Bin2 (bridging integrator 2) - Rat Genome Database

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Gene: Bin2 (bridging integrator 2) Rattus norvegicus
Analyze
Symbol: Bin2
Name: bridging integrator 2
RGD ID: 1306789
Description: Predicted to enable phospholipid binding activity. Predicted to be involved in several processes, including phagocytosis, engulfment; plasma membrane tubulation; and podosome assembly. Predicted to be located in several cellular components, including anchoring junction; cell cortex; and cell projection. Predicted to be active in plasma membrane and podosome. Predicted to colocalize with phagocytic cup. Orthologous to human BIN2 (bridging integrator 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC366988
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87133,620,782 - 133,647,019 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7133,620,140 - 133,647,218 (-)EnsemblGRCr8
mRatBN7.27131,742,001 - 131,768,208 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7131,742,002 - 131,786,285 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7133,544,073 - 133,570,314 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07135,769,655 - 135,795,899 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07135,683,292 - 135,709,465 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07142,273,832 - 142,304,731 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,273,833 - 142,300,382 (-)Ensemblrn6Rnor6.0
Rnor_5.07140,078,978 - 140,105,528 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47139,408,145 - 139,434,350 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7128,218,252 - 128,244,472 (-)NCBICelera
RGSC_v3.17139,484,581 - 139,510,787 (-)NCBI
Cytogenetic Map7q36NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell chemotaxis  (IEA,ISO,ISS)
phagocytosis, engulfment  (IBA,IEA,ISO)
plasma membrane tubulation  (IBA,IEA,ISO,ISS)
podosome assembly  (IBA,IEA,ISO,ISS)

Cellular Component
cell cortex  (IEA)
cell projection  (IEA)
cytoplasm  (IEA)
phagocytic cup  (IBA,IEA,ISO,ISS)
plasma membrane  (IBA,IEA,ISO)
podosome  (IBA,IEA,ISO,ISS)

Molecular Function
phospholipid binding  (IBA,IEA,ISO,ISS)
protein binding  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:19144635   PMID:23285027  


Genomics

Comparative Map Data
Bin2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87133,620,782 - 133,647,019 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7133,620,140 - 133,647,218 (-)EnsemblGRCr8
mRatBN7.27131,742,001 - 131,768,208 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7131,742,002 - 131,786,285 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7133,544,073 - 133,570,314 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07135,769,655 - 135,795,899 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07135,683,292 - 135,709,465 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07142,273,832 - 142,304,731 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,273,833 - 142,300,382 (-)Ensemblrn6Rnor6.0
Rnor_5.07140,078,978 - 140,105,528 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47139,408,145 - 139,434,350 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7128,218,252 - 128,244,472 (-)NCBICelera
RGSC_v3.17139,484,581 - 139,510,787 (-)NCBI
Cytogenetic Map7q36NCBI
BIN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381251,281,038 - 51,324,668 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1251,281,038 - 51,324,668 (-)Ensemblhg38GRCh38
GRCh371251,674,822 - 51,718,452 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361249,961,089 - 50,004,205 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341249,961,089 - 50,004,205NCBI
Celera1250,476,304 - 50,519,423 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1248,707,566 - 48,750,862 (-)NCBIHuRef
CHM1_11251,641,019 - 51,684,174 (-)NCBICHM1_1
T2T-CHM13v2.01251,243,929 - 51,287,483 (-)NCBIT2T-CHM13v2.0
Bin2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915100,538,963 - 100,567,384 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15100,538,958 - 100,567,434 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3815100,641,082 - 100,669,503 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15100,641,077 - 100,669,553 (-)Ensemblmm10GRCm38
MGSCv3715100,470,388 - 100,499,933 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3615100,464,266 - 100,497,536 (-)NCBIMGSCv36mm8
Celera15102,795,111 - 102,822,575 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.37NCBI
Bin2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555471,774,330 - 1,798,031 (-)NCBIChiLan1.0ChiLan1.0
BIN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21042,862,523 - 42,905,717 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11242,859,285 - 42,902,479 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01237,430,061 - 37,473,182 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11238,314,443 - 38,357,264 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1238,314,126 - 38,357,264 (+)EnsemblpanPan2panpan1.1
BIN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,563,431 - 3,597,363 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,563,475 - 3,596,817 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2742,660,984 - 42,694,586 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0273,608,352 - 3,641,907 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,557,543 - 3,641,427 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,575,875 - 3,609,440 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0273,562,423 - 3,595,991 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02743,058,238 - 43,091,854 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bin2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494564,263,598 - 64,295,980 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365128,869,131 - 8,901,171 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BIN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.2517,315,117 - 17,331,326 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BIN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11147,480,322 - 47,521,970 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037198,573,888 - 198,616,360 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bin2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624816941,199 - 992,157 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Bin2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11262,440,827 - 262,474,991 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bin2
86 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:48
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000048262
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)7132099939137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 157 91 90 59 92 59 6 356 192 11 133 81 92 31 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000006351   ⟹   ENSRNOP00000006351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7131,773,163 - 131,786,285 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000048262   ⟹   ENSRNOP00000039630
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7131,742,002 - 131,768,308 (-)Ensembl
Rnor_6.0 Ensembl7142,273,833 - 142,300,382 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097496   ⟹   ENSRNOP00000079003
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7131,745,813 - 131,761,236 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103654   ⟹   ENSRNOP00000084036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7131,742,002 - 131,786,285 (-)Ensembl
RefSeq Acc Id: NM_001012223   ⟹   NP_001012223
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,620,782 - 133,646,986 (-)NCBI
mRatBN7.27131,742,001 - 131,768,208 (-)NCBI
Rnor_6.07142,273,832 - 142,300,382 (-)NCBI
Rnor_5.07140,078,978 - 140,105,528 (-)NCBI
RGSC_v3.47139,408,145 - 139,434,350 (-)RGD
Celera7128,218,252 - 128,244,472 (-)RGD
Sequence:
RefSeq Acc Id: XM_063264073   ⟹   XP_063120143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,620,788 - 133,647,019 (-)NCBI
RefSeq Acc Id: XR_010053025
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,627,784 - 133,647,019 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001012223 (Get FASTA)   NCBI Sequence Viewer  
  XP_063120143 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79406 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000039630
  ENSRNOP00000084036
GenBank Protein Q68FR2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001012223   ⟸   NM_001012223
- UniProtKB: Q68FR2 (UniProtKB/Swiss-Prot),   A0A8L2QLP3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000039630   ⟸   ENSRNOT00000048262
Ensembl Acc Id: ENSRNOP00000079003   ⟸   ENSRNOT00000097496
Ensembl Acc Id: ENSRNOP00000006351   ⟸   ENSRNOT00000006351
Ensembl Acc Id: ENSRNOP00000084036   ⟸   ENSRNOT00000103654
RefSeq Acc Id: XP_063120143   ⟸   XM_063264073
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QLP3 (UniProtKB/TrEMBL)
Protein Domains
BAR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q68FR2-F1-model_v2 AlphaFold Q68FR2 1-507 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695663
Promoter ID:EPDNEW_R6187
Type:initiation region
Name:Bin2_1
Description:bridging integrator 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07142,300,350 - 142,300,410EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306789 AgrOrtholog
BioCyc Gene G2FUF-32012 BioCyc
Ensembl Genes ENSRNOG00000031930 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000048262 ENTREZGENE
  ENSRNOT00000103654 ENTREZGENE
Gene3D-CATH 1.20.1270.60 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7112822 IMAGE-MGC_LOAD
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot
  Amphiphysin UniProtKB/Swiss-Prot
  BAR_Bin2 UniProtKB/Swiss-Prot
  BAR_dom UniProtKB/Swiss-Prot
  Bin2_C UniProtKB/Swiss-Prot
KEGG Report rno:366988 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94939 IMAGE-MGC_LOAD
NCBI Gene 366988 ENTREZGENE
PANTHER AMPHIPHYSIN UniProtKB/Swiss-Prot
  PTHR46514:SF1 UniProtKB/Swiss-Prot
Pfam BAR UniProtKB/Swiss-Prot
  Bin2_C UniProtKB/Swiss-Prot
PhenoGen Bin2 PhenoGen
PRINTS AMPHIPHYSIN UniProtKB/Swiss-Prot
PROSITE BAR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000031930 RatGTEx
SMART BAR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF103657 UniProtKB/Swiss-Prot
UniProt A0A8I5ZM51_RAT UniProtKB/TrEMBL
  A0A8I5ZY98_RAT UniProtKB/TrEMBL
  A0A8L2QLP3 ENTREZGENE, UniProtKB/TrEMBL
  BIN2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Bin2  bridging integrator 2  Bin2_predicted  bridging integrator 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Bin2_predicted  bridging integrator 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED