Dna2 (DNA replication helicase/nuclease 2) - Rat Genome Database

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Gene: Dna2 (DNA replication helicase/nuclease 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Dna2 (Ensembl: Slc25a16)
Name: DNA replication helicase/nuclease 2 (Ensembl:solute carrier family 25 member 16)
RGD ID: 1306791
Description: Predicted to enable several functions, including ATP hydrolysis activity; DNA binding activity; and catalytic activity, acting on DNA. Predicted to be involved in DNA metabolic process and DNA replication checkpoint signaling. Predicted to be located in mitochondrion and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Seckel syndrome 8; autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 6; isolated growth hormone deficiency type IA; and mitochondrial myopathy. Orthologous to human DNA2 (DNA replication helicase/nuclease 2); PARTICIPATES IN homologous recombination pathway of double-strand break repair; DNA replication pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA replication ATP-dependent helicase-like homolog; DNA replication ATP-dependent helicase/nuclease DNA2; DNA replication helicase 2 homolog; DNA replication helicase 2 homolog (yeast); DNA2 DNA replication helicase 2-like; DNA2 DNA replication helicase 2-like (yeast); DNA2-like helicase; Dna2l; LOC309762; similar to DNA2 DNA replication helicase 2-like
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82025,660,339 - 25,689,285 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.22025,661,652 - 25,690,598 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2025,662,055 - 25,716,319 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2026,355,103 - 26,384,055 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02025,708,131 - 25,737,083 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02026,294,181 - 26,323,127 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_5.02029,093,620 - 29,123,086 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42025,288,326 - 25,316,851 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2026,956,734 - 26,986,153 (-)NCBICelera
RGSC_v3.12025,302,172 - 25,363,960 (+)NCBI
Cytogenetic Map20q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Regulation of homologous recombination in eukaryotes. Heyer WD, etal., Annu Rev Genet. 2010;44:113-39. doi: 10.1146/annurev-genet-051710-150955.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Mutations in DNA2 link progressive myopathy to mitochondrial DNA instability. Ronchi D, etal., Am J Hum Genet. 2013 Feb 7;92(2):293-300. doi: 10.1016/j.ajhg.2012.12.014. Epub 2013 Jan 24.
9. Genomic analysis of primordial dwarfism reveals novel disease genes. Shaheen R, etal., Genome Res. 2014 Feb;24(2):291-9. doi: 10.1101/gr.160572.113. Epub 2014 Jan 3.
Additional References at PubMed
PMID:31904090  


Genomics

Variants

.
Variants in Dna2
44 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:72
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000000438
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)202074558556021148Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
RH128448  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22025,692,082 - 25,692,283 (+)MAPPERmRatBN7.2
Rnor_6.02027,283,901 - 27,284,101NCBIRnor6.0
Rnor_5.02029,124,544 - 29,124,744UniSTSRnor5.0
RGSC_v3.42025,286,626 - 25,286,826UniSTSRGSC3.4
Celera2026,987,633 - 26,987,833UniSTS
Cytogenetic Map20p11UniSTS
AU049833  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22025,685,479 - 25,685,664 (+)MAPPERmRatBN7.2
Rnor_6.02027,277,300 - 27,277,482NCBIRnor6.0
Rnor_5.02029,117,943 - 29,118,125UniSTSRnor5.0
RGSC_v3.42025,293,245 - 25,293,427UniSTSRGSC3.4
Celera2026,981,032 - 26,981,214UniSTS
Cytogenetic Map20p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 17 48 67 136 94 11 47 35 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000000438   ⟹   ENSRNOP00000000438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2025,663,299 - 25,716,319 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000056047   ⟹   ENSRNOP00000052899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2025,691,567 - 25,716,319 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102171   ⟹   ENSRNOP00000077473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2025,663,299 - 25,707,418 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103093   ⟹   ENSRNOP00000083522
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2025,662,055 - 25,690,593 (-)Ensembl
RefSeq Acc Id: NM_001389622   ⟹   NP_001376551
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,660,339 - 25,689,285 (-)NCBI
mRatBN7.22025,661,652 - 25,690,598 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001376551 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D3ZG52 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001376551   ⟸   NM_001389622
- UniProtKB: D3ZG52 (UniProtKB/Swiss-Prot),   A0A8I5ZZI9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000000438   ⟸   ENSRNOT00000000438
Ensembl Acc Id: ENSRNOP00000052899   ⟸   ENSRNOT00000056047
Ensembl Acc Id: ENSRNOP00000077473   ⟸   ENSRNOT00000102171
Ensembl Acc Id: ENSRNOP00000083522   ⟸   ENSRNOT00000103093
Protein Domains
DNA replication factor Dna2 N-terminal   DNA2 rift barrel   DNA2/NAM7 helicase helicase   DNA2/NAM7 helicase-like C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZG52-F1-model_v2 AlphaFold D3ZG52 1-1059 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306791 AgrOrtholog
BioCyc Gene G2FUF-3807 BioCyc
Ensembl Genes ENSRNOG00000000387 Ensembl
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
  3.90.320.10 UniProtKB/Swiss-Prot
InterPro Dna2 UniProtKB/Swiss-Prot
  DNA2/NAM7-like UniProtKB/Swiss-Prot
  DNA2/NAM7-like_AAA UniProtKB/Swiss-Prot
  DNA2/NAM7_AAA_11 UniProtKB/Swiss-Prot
  DNA2_Rift UniProtKB/Swiss-Prot
  DNA_replication_fac_Dna2_N UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  PDDEXK-like_dom_sf UniProtKB/Swiss-Prot
  SF1_C_Upf1 UniProtKB/Swiss-Prot
NCBI Gene 309762 ENTREZGENE
PANTHER PTHR10887 UniProtKB/Swiss-Prot
  PTHR10887:SF433 UniProtKB/Swiss-Prot
Pfam AAA_11 UniProtKB/Swiss-Prot
  AAA_12 UniProtKB/Swiss-Prot
  Dna2 UniProtKB/Swiss-Prot
  Dna2_Rift UniProtKB/Swiss-Prot
PhenoGen Dna2 PhenoGen
RatGTEx ENSRNOG00000000387 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8I5ZZI9 ENTREZGENE, UniProtKB/TrEMBL
  D3ZG52 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Dna2  DNA replication helicase/nuclease 2  LOC687919  similar to DNA2 DNA replication helicase 2-like  Data merged from RGD:1594929 1643240 APPROVED
2013-05-22 Dna2  DNA replication helicase/nuclease 2  Dna2  DNA replication helicase 2 homolog (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-25 Dna2  DNA replication helicase 2 homolog (yeast)  Dna2l_predicted  DNA2 DNA replication helicase 2-like (yeast) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC687919  similar to DNA2 DNA replication helicase 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Dna2l_predicted  DNA2 DNA replication helicase 2-like (yeast) (predicted)      Symbol and Name status set to approved 70820 APPROVED