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Gene: Kpna6 (karyopherin subunit alpha 6) Rattus norvegicus

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Symbol:

Kpna6

Name:

karyopherin subunit alpha 6

RGD ID:

1306570

Description:

Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to act upstream of or within several processes, including entry of viral genome into host nucleus through nuclear pore complex via importin; positive regulation of macromolecule biosynthetic process; and protein import into nucleus. Predicted to be located in cytoplasm and host cell. Predicted to be part of NLS-dependent protein nuclear import complex. Predicted to be active in nucleoplasm. Orthologous to human KPNA6 (karyopherin subunit alpha 6); INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

importin; importin subunit alpha-7; karyopherin (importin) alpha 6; karyopherin (importin) alpha 6-like; karyopherin alpha 6; karyopherin alpha 6 (importin alpha 7); LOC362607; MGC124892

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	KPNA6 (karyopherin subunit alpha 6)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Kpna6 (karyopherin subunit alpha 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Kpna6 (karyopherin subunit alpha 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	KPNA6 (karyopherin subunit alpha 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	KPNA6 (karyopherin subunit alpha 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Kpna6 (karyopherin subunit alpha 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	KPNA6 (karyopherin subunit alpha 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	KPNA6 (karyopherin subunit alpha 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Kpna6 (karyopherin subunit alpha 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Kpna6 (karyopherin subunit alpha 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	KPNA6 (karyopherin subunit alpha 6)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	KPNA6 (karyopherin subunit alpha 6)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Kpna6 (karyopherin subunit alpha 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Kpna6 (karyopherin subunit alpha 6)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	kpna6 (karyopherin alpha 6 (importin alpha 7))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SRP1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SRP1	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Kap-alpha1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Kap-alpha1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	kpna6	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	kpna6	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ima-1	Alliance	DIOPT (Ensembl Compara\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ima-1	Alliance	DIOPT (Ensembl Compara\|PhylomeDB)
Caenorhabditis elegans (roundworm):	F53B2.5	Alliance	DIOPT (Ensembl Compara\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	147,272,466 - 147,307,523 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	147,275,918 - 147,305,851 (-)	Ensembl				GRCr8
mRatBN7.2	5	141,988,111 - 142,021,483 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	141,991,568 - 142,021,120 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	144,692,338 - 144,707,236 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	146,462,164 - 146,477,056 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	146,458,885 - 146,473,792 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	147,852,738 - 147,867,600 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	147,850,275 - 147,886,615 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	151,581,761 - 151,594,918 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	148,783,562 - 148,793,599 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	140,466,074 - 140,479,954 (-)	NCBI		Celera
RGSC_v3.1	5	148,793,600 - 148,803,633 (-)	NCBI
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (EXP,ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

2,4,6-tribromophenol (ISO)

2-bromohexadecanoic acid (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-naphthoflavone (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

chloropicrin (ISO)

cisplatin (ISO)

clothianidin (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

dexamethasone (EXP,ISO)

dibutyl phthalate (EXP)

elemental selenium (ISO)

ethanol (ISO)

flutamide (EXP)

folic acid (ISO)

indole-3-methanol (EXP)

indometacin (ISO)

isoprenaline (EXP)

ivermectin (ISO)

lead(0) (ISO)

pentachlorophenol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

selenium atom (ISO)

Soman (EXP)

thioacetamide (EXP)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

troglitazone (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

entry of viral genome into host nucleus through nuclear pore complex via importin (ISO)

maternal process involved in female pregnancy (ISO)

NLS-bearing protein import into nucleus (IBA)

positive regulation of cytokine production involved in inflammatory response (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

positive regulation of viral life cycle (ISO)

protein import into nucleus (IEA,ISO)

protein transport (IEA)

viral genome replication (ISO)

Cellular Component

cytoplasm (IEA)

host cell (IEA)

NLS-dependent protein nuclear import complex (IBA)

nucleus (IBA)

Molecular Function

nuclear import signal receptor activity (IBA,IEA,ISO)

nuclear localization sequence binding (IBA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15689618	PMID:16906019	PMID:19946888	PMID:21479251	PMID:28189564

Genomics

Comparative Map Data

Kpna6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	147,272,466 - 147,307,523 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	147,275,918 - 147,305,851 (-)	Ensembl				GRCr8
mRatBN7.2	5	141,988,111 - 142,021,483 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	141,991,568 - 142,021,120 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	144,692,338 - 144,707,236 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	146,462,164 - 146,477,056 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	146,458,885 - 146,473,792 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	147,852,738 - 147,867,600 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	147,850,275 - 147,886,615 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	151,581,761 - 151,594,918 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	148,783,562 - 148,793,599 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	140,466,074 - 140,479,954 (-)	NCBI		Celera
RGSC_v3.1	5	148,793,600 - 148,803,633 (-)	NCBI
Cytogenetic Map	5	q36	NCBI

KPNA6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	32,108,056 - 32,176,563 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	32,108,056 - 32,176,563 (+)	Ensembl			hg38	GRCh38
GRCh37	1	32,573,657 - 32,642,164 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	32,346,231 - 32,414,756 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	32,242,749 - 32,307,867	NCBI
Celera	1	30,843,548 - 30,912,069 (+)	NCBI		Celera
Cytogenetic Map	1	p35.2	NCBI
HuRef	1	30,689,950 - 30,758,546 (+)	NCBI		HuRef
CHM1_1	1	32,689,241 - 32,757,720 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	31,965,999 - 32,034,460 (+)	NCBI		T2T-CHM13v2.0

Kpna6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	129,537,772 - 129,566,560 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	129,537,773 - 129,566,560 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	129,643,979 - 129,672,767 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	129,643,980 - 129,672,767 (-)	Ensembl			mm10	GRCm38
MGSCv37	4	129,321,223 - 129,350,011 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	129,146,288 - 129,175,055 (-)	NCBI		MGSCv36	mm8
Celera	4	127,976,916 - 128,007,095 (-)	NCBI		Celera
Cytogenetic Map	4	D2.2	NCBI
cM Map	4	63.28	NCBI

Kpna6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	10,492,653 - 10,542,898 (+)	Ensembl
ChiLan1.0	NW_004955452	10,493,025 - 10,542,898 (+)	NCBI	ChiLan1.0	ChiLan1.0

KPNA6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	194,650,434 - 194,719,262 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	193,771,870 - 193,840,657 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	31,394,159 - 31,462,821 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	32,406,326 - 32,471,488 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	32,406,326 - 32,471,488 (+)	Ensembl			panPan2	panpan1.1

KPNA6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	69,025,409 - 69,078,635 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	69,030,228 - 69,077,912 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	65,606,196 - 65,658,834 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	69,592,307 - 69,644,942 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	69,592,320 - 69,644,880 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	66,428,697 - 66,481,061 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	67,424,402 - 67,477,046 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	68,423,801 - 68,476,444 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Kpna6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	49,343,513 - 49,405,095 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	15,168,310 - 15,229,902 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	15,168,344 - 15,229,864 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KPNA6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	88,611,471 - 88,656,279 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	88,611,128 - 88,656,281 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	82,613,725 - 82,640,028 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KPNA6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	100,699,653 - 100,769,787 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	100,701,947 - 100,769,766 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666033	15,923,419 - 15,990,214 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kpna6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	15,327,190 - 15,400,716 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624764	15,374,707 - 15,405,024 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Kpna6
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	28,473,626 - 28,505,870 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Kpna6
195 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	254
Count of miRNA genes:	171
Interacting mature miRNAs:	190
Transcripts:	ENSRNOT00000000139
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	102105698	152749382	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	130249266	172190305	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	44924861	153890773	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	116702075	161702075	Rat
1354583	Despr3	Despair related QTL3	4.98	0.0002	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	5	132930505	172190305	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	141212838	172190305	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	99905133	172190305	Rat
70156	Niddm30	Non-insulin dependent diabetes mellitus QTL 30	3.98		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	5	134369218	156289444	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	133789363	172190305	Rat
1331803	Rf32	Renal function QTL 32	2.798		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	134369199	172190305	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	136631198	172190305	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	112142946	157142946	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	112142946	157142946	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	110770739	155770739	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	133081618	172190305	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	138002522	170842766	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	112142946	157142946	Rat
1581505	Rf54	Renal function QTL 54			kidney physiology trait (VT:0002136)	kidney 20-HETE level (CMO:0001854)	5	133270647	172190305	Rat
2317753	Glom24	Glomerulus QTL 24	3.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	5	141764300	172190305	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	133789363	172190305	Rat
1581510	Cm54	Cardiac mass QTL 54	3.4	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	125969677	172190305	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
2317056	Wbc3	White blood cell count QTL 3	2.51	0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	5	111236572	156236572	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	131708216	172190305	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	114131300	159131300	Rat
2293642	Bss37	Bone structure and strength QTL 37	4.64	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	125969677	156302135	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	112142946	157142946	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	116702075	161702075	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	112142946	157142946	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	116702075	161702075	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	74335621	156302135	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	116702075	161702075	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	114131300	159131300	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	133081618	172190305	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	104262817	153890625	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	92	59	6	356	192	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001015029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001443946	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001443947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039110358	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039110360	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063288025	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY148303	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY779030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC105813	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000000139 ⟹ ENSRNOP00000000139

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	141,991,568 - 142,006,003 (-)	Ensembl
Rnor_6.0 Ensembl	5	147,853,243 - 147,867,583 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000087556 ⟹ ENSRNOP00000071158

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	147,275,918 - 147,305,851 (-)	Ensembl
mRatBN7.2 Ensembl	5	141,991,568 - 142,021,120 (-)	Ensembl
Rnor_6.0 Ensembl	5	147,850,275 - 147,886,615 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096749 ⟹ ENSRNOP00000079464

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	147,275,918 - 147,290,757 (-)	Ensembl
mRatBN7.2 Ensembl	5	141,991,568 - 142,006,407 (-)	Ensembl

RefSeq Acc Id:

NM_001015029 ⟹ NP_001015029

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	147,275,916 - 147,290,757 (-)	NCBI
mRatBN7.2	5	141,991,566 - 142,006,407 (-)	NCBI
Rnor_6.0	5	147,852,738 - 147,867,600 (-)	NCBI
Rnor_5.0	5	151,581,761 - 151,594,918 (-)	NCBI
RGSC_v3.4	5	148,783,562 - 148,793,599 (-)	RGD
Celera	5	140,466,074 - 140,479,954 (-)	NCBI

Sequence:

show sequence

CAGCCTCTGGGACAGCACAGGCTCAATCATGAAAAACTATGTGTCAGAGACCATGGCAAGCCCA
GGGAAAGACAATTATCGAATGAAGAGCTATAAGAACAATGCCTTAAACCCTGAGGAAATGAGAC
GAAGAAGGGAGGAAGAGGGCATTCAGCTTCGGAAACAGAAGCGGGAGCAGCAACTTTTTAAACG
GAGAAATGTGGAGCTGATTAATGAAGAAGCTGCCATGTTTGACAGTCTGCTGATGGATTCCTAC
GTGAGCTCCACAACTGGGGAGAGTGTGATCACAAGGGAAATGGTGGAGATGCTCTTTTCTGACG
ATTCTGACTTACAGTTAGCAACCACACAGAAATTCCGGAAACTCCTTTCCAAAGAGCCAAGTCC
TCCAATAGATGAAGTTATTAACACTCCAGGAGTAGTTGATCGGTTTGTGGAGTTTCTGAAGAGG
AGTGAGAATTGTACATTACAGTTTGAAGCTGCCTGGGCTCTAACAAACATTGCCTCTGGAACCT
CTCAGCAGACCAAAATTGTCATTGAAGCAGGAGCTGTCCCCATTTTTATAGAGCTGCTTAACTC
AGACTTTGAAGATGTACAAGAACAGGCAGTCTGGGCTCTTGGAAACATAGCTGGAGACAGTTCA
GTCTGCAGAGACTATGTCTTGAATTGTTCCATCCTTAATCCTCTGTTAACACTCCTTACTAAGT
CCACACGACTGACGATGACACGGAATGCAGTCTGGGCCCTGTCAAACCTCTGCCGAGGGAAGAA
CCCTCCTCCAGAGTTCGCAAAGGTCTCTCCTTGTTTGCCTGTATTGTCTCGCCTACTCTTCAGC
AGCGACTCAGACTTGCTGGCAGATGCTTGCTGGGCCCTCTCTTACCTGTCTGATGGCCCCAATG
AGAAGATCCAGGCAGTCATAGACTCTGGAGTCTGCCGGAGATTGGTAGAGCTTCTGATGCACAA
CGATTACAAAGTGGCGTCTCCTGCCTTGAGAGCTGTGGGTAATATTGTCACCGGGGATGATATC
CAGACCCAGGTCATTCTTAACTGTTCAGCCCTCCCTTGCCTCCTCCACCTGCTGAGCAGCTCTA
AGGAATCAATCCGGAAGGAAGCTTGCTGGACCATTTCAAACATCACTGCTGGCAACAGGGCTCA
AATACAGGCTGTCATAGATGCAAATATCTTCCCTGTATTGATCGAAATCCTTCAGAAAGCAGAG
TTCCGTACGAGGAAAGAAGCAGCCTGGGCCATCACCAATGCAACCTCAGGAGGAACCCCTGAGC
AAATCAGGTACTTGGTATCACTGGGCTGCATTAAGCCCCTGTGTGACTTGCTGACTGTAATGGA
TTCAAAAATTGTACAAGTGGCCCTCAATGGACTAGAGAACATTCTGCGGCTCGGAGAGCAAGAG
GGCAAGCGCAGTGGCTCAGGGGTCAATCCCTACTGTGGCCTCATCGAGGAAGCCTATGGCTTGG
ATAAGATTGAGTTTCTCCAGAGCCATGAGAACCAGGAGATCTACCAGAAGGCCTTTGACCTCAT
CGAGCACTACTTTGGTGTAGAGGATGACGACAGCAGCCTGGCCCCTCAGGTGGACGAGACTCAG
CAGCAGTTCATCTTCCAGCAGCCCGAGGCCCCCATGGAGGGCTTCCAGCTATAATGTCCGCCTC
CGGGGAGGGGGCAGGGCACGGCATGCACCAGCAGCCAGCAGAGGAGCAGCCTTCTGGTGGGCAG
GAGAACAGGCCCCACCAGCCCCGCACACCTGCTGCCCTGGACACTGTGTTCGTGACCTGCTCAC
CCCTTCCCTGGAGGAGGGAGTGCCCTCGGGACAGACAGAACCATCAGAGGCTCACAGTGGGTTT
GTGACAAGAAGGGGACGTGCGGGTCTATCTTCCTTACACTTTATTTTGGCTGCACACATGTCTT
TAACCCAGGAGCCCAGGGGTAGACAAAGGAGGACTGAGGTAATCAATTTGCACCTTTAAATTTT
TTTCTTTTATTTTCTTTAGTGGTGACTTCCTTCCCAGTTATCTTTCTTCATCCATCCCAGTCCT
CTGCCCTGACATGTGTAACTCTTGGGTACTTGAGCAGATGGAATATTCCAGAGGTGGGAGGTGG
GAGGGGAGGGGAGAAGTCCGAAACAAAGTGTTCTTGCTCTGACCGAAAAAAAAAAAAAAAAAAA
AAAAA

hide sequence

RefSeq Acc Id:

XM_039110358 ⟹ XP_038966286

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	147,272,466 - 147,307,523 (-)	NCBI
mRatBN7.2	5	141,988,111 - 142,021,483 (-)	NCBI

RefSeq Acc Id:

XM_039110360 ⟹ XP_038966288

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	147,272,466 - 147,305,154 (-)	NCBI
mRatBN7.2	5	141,988,111 - 142,020,821 (-)	NCBI

RefSeq Acc Id:

XM_063288025 ⟹ XP_063144095

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	147,272,466 - 147,292,645 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001015029	(Get FASTA)	NCBI Sequence Viewer
	NP_001430875	(Get FASTA)	NCBI Sequence Viewer
	NP_001430876	(Get FASTA)	NCBI Sequence Viewer
	XP_038966286	(Get FASTA)	NCBI Sequence Viewer
	XP_038966288	(Get FASTA)	NCBI Sequence Viewer
	XP_063144095	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI05814	(Get FASTA)	NCBI Sequence Viewer
	AAX07457	(Get FASTA)	NCBI Sequence Viewer
	EDL80567	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000071158
	ENSRNOP00000071158.1
	ENSRNOP00000079464
	ENSRNOP00000079464.1

RefSeq Acc Id:

NP_001015029 ⟸ NM_001015029

- UniProtKB:

Q3KR98 (UniProtKB/TrEMBL), A0A8I5ZNJ2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKNYVSETMASPGKDNYRMKSYKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVELINEE
AAMFDSLLMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVINTP
GVVDRFVEFLKRSENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQA
VWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKVS
PCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPAL
RAVGNIVTGDDIQTQVILNCSALPCLLHLLSSSKESIRKEACWTISNITAGNRAQIQAVIDANI
FPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCIKPLCDLLTVMDSKIVQVALN
GLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDD
DSSLAPQVDETQQQFIFQQPEAPMEGFQL

hide sequence

Ensembl Acc Id:

ENSRNOP00000000139 ⟸ ENSRNOT00000000139

Ensembl Acc Id:

ENSRNOP00000071158 ⟸ ENSRNOT00000087556

RefSeq Acc Id:	XP_038966286 ⟸ XM_039110358
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JZS1 (UniProtKB/TrEMBL), A0A8I5ZNJ2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038966288 ⟸ XM_039110360
- Peptide Label:	isoform X2
- UniProtKB:	Q56R15 (UniProtKB/TrEMBL), A0A8I5ZNJ2 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000079464 ⟸ ENSRNOT00000096749

RefSeq Acc Id:	XP_063144095 ⟸ XM_063288025
- Peptide Label:	isoform X2
- UniProtKB:	Q56R15 (UniProtKB/TrEMBL), A0A8I5ZNJ2 (UniProtKB/TrEMBL)

Protein Domains

IBB

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1LT58-F1-model_v2	AlphaFold	F1LT58	1-541	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306570	AgrOrtholog
BioCyc Gene	G2FUF-39781	BioCyc
Ensembl Genes	ENSRNOG00000000127	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000087556	ENTREZGENE
	ENSRNOT00000087556.3	UniProtKB/TrEMBL
	ENSRNOT00000096749	ENTREZGENE
	ENSRNOT00000096749.2	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.690	UniProtKB/TrEMBL
	1.25.10.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7112648	IMAGE-MGC_LOAD
InterPro	ARM-like	UniProtKB/TrEMBL
	ARM-type_fold	UniProtKB/TrEMBL
	Arm_3	UniProtKB/TrEMBL
	Armadillo	UniProtKB/TrEMBL
	HEAT	UniProtKB/TrEMBL
	Importin-a-like_IBB-bd_dom	UniProtKB/TrEMBL
	Importin-a_IBB_sf	UniProtKB/TrEMBL
	Importing_su_alpha	UniProtKB/TrEMBL
KEGG Report	rno:362607	UniProtKB/TrEMBL
MGC_CLONE	MGC:124892	IMAGE-MGC_LOAD
NCBI Gene	362607	ENTREZGENE
PANTHER	IMPORTIN ALPHA	UniProtKB/TrEMBL
Pfam	Arm	UniProtKB/TrEMBL
	Arm_3	UniProtKB/TrEMBL
	HEAT	UniProtKB/TrEMBL
	IBB	UniProtKB/TrEMBL
PhenoGen	Kpna6	PhenoGen
PIRSF	Importin_alpha	UniProtKB/TrEMBL
PROSITE	ARM_REPEAT	UniProtKB/TrEMBL
	IBB	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000000127	RatGTEx
SMART	ARM	UniProtKB/TrEMBL
Superfamily-SCOP	ARM-type_fold	UniProtKB/TrEMBL
UniProt	A0A0G2JZS1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZNJ2	ENTREZGENE, UniProtKB/TrEMBL
	A6ISL6_RAT	UniProtKB/TrEMBL
	Q3KR98	ENTREZGENE, UniProtKB/TrEMBL
	Q56R15	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-11	Kpna6	karyopherin subunit alpha 6	Kpna6	karyopherin alpha 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-01-27	Kpna6	karyopherin alpha 6	Kpna6	karyopherin alpha 6 (importin alpha 7)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-05-24	Kpna6	karyopherin alpha 6 (importin alpha 7)	LOC100363922	karyopherin (importin) alpha 6-like	Data merged from RGD:2322034	1643240	APPROVED
2010-05-06	LOC100363922	karyopherin (importin) alpha 6-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-09-09	Kpna6	karyopherin alpha 6 (importin alpha 7)	Kpna6	karyopherin (importin) alpha 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Kpna6	karyopherin (importin) alpha 6	Kpna6_predicted	karyopherin (importin) alpha 6 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Kpna6_predicted	karyopherin (importin) alpha 6 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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