Larp1 (La ribonucleoprotein 1, translational regulator) - Rat Genome Database

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Gene: Larp1 (La ribonucleoprotein 1, translational regulator) Rattus norvegicus
Analyze
Symbol: Larp1
Name: La ribonucleoprotein 1, translational regulator
RGD ID: 1306683
Description: Predicted to enable several functions, including RNA binding activity; eukaryotic initiation factor 4E binding activity; and ribosomal small subunit binding activity. Predicted to be involved in several processes, including TORC1 signaling; cellular response to rapamycin; and post-transcriptional regulation of gene expression. Predicted to be located in cytoplasm. Predicted to be part of TORC1 complex. Predicted to be active in cytoplasmic stress granule and cytosol. Orthologous to human LARP1 (La ribonucleoprotein 1, translational regulator); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: La ribonucleoprotein domain family, member 1; la-related protein 1; LOC303158; RGD1306683; similar to KIAA0731 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81042,691,833 - 42,746,816 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1042,691,600 - 42,746,816 (+)EnsemblGRCr8
mRatBN7.21042,191,378 - 42,246,361 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1042,191,325 - 42,243,371 (+)EnsemblmRatBN7.2
Rnor_6.01043,435,738 - 43,501,186 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1043,446,526 - 43,498,066 (+)Ensemblrn6Rnor6.0
Rnor_5.01043,243,479 - 43,297,161 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41043,608,207 - 43,676,236 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1041,482,583 - 41,536,302 (+)NCBICelera
RGSC_v3.11043,646,021 - 43,688,503 (+)NCBI
Cytogenetic Map10q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
aflatoxin B1  (ISO)
amino acid  (ISO)
amphetamine  (EXP)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
chloroethene  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
coumarin  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
erianin  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furfural  (ISO)
gentamycin  (EXP)
hexadecanoic acid  (ISO)
indometacin  (ISO)
inulin  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
torin 1  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
cytoplasmic stress granule  (IBA,IEA,ISO)
cytosol  (IBA,IEA,ISO)
TORC1 complex  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15632090   PMID:19946888   PMID:20430826   PMID:22354037   PMID:22658674   PMID:22681889   PMID:23711370   PMID:24532714   PMID:25468996   PMID:25931508   PMID:25940091   PMID:26206669  
PMID:26735137   PMID:28379136   PMID:28673543   PMID:29244122  


Genomics

Comparative Map Data
Larp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81042,691,833 - 42,746,816 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1042,691,600 - 42,746,816 (+)EnsemblGRCr8
mRatBN7.21042,191,378 - 42,246,361 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1042,191,325 - 42,243,371 (+)EnsemblmRatBN7.2
Rnor_6.01043,435,738 - 43,501,186 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1043,446,526 - 43,498,066 (+)Ensemblrn6Rnor6.0
Rnor_5.01043,243,479 - 43,297,161 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41043,608,207 - 43,676,236 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1041,482,583 - 41,536,302 (+)NCBICelera
RGSC_v3.11043,646,021 - 43,688,503 (+)NCBI
Cytogenetic Map10q22NCBI
LARP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385154,682,979 - 154,817,605 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5154,682,986 - 154,817,605 (+)Ensemblhg38GRCh38
GRCh375154,062,539 - 154,197,165 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365154,072,655 - 154,177,358 (+)NCBIBuild 36Build 36hg18NCBI36
Celera5150,169,448 - 150,274,651 (+)NCBICelera
Cytogenetic Map5q33.2NCBI
HuRef5149,234,294 - 149,339,464 (+)NCBIHuRef
CHM1_15153,524,904 - 153,629,585 (+)NCBICHM1_1
T2T-CHM13v2.05155,216,967 - 155,351,568 (+)NCBIT2T-CHM13v2.0
Larp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391157,899,711 - 57,952,860 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1157,899,890 - 57,952,860 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381157,973,418 - 58,062,034 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1158,009,064 - 58,062,034 (+)Ensemblmm10GRCm38
MGSCv371157,822,566 - 57,875,536 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361157,824,441 - 57,878,230 (+)NCBIMGSCv36mm8
MGSCv361158,519,580 - 58,571,809 (+)NCBIMGSCv36mm8
Celera1162,767,009 - 62,819,040 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1135.55NCBI
Larp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554089,002,458 - 9,080,938 (+)Ensembl
ChiLan1.0NW_0049554089,002,443 - 9,080,938 (+)NCBIChiLan1.0ChiLan1.0
LARP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24149,891,761 - 150,021,406 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15148,031,530 - 148,160,951 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05150,086,829 - 150,221,401 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15156,083,059 - 156,216,706 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5156,112,358 - 156,216,706 (+)EnsemblpanPan2panpan1.1
LARP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1454,991,528 - 55,045,976 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl454,994,227 - 55,017,098 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha454,883,281 - 54,967,942 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0455,425,838 - 55,510,674 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl455,428,599 - 55,481,201 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1455,256,881 - 55,341,438 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0455,354,301 - 55,439,652 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0455,858,031 - 55,942,624 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Larp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213109,590,544 - 109,675,531 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365158,043,436 - 8,063,964 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365158,039,887 - 8,125,006 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LARP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1668,390,880 - 68,484,918 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11668,390,879 - 68,451,605 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21674,312,951 - 74,401,405 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LARP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12357,126,878 - 57,265,243 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2357,238,336 - 57,261,710 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603420,397,476 - 20,536,542 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Larp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473334,507,618 - 34,560,901 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473334,504,259 - 34,593,223 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Larp1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1940,170,459 - 40,261,310 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Larp1
455 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:47
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000036959
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH128362  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21042,245,930 - 42,246,134 (+)MAPPERmRatBN7.2
Rnor_6.01043,500,756 - 43,500,959NCBIRnor6.0
Rnor_5.01043,296,731 - 43,296,934UniSTSRnor5.0
RGSC_v3.41043,677,768 - 43,677,971UniSTSRGSC3.4
Celera1041,535,872 - 41,536,075UniSTS
RH 3.4 Map10523.99UniSTS
Cytogenetic Map10q22UniSTS
RH142353  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21042,245,931 - 42,246,122 (+)MAPPERmRatBN7.2
Rnor_6.01043,500,757 - 43,500,947NCBIRnor6.0
Rnor_5.01043,296,732 - 43,296,922UniSTSRnor5.0
RGSC_v3.41043,677,769 - 43,677,959UniSTSRGSC3.4
Celera1041,535,873 - 41,536,063UniSTS
RH 3.4 Map10440.2UniSTS
Cytogenetic Map10q22UniSTS
RH137051  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,208,703 - 86,208,921 (+)MAPPERmRatBN7.2
mRatBN7.21042,211,767 - 42,211,985 (+)MAPPERmRatBN7.2
Rnor_6.01089,187,263 - 89,187,480NCBIRnor6.0
Rnor_6.01043,465,374 - 43,465,591NCBIRnor6.0
Rnor_5.01088,985,759 - 88,985,976UniSTSRnor5.0
Rnor_5.01043,262,608 - 43,262,825UniSTSRnor5.0
RGSC_v3.41043,631,779 - 43,631,996UniSTSRGSC3.4
RGSC_v3.41090,295,283 - 90,295,500UniSTSRGSC3.4
Celera1084,926,705 - 84,926,922UniSTS
Celera1041,501,879 - 41,502,096UniSTS
Cytogenetic Map10q32.1UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map1q54UniSTS
AI136666  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21042,241,560 - 42,241,760 (+)MAPPERmRatBN7.2
Rnor_6.01043,496,388 - 43,496,587NCBIRnor6.0
Rnor_5.01043,292,363 - 43,292,562UniSTSRnor5.0
RGSC_v3.41043,673,400 - 43,673,599UniSTSRGSC3.4
Celera1041,531,501 - 41,531,700UniSTS
RH 3.4 Map10453.5UniSTS
Cytogenetic Map10q22UniSTS
RH135912  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21042,241,480 - 42,242,886 (+)MAPPERmRatBN7.2
Rnor_6.01043,496,308 - 43,497,713NCBIRnor6.0
Rnor_5.01043,292,283 - 43,293,688UniSTSRnor5.0
RGSC_v3.41043,673,320 - 43,674,725UniSTSRGSC3.4
Celera1041,531,421 - 41,532,826UniSTS
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000036959   ⟹   ENSRNOP00000037598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1042,691,833 - 42,746,816 (+)Ensembl
mRatBN7.2 Ensembl1042,223,774 - 42,243,371 (+)Ensembl
Rnor_6.0 Ensembl1043,446,526 - 43,498,066 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113107   ⟹   ENSRNOP00000091072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1042,691,600 - 42,746,816 (+)Ensembl
mRatBN7.2 Ensembl1042,191,325 - 42,243,371 (+)Ensembl
RefSeq Acc Id: NM_001427639   ⟹   NP_001414568
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81042,691,833 - 42,746,816 (+)NCBI
RefSeq Acc Id: XM_039087207   ⟹   XP_038943135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81042,692,842 - 42,746,816 (+)NCBI
mRatBN7.21042,192,411 - 42,246,361 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001414568 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943135 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM04507 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000037598.8
  ENSRNOP00000091072
  ENSRNOP00000091072.2
Ensembl Acc Id: ENSRNOP00000037598   ⟸   ENSRNOT00000036959
RefSeq Acc Id: XP_038943135   ⟸   XM_039087207
- Peptide Label: isoform X1
- UniProtKB: F1M062 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000091072   ⟸   ENSRNOT00000113107
RefSeq Acc Id: NP_001414568   ⟸   NM_001427639
- UniProtKB: A0A8I6GJC3 (UniProtKB/TrEMBL),   F1M062 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M062-F1-model_v2 AlphaFold F1M062 1-931 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697211
Promoter ID:EPDNEW_R7731
Type:single initiation site
Name:Larp1_1
Description:La ribonucleoprotein domain family, member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01043,446,547 - 43,446,607EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306683 AgrOrtholog
BioCyc Gene G2FUF-25013 BioCyc
Ensembl Genes ENSRNOG00000031544 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036959.8 UniProtKB/TrEMBL
  ENSRNOT00000113107 ENTREZGENE
  ENSRNOT00000113107.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
InterPro DM15 UniProtKB/TrEMBL
  La_dom_prot UniProtKB/TrEMBL
  Lupus_La_RNA-bd UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene 303158 ENTREZGENE
PANTHER LA-RELATED PROTEIN 1 UniProtKB/TrEMBL
  PTHR22792 UniProtKB/TrEMBL
Pfam LARP1_HEAT UniProtKB/TrEMBL
  PF05383 UniProtKB/TrEMBL
PhenoGen Larp1 PhenoGen
PROSITE HTH_LA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031544 RatGTEx
SMART DM15 UniProtKB/TrEMBL
  SM00715 UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
UniProt A0A8I6GJC3 ENTREZGENE, UniProtKB/TrEMBL
  F1M062 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-13 Larp1  La ribonucleoprotein 1, translational regulator  Larp1  La ribonucleoprotein domain family, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Larp1  La ribonucleoprotein domain family, member 1   Larp1_predicted  La ribonucleoprotein domain family, member 1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Larp1_predicted  La ribonucleoprotein domain family, member 1 (predicted)  RGD1306683_predicted  similar to KIAA0731 protein (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1306683_predicted  similar to KIAA0731 protein (predicted)  LOC303158_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC303158_predicted  similar to KIAA0731 protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL