Cyp46a1 (cytochrome P450, family 46, subfamily a, polypeptide 1) - Rat Genome Database

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Gene: Cyp46a1 (cytochrome P450, family 46, subfamily a, polypeptide 1) Rattus norvegicus
Analyze
Symbol: Cyp46a1
Name: cytochrome P450, family 46, subfamily a, polypeptide 1
RGD ID: 1306605
Description: Predicted to enable cholesterol 24-hydroxylase activity; heme binding activity; and steroid hydroxylase activity. Predicted to be involved in regulation of long-term synaptic potentiation; steroid metabolic process; and xenobiotic metabolic process. Predicted to act upstream of with a negative effect on protein localization to membrane raft. Predicted to be located in several cellular components, including dendrite; endoplasmic reticulum membrane; and postsynapse. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CYP46A1 (cytochrome P450 family 46 subfamily A member 1); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cholesterol 24-hydroxylase; LOC362782
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86133,011,948 - 133,039,167 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6133,011,989 - 133,041,971 (+)EnsemblGRCr8
mRatBN7.26127,247,543 - 127,274,765 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6127,243,315 - 127,274,760 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6127,372,445 - 127,399,673 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06127,667,502 - 127,694,730 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06127,025,379 - 127,052,595 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06132,242,328 - 132,273,788 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6132,242,328 - 132,273,787 (+)Ensemblrn6Rnor6.0
Rnor_5.06141,412,601 - 141,443,684 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46132,700,554 - 132,731,982 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6124,801,923 - 124,833,398 (+)NCBICelera
RGSC_v3.16132,711,108 - 132,737,620 (+)NCBI
Cytogenetic Map6q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(24S)-24-hydroxycholesterol  (ISO)
(5alpha)-cholestan-3beta-ol  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
7alpha-hydroxycholesterol  (ISO)
aflatoxin B1  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
cadmium dichloride  (EXP,ISO)
CGP 52608  (ISO)
cholesterol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dextromethorphan  (ISO)
Di-n-hexyl phthalate  (EXP)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicyclanil  (ISO)
diethyl phthalate  (EXP)
dizocilpine maleate  (ISO)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
fenthion  (ISO)
fipronil  (ISO)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
glyphosate  (EXP)
ketamine  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (EXP)
methidathion  (ISO)
monosodium L-glutamate  (EXP,ISO)
N,N-diethyl-m-toluamide  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
O-methyleugenol  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
PCB138  (ISO)
phenacetin  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sunitinib  (ISO)
tebuconazole  (ISO)
testosterone  (ISO)
tetracycline  (ISO)
titanium dioxide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
dendrite  (IEA,ISO)
endoplasmic reticulum membrane  (IEA,ISO)
postsynapse  (IEA,ISO)
presynapse  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Persistent Neuroadaptations in the Expression of Genes Involved in Cholesterol Homeostasis Induced by Chronic, Voluntary Alcohol Intake in Rats. Alsebaaly J, etal., Front Mol Neurosci. 2018 Dec 13;11:457. doi: 10.3389/fnmol.2018.00457. eCollection 2018.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease. Kolsch H, etal., Mol Psychiatry 2002;7(8):899-902.
5. Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover. Lund EG, etal., J Biol Chem 2003 Jun 20;278(25):22980-8. Epub 2003 Apr 9.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10377398   PMID:12477932   PMID:14640697   PMID:16505352   PMID:17453958   PMID:18241055   PMID:18621681   PMID:18729719   PMID:20193040   PMID:20559650   PMID:20667828   PMID:23288837  
PMID:25017465  


Genomics

Comparative Map Data
Cyp46a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86133,011,948 - 133,039,167 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6133,011,989 - 133,041,971 (+)EnsemblGRCr8
mRatBN7.26127,247,543 - 127,274,765 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6127,243,315 - 127,274,760 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6127,372,445 - 127,399,673 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06127,667,502 - 127,694,730 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06127,025,379 - 127,052,595 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06132,242,328 - 132,273,788 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6132,242,328 - 132,273,787 (+)Ensemblrn6Rnor6.0
Rnor_5.06141,412,601 - 141,443,684 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46132,700,554 - 132,731,982 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6124,801,923 - 124,833,398 (+)NCBICelera
RGSC_v3.16132,711,108 - 132,737,620 (+)NCBI
Cytogenetic Map6q32NCBI
CYP46A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381499,684,298 - 99,727,301 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1499,684,250 - 99,727,318 (+)Ensemblhg38GRCh38
GRCh3714100,150,635 - 100,193,638 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361499,220,508 - 99,263,391 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341499,220,507 - 99,263,390NCBI
Celera1480,205,602 - 80,248,517 (+)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1480,333,998 - 80,376,909 (+)NCBIHuRef
CHM1_114100,088,519 - 100,131,398 (+)NCBICHM1_1
T2T-CHM13v2.01493,915,741 - 93,958,738 (+)NCBIT2T-CHM13v2.0
Cyp46a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912108,300,568 - 108,328,497 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12108,300,640 - 108,328,493 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3812108,334,268 - 108,362,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12108,334,381 - 108,362,234 (+)Ensemblmm10GRCm38
MGSCv3712109,572,591 - 109,600,444 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612108,782,188 - 108,810,041 (+)NCBIMGSCv36mm8
Celera12109,576,067 - 109,604,342 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1259.41NCBI
LOC102030124
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543820,961,365 - 20,985,749 (+)Ensembl
ChiLan1.0NW_00495543820,961,621 - 20,986,260 (+)NCBIChiLan1.0ChiLan1.0
CYP46A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215100,840,224 - 100,882,729 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114100,056,722 - 100,099,224 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01480,309,698 - 80,352,181 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11499,628,511 - 99,671,218 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1499,628,511 - 99,671,218 (+)EnsemblpanPan2panpan1.1
CYP46A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1868,064,898 - 68,095,537 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl868,041,344 - 68,095,212 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha867,588,798 - 67,617,580 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0868,352,536 - 68,381,116 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl868,352,532 - 68,381,111 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1868,013,336 - 68,042,112 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0868,079,753 - 68,108,514 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0868,477,349 - 68,506,246 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101961079
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086406,591,776 - 6,630,640 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366043,451,842 - 3,491,159 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366043,451,853 - 3,490,688 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP46A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7120,661,111 - 120,695,016 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.17120,658,781 - 120,695,031 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27128,276,297 - 128,302,580 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYP46A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12477,641,068 - 77,684,722 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2477,641,034 - 77,684,741 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605364,780,651 - 64,824,401 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101708822
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247344,242,511 - 4,266,975 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247344,242,070 - 4,267,027 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
LOC116905449
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v17126,008,920 - 126,035,627 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cyp46a1
1489 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:365
Count of miRNA genes:184
Interacting mature miRNAs:213
Transcripts:ENSRNOT00000009896
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6131392689143944780Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat

Markers in Region
RH142799  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26127,242,367 - 127,242,532 (+)MAPPERmRatBN7.2
Rnor_6.06132,241,381 - 132,241,545NCBIRnor6.0
Rnor_5.06141,411,654 - 141,411,818UniSTSRnor5.0
RGSC_v3.46132,699,607 - 132,699,771UniSTSRGSC3.4
Celera6124,800,976 - 124,801,140UniSTS
RH 3.4 Map6791.5UniSTS
Cytogenetic Map6q32UniSTS
RH134732  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26127,274,566 - 127,274,754 (+)MAPPERmRatBN7.2
Rnor_6.06132,273,594 - 132,273,781NCBIRnor6.0
Rnor_5.06141,443,486 - 141,443,673UniSTSRnor5.0
RGSC_v3.46132,731,789 - 132,731,976UniSTSRGSC3.4
Celera6124,833,205 - 124,833,392UniSTS
RH 3.4 Map6789.9UniSTS
Cytogenetic Map6q32UniSTS
RH141974  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26127,249,092 - 127,249,273 (+)MAPPERmRatBN7.2
Rnor_6.06132,248,104 - 132,248,284NCBIRnor6.0
Rnor_5.06141,418,377 - 141,418,557UniSTSRnor5.0
RGSC_v3.46132,706,330 - 132,706,510UniSTSRGSC3.4
Celera6124,807,732 - 124,807,912UniSTS
RH 3.4 Map6791.3UniSTS
Cytogenetic Map6q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 12 67 161 91 90 59 59 59 6 320 159 11 140 79 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000009896   ⟹   ENSRNOP00000009896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6133,011,989 - 133,039,166 (+)Ensembl
mRatBN7.2 Ensembl6127,247,591 - 127,274,760 (+)Ensembl
Rnor_6.0 Ensembl6132,246,602 - 132,273,787 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081088   ⟹   ENSRNOP00000069874
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6133,012,002 - 133,039,166 (+)Ensembl
mRatBN7.2 Ensembl6127,243,315 - 127,274,760 (+)Ensembl
Rnor_6.0 Ensembl6132,242,328 - 132,273,787 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000129298   ⟹   ENSRNOP00000107670
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6133,011,989 - 133,040,508 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000168357   ⟹   ENSRNOP00000109444
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6133,011,989 - 133,041,971 (+)Ensembl
RefSeq Acc Id: NM_001399701   ⟹   NP_001386630
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,011,990 - 133,039,167 (+)NCBI
mRatBN7.26127,247,583 - 127,274,761 (+)NCBI
RefSeq Acc Id: XM_063262134   ⟹   XP_063118204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,011,948 - 133,038,206 (+)NCBI
Ensembl Acc Id: ENSRNOP00000009896   ⟸   ENSRNOT00000009896
Ensembl Acc Id: ENSRNOP00000069874   ⟸   ENSRNOT00000081088
RefSeq Acc Id: NP_001386630   ⟸   NM_001399701
- Peptide Label: precursor
- UniProtKB: A0A8J8Y4X4 (UniProtKB/TrEMBL),   B1WC64 (UniProtKB/TrEMBL),   F7EN52 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118204   ⟸   XM_063262134
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000107670   ⟸   ENSRNOT00000129298
Ensembl Acc Id: ENSRNOP00000109444   ⟸   ENSRNOT00000168357

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7EN52-F1-model_v2 AlphaFold F7EN52 1-500 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306605 AgrOrtholog
BioCyc Gene G2FUF-36301 BioCyc
Ensembl Genes ENSRNOG00000007147 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009896 ENTREZGENE
  ENSRNOT00000009896.8 UniProtKB/TrEMBL
  ENSRNOT00000081088.3 UniProtKB/TrEMBL
  ENSRNOT00000129298 ENTREZGENE
  ENSRNOT00000129298.1 UniProtKB/TrEMBL
  ENSRNOT00000168357.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9098323 IMAGE-MGC_LOAD
InterPro CYP46A1 UniProtKB/TrEMBL
  Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
MGC_CLONE MGC:187896 IMAGE-MGC_LOAD
NCBI Gene 362782 ENTREZGENE
PANTHER CHOLESTEROL 24-HYDROXYLASE UniProtKB/TrEMBL
  PTHR24293 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PhenoGen Cyp46a1 PhenoGen
PRINTS EP450I UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007147 RatGTEx
Superfamily-SCOP Cytochrome_P450 UniProtKB/TrEMBL
UniProt A0A0G2JWG7_RAT UniProtKB/TrEMBL
  A0A8J8Y4X4 ENTREZGENE
  A0ABK0LAN2_RAT UniProtKB/TrEMBL
  A0ABK0LFA2_RAT UniProtKB/TrEMBL
  B1WC64 ENTREZGENE
  F7EN52 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A8J8Y4X4 UniProtKB/TrEMBL
  B1WC64 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Cyp46a1  cytochrome P450, family 46, subfamily a, polypeptide 1   Cyp46a1_predicted  cytochrome P450, family 46, subfamily a, polypeptide 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cyp46a1_predicted  cytochrome P450, family 46, subfamily a, polypeptide 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED