Noxa1 (NADPH oxidase activator 1)

Gene: Noxa1 (NADPH oxidase activator 1) Rattus norvegicus

Analyze

Symbol:

Noxa1

Name:

NADPH oxidase activator 1

RGD ID:

1306687

Description:

Predicted to enable several functions, including SH3 domain binding activity; small GTPase binding activity; and superoxide-generating NADPH oxidase activator activity. Predicted to be involved in regulation of hydrogen peroxide metabolic process; regulation of respiratory burst; and superoxide anion generation. Predicted to be located in cytoplasm. Predicted to be part of NADPH oxidase complex. Orthologous to human NOXA1 (NADPH oxidase activator 1); INTERACTS WITH 17beta-estradiol; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC311793; predicted NADPH oxidase activator 1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NOXA1 (NADPH oxidase activator 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Noxa1 (NADPH oxidase activator 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Noxa1 (NADPH oxidase activator 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NOXA1 (NADPH oxidase activator 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NOXA1 (NADPH oxidase activator 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Noxa1 (NADPH oxidase activator 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NOXA1 (NADPH oxidase activator 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NOXA1 (NADPH oxidase activator 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Noxa1 (NADPH oxidase activator 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	NOXA1 (NADPH oxidase activator 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Noxa1 (NADPH oxidase activator 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	noxa1 (NADPH oxidase activator 1)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	noxa1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	28,293,643 - 28,309,828 (-)	NCBI		GRCr8
mRatBN7.2	3	7,895,488 - 7,907,011 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	7,895,488 - 7,905,967 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	11,000,504 - 11,010,859 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	19,586,732 - 19,597,089 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	17,776,578 - 17,786,931 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	2,299,676 - 2,309,491 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	2,299,691 - 2,309,179 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	2,281,046 - 2,290,833 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	3,244,484 - 3,254,647 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	3,244,480 - 3,315,883 (-)	NCBI
Celera	3	2,723,315 - 2,733,478 (-)	NCBI		Celera
Cytogenetic Map	3	p13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Adams-Oliver Syndrome 5 (ISO)

autosomal dominant intellectual developmental disorder 8 (ISO)

developmental and epileptic encephalopathy 14 (ISO)

epilepsy (ISO)

genetic disease (ISO)

Joubert syndrome 1 (ISO)

Kleefstra syndrome 1 (ISO)

primary coenzyme Q10 deficiency 7 (ISO)

Rafiq syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,6-dinitrotoluene (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

amitrole (EXP)

apocynin (EXP)

arsenite(3-) (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

choline (ISO)

chrysene (ISO)

cisplatin (ISO)

decabromodiphenyl ether (ISO)

dexamethasone (ISO)

dioxygen (EXP)

ethanol (ISO)

folic acid (ISO)

furan (EXP)

hexadecanoic acid (EXP)

indometacin (ISO)

L-methionine (ISO)

methimazole (EXP)

N-methyl-4-phenylpyridinium (ISO)

ochratoxin A (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

progesterone (ISO)

rotenone (ISO)

silicon dioxide (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

testosterone (ISO)

titanium dioxide (EXP,ISO)

trichloroethene (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

regulation of hydrogen peroxide metabolic process (ISO)

regulation of respiratory burst (ISO)

superoxide anion generation (IBA)

superoxide metabolic process (ISO,ISS)

Cellular Component

cytoplasm (IEA)

NADPH oxidase complex (ISO)

Molecular Function

enzyme binding (ISO)

identical protein binding (ISO)

protein binding (IPI,ISO)

SH3 domain binding (ISO)

small GTPase binding (ISO)

superoxide-generating NADPH oxidase activator activity (IBA,ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Phosphorylation of Nox1 regulates association with NoxA1 activation domain.	Streeter J, etal., Circ Res. 2014 Nov 7;115(11):911-8. doi: 10.1161/CIRCRESAHA.115.304267. Epub 2014 Sep 16.

Additional References at PubMed

PMID:12473664	PMID:16381931	PMID:16636067	PMID:17612411	PMID:19755710	PMID:20609497

Genomics

Comparative Map Data

Noxa1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	28,293,643 - 28,309,828 (-)	NCBI		GRCr8
mRatBN7.2	3	7,895,488 - 7,907,011 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	7,895,488 - 7,905,967 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	11,000,504 - 11,010,859 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	19,586,732 - 19,597,089 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	17,776,578 - 17,786,931 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	2,299,676 - 2,309,491 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	2,299,691 - 2,309,179 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	2,281,046 - 2,290,833 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	3,244,484 - 3,254,647 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	3,244,480 - 3,315,883 (-)	NCBI
Celera	3	2,723,315 - 2,733,478 (-)	NCBI		Celera
Cytogenetic Map	3	p13	NCBI

NOXA1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	137,423,393 - 137,434,406 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	137,423,350 - 137,434,406 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	140,317,845 - 140,328,858 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	139,437,668 - 139,448,679 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	137,593,683 - 137,604,694	NCBI
Celera	9	110,821,880 - 110,855,036 (+)	NCBI		Celera
Cytogenetic Map	9	q34.3	NCBI
HuRef	9	109,781,830 - 109,793,377 (+)	NCBI		HuRef
CHM1_1	9	140,466,579 - 140,477,568 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	149,674,014 - 149,685,028 (+)	NCBI		T2T-CHM13v2.0

Noxa1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	24,975,679 - 24,985,217 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	24,975,679 - 24,985,161 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	25,085,667 - 25,095,205 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	25,085,667 - 25,095,149 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	24,941,187 - 24,950,725 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	24,907,676 - 24,917,157 (-)	NCBI		MGSCv36	mm8
Celera	2	24,812,845 - 24,822,383 (-)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI
cM Map	2	16.97	NCBI

Noxa1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955513	5,345,619 - 5,352,834 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955513	5,345,521 - 5,352,879 (+)	NCBI	ChiLan1.0	ChiLan1.0

NOXA1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	1,955,694 - 1,968,699 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	1,958,000 - 1,971,016 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	108,490,455 - 108,503,555 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	137,455,874 - 137,468,612 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	137,455,874 - 137,468,196 (+)	Ensembl	panpan1.1		panPan2

NOXA1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	48,306,652 - 48,316,196 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	48,313,723 - 48,316,201 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	47,493,744 - 47,503,295 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	49,168,656 - 49,178,815 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	49,168,675 - 49,178,767 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	47,945,025 - 47,954,587 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	48,244,000 - 48,253,549 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	48,290,499 - 48,300,653 (-)	NCBI		UU_Cfam_GSD_1.0

Noxa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	202,732,032 - 202,742,194 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936669	631,496 - 641,569 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936669	632,864 - 641,257 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NOXA1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa10.2	1	314,012,280 - 314,022,093 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NOXA1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	758,107 - 769,252 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	758,152 - 769,095 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666058	4,571,518 - 4,588,988 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Noxa1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	603,528 - 610,942 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624760	602,403 - 610,775 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Noxa1
34 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	91
Count of miRNA genes:	77
Interacting mature miRNAs:	82
Transcripts:	ENSRNOT00000012375
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70202	Alc19	Alcohol consumption QTL 19	2.5		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	3	1	27494778	Rat
631679	Cm10	Cardiac mass QTL 10	7.34	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	1	31158234	Rat
631831	Alc8	Alcohol consumption QTL 8	2.7		consumption behavior trait (VT:0002069)	calculated ethanol drink intake rate (CMO:0001615)	3	1	33230976	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	diastolic blood pressure (CMO:0000005)	3	1	33278763	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	3	1	33278763	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	pulse pressure (CMO:0000292)	3	1	33278763	Rat
631545	Bp85	Blood pressure QTL 85	3.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	33278763	Rat
4889966	Bss95	Bone structure and strength QTL 95	4.4		tibia area (VT:1000281)	tibia-fibula cross-sectional area (CMO:0001718)	3	1	36847613	Rat
2312664	Scl62	Serum cholesterol level QTL 62		0.05	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	1	38710544	Rat
631568	Bp92	Blood pressure QTL 92	2.2	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	39874793	Rat
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
1358185	Ept6	Estrogen-induced pituitary tumorigenesis QTL 6	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6537645	10778823	Rat
2292615	Ept17	Estrogen-induced pituitary tumorigenesis QTL 17	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6537645	10778823	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	nervous system	renal system	reproductive system	respiratory system
High
Medium	2
Low	1		1	1	8	1	49	14	24	4
Below cutoff		18	27	17	8	17	18	8	13	7

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001100171	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006233600	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591817	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591818	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591819	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591820	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BR000299	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000012375 ⟹ ENSRNOP00000012375

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	7,895,488 - 7,905,967 (-)	Ensembl
Rnor_6.0 Ensembl	3	2,299,691 - 2,309,179 (-)	Ensembl

RefSeq Acc Id:

NM_001100171 ⟹ NP_001093641

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	28,293,658 - 28,303,823 (-)	NCBI
mRatBN7.2	3	7,895,488 - 7,905,655 (-)	NCBI
Rnor_6.0	3	2,299,691 - 2,309,179 (-)	NCBI
Rnor_5.0	3	2,281,046 - 2,290,833 (-)	NCBI
RGSC_v3.4	3	3,244,484 - 3,254,647 (-)	RGD
Celera	3	2,723,315 - 2,733,478 (-)	RGD

Sequence:

show sequence

ATGAGCTCTCTAGGGGATCAGATACGGGACTGGCACCGGGGCGTACTGGCCGTAGCACGCGAAG
ACTGGGACTCTGCACTGTGCTTCTTTTCAGATGTCCGGGAGCCGCTGGCTAAGATGTACTTCAA
CATGGGCTGCGTGCACCTGATGGCAGGGGATCCCGAGGCTGCGCTGAGGGCATTTGACCAAGCA
GTGACCAAGGACACCTGCATGGCTGTTGGCTTCCTCCAGCGGGGAGTGGCCAATTTCCAGCTGC
AGAGGCTCCAGGAGGCTGTGTCCGACTTCCAGTTGGCCCTGGCACAGCTGAGGGGCAATGCTGC
CATTGACTACACACAACTGGGTCTGGACTTCAAACTGCAAGCCTGGGAGGTCCTATATAACATG
GCATCAGTGCAGTGCCAGGCAGGGCTCTGGACCAAGGCTGCCAATACTCTAGTAGAAGCAATCT
CCAAACGGCCAGAGGGGGCCCAAGACACCCTGGAGGCTGCCATGGACAAAGTGCAGAAACAGGT
ACCACTGCAGCTGCGGCAAGTGCCCAAGGGGGAGGTCTTCCAGCCTCCTCGGCGATACCTGAAA
CATCTGGAGCCCATGGATTTCCTCGGCAAGGCTAAGGTGGTGGCTTCTGTCATCCCTGATGACC
ACAACTCGGACATCCAGCCTCAGCAGAGCTCCCAGGTGGAGCAAGCCGGCCTCCAGTCGTCCTC
ACCCGTGTGTAAGAGGGTCCTGAGCACAAGGGGTGGTCACATGAGCCCTGGCCTATGGGACAGT
TTGCTGGCAACTGGAGGGCCTGTCCCGGGCCCCTCTGAAGATTCCTCTAGTGCTGAGGGAACAG
CTACAAAGGACCCTGAATCCTTGGTGACTGTCACTGTGCAGTGCCACTTTACTGTGCCCCTGAA
GGTCCCCAGAGGAACTGACCTGTCCAGTTTTCGGACACTACTGTCTCAAGCTCTCCTTCAGCAG
ACCCAGAAGGGGCAGTTCAGCTACAAAGCCCGAGGAGAGGACAGAGCCTGGGTCCCCATCTCCA
CGGAGGACTCACTGCAGAGTGTATGGAGGAATGTGCCAGTGAGCCCAAGAGGCTTGCAGCTCCA
GTGCCGGGGGGCCTGGGGCCGGCCAGTCCTCTACCAAGTGGTAGCTCAGTACGACTATCGTGCC
CAAAGGCCGGAGGACTTGGACTTCCGCCAAGGGGACACAGTGGATGTTCTGTGTGAAGTGGACG
AAGCATGGCTGGAGGGACACCGAGATGGCCGTGTTGGTATTTTCCCCAAGTGCTTTGTAGTCCC
AGCTGCCACCTGTGTGGAAGCCCTGCCTGTACCTGAACCCCAGCCAGGAGAACAGCACTAGCAA
TAAATACCGTGACAAAACCAGCTTTAATTTAAAC

hide sequence

RefSeq Acc Id:

XM_017591817 ⟹ XP_017447306

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	28,293,643 - 28,309,828 (-)	NCBI
mRatBN7.2	3	7,895,488 - 7,907,011 (-)	NCBI
Rnor_6.0	3	2,299,676 - 2,309,469 (-)	NCBI

Sequence:

show sequence

TGAAGGGGCATGGCTAAGTAATCGAAGACCGCTTCTCAGGCTAAGTGGTTCAAGGCGGGGCGTG
AGAGAGGGGCCTCGGCCTTGGACCATCTACTCAGTATCAAGGACAGATTGTCACAACTCCAGTT
GGCTTGCTACCAGCTGCTTCTCGTTGTTGTCCTGGTCCCCTTGCCCCTGGCCCTGCCCCTGGCC
CACGGTCCCCCAGTTTCTGTGGGGCACACTCTTCCTGTCCCGCGCGCTTCAGCTAGAATCGCTA
ACTTCCTTCGCCGCAAAGCAGGCGTCCTCACTCCATGAGCTCTCTAGGGGATCAGATACGGGAC
TGGCACCGGGGCGTACTGGCCGTAGCACGCGAAGACTGGGACTCTGCACTGTGCTTCTTTTCAG
ATGTCCGGGAGCCGCTGGCTAAGATGTACTTCAACATGGGCTGCGTGCACCTGATGGCAGGGGA
TCCCGAGGCTGCGCTGAGGGCATTTGACCAAGCAGTGACCAAGGACACCTGCATGGCTGTTGGC
TTCCTCCAGCGGGGAGTGGCCAATTTCCAGCTGCAGAGGCTCCAGGAGGCTGTGTCCGACTTCC
AGTTGGCCCTGGCACAGCTGAGGGGCAATGCTGCCATTGACTACACACAACTGGGTCTGGACTT
CAAACTGCAAGCCTGGGAGGTCCTATATAACATGGCATCAGTGCAGTGCCAGGCAGGGCTCTGG
ACCAAGGCTGCCAATACTCTAGTAGAAGCAATCTCCAAACGGCCAGAGGGGGCCCAAGACACCC
TGGAGGCTGCCATGGACAAAGTGCAGAAACAGGTACCACTGCAGCTGCGGCAAGTGCCCAAGGG
GGAGGTCTTCCAGCCTCCTCGGCGATACCTGAAACATCTGGAGCCCATGGATTTCCTCGGCAAG
GCTAAGGTGGTGGCTTCTGTCATCCCTGATGACCACAACTCGGACATCCAGCCTCAGCAGAGCT
CCCAGGTGGAGCAAGCCGGCCTCCAGTCGTCCTCACCCGTGTGTAAGAGGGTCCTGAGCACAAG
GGGTGGTCACATGAGCCCTGGCCTATGGGACAGTTTGCTGGCAACTGGAGGGCCTGTCCCGGGC
CCCTCTGAAGATTCCTCTAGTGCTGAGGGAACAGCTACAAAGGACCCTGAATCCTTGGTGACTG
TCACTGTGCAGTGCCACTTTACTGTGCCCCTGAAGGTCCCCAGAGGAACTGACCTGTCCAGTTT
TCGGACACTACTGTCTCAAGCTCTCCTTCAGCAGACCCAGAAGGGGCAGTTCAGCTACAAAGCC
CGAGGAGAGGACAGAGCCTGGGTCCCCATCTCCACGGAGGACTCACTGCAGAGTGTATGGAGGA
ATGTGCCAGTGAGCCCAAGAGGCTTGCAGCTCCAGTGCCGGGTGAGCCAAGGGGAGAGACTGGT
GCCTGCTGTGGGCAGCCCAGGCAGTTGGAAGGGAAGCCCCTCGAGTGCACTGCCCCTGCAGCCC
ACTCTTCTATTACAGGGGGCCTGGGGCCGGCCAGTCCTCTACCAAGTGGTAGCTCAGTACGACT
ATCGTGCCCAAAGGCCGGAGGACTTGGACTTCCGCCAAGGGGACACAGTGGATGTTCTGTGTGA
AGTGGACGAAGCATGGCTGGAGGGACACCGAGATGGCCGTGTTGGTATTTTCCCCAAGTGCTTT
GTAGTCCCAGCTGCCACCTGTGTGGAAGCCCTGCCTGTACCTGAACCCCAGCCAGGAGAACAGC
ACTAGCAATAAATACCGTGACAAAACCAGCTTTAATTTAAACAAACAAACAAAACTA

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Protein Sequences


Protein RefSeqs	NP_001093641	(Get FASTA)	NCBI Sequence Viewer
	XP_017447306	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	A7E3N7	(Get FASTA)	NCBI Sequence Viewer
	EDL93638	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000012375
	ENSRNOP00000012375.5
	ENSRNOP00055000649
	ENSRNOP00060037076
	ENSRNOP00065033788
GenBank Protein	FAA00366	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001093641 ⟸ NM_001100171

- UniProtKB:

A7E3N7 (UniProtKB/Swiss-Prot), A6JT09 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSSLGDQIRDWHRGVLAVAREDWDSALCFFSDVREPLAKMYFNMGCVHLMAGDPEAALRAFDQA
VTKDTCMAVGFLQRGVANFQLQRLQEAVSDFQLALAQLRGNAAIDYTQLGLDFKLQAWEVLYNM
ASVQCQAGLWTKAANTLVEAISKRPEGAQDTLEAAMDKVQKQVPLQLRQVPKGEVFQPPRRYLK
HLEPMDFLGKAKVVASVIPDDHNSDIQPQQSSQVEQAGLQSSSPVCKRVLSTRGGHMSPGLWDS
LLATGGPVPGPSEDSSSAEGTATKDPESLVTVTVQCHFTVPLKVPRGTDLSSFRTLLSQALLQQ
TQKGQFSYKARGEDRAWVPISTEDSLQSVWRNVPVSPRGLQLQCRGAWGRPVLYQVVAQYDYRA
QRPEDLDFRQGDTVDVLCEVDEAWLEGHRDGRVGIFPKCFVVPAATCVEALPVPEPQPGEQH

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RefSeq Acc Id:

XP_017447306 ⟸ XM_017591817

- Peptide Label:

isoform X1

- Sequence:

show sequence

MSSLGDQIRDWHRGVLAVAREDWDSALCFFSDVREPLAKMYFNMGCVHLMAGDPEAALRAFDQA
VTKDTCMAVGFLQRGVANFQLQRLQEAVSDFQLALAQLRGNAAIDYTQLGLDFKLQAWEVLYNM
ASVQCQAGLWTKAANTLVEAISKRPEGAQDTLEAAMDKVQKQVPLQLRQVPKGEVFQPPRRYLK
HLEPMDFLGKAKVVASVIPDDHNSDIQPQQSSQVEQAGLQSSSPVCKRVLSTRGGHMSPGLWDS
LLATGGPVPGPSEDSSSAEGTATKDPESLVTVTVQCHFTVPLKVPRGTDLSSFRTLLSQALLQQ
TQKGQFSYKARGEDRAWVPISTEDSLQSVWRNVPVSPRGLQLQCRVSQGERLVPAVGSPGSWKG
SPSSALPLQPTLLLQGAWGRPVLYQVVAQYDYRAQRPEDLDFRQGDTVDVLCEVDEAWLEGHRD
GRVGIFPKCFVVPAATCVEALPVPEPQPGEQH

hide sequence

RefSeq Acc Id:

ENSRNOP00000012375 ⟸ ENSRNOT00000012375

Protein Domains

PB1 SH3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A7E3N7-F1-model_v2	AlphaFold	A7E3N7	1-446	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306687	AgrOrtholog
BioCyc Gene	G2FUF-50486	BioCyc
Ensembl Genes	ENSRNOG00000009286	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOG00055000484	UniProtKB/Swiss-Prot
	ENSRNOG00060025830	UniProtKB/Swiss-Prot
	ENSRNOG00065024120	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000012375	ENTREZGENE
	ENSRNOT00000012375.6	UniProtKB/Swiss-Prot
	ENSRNOT00055000835	UniProtKB/Swiss-Prot
	ENSRNOT00060044725	UniProtKB/Swiss-Prot
	ENSRNOT00065041366	UniProtKB/Swiss-Prot
Gene3D-CATH	1.25.40.10	UniProtKB/Swiss-Prot
	SH3 Domains	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tetratricopeptide repeat domain	UniProtKB/TrEMBL
InterPro	PB1_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TPR-like_helical_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TPR_repeat	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:311793	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	311793	ENTREZGENE
PANTHER	NADPH OXIDASE ACTIVATOR 1	UniProtKB/TrEMBL
	NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR15175:SF4	UniProtKB/Swiss-Prot
Pfam	PB1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Noxa1	PhenoGen
PRINTS	P67PHOX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	PB1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TPR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TPR_REGION	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000009286	RatGTEx
	ENSRNOG00055000484	RatGTEx
	ENSRNOG00060025830	RatGTEx
	ENSRNOG00065024120	RatGTEx
SMART	PB1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TPR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	CAD & PB1 domains	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3-domain	UniProtKB/TrEMBL
	SSF48452	UniProtKB/Swiss-Prot
	SSF50044	UniProtKB/Swiss-Prot
	TPR-like	UniProtKB/TrEMBL
UniProt	A6JT09	ENTREZGENE, UniProtKB/TrEMBL
	A7E3N7	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Noxa1	NADPH oxidase activator 1	Noxa1_predicted	NADPH oxidase activator 1 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Noxa1_predicted	NADPH oxidase activator 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar