Advanced Search (OLGA)

Gene: Mblac2 (metallo-beta-lactamase domain containing 2) Rattus norvegicus

Analyze

Symbol:

Mblac2

Name:

metallo-beta-lactamase domain containing 2

RGD ID:

1306703

Description:

Predicted to enable beta-lactamase activity and long-chain fatty acyl-CoA hydrolase activity. Predicted to be involved in fatty acid metabolic process. Predicted to be located in endoplasmic reticulum membrane and plasma membrane. Orthologous to human MBLAC2 (metallo-beta-lactamase domain containing 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acetamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

acyl-coenzyme A thioesterase MBLAC2; LOC365627; metallo-beta-lactamase domain-containing protein 2; RGD1306703; similar to metallo-beta-lactamase superfamily protein like (XL884)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	13,721,752 - 13,764,558 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	13,721,360 - 13,766,626 (+)	Ensembl				GRCr8
mRatBN7.2	2	11,986,075 - 12,028,882 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	11,986,027 - 12,030,950 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	19,099,211 - 19,141,454 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	17,198,732 - 17,240,977 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	11,853,574 - 11,902,803 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	9,578,501 - 9,621,297 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	9,578,345 - 9,623,513 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	9,458,243 - 9,501,526 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	9,804,235 - 9,847,031 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	8,345,061 - 8,388,084 (+)	NCBI		Celera
RGSC_v3.1	2	9,728,078 - 9,771,624 (+)	NCBI
Cytogenetic Map	2	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Hereditary Neoplastic Syndromes (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2-palmitoylglycerol (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acetaldehyde (ISO)

acetamide (EXP)

acrylamide (ISO)

amphetamine (EXP)

aristolochic acid A (ISO)

avobenzone (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

cyclosporin A (ISO)

dioxygen (ISO)

doxorubicin (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

fluoranthene (ISO)

folic acid (ISO)

formaldehyde (ISO)

furan (EXP)

gentamycin (EXP)

GSK-J4 (ISO)

iron dichloride (ISO)

ivermectin (ISO)

lead(0) (ISO)

maneb (ISO)

methidathion (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

okadaic acid (ISO)

paracetamol (EXP)

paraquat (ISO)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

poly(I:C) (EXP)

pregnenolone 16alpha-carbonitrile (ISO)

quercetin (ISO)

resveratrol (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tetrachloromethane (EXP,ISO)

thiram (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

fatty acid metabolic process (IEA)

lipid metabolic process (IEA)

Cellular Component

endoplasmic reticulum membrane (IEA,ISO)

mitochondrion (ISO)

plasma membrane (IEA,ISO)

Molecular Function

beta-lactamase activity (IEA,ISO)

hydrolase activity (IEA)

long-chain fatty acyl-CoA hydrolase activity (IEA,ISO)

metal ion binding (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:20458337	PMID:34800366

Genomics

Comparative Map Data

Mblac2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	13,721,752 - 13,764,558 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	13,721,360 - 13,766,626 (+)	Ensembl				GRCr8
mRatBN7.2	2	11,986,075 - 12,028,882 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	11,986,027 - 12,030,950 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	19,099,211 - 19,141,454 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	17,198,732 - 17,240,977 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	11,853,574 - 11,902,803 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	9,578,501 - 9,621,297 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	9,578,345 - 9,623,513 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	9,458,243 - 9,501,526 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	9,804,235 - 9,847,031 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	8,345,061 - 8,388,084 (+)	NCBI		Celera
RGSC_v3.1	2	9,728,078 - 9,771,624 (+)	NCBI
Cytogenetic Map	2	q11	NCBI

MBLAC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	90,458,209 - 90,474,771 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	90,458,209 - 90,474,771 (-)	Ensembl			hg38	GRCh38
GRCh37	5	89,754,026 - 89,770,588 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	89,789,776 - 89,806,341 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	5	85,655,867 - 85,672,432 (-)	NCBI		Celera
Cytogenetic Map	5	q14.3	NCBI
HuRef	5	84,964,668 - 84,981,233 (-)	NCBI		HuRef
CHM1_1	5	89,186,695 - 89,203,263 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	90,944,765 - 90,961,329 (-)	NCBI		T2T-CHM13v2.0

Mblac2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	81,859,536 - 81,901,394 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	81,859,460 - 81,901,394 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	13	81,711,417 - 81,753,275 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	81,711,341 - 81,753,275 (+)	Ensembl			mm10	GRCm38
MGSCv37	13	81,850,416 - 81,892,274 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	13	82,188,754 - 82,230,612 (+)	NCBI		MGSCv36	mm8
Celera	13	83,972,117 - 84,010,724 (+)	NCBI		Celera
Cytogenetic Map	13	C3	NCBI
cM Map	13	43.68	NCBI

Mblac2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955418	21,150,008 - 21,170,467 (+)	Ensembl
ChiLan1.0	NW_004955418	21,150,011 - 21,170,283 (+)	NCBI	ChiLan1.0	ChiLan1.0

MBLAC2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	24,920,736 - 24,937,034 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	23,074,549 - 23,090,654 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	24,895,973 - 24,912,512 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	25,030,102 - 25,046,646 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	25,030,097 - 25,046,646 (+)	Ensembl			panPan2	panpan1.1

MBLAC2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	18,467,948 - 18,485,700 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	18,468,216 - 18,482,825 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	19,835,803 - 19,853,103 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	18,374,644 - 18,391,956 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	18,374,578 - 18,391,953 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	18,348,289 - 18,365,583 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	18,313,788 - 18,331,193 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	18,602,378 - 18,619,809 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Mblac2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	174,051,995 - 174,067,309 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	8,558,449 - 8,574,459 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	8,558,457 - 8,574,085 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MBLAC2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	97,632,419 - 97,648,137 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	97,632,411 - 97,648,147 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	100,710,390 - 100,725,783 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MBLAC2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	84,399,724 - 84,418,838 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	84,399,103 - 84,419,176 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666049	33,459,198 - 33,478,373 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mblac2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624743	9,714,034 - 9,733,370 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624743	9,714,277 - 9,733,372 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Mblac2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	214,614,984 - 214,664,538 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Mblac2
284 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	86
Count of miRNA genes:	69
Interacting mature miRNAs:	78
Transcripts:	ENSRNOT00000021756
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578664	Bmd9	Bone mineral QTL density 9	5		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	2	5736325	50736325	Rat
738010	Lnnr3	Liver neoplastic nodule remodeling QTL 3	2.94		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	2	1	42977529	Rat
9590080	Insglur4	Insulin/glucose ratio QTL 4	28.7	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	2	6152767	51152767	Rat
10755430	Coatc6	Coat color QTL 6		0.02576	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	13325041	58325041	Rat
1600379	Mcs18	Mammary carcinoma susceptibility QTL 18	2.6		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	9623581	44538110	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
731166	Mamtr2	Mammary tumor resistance QTL 2		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	9623581	54623581	Rat
61368	Mcs1	Mammary carcinoma susceptibility QTL 1	4.4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	9623581	25054526	Rat
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	7605533	104774005	Rat

Markers in Region

RH132237

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	11,993,905 - 11,994,086 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	9,586,322 - 9,586,502	NCBI	Rnor6.0
Rnor_5.0	2	9,466,074 - 9,466,254	UniSTS	Rnor5.0
RGSC_v3.4	2	9,812,056 - 9,812,236	UniSTS	RGSC3.4
Celera	2	8,352,892 - 8,353,072	UniSTS
Cytogenetic Map	2	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	88	59	6	351	188	11	142	80	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108934	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC099304	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473955	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000021756 ⟹ ENSRNOP00000021756

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	13,721,360 - 13,766,626 (+)	Ensembl
mRatBN7.2 Ensembl	2	11,986,027 - 12,030,950 (+)	Ensembl
Rnor_6.0 Ensembl	2	9,578,345 - 9,623,513 (+)	Ensembl

RefSeq Acc Id:

NM_001108934 ⟹ NP_001102404

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	13,721,752 - 13,764,558 (+)	NCBI
mRatBN7.2	2	11,986,075 - 12,028,882 (+)	NCBI
Rnor_6.0	2	9,578,501 - 9,621,297 (+)	NCBI
Rnor_5.0	2	9,458,243 - 9,501,526 (+)	NCBI
RGSC_v3.4	2	9,804,235 - 9,847,031 (+)	RGD
Celera	2	8,345,061 - 8,388,084 (+)	RGD

Sequence:

show sequence

CACCCACCTTGCCCGGCCGCACCCCTGCGCATCGGCATGTCGGCACTCGAGTGGTATGCCCACA
AGTCTCTGGGCGATGGCATCTTCTGGATTCAAGAACGGTTCTACGAGTCAGGCAACCGGGCCAA
CATCTGGCTGGTGCGCGGCTCGGAGCAGGACGTGGTGATCGACACGGGCCTGGGGCTACGCAGC
CTCCCGGAGTACCTCTACTCCTCCGGCCTCTTGCAGGATTGTGGTGCCAAAGAGGATGCAGGAC
GTCGGCCGCTGCTGGCCGTGGCCACCCACGTGCACTTTGATCACTCCGGCGGGCTCTATCAGTT
CGACCAGGTGGCTGTGCACCGCGCCGAAGCCGAGGCCCTGGCTCGCGGGGACAACTTTGAGACC
GTGACCTGGCTCTCTGACAGCGAGGTGGTGCGGGCGCCCAGCCCTGGCTGGAGGGCCAGGCAAT
TCCGAGTGCAGGCAGTGCAACCCACCCTCATTCTGCAGGATGGGGATGTGATCAACCTTGGCGA
CAGACAGCTCACTGTTATGCACATGCCAGGTCACTCCAGAGGCAGTATTTGCTTACATGATAAA
GACCGCAAGGTACTCTTCAGTGGTGACGTCGTGTATGATGGATCACTGATTGACTGGCTCCCAT
ACAGCAGGATCAGTGACTATGTTGGAACTTGTGAACGTCTCATAGAGTTGGTGGACAGAGGTCT
TGTGGAGAAGGTGCTTCCTGGGCACTTCAATACCTTTGGTGCTGAAAGGCTGTTTCGTTTAGCT
TCTAACTATATTTCAAAAGCTGGGATATGCCACAAAGTGTCTACTTTTGCCATGAGATCTCTTG
CAAGTTTAGCTCTCCGTGTAACAAATCCTAGGACCTCACCCTAGTATCTACACTGGTCATTTGT
TTATATTAACTGTATAAATTAACCCAGTTCCCCTGTGTTGTTGGAAAGTTACTAGTGAGCATTT
CAAAAAGTGCTTTAATATCACCATTGTATGTTAGAGAAAAAGAGGATTAAGGAGGAAGAAAAAA
TAAACAGTCTGAGCTTAGTATCTTTTTCTTTTCTCCAAGGAATAAGCCACTTAAGAAAGCTTGT
TATTGGCCAGTGCTGTCTTTCAGAGTGTGTTCTGACCGTGCTGTGGGTGCTCCAGGCAGCAAGG
ATGCACTTATGCAGCACAAGCAGCTGCCCTTGCCCCATAGTTTATTTCCCTAGATACTGAGGGG
AAATGGTATGGGAAATGATTGGGGGGGGGGGGCTCTATGCTTACACTGTAAACTTCATTTTATC
TCCGGATTTTATTTAAAGATAAAGTTTCTTGGGTTCAAAAATAAAGTAGAACTCAGTATAAACT
AGCATTTAGAATGACAGCTACAACAGCCCATGTTTGTGATTGTATTTCTCCTTTTTTATTGTTA
ATTCTTTATATAAGTATAAGGCACATAACATGCTATATAATTTAAGGAATGAACAGTACAATGG
ATTTGTGTCTTACTGCAAAGCTTTAATGTAAATTGCAGAGCACTTCAGTGAAAAGCTACTGTTG
TTGTTATTGTGCAAGTAATATTTTCAGTCATGAACATGAAATTCAAATGTATGTTACCTATATA
TAAATTGTCAGATTTCTTAAAAGGACACTGTCAGGCAATTTGAAAATAAACATATTGATAATAA
TTTTTTATTATATCCTATTTTAGTATTAATAGATACTATAAACAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001102404	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM09949	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000021756
	ENSRNOP00000021756.4

RefSeq Acc Id:

NP_001102404 ⟸ NM_001108934

- UniProtKB:

D4A249 (UniProtKB/TrEMBL), A6I4J1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSALEWYAHKSLGDGIFWIQERFYESGNRANIWLVRGSEQDVVIDTGLGLRSLPEYLYSSGLLQ
DCGAKEDAGRRPLLAVATHVHFDHSGGLYQFDQVAVHRAEAEALARGDNFETVTWLSDSEVVRA
PSPGWRARQFRVQAVQPTLILQDGDVINLGDRQLTVMHMPGHSRGSICLHDKDRKVLFSGDVVY
DGSLIDWLPYSRISDYVGTCERLIELVDRGLVEKVLPGHFNTFGAERLFRLASNYISKAGICHK
VSTFAMRSLASLALRVTNPRTSP

hide sequence

Ensembl Acc Id:

ENSRNOP00000021756 ⟸ ENSRNOT00000021756

Protein Domains

Metallo-beta-lactamase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A249-F1-model_v2	AlphaFold	D4A249	1-279	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691046

Promoter ID:

EPDNEW_R1571

Type:

single initiation site

Name:

Mblac2_1

Description:

metallo-beta-lactamase domain containing 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	9,578,443 - 9,578,503	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306703	AgrOrtholog
BioCyc Gene	G2FUF-55013	BioCyc
Ensembl Genes	ENSRNOG00000016252	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000021756	ENTREZGENE
	ENSRNOT00000021756.8	UniProtKB/TrEMBL
Gene3D-CATH	3.60.15.10	UniProtKB/TrEMBL
InterPro	Blactmase-like	UniProtKB/TrEMBL
	Metallo-beta-lactamase_sf	UniProtKB/TrEMBL
	Metallo-hydrolase/OxRdtase	UniProtKB/TrEMBL
KEGG Report	rno:365627	UniProtKB/TrEMBL
NCBI Gene	365627	ENTREZGENE
PANTHER	METALLO-BETA-LACTAMASE DOMAIN-CONTAINING	UniProtKB/TrEMBL
	METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 2	UniProtKB/TrEMBL
Pfam	Lactamase_B	UniProtKB/TrEMBL
PhenoGen	Mblac2	PhenoGen
RatGTEx	ENSRNOG00000016252	RatGTEx
SMART	Lactamase_B	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56281	UniProtKB/TrEMBL
UniProt	A6I4J1	ENTREZGENE, UniProtKB/TrEMBL
	D4A249	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2009-06-12	Mblac2	metallo-beta-lactamase domain containing 2	RGD1306703	similar to metallo-beta-lactamase superfamily protein like (XL884)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1306703	similar to metallo-beta-lactamase superfamily protein like (XL884)	RGD1306703_predicted	similar to metallo-beta-lactamase superfamily protein like (XL884) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-20	RGD1306703_predicted	similar to metallo-beta-lactamase superfamily protein like (XL884) (predicted)	LOC365627_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC365627_predicted	similar to metallo-beta-lactamase superfamily protein like (XL884) (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - ClinVar