Erlec1 (endoplasmic reticulum lectin 1) - Rat Genome Database

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Gene: Erlec1 (endoplasmic reticulum lectin 1) Rattus norvegicus
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Symbol: Erlec1
Name: endoplasmic reticulum lectin 1
RGD ID: 1306508
Description: Predicted to enable unfolded protein binding activity. Predicted to be involved in negative regulation of retrograde protein transport, ER to cytosol and retrograde protein transport, ER to cytosol. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum lumen. Orthologous to human ERLEC1 (endoplasmic reticulum lectin 1); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC289874; RGD1306508; similar to hypothetical protein CL25084
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814108,856,661 - 108,894,511 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl14108,856,661 - 108,894,297 (-)EnsemblGRCr8
mRatBN7.214104,655,745 - 104,693,508 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl14104,655,673 - 104,693,480 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx14108,967,766 - 109,005,451 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014110,194,745 - 110,232,411 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014106,667,186 - 106,704,842 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd14109,341,312 - 109,379,023 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive14107,971,076 - 108,008,758 (-)NCBILyon_Normotensive
Lyon_Hypertensive14109,517,153 - 109,554,842 (-)NCBILyon_Hypertensive
F344_StmMcwi14108,339,631 - 108,377,316 (-)NCBIF344_StmMcwi
Rnor_6.014115,314,890 - 115,352,871 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14115,314,890 - 115,352,562 (-)Ensemblrn6Rnor6.0
Rnor_5.014114,972,393 - 115,009,275 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.414112,046,496 - 112,086,271 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera14103,493,416 - 103,531,051 (-)NCBICelera
RGSC_v3.114112,072,200 - 112,112,551 (-)NCBI
Cytogenetic Map14q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:16531414   PMID:18264092   PMID:18502753   PMID:21062743   PMID:25660456  


Genomics

Comparative Map Data
Erlec1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814108,856,661 - 108,894,511 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl14108,856,661 - 108,894,297 (-)EnsemblGRCr8
mRatBN7.214104,655,745 - 104,693,508 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl14104,655,673 - 104,693,480 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx14108,967,766 - 109,005,451 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014110,194,745 - 110,232,411 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014106,667,186 - 106,704,842 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd14109,341,312 - 109,379,023 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive14107,971,076 - 108,008,758 (-)NCBILyon_Normotensive
Lyon_Hypertensive14109,517,153 - 109,554,842 (-)NCBILyon_Hypertensive
F344_StmMcwi14108,339,631 - 108,377,316 (-)NCBIF344_StmMcwi
Rnor_6.014115,314,890 - 115,352,871 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14115,314,890 - 115,352,562 (-)Ensemblrn6Rnor6.0
Rnor_5.014114,972,393 - 115,009,275 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.414112,046,496 - 112,086,271 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera14103,493,416 - 103,531,051 (-)NCBICelera
RGSC_v3.114112,072,200 - 112,112,551 (-)NCBI
Cytogenetic Map14q22NCBI
ERLEC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38253,787,044 - 53,818,796 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl253,787,009 - 53,833,038 (+)Ensemblhg38GRCh38
GRCh37254,014,181 - 54,045,933 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36253,867,721 - 53,899,437 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34253,925,867 - 53,957,584NCBI
Celera253,854,922 - 53,887,349 (+)NCBICelera
Cytogenetic Map2p16.2NCBI
HuRef253,748,407 - 53,780,295 (+)NCBIHuRef
CHM1_1253,945,053 - 53,976,959 (+)NCBICHM1_1
T2T-CHM13v2.0253,783,247 - 53,814,984 (+)NCBIT2T-CHM13v2.0
Erlec1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391130,812,794 - 30,904,385 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1130,880,774 - 30,904,335 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381130,862,794 - 30,954,386 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1130,930,774 - 30,954,335 (-)Ensemblmm10GRCm38
MGSCv371130,829,784 - 30,854,131 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361130,831,419 - 30,854,123 (-)NCBIMGSCv36mm8
Celera1133,335,160 - 33,359,441 (-)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1118.18NCBI
Erlec1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544119,535,425 - 19,557,458 (+)Ensembl
ChiLan1.0NW_00495544119,535,425 - 19,557,960 (+)NCBIChiLan1.0ChiLan1.0
ERLEC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21272,539,517 - 72,571,280 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A72,543,487 - 72,575,091 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A53,930,280 - 53,962,178 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A54,842,228 - 54,874,068 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A54,842,228 - 54,874,068 (+)EnsemblpanPan2panpan1.1
ERLEC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11054,815,592 - 54,845,776 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1054,815,638 - 54,845,080 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1054,767,465 - 54,797,664 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01055,814,249 - 55,845,028 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1055,814,274 - 55,845,027 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11055,507,493 - 55,537,678 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01055,793,731 - 55,824,185 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01056,080,596 - 56,110,787 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Erlec1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629228,193,321 - 28,219,474 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936491351,420 - 378,441 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936491351,813 - 377,978 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERLEC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl387,355,904 - 87,389,814 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1387,362,166 - 87,389,814 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2392,521,490 - 92,549,096 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ERLEC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11453,150,627 - 53,188,821 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1453,154,556 - 53,188,538 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604558,516,256 - 58,554,383 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Erlec1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248337,964,810 - 7,992,582 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248337,964,815 - 7,992,277 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Erlec1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11198,423,402 - 98,463,030 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:303
Count of miRNA genes:186
Interacting mature miRNAs:208
Transcripts:ENSRNOT00000050321
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000050321   ⟹   ENSRNOP00000043115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl14108,856,661 - 108,894,297 (-)Ensembl
mRatBN7.2 Ensembl14104,655,673 - 104,693,480 (-)Ensembl
Rnor_6.0 Ensembl14115,314,890 - 115,352,562 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000135315   ⟹   ENSRNOP00000106637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl14108,856,661 - 108,894,297 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000148117   ⟹   ENSRNOP00000099337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl14108,856,661 - 108,894,297 (-)Ensembl
RefSeq Acc Id: NM_001106023   ⟹   NP_001099493
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814108,856,661 - 108,894,297 (-)NCBI
mRatBN7.214104,655,745 - 104,693,383 (-)NCBI
Dahl_SR_JrHsd14109,341,312 - 109,379,023 (-)NCBI
Lyon_Normotensive14107,971,076 - 108,008,758 (-)NCBI
Lyon_Hypertensive14109,517,153 - 109,554,842 (-)NCBI
F344_StmMcwi14108,339,631 - 108,377,316 (-)NCBI
Rnor_6.014115,314,890 - 115,352,562 (-)NCBI
Rnor_5.014114,972,393 - 115,009,275 (-)NCBI
RGSC_v3.414112,046,496 - 112,086,271 (-)RGD
Celera14103,493,416 - 103,531,051 (-)RGD
Sequence:
RefSeq Acc Id: XM_039091779   ⟹   XP_038947707
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814108,856,842 - 108,894,511 (-)NCBI
mRatBN7.214104,655,926 - 104,693,490 (-)NCBI
RefSeq Acc Id: XM_063272989   ⟹   XP_063129059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814108,860,225 - 108,894,511 (-)NCBI
RefSeq Acc Id: NP_001099493   ⟸   NM_001106023
- Peptide Label: precursor
- UniProtKB: D3ZF97 (UniProtKB/TrEMBL),   A6JQD3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043115   ⟸   ENSRNOT00000050321
RefSeq Acc Id: XP_038947707   ⟸   XM_039091779
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063129059   ⟸   XM_063272989
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000106637   ⟸   ENSRNOT00000135315
Ensembl Acc Id: ENSRNOP00000099337   ⟸   ENSRNOT00000148117
Protein Domains
MRH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZF97-F1-model_v2 AlphaFold D3ZF97 1-482 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699541
Promoter ID:EPDNEW_R10065
Type:multiple initiation site
Name:Erlec1_1
Description:endoplasmic reticulum lectin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.014115,352,645 - 115,352,705EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306508 AgrOrtholog
BioCyc Gene G2FUF-14626 BioCyc
Ensembl Genes ENSRNOG00000007283 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000050321 ENTREZGENE
  ENSRNOT00000050321.6 UniProtKB/TrEMBL
  ENSRNOT00000135315.1 UniProtKB/TrEMBL
  ENSRNOT00000148117.1 UniProtKB/TrEMBL
Gene3D-CATH 2.70.130.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7303938 IMAGE-MGC_LOAD
InterPro Man6P_isomerase_rcpt-bd_dom UniProtKB/TrEMBL
  MRH_dom UniProtKB/TrEMBL
  OS-9-like UniProtKB/TrEMBL
  PRKCSH UniProtKB/TrEMBL
KEGG Report rno:289874 UniProtKB/TrEMBL
MGC_CLONE MGC:189119 IMAGE-MGC_LOAD
NCBI Gene 289874 ENTREZGENE
PANTHER ENDOPLASMIC RETICULUM LECTIN 1 UniProtKB/TrEMBL
  PTHR15414 UniProtKB/TrEMBL
Pfam PRKCSH UniProtKB/TrEMBL
PhenoGen Erlec1 PhenoGen
PROSITE MRH UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007283 RatGTEx
Superfamily-SCOP SSF50911 UniProtKB/TrEMBL
UniProt A0ABK0LEX4_RAT UniProtKB/TrEMBL
  A0ABK0LXE6_RAT UniProtKB/TrEMBL
  A6JQD3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZF97 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-02-12 Erlec1  endoplasmic reticulum lectin 1  RGD1306508  similar to hypothetical protein CL25084   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1306508  similar to hypothetical protein CL25084   RGD1306508_predicted  similar to hypothetical protein CL25084 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1306508_predicted  similar to hypothetical protein CL25084 (predicted)  LOC289874_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC289874_predicted  similar to hypothetical protein CL25084 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL