Il36a (interleukin 36, alpha) - Rat Genome Database

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Gene: Il36a (interleukin 36, alpha) Rattus norvegicus
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Symbol: Il36a
Name: interleukin 36, alpha
RGD ID: 1306869
Description: Predicted to enable cytokine activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; cytokine-mediated signaling pathway; and inflammatory response. Predicted to act upstream of or within positive regulation of interleukin-6 production. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human IL36A (interleukin 36 alpha); INTERACTS WITH bisphenol A; 4-hydroxynon-2-enal (ortholog); aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Il1f6; interleukin 1 family, member 6; interleukin-1 family member 6; interleukin-36 alpha; LOC296541
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8327,395,146 - 27,399,695 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl327,395,146 - 27,399,695 (+)EnsemblGRCr8
mRatBN7.236,996,851 - 7,001,400 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl36,996,851 - 7,001,400 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx310,091,850 - 10,096,462 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0318,678,075 - 18,682,687 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0316,867,882 - 16,872,494 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.031,330,790 - 1,335,811 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl31,331,226 - 1,335,775 (+)Ensemblrn6Rnor6.0
Rnor_5.031,323,993 - 1,328,542 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.432,482,480 - 2,487,029 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera31,834,196 - 1,838,742 (+)NCBICelera
RGSC_v3.132,473,610 - 2,485,996 (+)NCBI
Cytogenetic Map3p13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19717513   PMID:21860022  


Genomics

Comparative Map Data
Il36a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8327,395,146 - 27,399,695 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl327,395,146 - 27,399,695 (+)EnsemblGRCr8
mRatBN7.236,996,851 - 7,001,400 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl36,996,851 - 7,001,400 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx310,091,850 - 10,096,462 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0318,678,075 - 18,682,687 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0316,867,882 - 16,872,494 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.031,330,790 - 1,335,811 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl31,331,226 - 1,335,775 (+)Ensemblrn6Rnor6.0
Rnor_5.031,323,993 - 1,328,542 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.432,482,480 - 2,487,029 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera31,834,196 - 1,838,742 (+)NCBICelera
RGSC_v3.132,473,610 - 2,485,996 (+)NCBI
Cytogenetic Map3p13NCBI
IL36A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382113,005,459 - 113,011,072 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2113,005,459 - 113,008,044 (+)Ensemblhg38GRCh38
GRCh372113,763,036 - 113,765,621 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362113,479,920 - 113,482,092 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342113,479,679 - 113,481,852NCBI
Celera2107,148,610 - 107,150,782 (+)NCBICelera
Cytogenetic Map2q14.1NCBI
HuRef2106,218,002 - 106,220,174 (+)NCBIHuRef
CHM1_12113,767,604 - 113,769,776 (+)NCBICHM1_1
T2T-CHM13v2.02113,431,988 - 113,437,599 (+)NCBIT2T-CHM13v2.0
Il36a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39224,105,429 - 24,115,713 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl224,105,430 - 24,115,714 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38224,215,417 - 24,225,701 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl224,215,418 - 24,225,702 (+)Ensemblmm10GRCm38
MGSCv37224,070,937 - 24,081,221 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36224,037,426 - 24,047,710 (+)NCBIMGSCv36mm8
Celera223,934,862 - 23,945,148 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map216.26NCBI
IL36A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21215,143,627 - 15,157,101 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A15,146,393 - 15,151,862 (-)NCBINHGRI_mPanPan1
Il36a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629282,474,970 - 82,476,974 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367831,369,537 - 1,371,458 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367831,369,454 - 1,371,458 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL36A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11416,017,847 - 16,030,680 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1416,028,002 - 16,030,097 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660803,651,138 - 3,653,829 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il36a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1512,974,710 - 12,979,739 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Il36a
21 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:166
Count of miRNA genes:117
Interacting mature miRNAs:128
Transcripts:ENSRNOT00000007540
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 4 13 23 11 11 11 3 28 11 1 3 36 12

Sequence


Ensembl Acc Id: ENSRNOT00000007540   ⟹   ENSRNOP00000007540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl327,395,146 - 27,399,695 (+)Ensembl
mRatBN7.2 Ensembl36,996,851 - 7,001,400 (+)Ensembl
Rnor_6.0 Ensembl31,331,226 - 1,335,775 (+)Ensembl
RefSeq Acc Id: NM_001106554   ⟹   NP_001100024
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8327,395,146 - 27,399,695 (+)NCBI
mRatBN7.236,996,851 - 7,001,400 (+)NCBI
Rnor_6.031,331,226 - 1,335,775 (+)NCBI
Rnor_5.031,323,993 - 1,328,542 (+)NCBI
RGSC_v3.432,482,480 - 2,487,029 (+)RGD
Celera31,834,196 - 1,838,742 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100024 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93670 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007540
  ENSRNOP00000007540.4
RefSeq Acc Id: NP_001100024   ⟸   NM_001106554
- UniProtKB: D4A1I2 (UniProtKB/TrEMBL),   A6JSX7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007540   ⟸   ENSRNOT00000007540

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A1I2-F1-model_v2 AlphaFold D4A1I2 1-160 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306869 AgrOrtholog
BioCyc Gene G2FUF-50512 BioCyc
Ensembl Genes ENSRNOG00000005722 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007540 ENTREZGENE
  ENSRNOT00000007540.7 UniProtKB/TrEMBL
Gene3D-CATH 2.80.10.50 UniProtKB/TrEMBL
InterPro Cytokine_IL1-like UniProtKB/TrEMBL
  IL_rcpt_IL1RA UniProtKB/TrEMBL
  Interleukin_1 UniProtKB/TrEMBL
KEGG Report rno:296541 UniProtKB/TrEMBL
NCBI Gene 296541 ENTREZGENE
PANTHER PTHR10078 UniProtKB/TrEMBL
  PTHR10078:SF25 UniProtKB/TrEMBL
Pfam IL1 UniProtKB/TrEMBL
PhenoGen Il36a PhenoGen
PRINTS INTERLEUKIN1 UniProtKB/TrEMBL
  INTRLEUKIN1X UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005722 RatGTEx
SMART IL1 UniProtKB/TrEMBL
Superfamily-SCOP Cytok_IL1_like UniProtKB/TrEMBL
UniProt A6JSX7 ENTREZGENE, UniProtKB/TrEMBL
  D4A1I2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-03 Il36a  interleukin 36, alpha  Il1f6  interleukin 1 family, member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Il1f6  interleukin 1 family, member 6   Il1f6_predicted  interleukin 1 family, member 6 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Il1f6_predicted  interleukin 1 family, member 6 (predicted)      Symbol and Name status set to approved 70820 APPROVED