Noxa1 (NADPH oxidase activator 1) - Rat Genome Database

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Gene: Noxa1 (NADPH oxidase activator 1) Rattus norvegicus
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Symbol: Noxa1
Name: NADPH oxidase activator 1
RGD ID: 1306687
Description: Predicted to enable several functions, including SH3 domain binding activity; small GTPase binding activity; and superoxide-generating NADPH oxidase activator activity. Predicted to be involved in regulation of hydrogen peroxide metabolic process; regulation of respiratory burst; and superoxide anion generation. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of NADPH oxidase complex. Orthologous to human NOXA1 (NADPH oxidase activator 1); INTERACTS WITH 17beta-estradiol; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC311793; predicted NADPH oxidase activator 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,293,643 - 28,309,828 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl328,293,658 - 28,304,022 (-)EnsemblGRCr8
mRatBN7.237,895,488 - 7,907,011 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl37,895,488 - 7,905,967 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx311,000,504 - 11,010,859 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,586,732 - 19,597,089 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0317,776,578 - 17,786,931 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,299,676 - 2,309,491 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,299,691 - 2,309,179 (-)Ensemblrn6Rnor6.0
Rnor_5.032,281,046 - 2,290,833 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.433,244,484 - 3,254,647 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera32,723,315 - 2,733,478 (-)NCBICelera
RGSC_v3.133,244,480 - 3,315,883 (-)NCBI
Cytogenetic Map3p13NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Phosphorylation of Nox1 regulates association with NoxA1 activation domain. Streeter J, etal., Circ Res. 2014 Nov 7;115(11):911-8. doi: 10.1161/CIRCRESAHA.115.304267. Epub 2014 Sep 16.
Additional References at PubMed
PMID:12473664   PMID:16381931   PMID:16636067   PMID:17612411   PMID:19755710   PMID:20609497  


Genomics

Comparative Map Data
Noxa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,293,643 - 28,309,828 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl328,293,658 - 28,304,022 (-)EnsemblGRCr8
mRatBN7.237,895,488 - 7,907,011 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl37,895,488 - 7,905,967 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx311,000,504 - 11,010,859 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,586,732 - 19,597,089 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0317,776,578 - 17,786,931 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,299,676 - 2,309,491 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,299,691 - 2,309,179 (-)Ensemblrn6Rnor6.0
Rnor_5.032,281,046 - 2,290,833 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.433,244,484 - 3,254,647 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera32,723,315 - 2,733,478 (-)NCBICelera
RGSC_v3.133,244,480 - 3,315,883 (-)NCBI
Cytogenetic Map3p13NCBI
NOXA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389137,423,393 - 137,434,406 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9137,423,350 - 137,434,451 (+)Ensemblhg38GRCh38
GRCh379140,317,845 - 140,328,858 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,437,668 - 139,448,679 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349137,593,683 - 137,604,694NCBI
Celera9110,821,880 - 110,855,036 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,781,830 - 109,793,377 (+)NCBIHuRef
CHM1_19140,466,579 - 140,477,568 (+)NCBICHM1_1
T2T-CHM13v2.09149,674,014 - 149,685,028 (+)NCBIT2T-CHM13v2.0
Noxa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39224,975,679 - 24,985,217 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl224,975,679 - 24,985,161 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38225,085,667 - 25,095,205 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,085,667 - 25,095,149 (-)Ensemblmm10GRCm38
MGSCv37224,941,187 - 24,950,725 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36224,907,676 - 24,917,157 (-)NCBIMGSCv36mm8
Celera224,812,845 - 24,822,383 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map216.97NCBI
Noxa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,345,619 - 5,352,834 (+)Ensembl
ChiLan1.0NW_0049555135,345,521 - 5,352,879 (+)NCBIChiLan1.0ChiLan1.0
NOXA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2111,955,694 - 1,968,699 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan191,958,000 - 1,971,016 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09108,490,455 - 108,503,555 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19137,455,874 - 137,468,612 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,455,874 - 137,468,196 (+)EnsemblpanPan2panpan1.1
NOXA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,306,652 - 48,316,196 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,313,723 - 48,316,201 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha947,493,744 - 47,503,295 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0949,168,656 - 49,178,815 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,168,675 - 49,178,767 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1947,945,025 - 47,954,587 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,244,000 - 48,253,549 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,290,499 - 48,300,653 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Noxa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,732,032 - 202,742,194 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936669631,496 - 641,569 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936669632,864 - 641,257 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOXA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21314,012,280 - 314,022,093 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NOXA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112758,107 - 769,252 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12758,152 - 769,095 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660584,571,518 - 4,588,988 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Noxa1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760603,528 - 610,942 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624760602,403 - 610,775 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Noxa1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1512,089,544 - 12,099,895 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Noxa1
73 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:77
Interacting mature miRNAs:82
Transcripts:ENSRNOT00000012375
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 31 124 55 57 29 65 29 6 208 116 3 109 47 88 28 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000012375   ⟹   ENSRNOP00000012375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl328,293,658 - 28,304,022 (-)Ensembl
mRatBN7.2 Ensembl37,895,488 - 7,905,967 (-)Ensembl
Rnor_6.0 Ensembl32,299,691 - 2,309,179 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000157659   ⟹   ENSRNOP00000107283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl328,293,833 - 28,304,022 (-)Ensembl
RefSeq Acc Id: NM_001100171   ⟹   NP_001093641
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,293,658 - 28,303,823 (-)NCBI
mRatBN7.237,895,488 - 7,905,655 (-)NCBI
Rnor_6.032,299,691 - 2,309,179 (-)NCBI
Rnor_5.032,281,046 - 2,290,833 (-)NCBI
RGSC_v3.433,244,484 - 3,254,647 (-)RGD
Celera32,723,315 - 2,733,478 (-)RGD
Sequence:
RefSeq Acc Id: XM_017591817   ⟹   XP_017447306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,293,643 - 28,309,828 (-)NCBI
mRatBN7.237,895,488 - 7,907,011 (-)NCBI
Rnor_6.032,299,676 - 2,309,469 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001093641 (Get FASTA)   NCBI Sequence Viewer  
  XP_017447306 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A7E3N7 (Get FASTA)   NCBI Sequence Viewer  
  EDL93638 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012375
  ENSRNOP00000012375.5
GenBank Protein FAA00366 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001093641   ⟸   NM_001100171
- UniProtKB: A7E3N7 (UniProtKB/Swiss-Prot),   A6JT09 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447306   ⟸   XM_017591817
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000012375   ⟸   ENSRNOT00000012375
Ensembl Acc Id: ENSRNOP00000107283   ⟸   ENSRNOT00000157659
Protein Domains
PB1   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A7E3N7-F1-model_v2 AlphaFold A7E3N7 1-446 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306687 AgrOrtholog
BioCyc Gene G2FUF-50486 BioCyc
Ensembl Genes ENSRNOG00000009286 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012375 ENTREZGENE
  ENSRNOT00000012375.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
InterPro NCF2_NOXA1 UniProtKB/Swiss-Prot
  PB1-like UniProtKB/Swiss-Prot
  PB1_dom UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot
  TPR_repeat UniProtKB/Swiss-Prot
KEGG Report rno:311793 UniProtKB/Swiss-Prot
NCBI Gene 311793 ENTREZGENE
PANTHER NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2 UniProtKB/Swiss-Prot
  PTHR15175:SF4 UniProtKB/Swiss-Prot
Pfam PB1 UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
PhenoGen Noxa1 PhenoGen
PRINTS P67PHOX UniProtKB/Swiss-Prot
  SH3DOMAIN UniProtKB/Swiss-Prot
PROSITE PB1 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
  TPR UniProtKB/Swiss-Prot
  TPR_REGION UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009286 RatGTEx
SMART PB1 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
  TPR UniProtKB/Swiss-Prot
Superfamily-SCOP CAD & PB1 domains UniProtKB/Swiss-Prot
  SSF48452 UniProtKB/Swiss-Prot
  SSF50044 UniProtKB/Swiss-Prot
UniProt A0ABK0LT89_RAT UniProtKB/TrEMBL
  A6JT09 ENTREZGENE, UniProtKB/TrEMBL
  A7E3N7 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Noxa1  NADPH oxidase activator 1   Noxa1_predicted  NADPH oxidase activator 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Noxa1_predicted  NADPH oxidase activator 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED