Zc3h12a (zinc finger CCCH type containing 12A) - Rat Genome Database

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Gene: Zc3h12a (zinc finger CCCH type containing 12A) Rattus norvegicus
Analyze
Symbol: Zc3h12a
Name: zinc finger CCCH type containing 12A
RGD ID: 1306776
Description: Predicted to enable several functions, including RNA binding activity; RNA nuclease activity; and ribosome binding activity. Predicted to contribute to cysteine-type deubiquitinase activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; regulation of intracellular signal transduction; and regulation of macromolecule metabolic process. Predicted to be located in P-body; cytoskeleton; and rough endoplasmic reticulum membrane. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Human ortholog(s) of this gene implicated in hepatitis B. Orthologous to human ZC3H12A (zinc finger CCCH-type containing 12A); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: bifunctional endoribonuclease and deubiquitinase ZC3H12A; endoribonuclease ZC3H12A; LOC103692471; LOC313587; MCP-induced protein 1; MCPIP-1; MGC156729; monocyte chemotactic protein-induced protein 1; Reg1; regnase-1; RGD1306776; ribonuclease ZC3H12A; similar to hypothetical protein MGC41320; uncharacterized LOC103692471; Zinc finger CCCH domain-containing protein 12A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85142,661,193 - 142,670,051 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5142,661,199 - 142,669,985 (-)EnsemblGRCr8
mRatBN7.25137,376,562 - 137,385,351 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5137,376,564 - 137,385,351 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5140,080,427 - 140,089,206 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05141,850,422 - 141,859,201 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05141,857,598 - 141,866,378 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05143,111,342 - 143,120,131 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5143,111,074 - 143,120,165 (-)Ensemblrn6Rnor6.0
Rnor_5.05146,878,968 - 146,887,760 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45144,457,753 - 144,467,275 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5135,894,447 - 135,903,150 (-)NCBICelera
RGSC_v3.15144,468,090 - 144,476,486 (-)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-hydroxypropanoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
alpha-pinene  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
calcium silicate  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
chenodeoxycholic acid  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
DDE  (ISO)
deoxycholic acid  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
fipronil  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
furan  (EXP)
gedunin  (ISO)
gentamycin  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GSK-J4  (ISO)
L-methionine  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
LY294002  (EXP)
melphalan  (ISO)
menadione  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
nickel atom  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
pravastatin  (EXP,ISO)
rac-lactic acid  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (EXP)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
succimer  (ISO)
tartrazine  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
3'-UTR-mediated mRNA destabilization  (IBA,IEA,ISO,ISS)
angiogenesis  (IEA)
apoptotic process  (IEA)
cell differentiation  (IEA)
cellular response to chemokine  (IEA,ISO,ISS)
cellular response to glucose starvation  (IEA,ISO)
cellular response to ionomycin  (IEA,ISO,ISS)
cellular response to lipopolysaccharide  (IEA,ISO,ISS)
cellular response to oxidative stress  (IEA,ISO)
cellular response to sodium arsenite  (IEA,ISO)
cellular response to tumor necrosis factor  (IEA,ISO,ISS)
cellular response to virus  (IEA,ISO)
DNA damage response  (IEA,ISO,ISS)
host-mediated suppression of viral genome replication  (IEA,ISO)
immune response-activating signaling pathway  (IEA,ISO,ISS)
immune system process  (IEA)
inflammatory response  (IEA)
miRNA catabolic process  (IEA,ISO,ISS)
mRNA catabolic process  (IEA,ISO)
negative regulation of canonical NF-kappaB signal transduction  (IEA,ISO,ISS)
negative regulation of cardiac muscle contraction  (IEA,ISO,ISS)
negative regulation of cytokine production involved in inflammatory response  (IEA,ISO,ISS)
negative regulation of gene expression  (IEA,ISO)
negative regulation of interleukin-1 beta production  (IEA,ISO,ISS)
negative regulation of interleukin-6 production  (IEA,ISO,ISS)
negative regulation of macrophage activation  (ISO)
negative regulation of muscle cell apoptotic process  (IEA,ISO,ISS)
negative regulation of nitric oxide biosynthetic process  (IEA,ISO,ISS)
negative regulation of non-canonical NF-kappaB signal transduction  (IEA,ISO,ISS)
negative regulation of protein phosphorylation  (ISO)
negative regulation of T-helper 17 cell differentiation  (IEA,ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of tumor necrosis factor production  (IEA,ISO,ISS)
negative regulation of type II interferon production  (IEA,ISO,ISS)
nervous system development  (IEA)
positive regulation of angiogenesis  (IEA,ISO,ISS)
positive regulation of autophagy  (IEA,ISO)
positive regulation of defense response to virus by host  (IEA,ISO)
positive regulation of endothelial cell migration  (IEA,ISO,ISS)
positive regulation of execution phase of apoptosis  (IEA,ISO)
positive regulation of fat cell differentiation  (IEA,ISO,ISS)
positive regulation of gene expression  (IEA,ISO)
positive regulation of lipid storage  (IEA,ISO)
positive regulation of miRNA catabolic process  (IEA,ISO)
positive regulation of mRNA catabolic process  (IEA,ISO,ISS)
positive regulation of p38MAPK cascade  (IEA,ISO)
positive regulation of protein deubiquitination  (IEA,ISO,ISS)
positive regulation of protein import into nucleus  (IEA,ISO)
positive regulation of reactive oxygen species metabolic process  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
protein complex oligomerization  (IEA,ISO,ISS)
protein deubiquitination  (IEA,ISO)
regulation of gene expression  (IEA,ISO)
T cell receptor signaling pathway  (IEA,ISO,ISS)

Cellular Component
cytoplasm  (IEA,ISO,ISS)
cytoplasmic ribonucleoprotein granule  (IBA,IEA,ISO)
cytoskeleton  (IEA,ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO,ISS)
P-body  (IEA,ISO,ISS)
protein-containing complex  (IEA,ISO,ISS)
rough endoplasmic reticulum  (IEA,ISO)
rough endoplasmic reticulum membrane  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MCPIP1 Endoribonuclease Activity Negatively Regulates Interleukin-17-Mediated Signaling and Inflammation. Garg AV, etal., Immunity. 2015 Sep 15;43(3):475-87. doi: 10.1016/j.immuni.2015.07.021. Epub 2015 Aug 25.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. MCPIP1 negatively regulates toll-like receptor 4 signaling and protects mice from LPS-induced septic shock. Huang S, etal., Cell Signal. 2013 May;25(5):1228-34. doi: 10.1016/j.cellsig.2013.02.009. Epub 2013 Feb 17.
4. MCPIP1 inhibits Hepatitis B virus replication by destabilizing viral RNA and negatively regulates the virus-induced innate inflammatory responses. Li M, etal., Antiviral Res. 2020 Feb;174:104705. doi: 10.1016/j.antiviral.2020.104705. Epub 2020 Jan 9.
5. MCPIP1 inhibits coxsackievirus B3 replication by targeting viral RNA and negatively regulates virus-induced inflammation. Li M, etal., Med Microbiol Immunol. 2018 Feb;207(1):27-38. doi: 10.1007/s00430-017-0523-0. Epub 2017 Oct 17.
6. MCPIP1 suppresses hepatitis C virus replication and negatively regulates virus-induced proinflammatory cytokine responses. Lin RJ, etal., J Immunol. 2014 Oct 15;193(8):4159-68. doi: 10.4049/jimmunol.1400337. Epub 2014 Sep 15.
7. Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia. Nakatsuka Y, etal., Mucosal Immunol. 2018 Jul;11(4):1203-1218. doi: 10.1038/s41385-018-0024-5. Epub 2018 Apr 25.
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:16574901   PMID:18178554   PMID:18364357   PMID:19322177   PMID:19666473   PMID:19909337   PMID:20356868   PMID:21616078   PMID:21971051   PMID:22055188  
PMID:22739135   PMID:23185455   PMID:23355615   PMID:24048733   PMID:25282160   PMID:25861989   PMID:26000482   PMID:26134560   PMID:26255671   PMID:26812136   PMID:26865670   PMID:27044405  
PMID:30631045   PMID:31323531  


Genomics

Comparative Map Data
Zc3h12a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85142,661,193 - 142,670,051 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5142,661,199 - 142,669,985 (-)EnsemblGRCr8
mRatBN7.25137,376,562 - 137,385,351 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5137,376,564 - 137,385,351 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5140,080,427 - 140,089,206 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05141,850,422 - 141,859,201 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05141,857,598 - 141,866,378 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05143,111,342 - 143,120,131 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5143,111,074 - 143,120,165 (-)Ensemblrn6Rnor6.0
Rnor_5.05146,878,968 - 146,887,760 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45144,457,753 - 144,467,275 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5135,894,447 - 135,903,150 (-)NCBICelera
RGSC_v3.15144,468,090 - 144,476,486 (-)NCBI
Cytogenetic Map5q36NCBI
ZC3H12A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38137,474,580 - 37,484,377 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl137,474,496 - 37,484,379 (+)Ensemblhg38GRCh38
GRCh37137,940,181 - 37,949,978 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36137,712,706 - 37,722,565 (+)NCBIBuild 36Build 36hg18NCBI36
Celera136,218,067 - 36,227,926 (+)NCBICelera
Cytogenetic Map1p34.3NCBI
HuRef136,057,283 - 36,067,022 (+)NCBIHuRef
CHM1_1138,056,246 - 38,066,105 (+)NCBICHM1_1
T2T-CHM13v2.0137,339,334 - 37,349,131 (+)NCBIT2T-CHM13v2.0
Zc3h12a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394125,012,207 - 125,021,674 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4125,012,216 - 125,021,633 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384125,118,414 - 125,127,881 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4125,118,423 - 125,127,840 (-)Ensemblmm10GRCm38
MGSCv374124,795,658 - 124,805,125 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364124,620,727 - 124,630,144 (-)NCBIMGSCv36mm8
Celera4123,439,822 - 123,449,288 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map458.1NCBI
Zc3h12a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545215,305,775 - 15,314,959 (+)Ensembl
ChiLan1.0NW_00495545215,306,398 - 15,314,959 (+)NCBIChiLan1.0ChiLan1.0
ZC3H12A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21189,358,963 - 189,374,172 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11188,487,843 - 188,496,719 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0136,743,341 - 36,753,261 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1138,093,036 - 38,103,556 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl138,093,917 - 38,103,556 (+)EnsemblpanPan2panpan1.1
ZC3H12A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1154,972,369 - 4,984,218 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl154,972,956 - 4,980,371 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha155,219,328 - 5,230,693 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0155,105,439 - 5,116,772 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl155,105,420 - 5,113,966 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1154,965,670 - 4,977,036 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0155,032,089 - 5,043,421 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0155,047,843 - 5,059,188 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Zc3h12a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505853,888,781 - 53,897,730 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647419,714,153 - 19,722,528 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647419,714,145 - 19,722,512 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZC3H12A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl693,541,334 - 93,551,193 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1693,541,334 - 93,551,200 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ZC3H12A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12095,388,469 - 95,398,305 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2095,388,477 - 95,397,960 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603321,417,693 - 21,427,581 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zc3h12a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476420,224,906 - 20,234,629 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476420,224,919 - 20,234,108 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Zc3h12a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1133,178,537 - 33,187,725 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Zc3h12a
82 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:215
Count of miRNA genes:144
Interacting mature miRNAs:157
Transcripts:ENSRNOT00000012314
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5130678987145274255Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
7411722Strs6Sensitivity to stroke QTL 63.9cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)5140258140143398122Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
BE101710  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25137,371,420 - 137,371,576 (+)MAPPERmRatBN7.2
Rnor_6.05143,106,201 - 143,106,356NCBIRnor6.0
Rnor_5.05146,873,830 - 146,873,985UniSTSRnor5.0
RGSC_v3.45144,452,612 - 144,452,767UniSTSRGSC3.4
Celera5135,889,306 - 135,889,461UniSTS
RH 3.4 Map5897.4UniSTS
Cytogenetic Map5q36UniSTS
RH135324  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25137,377,907 - 137,378,107 (+)MAPPERmRatBN7.2
Rnor_6.05143,112,688 - 143,112,887NCBIRnor6.0
Rnor_5.05146,880,317 - 146,880,516UniSTSRnor5.0
RGSC_v3.45144,459,099 - 144,459,298UniSTSRGSC3.4
Celera5135,895,793 - 135,895,992UniSTS
RH 3.4 Map5897.4UniSTS
Cytogenetic Map5q36UniSTS
RH141495  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25137,368,037 - 137,368,243 (+)MAPPERmRatBN7.2
Rnor_6.05143,102,824 - 143,103,029NCBIRnor6.0
Rnor_5.05146,870,453 - 146,870,658UniSTSRnor5.0
RGSC_v3.45144,449,235 - 144,449,440UniSTSRGSC3.4
RH 3.4 Map5891.0UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000012314   ⟹   ENSRNOP00000012314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5142,661,199 - 142,669,985 (-)Ensembl
mRatBN7.2 Ensembl5137,376,564 - 137,385,351 (-)Ensembl
Rnor_6.0 Ensembl5143,111,074 - 143,120,165 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089677
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5142,405,310 - 142,407,701 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5142,405,310 - 142,407,701 (-)Ensembl
RefSeq Acc Id: NM_001077671   ⟹   NP_001071139
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85142,661,197 - 142,669,985 (-)NCBI
mRatBN7.25137,376,562 - 137,385,351 (-)NCBI
Rnor_6.05143,111,342 - 143,120,131 (-)NCBI
Rnor_5.05146,878,968 - 146,887,760 (-)NCBI
RGSC_v3.45144,457,753 - 144,467,275 (-)RGD
Celera5135,894,447 - 135,903,150 (-)RGD
Sequence:
RefSeq Acc Id: XM_063287751   ⟹   XP_063143821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85142,661,193 - 142,670,051 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001071139 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143821 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A0JPN4 (Get FASTA)   NCBI Sequence Viewer  
  AAI27517 (Get FASTA)   NCBI Sequence Viewer  
  EDL80428 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012314
  ENSRNOP00000012314.4
RefSeq Acc Id: NP_001071139   ⟸   NM_001077671
- UniProtKB: A0JPN4 (UniProtKB/Swiss-Prot),   A6IS77 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012314   ⟸   ENSRNOT00000012314
RefSeq Acc Id: XP_063143821   ⟸   XM_063287751
- Peptide Label: isoform X1
Protein Domains
Endoribonuclease Regnase 1/ZC3H12 C-terminal   Rege-1 UBA-like   RNase NYN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0JPN4-F1-model_v2 AlphaFold A0JPN4 1-596 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694024
Promoter ID:EPDNEW_R4548
Type:initiation region
Name:Zc3h12a_1
Description:zinc finger CCCH type containing 12A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05143,120,138 - 143,120,198EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306776 AgrOrtholog
BioCyc Gene G2FUF-39932 BioCyc
Ensembl Genes ENSRNOG00000009131 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000058834 Ensembl
Ensembl Transcript ENSRNOT00000012314 ENTREZGENE
  ENSRNOT00000012314.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.11980 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7102954 IMAGE-MGC_LOAD
InterPro Rege-1_UBA-like UniProtKB/Swiss-Prot
  Regnase_1/ZC3H12_C UniProtKB/Swiss-Prot
  RNase_Zc3h12_NYN UniProtKB/Swiss-Prot
  ZC3H12/N4BP1_RNase_Reg UniProtKB/Swiss-Prot
KEGG Report rno:313587 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156729 IMAGE-MGC_LOAD
NCBI Gene 313587 ENTREZGENE
PANTHER ENDORIBONUCLEASE ZC3H12A UniProtKB/Swiss-Prot
  N4BP1-RELATED UniProtKB/Swiss-Prot
Pfam Regnase_1_C UniProtKB/Swiss-Prot
  RNase_Zc3h12a UniProtKB/Swiss-Prot
  UBA_6 UniProtKB/Swiss-Prot
PhenoGen Zc3h12a PhenoGen
RatGTEx ENSRNOG00000009131 RatGTEx
  ENSRNOG00000058834 RatGTEx
UniProt A0JPN4 ENTREZGENE
  A6IS77 ENTREZGENE, UniProtKB/TrEMBL
  ZC12A_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Zc3h12a  zinc finger CCCH type containing 12A  LOC103692471  uncharacterized LOC103692471  Data merged from RGD:9409388 737654 PROVISIONAL
2014-08-25 LOC103692471  uncharacterized LOC103692471      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Zc3h12a  zinc finger CCCH type containing 12A   Zc3h12a_predicted  zinc finger CCCH type containing 12A (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Zc3h12a_predicted  zinc finger CCCH type containing 12A (predicted)  RGD1306776_predicted  similar to hypothetical protein MGC41320 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1306776_predicted  similar to hypothetical protein MGC41320 (predicted)  LOC313587_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC313587_predicted  similar to hypothetical protein MGC41320 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL