Ceacam12 (CEA cell adhesion molecule 12) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ceacam12 (CEA cell adhesion molecule 12) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ceacam12
Name: CEA cell adhesion molecule 12
RGD ID: 1306754
Description: Predicted to be involved in T cell activation and immune response. Predicted to be active in external side of plasma membrane. Orthologous to several human genes including CEACAM4 (CEA cell adhesion molecule 4); INTERACTS WITH bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: carcinoembryonic antigen-related cell adhesion molecule 12; carcinoembryonic antigen-related cell adhesion molecule 3; CEA-related cell adhesion molecule 12; IGF-like family member 3; IGF-like family member 3-like; Igfl3; LOC361516
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8187,344,541 - 87,351,596 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl187,344,582 - 87,351,588 (+)EnsemblGRCr8
mRatBN7.2178,216,471 - 78,223,526 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,216,512 - 78,223,518 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx183,599,962 - 83,607,036 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0192,164,030 - 92,171,104 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0185,355,085 - 85,362,159 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,474,809 - 79,481,865 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,474,809 - 79,481,865 (+)Ensemblrn6Rnor6.0
Rnor_5.0180,719,459 - 80,726,515 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4177,915,708 - 78,009,203 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera172,683,584 - 72,690,639 (+)NCBICelera
RGSC_v3.1177,993,854 - 78,105,169 (+)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
bisphenol A  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10436421   PMID:12477932  


Genomics

Variants

.
Variants in Ceacam12
75 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat


Expression

RNA-SEQ Expression

ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
19 4 4 2 2 2 6 2 19 2 15 2

Sequence


Ensembl Acc Id: ENSRNOT00000044927   ⟹   ENSRNOP00000047257
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl187,344,582 - 87,351,588 (+)Ensembl
mRatBN7.2 Ensembl178,216,512 - 78,223,518 (+)Ensembl
Rnor_6.0 Ensembl179,474,809 - 79,481,865 (+)Ensembl
RefSeq Acc Id: NM_001108474   ⟹   NP_001101944
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,344,541 - 87,351,596 (+)NCBI
mRatBN7.2178,216,471 - 78,223,526 (+)NCBI
Rnor_6.0179,474,809 - 79,481,865 (+)NCBI
Rnor_5.0180,719,459 - 80,726,515 (+)NCBI
Celera172,683,584 - 72,690,639 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101944 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI58847 (Get FASTA)   NCBI Sequence Viewer  
  EDM08263 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000047257
  ENSRNOP00000047257.5
RefSeq Acc Id: NP_001101944   ⟸   NM_001108474
- UniProtKB: B0BNJ2 (UniProtKB/TrEMBL),   D4A2T3 (UniProtKB/TrEMBL),   A0A8J8YCD1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000047257   ⟸   ENSRNOT00000044927
Protein Domains
Immunoglobulin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B0BNJ2-F1-model_v2 AlphaFold B0BNJ2 1-302 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306754 AgrOrtholog
BioCyc Gene G2FUF-60568 BioCyc
Ensembl Genes ENSRNOG00000042158 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044927 ENTREZGENE
  ENSRNOT00000044927.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7443540 IMAGE-MGC_LOAD
InterPro CEA_cell_adhesion UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
KEGG Report rno:361516 UniProtKB/TrEMBL
MGC_CLONE MGC:188322 IMAGE-MGC_LOAD
NCBI Gene 361516 ENTREZGENE
PANTHER CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 1 UniProtKB/TrEMBL
  CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19 UniProtKB/TrEMBL
Pfam V-set UniProtKB/TrEMBL
PhenoGen Ceacam12 PhenoGen
RatGTEx ENSRNOG00000042158 RatGTEx
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A8J8YCD1 ENTREZGENE, UniProtKB/TrEMBL
  B0BNJ2 ENTREZGENE, UniProtKB/TrEMBL
  D4A2T3 ENTREZGENE
UniProt Secondary D4A2T3 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-04-30 Ceacam12  CEA cell adhesion molecule 12  Ceacam12  carcinoembryonic antigen-related cell adhesion molecule 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-07-18 Ceacam12  carcinoembryonic antigen-related cell adhesion molecule 12  Igfl3  IGF-like family member 3  Name and Symbol changed 629549 APPROVED
2013-05-24 Igfl3  IGF-like family member 3  LOC100362680  IGF-like family member 3-like  Data merged from RGD:2324278 1643240 APPROVED
2010-05-06 LOC100362680  IGF-like family member 3-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-03 Igfl3  IGF-like family member 3  Ceacam12_predicted  CEA-related cell adhesion molecule 12 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Ceacam12_predicted  CEA-related cell adhesion molecule 12 (predicted)      Symbol and Name status set to approved 70820 APPROVED