Slitrk6 (SLIT and NTRK-like family, member 6) - Rat Genome Database

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Gene: Slitrk6 (SLIT and NTRK-like family, member 6) Rattus norvegicus
Analyze
Symbol: Slitrk6
Name: SLIT and NTRK-like family, member 6
RGD ID: 1306550
Description: Predicted to be involved in axonogenesis and positive regulation of synapse assembly. Predicted to act upstream of or within several processes, including auditory behavior; linear vestibuloocular reflex; and nervous system development. Predicted to be located in cell periphery and cell surface. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in high myopia-sensorineural deafness syndrome. Orthologous to human SLITRK6 (SLIT and NTRK like family member 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; atrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC290467; SLIT and NTRK-like protein 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81593,977,812 - 93,984,431 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1593,969,038 - 93,984,526 (-)EnsemblGRCr8
mRatBN7.21587,563,506 - 87,570,125 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1587,563,322 - 87,570,393 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1591,506,334 - 91,512,973 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01592,639,255 - 92,645,886 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01589,555,945 - 89,562,571 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01595,507,632 - 95,514,259 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1595,507,640 - 95,514,259 (-)Ensemblrn6Rnor6.0
Rnor_5.01598,989,203 - 98,995,830 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41595,106,364 - 95,112,983 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1586,576,029 - 86,582,648 (-)NCBICelera
RGSC_v3.11595,122,135 - 95,128,679 (-)NCBI
Cytogenetic Map15q23NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell periphery  (IEA,ISO)
cell surface  (ISO)
membrane  (IEA)
plasma membrane  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14550773   PMID:19936227   PMID:21298075   PMID:23543054   PMID:24613359  


Genomics

Comparative Map Data
Slitrk6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81593,977,812 - 93,984,431 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1593,969,038 - 93,984,526 (-)EnsemblGRCr8
mRatBN7.21587,563,506 - 87,570,125 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1587,563,322 - 87,570,393 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1591,506,334 - 91,512,973 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01592,639,255 - 92,645,886 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01589,555,945 - 89,562,571 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01595,507,632 - 95,514,259 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1595,507,640 - 95,514,259 (-)Ensemblrn6Rnor6.0
Rnor_5.01598,989,203 - 98,995,830 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41595,106,364 - 95,112,983 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1586,576,029 - 86,582,648 (-)NCBICelera
RGSC_v3.11595,122,135 - 95,128,679 (-)NCBI
Cytogenetic Map15q23NCBI
SLITRK6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381385,792,790 - 85,799,419 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1385,792,790 - 85,806,683 (-)Ensemblhg38GRCh38
GRCh371386,366,925 - 86,373,554 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361385,264,923 - 85,271,484 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341385,264,922 - 85,271,484NCBI
Celera1367,280,318 - 67,286,879 (-)NCBICelera
Cytogenetic Map13q31.1NCBI
HuRef1367,078,179 - 67,084,734 (-)NCBIHuRef
CHM1_11386,335,513 - 86,342,073 (-)NCBICHM1_1
T2T-CHM13v2.01385,041,234 - 85,047,862 (-)NCBIT2T-CHM13v2.0
Slitrk6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914110,984,770 - 110,992,640 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14110,986,012 - 110,992,581 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3814110,747,338 - 110,755,204 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14110,748,580 - 110,755,149 (-)Ensemblmm10GRCm38
MGSCv3714111,147,800 - 111,154,371 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3614109,630,422 - 109,636,908 (-)NCBIMGSCv36mm8
Celera14109,332,207 - 109,338,788 (-)NCBICelera
Cytogenetic Map14E3NCBI
cM Map1457.2NCBI
Slitrk6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540422,737,974 - 22,745,046 (+)Ensembl
ChiLan1.0NW_00495540422,738,080 - 22,744,601 (+)NCBIChiLan1.0ChiLan1.0
SLITRK6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21487,342,596 - 87,353,580 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11385,938,088 - 85,949,058 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01366,990,025 - 67,003,900 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11386,160,711 - 86,167,332 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1386,161,905 - 86,164,430 (-)EnsemblpanPan2panpan1.1
SLITRK6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12237,911,533 - 37,918,273 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2237,912,612 - 37,925,177 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2237,737,693 - 37,745,442 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02238,283,620 - 38,291,371 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2238,284,966 - 38,288,341 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12237,922,146 - 37,929,894 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02238,028,765 - 38,036,516 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02238,036,205 - 38,043,951 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slitrk6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945121,376,350 - 121,383,016 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936866412,818 - 419,381 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936866412,719 - 419,381 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLITRK6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1156,508,767 - 56,522,197 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11156,508,713 - 56,522,270 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21162,016,419 - 62,023,681 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLITRK6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1364,808,716 - 64,822,519 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl364,809,920 - 64,812,442 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604621,173,421 - 21,180,352 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slitrk6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247797,030,395 - 7,036,108 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247797,030,017 - 7,036,581 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Slitrk6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11214,525,927 - 14,529,654 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slitrk6
48 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:559
Count of miRNA genes:275
Interacting mature miRNAs:347
Transcripts:ENSRNOT00000038433
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1544806773104695021Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)1560213984105213984Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1582194914108192169Rat
61477Aia4Adjuvant induced arthritis QTL 43joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)156244089297773284Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1574735564106469153Rat
1300118Bp190Blood pressure QTL 1902.94arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1588677086104695021Rat
1358354Srcrt5Stress Responsive Cort QTL 53.38blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1582503470108192169Rat
70182BpQTLcluster12Blood pressure QTL cluster 123.53arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)1572716871101425383Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1582714037106778197Rat
1300120Kidm7Kidney mass QTL 73.55kidney mass (VT:0002707)left kidney wet weight to body weight ratio (CMO:0001954)1588677086104695021Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1564571127108192169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
7411646Foco21Food consumption QTL 2123.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1584278281108192169Rat
631516Gluco31Glucose level QTL 317blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1572716871101425383Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)1561710951106710951Rat
1331724Bp223Blood pressure QTL 2233.53715arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1575928947101425383Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)1583700787108192169Rat
2317050Aia24Adjuvant induced arthritis QTL 242.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1559257087104257087Rat
2313080Bss65Bone structure and strength QTL 653.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1567399137108192169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1582194914108192169Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 65 146 82 81 50 26 50 6 253 123 11 125 56 78 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000038433   ⟹   ENSRNOP00000034471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1593,977,710 - 93,984,526 (-)Ensembl
mRatBN7.2 Ensembl1587,563,322 - 87,570,393 (-)Ensembl
Rnor_6.0 Ensembl1595,507,640 - 95,514,259 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000168617   ⟹   ENSRNOP00000112189
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1593,977,807 - 93,983,074 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000174012   ⟹   ENSRNOP00000112323
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1593,969,038 - 93,984,431 (-)Ensembl
RefSeq Acc Id: NM_001106057   ⟹   NP_001099527
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81593,977,812 - 93,984,431 (-)NCBI
mRatBN7.21587,563,506 - 87,570,125 (-)NCBI
Rnor_6.01595,507,640 - 95,514,259 (-)NCBI
Rnor_5.01598,989,203 - 98,995,830 (-)NCBI
RGSC_v3.41595,106,364 - 95,112,983 (-)RGD
Celera1586,576,029 - 86,582,648 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099527 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM02496 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000034471
  ENSRNOP00000034471.4
  ENSRNOP00000112189.1
  ENSRNOP00000112323.1
RefSeq Acc Id: NP_001099527   ⟸   NM_001106057
- Peptide Label: precursor
- UniProtKB: D3ZP44 (UniProtKB/TrEMBL),   A6HUD3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034471   ⟸   ENSRNOT00000038433
Ensembl Acc Id: ENSRNOP00000112323   ⟸   ENSRNOT00000174012
Ensembl Acc Id: ENSRNOP00000112189   ⟸   ENSRNOT00000168617
Protein Domains
LRRCT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZP44-F1-model_v2 AlphaFold D3ZP44 1-840 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306550 AgrOrtholog
BioCyc Gene G2FUF-12579 BioCyc
Ensembl Genes ENSRNOG00000022337 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038433 ENTREZGENE
  ENSRNOT00000038433.6 UniProtKB/TrEMBL
  ENSRNOT00000168617.1 UniProtKB/TrEMBL
  ENSRNOT00000174012.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/TrEMBL
  L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
KEGG Report rno:290467 UniProtKB/TrEMBL
NCBI Gene 290467 ENTREZGENE
PANTHER PTHR45773 UniProtKB/TrEMBL
  SLIT AND NTRK-LIKE PROTEIN 6 UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/TrEMBL
PhenoGen Slitrk6 PhenoGen
PROSITE LRR UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022337 RatGTEx
SMART LRR_TYP UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
UniProt A6HUD3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZP44 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Slitrk6  SLIT and NTRK-like family, member 6   Slitrk6_predicted  SLIT and NTRK-like family, member 6 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Slitrk6_predicted  SLIT and NTRK-like family, member 6 (predicted)      Symbol and Name status set to approved 70820 APPROVED