-)NCBI
Rnor_5.063,710,777 - 3,762,198 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008764440   ⟹   XP_008762662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8619,677,039 - 19,728,944 (+)NCBI
mRatBN7.2613,924,742 - 13,976,183 (+)NCBI
Rnor_6.063,743,599 - 3,794,512 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594116   ⟹   XP_017449605
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8619,677,045 - 19,728,944 (+)NCBI
mRatBN7.2613,924,742 - 13,972,933 (+)NCBI
Rnor_6.063,746,910 - 3,794,512 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039112142   ⟹   XP_038968070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8619,677,045 - 19,728,944 (+)NCBI
mRatBN7.2613,924,742 - 13,976,173 (+)NCBI
RefSeq Acc Id: XM_039112143   ⟹   XP_038968071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8619,677,044 - 19,728,944 (+)NCBI
mRatBN7.2613,924,742 - 13,976,183 (+)NCBI
RefSeq Acc Id: XM_039112145   ⟹   XP_038968073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8619,677,045 - 19,723,197 (+)NCBI
mRatBN7.2613,924,742 - 13,970,951 (+)NCBI
RefSeq Acc Id: XM_063261827   ⟹   XP_063117897
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8619,677,045 - 19,728,944 (+)NCBI
RefSeq Acc Id: XR_005505504
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8619,677,039 - 19,704,510 (+)NCBI
mRatBN7.2613,924,742 - 13,952,212 (+)NCBI
RefSeq Acc Id: NP_001156978   ⟸   NM_001163506
- Peptide Label: isoform 1
- UniProtKB: D4A475 (UniProtKB/TrEMBL),   A6H9P7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001012108   ⟸   NM_001012108
- Peptide Label: isoform 2
- UniProtKB: A0A0G2K0N2 (UniProtKB/TrEMBL),   Q5FVM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239735   ⟸   XM_006239673
- Peptide Label: isoform X1
- UniProtKB: A6H9P7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239739   ⟸   XM_006239677
- Peptide Label: isoform X7
- UniProtKB: A0A0G2K0N2 (UniProtKB/TrEMBL),   Q5FVM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239737   ⟸   XM_006239675
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008762662   ⟸   XM_008764440
- Peptide Label: isoform X6
- UniProtKB: A0A0G2KA02 (UniProtKB/TrEMBL),   A0A0G2K0N2 (UniProtKB/TrEMBL),   Q5FVM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449605   ⟸   XM_017594116
- Peptide Label: isoform X8
- Sequence:
Ensembl Acc Id: ENSRNOP00000071513   ⟸   ENSRNOT00000084499
Ensembl Acc Id: ENSRNOP00000075202   ⟸   ENSRNOT00000087891
Ensembl Acc Id: ENSRNOP00000011000   ⟸   ENSRNOT00000011000
RefSeq Acc Id: XP_038968071   ⟸   XM_039112143
- Peptide Label: isoform X5
- UniProtKB: A0A0G2K0N2 (UniProtKB/TrEMBL),   Q5FVM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968070   ⟸   XM_039112142
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A3I0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968073   ⟸   XM_039112145
- Peptide Label: isoform X9
Ensembl Acc Id: ENSRNOP00000086376   ⟸   ENSRNOT00000100728
RefSeq Acc Id: NP_001397205   ⟸   NM_001410276
- Peptide Label: isoform 3
- UniProtKB: A6H9P7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117897   ⟸   XM_063261827
- Peptide Label: isoform X2
- UniProtKB: A6H9P7 (UniProtKB/TrEMBL)
Protein Domains
Ribosomal RNA large subunit methyltransferase K/L-   THUMP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A475-F1-model_v2 AlphaFold D4A475 1-549 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694369
Promoter ID:EPDNEW_R4894
Type:multiple initiation site
Name:Thumpd2_1
Description:THUMP domain containing 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.063,794,502 - 3,794,562EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306878 AgrOrtholog
BioCyc Gene G2FUF-38547 BioCyc
Ensembl Genes ENSRNOG00000008291 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011000 ENTREZGENE
  ENSRNOT00000011000.7 UniProtKB/TrEMBL
  ENSRNOT00000084499 ENTREZGENE
  ENSRNOT00000084499.3 UniProtKB/TrEMBL
  ENSRNOT00000087891 ENTREZGENE
  ENSRNOT00000087891.3 UniProtKB/TrEMBL
  ENSRNOT00000100728.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2130.30 UniProtKB/TrEMBL
  3.40.50.150 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7324079 IMAGE-MGC_LOAD
InterPro RNA_methylase UniProtKB/TrEMBL
  SAM-dependent_MTases-like UniProtKB/TrEMBL
  THUMP UniProtKB/TrEMBL
KEGG Report rno:313851 UniProtKB/TrEMBL
MGC_CLONE MGC:108999 IMAGE-MGC_LOAD
NCBI Gene 313851 ENTREZGENE
PANTHER THUMP DOMAIN-CONTAINING UniProtKB/TrEMBL
  THUMP DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
Pfam UPF0020 UniProtKB/TrEMBL
PhenoGen Thumpd2 PhenoGen
PROSITE THUMP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008291 RatGTEx
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
  THUMP domain-like UniProtKB/TrEMBL
UniProt A0A0G2K0N2 ENTREZGENE
  A0A0G2KA02 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A3I0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABZ3NNB4_RAT UniProtKB/TrEMBL
  A6H9P7 ENTREZGENE, UniProtKB/TrEMBL
  D4A475 ENTREZGENE, UniProtKB/TrEMBL
  Q5FVM9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A0G2K0N2 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-11-13 Thumpd2  THUMP domain 2 tRNA and snRNA guanosine methyltransferase  Thumpd2  THUMP domain containing 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Thumpd2  THUMP domain containing 2  Thumpd2_predicted  THUMP domain containing 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Thumpd2_predicted  THUMP domain containing 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED