Nanos3 (nanos C2HC-type zinc finger 3) - Rat Genome Database

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Gene: Nanos3 (nanos C2HC-type zinc finger 3) Rattus norvegicus
Analyze
Symbol: Nanos3
Name: nanos C2HC-type zinc finger 3
RGD ID: 1306672
Description: Predicted to enable enzyme activator activity and mRNA binding activity. Predicted to be involved in oogenesis; post-transcriptional regulation of gene expression; and regulation of cell cycle. Predicted to act upstream of or within negative regulation of apoptotic signaling pathway and spermatogenesis. Predicted to be located in P-body; cytoplasmic stress granule; and nucleus. Predicted to be active in perinuclear region of cytoplasm. Orthologous to human NANOS3 (nanos C2HC-type zinc finger 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bis(2-ethylhexyl) phthalate; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC288909; nanos homolog 3; nanos homolog 3 (Drosophila)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Nanos3em1(tdTomato)Nips
Genetic Models: WI-Nanos3em1(tdTomato)Nips
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81940,889,531 - 40,893,699 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1940,882,845 - 40,894,263 (+)EnsemblGRCr8
mRatBN7.21923,978,465 - 23,988,933 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,985,504 - 23,988,932 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1930,806,333 - 30,809,775 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01931,460,747 - 31,464,189 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01933,683,502 - 33,686,950 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01925,284,907 - 25,288,680 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,284,909 - 25,288,335 (-)Ensemblrn6Rnor6.0
Rnor_5.01936,262,007 - 36,265,766 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41925,669,353 - 25,672,779 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1923,534,011 - 23,537,437 (+)NCBICelera
RGSC_v3.11925,674,180 - 25,677,606 (+)NCBI
Cytogenetic Map19q11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12947200   PMID:18089289   PMID:18436203   PMID:19861488   PMID:21421998   PMID:22899867   PMID:24736845  


Genomics

Comparative Map Data
Nanos3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81940,889,531 - 40,893,699 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1940,882,845 - 40,894,263 (+)EnsemblGRCr8
mRatBN7.21923,978,465 - 23,988,933 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,985,504 - 23,988,932 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1930,806,333 - 30,809,775 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01931,460,747 - 31,464,189 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01933,683,502 - 33,686,950 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01925,284,907 - 25,288,680 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,284,909 - 25,288,335 (-)Ensemblrn6Rnor6.0
Rnor_5.01936,262,007 - 36,265,766 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41925,669,353 - 25,672,779 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1923,534,011 - 23,537,437 (+)NCBICelera
RGSC_v3.11925,674,180 - 25,677,606 (+)NCBI
Cytogenetic Map19q11NCBI
NANOS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381913,862,036 - 13,880,757 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1913,862,063 - 13,880,757 (+)Ensemblhg38GRCh38
GRCh371913,972,850 - 13,991,571 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361913,848,950 - 13,852,571 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1913,881,695 - 13,885,316 (+)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1913,559,374 - 13,562,880 (+)NCBIHuRef
CHM1_11913,988,759 - 13,992,267 (+)NCBICHM1_1
T2T-CHM13v2.01913,988,190 - 14,006,913 (+)NCBIT2T-CHM13v2.0
Nanos3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,900,359 - 84,911,396 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl884,900,360 - 84,911,846 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38884,173,733 - 84,176,552 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,173,731 - 84,185,217 (-)Ensemblmm10GRCm38
MGSCv37886,697,632 - 86,700,451 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36887,063,838 - 87,066,657 (-)NCBIMGSCv36mm8
Celera888,474,167 - 88,476,986 (-)NCBICelera
Cytogenetic Map8C2NCBI
cM Map840.45NCBI
Nanos3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541532,649,054 - 32,651,936 (+)Ensembl
ChiLan1.0NW_00495541532,648,455 - 32,651,909 (+)NCBIChiLan1.0ChiLan1.0
NANOS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22018,803,335 - 18,810,183 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11917,804,178 - 17,811,032 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01913,427,661 - 13,443,218 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11914,170,500 - 14,173,267 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1914,170,699 - 14,173,013 (+)EnsemblpanPan2panpan1.1
NANOS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2048,462,638 - 48,466,024 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02049,106,830 - 49,110,203 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.12048,317,326 - 48,320,708 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02048,744,227 - 48,747,601 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02048,987,287 - 48,990,661 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nanos3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118207,761,224 - 207,767,021 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366592,589,962 - 2,593,484 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366592,590,291 - 2,593,482 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NANOS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1612,537,449 - 12,541,660 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl612,538,133 - 12,541,816 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660747,121,027 - 7,125,378 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nanos3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249011,169,022 - 1,172,192 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249011,167,052 - 1,171,915 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nanos3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11716,109,834 - 16,118,066 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nanos3
28 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:166
Count of miRNA genes:136
Interacting mature miRNAs:147
Transcripts:ENSRNOT00000050214
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)193128753251431640Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)194072709254856850Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)194072709254856850Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)194072709254856850Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)193009938347207961Rat

Markers in Region
RH133676  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21923,987,791 - 23,987,997 (-)MAPPERmRatBN7.2
Rnor_6.01925,285,844 - 25,286,049NCBIRnor6.0
Rnor_5.01936,262,944 - 36,263,149UniSTSRnor5.0
RGSC_v3.41925,671,639 - 25,671,844UniSTSRGSC3.4
Celera1923,536,297 - 23,536,502UniSTS
Cytogenetic Map19q11UniSTS


Genetic Models
This gene Nanos3 is modified in the following models/strains:
WI-Nanos3em1(tdTomato)Nips    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 10 65 147 58 57 26 48 26 6 269 144 11 126 77 91 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000050214   ⟹   ENSRNOP00000045882
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1940,882,845 - 40,894,263 (+)Ensembl
mRatBN7.2 Ensembl1923,985,504 - 23,988,932 (+)Ensembl
Rnor_6.0 Ensembl1925,284,909 - 25,288,335 (-)Ensembl
RefSeq Acc Id: NM_001105945   ⟹   NP_001099415
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,890,272 - 40,893,698 (+)NCBI
mRatBN7.21923,985,504 - 23,988,932 (+)NCBI
Rnor_6.01925,284,909 - 25,288,335 (-)NCBI
Rnor_5.01936,262,007 - 36,265,766 (-)NCBI
RGSC_v3.41925,669,353 - 25,672,779 (+)RGD
Celera1923,534,011 - 23,537,437 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255235   ⟹   XP_006255297
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81940,889,531 - 40,893,699 (+)NCBI
mRatBN7.21923,978,465 - 23,988,933 (+)NCBI
Rnor_6.01925,284,907 - 25,288,680 (-)NCBI
Rnor_5.01936,262,007 - 36,265,766 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001099415 (Get FASTA)   NCBI Sequence Viewer  
  NP_001424077 (Get FASTA)   NCBI Sequence Viewer  
  XP_006255297 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL92233 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000045882.4
RefSeq Acc Id: NP_001099415   ⟸   NM_001105945
- UniProtKB: D4A138 (UniProtKB/TrEMBL),   A6IYA5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255297   ⟸   XM_006255235
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000045882   ⟸   ENSRNOT00000050214
Protein Domains
Nanos-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A138-F1-model_v2 AlphaFold D4A138 1-178 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306672 AgrOrtholog
BioCyc Gene G2FUF-6073 BioCyc
Ensembl Genes ENSRNOG00000031593 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000050214.5 UniProtKB/TrEMBL
Gene3D-CATH 4.10.60.30 UniProtKB/TrEMBL
InterPro Nanos_sf UniProtKB/TrEMBL
  Znf_Nanos UniProtKB/TrEMBL
  Znf_nanos-typ UniProtKB/TrEMBL
KEGG Report rno:288909 UniProtKB/TrEMBL
NCBI Gene 288909 ENTREZGENE
PANTHER Znf_Nanos UniProtKB/TrEMBL
Pfam zf-nanos UniProtKB/TrEMBL
PhenoGen Nanos3 PhenoGen
PROSITE ZF_NANOS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031593 RatGTEx
UniProt A6IYA5 ENTREZGENE, UniProtKB/TrEMBL
  D4A138 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-10 Nanos3  nanos C2HC-type zinc finger 3  Nanos3  nanos homolog 3 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Nanos3  nanos homolog 3 (Drosophila)   Nanos3_predicted  nanos homolog 3 (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Nanos3_predicted  nanos homolog 3 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED