Nadk2 (NAD kinase 2, mitochondrial) - Rat Genome Database

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Gene: Nadk2 (NAD kinase 2, mitochondrial) Rattus norvegicus
Analyze
Symbol: Nadk2
Name: NAD kinase 2, mitochondrial
RGD ID: 1306809
Description: Predicted to enable NAD+ kinase activity and protein homodimerization activity. Predicted to be involved in NAD+ metabolic process and NADP+ biosynthetic process. Predicted to be active in mitochondrial matrix. Orthologous to human NADK2 (NAD kinase 2, mitochondrial); PARTICIPATES IN nicotinamide adenine dinucleotide metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC365699; LOC365699; MGC125061; mitochondrial NAD kinase; NAD kinase domain containing 1; NAD kinase domain-containing protein 1; NAD kinase domain-containing protein 1, mitochondrial; Nadkd1; RGD1306809; similar to hypothetical protein FLJ30596
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8259,844,854 - 59,886,989 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl259,844,854 - 59,886,988 (+)EnsemblGRCr8
mRatBN7.2258,117,674 - 58,159,815 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl258,117,674 - 58,159,808 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx265,215,434 - 65,257,679 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0263,327,755 - 63,369,942 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0258,329,066 - 58,371,261 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0258,462,588 - 58,504,735 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl258,462,588 - 58,504,728 (+)Ensemblrn6Rnor6.0
Rnor_5.0277,550,016 - 77,592,163 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4258,725,461 - 58,767,746 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera253,725,937 - 53,768,584 (+)NCBICelera
RGSC_v3.1258,653,693 - 58,694,420 (+)NCBI
Cytogenetic Map2q16NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
glafenine  (EXP)
GSK-J4  (ISO)
inulin  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosomorpholine  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrial matrix  (IEA,ISO)
mitochondrion  (IBA,IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. MNADK, a Long-Awaited Human Mitochondrion-Localized NAD Kinase. Zhang R J Cell Physiol. 2015 Aug;230(8):1697-701. doi: 10.1002/jcp.24926.
Additional References at PubMed
PMID:12477932   PMID:14651853   PMID:23212377  


Genomics

Comparative Map Data
Nadk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8259,844,854 - 59,886,989 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl259,844,854 - 59,886,988 (+)EnsemblGRCr8
mRatBN7.2258,117,674 - 58,159,815 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl258,117,674 - 58,159,808 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx265,215,434 - 65,257,679 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0263,327,755 - 63,369,942 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0258,329,066 - 58,371,261 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0258,462,588 - 58,504,735 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl258,462,588 - 58,504,728 (+)Ensemblrn6Rnor6.0
Rnor_5.0277,550,016 - 77,592,163 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4258,725,461 - 58,767,746 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera253,725,937 - 53,768,584 (+)NCBICelera
RGSC_v3.1258,653,693 - 58,694,420 (+)NCBI
Cytogenetic Map2q16NCBI
NADK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38536,192,589 - 36,242,279 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl536,192,589 - 36,242,279 (-)Ensemblhg38GRCh38
GRCh37536,192,691 - 36,242,381 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36536,228,451 - 36,278,015 (-)NCBIBuild 36Build 36hg18NCBI36
Celera536,078,373 - 36,127,931 (-)NCBICelera
Cytogenetic Map5p13.2NCBI
HuRef536,143,686 - 36,193,895 (-)NCBIHuRef
CHM1_1536,195,428 - 36,245,010 (-)NCBICHM1_1
T2T-CHM13v2.0536,440,876 - 36,490,588 (-)NCBIT2T-CHM13v2.0
Nadk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39159,071,340 - 9,110,584 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl159,071,340 - 9,110,979 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38159,071,260 - 9,110,496 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl159,071,260 - 9,110,891 (+)Ensemblmm10GRCm38
MGSCv37159,001,009 - 9,040,244 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36158,998,111 - 9,038,170 (+)NCBIMGSCv36mm8
Celera158,884,697 - 8,927,605 (+)NCBICelera
Cytogenetic Map15A1NCBI
cM Map153.82NCBI
Nadk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542621,004,785 - 21,049,050 (-)Ensembl
ChiLan1.0NW_00495542621,002,849 - 21,049,187 (-)NCBIChiLan1.0ChiLan1.0
NADK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2474,087,676 - 74,136,980 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1572,241,308 - 72,290,612 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0574,121,313 - 74,170,774 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1579,402,924 - 79,452,194 (+)NCBIPanPan1.1PanPan1.1panPan2
Nadk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213225,738,877 - 225,786,016 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365185,586,077 - 5,631,018 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365185,585,911 - 5,632,961 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NADK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1621,506,769 - 21,557,274 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11621,507,422 - 21,557,312 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21622,523,734 - 22,574,171 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NADK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1435,043,211 - 35,088,725 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl435,042,814 - 35,076,288 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607125,374,466 - 25,419,928 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nadk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475918,775,798 - 18,811,811 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475918,775,783 - 18,813,409 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nadk2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13171,474,876 - 171,516,495 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nadk2
287 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6480225Gdil1Gastrointestinal dilation QTL 1enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)25838820177302351Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23675034481750344Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24490435585286097Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)25126685996266859Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23686864381868643Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)24490435589904355Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)23326999678269996Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat

Markers in Region
RH138675  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2258,159,146 - 58,159,267 (+)MAPPERmRatBN7.2
Rnor_6.0258,504,067 - 58,504,187NCBIRnor6.0
Rnor_5.0277,591,495 - 77,591,615UniSTSRnor5.0
RGSC_v3.4258,767,085 - 58,767,205UniSTSRGSC3.4
Celera253,767,923 - 53,768,043UniSTS
Cytogenetic Map2q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000080618   ⟹   ENSRNOP00000074867
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl259,845,255 - 59,886,988 (+)Ensembl
mRatBN7.2 Ensembl258,117,984 - 58,159,808 (+)Ensembl
Rnor_6.0 Ensembl258,462,949 - 58,503,489 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083799   ⟹   ENSRNOP00000074419
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl259,844,854 - 59,886,988 (+)Ensembl
mRatBN7.2 Ensembl258,117,674 - 58,159,808 (+)Ensembl
Rnor_6.0 Ensembl258,462,588 - 58,504,728 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094491   ⟹   ENSRNOP00000079475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl259,845,255 - 59,886,988 (+)Ensembl
mRatBN7.2 Ensembl258,117,984 - 58,159,808 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111710   ⟹   ENSRNOP00000080674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl259,845,255 - 59,886,988 (+)Ensembl
mRatBN7.2 Ensembl258,117,984 - 58,159,808 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118441   ⟹   ENSRNOP00000080309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl259,845,576 - 59,886,988 (+)Ensembl
mRatBN7.2 Ensembl258,117,984 - 58,159,808 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000138669   ⟹   ENSRNOP00000106732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl259,845,255 - 59,885,428 (+)Ensembl
RefSeq Acc Id: NM_001044252   ⟹   NP_001037717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8259,844,854 - 59,886,988 (+)NCBI
mRatBN7.2258,117,674 - 58,159,808 (+)NCBI
Rnor_6.0258,462,588 - 58,504,728 (+)NCBI
Rnor_5.0277,550,016 - 77,592,163 (+)NCBI
RGSC_v3.4258,725,461 - 58,767,746 (+)RGD
Celera253,725,937 - 53,768,584 (+)RGD
Sequence:
RefSeq Acc Id: XM_006232014   ⟹   XP_006232076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8259,845,247 - 59,886,989 (+)NCBI
mRatBN7.2258,118,067 - 58,159,815 (+)NCBI
Rnor_6.0258,462,981 - 58,504,735 (+)NCBI
Rnor_5.0277,550,016 - 77,592,163 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006232015   ⟹   XP_006232077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8259,845,247 - 59,886,989 (+)NCBI
mRatBN7.2258,118,067 - 58,159,815 (+)NCBI
Rnor_6.0258,462,981 - 58,504,735 (+)NCBI
Rnor_5.0277,550,016 - 77,592,163 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006232016   ⟹   XP_006232078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8259,845,572 - 59,886,989 (+)NCBI
mRatBN7.2258,118,394 - 58,159,815 (+)NCBI
Rnor_6.0258,463,358 - 58,504,735 (+)NCBI
Rnor_5.0277,550,016 - 77,592,163 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102740   ⟹   XP_038958668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8259,845,788 - 59,886,989 (+)NCBI
mRatBN7.2258,118,604 - 58,159,815 (+)NCBI
RefSeq Acc Id: XM_039102741   ⟹   XP_038958669
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8259,847,061 - 59,886,989 (+)NCBI
mRatBN7.2258,118,858 - 58,159,815 (+)NCBI
RefSeq Acc Id: XM_063282248   ⟹   XP_063138318
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8259,845,702 - 59,886,989 (+)NCBI
RefSeq Acc Id: XM_063282249   ⟹   XP_063138319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8259,855,971 - 59,886,989 (+)NCBI
RefSeq Acc Id: NP_001037717   ⟸   NM_001044252
- Sequence:
RefSeq Acc Id: XP_006232076   ⟸   XM_006232014
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006232077   ⟸   XM_006232015
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006232078   ⟸   XM_006232016
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZN07 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074867   ⟸   ENSRNOT00000080618
Ensembl Acc Id: ENSRNOP00000074419   ⟸   ENSRNOT00000083799
RefSeq Acc Id: XP_038958668   ⟸   XM_039102740
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZN07 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958669   ⟸   XM_039102741
- Peptide Label: isoform X7
Ensembl Acc Id: ENSRNOP00000079475   ⟸   ENSRNOT00000094491
Ensembl Acc Id: ENSRNOP00000080309   ⟸   ENSRNOT00000118441
Ensembl Acc Id: ENSRNOP00000080674   ⟸   ENSRNOT00000111710
RefSeq Acc Id: XP_063138318   ⟸   XM_063282248
- Peptide Label: isoform X5
- UniProtKB: Q3B8P3 (UniProtKB/Swiss-Prot),   Q1HCL7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063138319   ⟸   XM_063282249
- Peptide Label: isoform X6
- UniProtKB: Q3B8P3 (UniProtKB/Swiss-Prot),   Q1HCL7 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000106732   ⟸   ENSRNOT00000138669

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q1HCL7-F1-model_v2 AlphaFold Q1HCL7 1-425 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691178
Promoter ID:EPDNEW_R1702
Type:initiation region
Name:Nadk2_1
Description:NAD kinase 2, mitochondrial
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0258,463,114 - 58,463,174EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306809 AgrOrtholog
BioCyc Gene G2FUF-54104 BioCyc
BioCyc Pathway NADPHOS-DEPHOS-PWY [NAD phosphorylation and dephosphorylation] BioCyc
  NADPHOS-DEPHOS-PWY-1 [NAD phosphorylation and transhydrogenation] BioCyc
  PWY-8148 [NADP biosynthesis] BioCyc
BioCyc Pathway Image NADPHOS-DEPHOS-PWY BioCyc
  NADPHOS-DEPHOS-PWY-1 BioCyc
  PWY-8148 BioCyc
Ensembl Genes ENSRNOG00000054157 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000080618 ENTREZGENE
  ENSRNOT00000083799.2 UniProtKB/Swiss-Prot
  ENSRNOT00000111710 ENTREZGENE
  ENSRNOT00000118441 ENTREZGENE
Gene3D-CATH Probable inorganic polyphosphate/atp-NAD kinase, domain 1 UniProtKB/Swiss-Prot
  Probable inorganic polyphosphate/atp-NAD kinase, domain 2 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7375971 IMAGE-MGC_LOAD
InterPro ATP-NAD_kinase_N UniProtKB/Swiss-Prot
  ATP-NAD_kinase_PpnK-typ_C UniProtKB/Swiss-Prot
  NAD/diacylglycerol_kinase_sf UniProtKB/Swiss-Prot
  NADK UniProtKB/Swiss-Prot
  NADK2_mit UniProtKB/Swiss-Prot
KEGG Report rno:365699 UniProtKB/Swiss-Prot
MGC_CLONE MGC:125061 IMAGE-MGC_LOAD
NCBI Gene 365699 ENTREZGENE
PANTHER NAD KINASE 2, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR13158 UniProtKB/Swiss-Prot
Pfam NAD_kinase UniProtKB/Swiss-Prot
PhenoGen Nadk2 PhenoGen
PIRSF Kin_ATP-NAD_euk UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000054157 RatGTEx
Superfamily-SCOP SSF111331 UniProtKB/Swiss-Prot
UniProt A0A096MKG5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZN07 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZPE9_RAT UniProtKB/TrEMBL
  A0A8I5ZQT4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LTW8_RAT UniProtKB/TrEMBL
  A6KGJ0 ENTREZGENE, UniProtKB/TrEMBL
  NAKD2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q3B8P3 ENTREZGENE
UniProt Secondary Q3B8P3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-09 Nadk2  NAD kinase 2, mitochondrial  Nadkd1  NAD kinase domain containing 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-01 Nadkd1  NAD kinase domain containing 1  RGD1306809  similar to hypothetical protein FLJ30596  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1306809  similar to hypothetical protein FLJ30596   RGD1306809_predicted  similar to hypothetical protein FLJ30596 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1306809_predicted  similar to hypothetical protein FLJ30596 (predicted)  LOC365699_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC365699_predicted  similar to hypothetical protein FLJ30596 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL