Rad54b (RAD54 homolog B) - Rat Genome Database

Name: Rad54b
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Rad54b (RAD54 homolog B) Rattus norvegicus

Analyze

Symbol:

Rad54b (Ensembl: Fsbp)

Name:

RAD54 homolog B (Ensembl:fibrinogen silencer binding protein)

RGD ID:

1306507

Description:

Predicted to enable DNA translocase activity and identical protein binding activity. Predicted to be involved in double-strand break repair via homologous recombination and reciprocal meiotic recombination. Predicted to act upstream of or within several processes, including DNA damage response; determination of adult lifespan; and response to ionizing radiation. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in colorectal cancer and non-Hodgkin lymphoma. Orthologous to human RAD54B (RAD54 homolog B); PARTICIPATES IN homologous recombination pathway of double-strand break repair; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

DNA repair and recombination protein RAD54B; fibrinogen silencer-binding protein; Fsbp; LOC313063; RAD54 homolog B (S. cerevisiae); RAD54, S. cerevisiae, homolog of, B; RGD1306507; similar to RAD54B homolog isoform 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RAD54B (RAD54 homolog B)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Treefam
Mus musculus (house mouse):	Rad54b (RAD54 homolog B (S. cerevisiae))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rad54b (RAD54 homolog B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RAD54B (RAD54 homolog B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RAD54B (RAD54 homolog B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rad54b (RAD54 homolog B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RAD54B (RAD54 homolog B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RAD54B (RAD54 homolog B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rad54b (RAD54 homolog B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Rad54b (RAD54 homolog B (S. cerevisiae))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	RAD54B (RAD54 homolog B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Fsbp (fibrinogen silencer binding protein)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rad54b (RAD54 homolog B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	Y116A8C.13	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	RDH54	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	rad54b	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	29,829,465 - 29,901,967 (+)	NCBI		GRCr8
mRatBN7.2	5	25,032,112 - 25,104,630 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	25,032,066 - 25,104,616 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	27,167,139 - 27,235,913 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	28,759,892 - 28,828,662 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	28,708,587 - 28,777,369 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	25,140,531 - 25,214,469 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	25,146,949 - 25,214,376 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	29,858,083 - 29,928,815 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	25,830,524 - 25,899,650 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	25,805,592 - 25,899,511 (+)	NCBI
Celera	5	24,374,271 - 24,442,857 (+)	NCBI		Celera
Cytogenetic Map	5	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

colon carcinoma (ISO)

colorectal cancer (ISO)

Colorectal Neoplasms (ISO)

genetic disease (ISO)

non-Hodgkin lymphoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-fluorouracil (ISO)

acetamide (EXP)

acrolein (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

alpha-Zearalanol (EXP)

amphotericin B (ISO)

arsenous acid (ISO)

azathioprine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

biphenyl-4-amine (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

cannabidiol (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

clorgyline (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dicrotophos (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

Enterolactone (ISO)

etoposide (ISO)

geraniol (ISO)

indometacin (ISO)

inulin (ISO)

L-ascorbic acid (ISO)

leflunomide (ISO)

melphalan (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

ochratoxin A (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

PCB138 (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

quercetin (ISO)

resveratrol (ISO)

rotenone (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium dichromate (ISO)

sunitinib (ISO)

temozolomide (ISO)

testosterone (EXP)

thioacetamide (EXP)

trichostatin A (ISO)

trimellitic anhydride (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

chromatin remodeling (IEA)

determination of adult lifespan (ISO)

DNA damage response (ISO)

double-strand break repair via homologous recombination (IBA,ISO)

reciprocal meiotic recombination (IBA)

response to ionizing radiation (ISO)

response to xenobiotic stimulus (ISO)

Cellular Component

nucleoplasm (ISO)

nucleus (IBA,ISO)

Molecular Function

ATP binding (IEA)

ATP-dependent chromatin remodeler activity (IEA)

DNA translocase activity (IBA,ISO)

helicase activity (IEA)

hydrolase activity (IEA)

identical protein binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

homologous recombination pathway of double-strand break repair (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Regulation of homologous recombination in eukaryotes.	Heyer WD, etal., Annu Rev Genet. 2010;44:113-39. doi: 10.1146/annurev-genet-051710-150955.
3.	An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter.	Lau KF, etal., Neuroreport. 2010 Aug 4;21(11):761-6. doi: 10.1097/WNR.0b013e32833bfca0.
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:16428451	PMID:19060904	PMID:19061978	PMID:25416956

Genomics

Comparative Map Data

Rad54b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	29,829,465 - 29,901,967 (+)	NCBI		GRCr8
mRatBN7.2	5	25,032,112 - 25,104,630 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	25,032,066 - 25,104,616 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	27,167,139 - 27,235,913 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	28,759,892 - 28,828,662 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	28,708,587 - 28,777,369 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	25,140,531 - 25,214,469 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	25,146,949 - 25,214,376 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	29,858,083 - 29,928,815 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	25,830,524 - 25,899,650 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	25,805,592 - 25,899,511 (+)	NCBI
Celera	5	24,374,271 - 24,442,857 (+)	NCBI		Celera
Cytogenetic Map	5	q13	NCBI

RAD54B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	94,371,960 - 94,475,115 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	94,371,960 - 94,475,115 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	95,384,188 - 95,487,343 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	95,453,364 - 95,556,486 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	8	91,570,193 - 91,673,298 (-)	NCBI		Celera
Cytogenetic Map	8	q22.1	NCBI
HuRef	8	90,593,192 - 90,696,254 (-)	NCBI		HuRef
CHM1_1	8	95,424,379 - 95,527,598 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	95,496,851 - 95,599,948 (-)	NCBI		T2T-CHM13v2.0

Rad54b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	11,558,930 - 11,615,806 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	11,558,922 - 11,615,805 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	11,558,920 - 11,615,808 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	11,558,922 - 11,615,805 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	11,486,119 - 11,542,954 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	11,486,119 - 11,542,954 (+)	NCBI		MGSCv36	mm8
Celera	4	11,370,521 - 11,427,320 (+)	NCBI		Celera
Cytogenetic Map	4	A1	NCBI
cM Map	4	5.11	NCBI

Rad54b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955417	10,597,450 - 10,686,005 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955417	10,598,295 - 10,685,999 (-)	NCBI	ChiLan1.0	ChiLan1.0

RAD54B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	111,704,488 - 111,807,369 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	87,239,631 - 87,344,434 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	90,995,229 - 91,098,149 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	92,939,322 - 93,041,620 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	92,939,535 - 93,034,060 (-)	Ensembl	panpan1.1		panPan2

RAD54B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	29	39,096,680 - 39,195,054 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	29	39,098,098 - 39,195,112 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	29	39,257,809 - 39,359,514 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	29	39,300,442 - 39,402,291 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	29	39,293,199 - 39,402,284 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	29	39,326,093 - 39,415,024 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	29	39,309,124 - 39,410,322 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	29	39,752,073 - 39,851,462 (-)	NCBI		UU_Cfam_GSD_1.0

Rad54b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	40,317,341 - 40,417,142 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936544	7,373,508 - 7,475,353 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936544	7,375,566 - 7,475,319 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RAD54B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	42,266,605 - 42,369,447 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	42,249,482 - 42,369,408 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	45,616,371 - 45,730,628 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RAD54B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	89,351,203 - 89,450,047 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	89,351,415 - 89,442,825 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	51,389,274 - 51,488,300 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rad54b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624763	1,773,725 - 1,878,641 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624763	1,773,943 - 1,878,032 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Rad54b
308 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	91
Count of miRNA genes:	75
Interacting mature miRNAs:	78
Transcripts:	ENSRNOT00000061370
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	1	90450412	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	1	131345958	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	729470	86724018	Rat
2312562	Pur18	Proteinuria QTL 18	2.6	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	5	2138965	32656739	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
8662454	Vetf3	Vascular elastic tissue fragility QTL 3	27.4		artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	5	2282226	69540447	Rat
2313085	Bss59	Bone structure and strength QTL 59	2.9	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	5	3844018	26141981	Rat
1300117	Hrtrt8	Heart rate QTL 8	3.49		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	3844018	47869213	Rat
61462	Niddm10	Non-insulin dependent diabetes mellitus QTL 10	3.9	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	5	5112159	47171491	Rat
2293666	Bmd38	Bone mineral density QTL 38	4.4		femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	5	8948228	53948228	Rat
7394712	Emca13	Estrogen-induced mammary cancer QTL 13			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	9823266	99753708	Rat
1641903	Alcrsp3	Alcohol response QTL 3			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	12689285	57689285	Rat
634305	Mamtr1	Mammary tumor resistance QTL 1		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	12789751	113558310	Rat
1600358	Mamtr5	Mammary tumor resistance QTL 5			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	18873947	63873947	Rat
1358353	Srcrtb2	Stress Responsive Cort Basal QTL 2	3.48	0.003	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	18873947	74251464	Rat
8552954	Pigfal14	Plasma insulin-like growth factor 1 level QTL 14	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	21226744	66226744	Rat
1549901	Neudeg2	Neurodegradation QTL 2	4	0	nervous system integrity trait (VT:0010566)	mononuclear cell count (CMO:0002119)	5	24838710	44045280	Rat

Markers in Region

RH140150

Rat Assembly	Chr	Position (strand)	Source	JBrowse
RGSC_v3.4	5	25,857,958 - 25,858,142	UniSTS	RGSC3.4
Celera	5	24,403,129 - 24,403,313	UniSTS
RH 3.4 Map	5	138.5	UniSTS
Cytogenetic Map	5	q13	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium									2		2
Low	3	27	39	25	19	25	2	2	69	23	39	10	2
Below cutoff		15	17	15		15	5	7	3	11		1	5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001191755	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006237891	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006237892	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008763543	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593341	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109802	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109806	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_353891	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473962	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000061370 ⟹ ENSRNOP00000058084

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	25,032,066 - 25,104,616 (+)	Ensembl
Rnor_6.0 Ensembl	5	25,146,949 - 25,214,376 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000094567 ⟹ ENSRNOP00000086936

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	25,032,066 - 25,063,879 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000097257 ⟹ ENSRNOP00000079617

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	25,035,164 - 25,057,029 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000104030 ⟹ ENSRNOP00000077486

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	25,058,012 - 25,063,879 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000105229 ⟹ ENSRNOP00000095798

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	25,035,164 - 25,104,616 (+)	Ensembl

RefSeq Acc Id:

NM_001191755 ⟹ NP_001178684

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	29,829,465 - 29,901,964 (+)	NCBI
mRatBN7.2	5	25,032,112 - 25,104,630 (+)	NCBI
Rnor_6.0	5	25,146,963 - 25,214,469 (+)	NCBI
Rnor_5.0	5	29,858,083 - 29,928,815 (+)	NCBI
Celera	5	24,374,271 - 24,442,857 (+)	NCBI

Sequence:

show sequence

ATGAGACGTTCTGCAGCACCAAGCCAGGTGCGGGGAAATTCCTCTAAAAAAGCAAGATTTGTAC
CTCCAGGAAGAAGTACTACAGGTGTGAGTAAGGAGATTTCGATGAGTCCAGAGGCAAAACTGGT
TCAGGGCGCCCACCAGTCACAAGGGGATGCAGGTGTGTGCAGTTCCAATCCTTGGCTCACTGAG
GGAAGCCCTGTGGAGATGGGTGACGGGGCTAGAGTAGATCCGCTTTCTCCAGTTCACTTGGCCT
CTAAAGAAATCATAGAGTCCAAGGCACAAGAAGAGGAAGCTAGCAGCTTGCTTAAATATTTCAG
TGTCGTTTGGTGTAAAGCTTCAAAGAAAAAACACAAGAAATGGGAAGGCGATGCTATTCTTATT
GTAAAAGGAAGGTCGTTCATATTGAAAGATATGGAAGGAAAAGATATTGGAAGAGGCATGGGAT
ATAAATTCAAAGAGCTTGAAAATGTAGAAGAAGGCCAAACATTGATGCTTGGTGGGAAAGAAAT
AGAGATCCTGGGTACAGTCTCTGCTGAGGACTTCAATAGTGGCAAGTGTTTTCAGGCTGGAAGC
GGAAGTCCTGCCGTCCCAAGTTCTCAGGCTGCCAGGAAATGCTTTTCTAACCCTTTCAAGAGTG
TGTGTCAGTCAACTCAAGCAAGGAGAGACAGAGGGAATGACTGGCAAAATTGCAAACCTCGCTA
TGACCCATACACACCAAATGCCCTTGTTATGCCTCGACCAGACAAGAGTCACCAGTGGGCGTTT
AATAGGAGCTGCCTTCCTACTGTGGATGTGGTGATAGACCCTCACCTTGTACGTCACCTCCGAC
CACACCAGAAAGATGGGGTCGCCTTCCTCTATGAGTGTGTGATGGGAATGAGAGCAGTTGGCAA
ATGTGGTGCCATTCTTGCTGATGAGATGGGATTAGGGAAAACCCTGCAGTGTATCTCGCTCATC
TGGACCCTCCAGTGTCAGGGGCCTTACGGGGGCAAGCCAATAGTAAAGAGGACACTTATTGTTA
CCCCTGGAAGCTTGGTGAATAATTGGAGAAAAGAATTTCAAAAATGGCTGGGAAGCGAAAGGAT
CAAGATATTCACTGTTGATCAGGACCATAAAGTCGAGGAGTTTATCAATTCTGCATTTCACTCT
GTTCTTATCATCAGTTATGAAATGTTACTTCGTTCTCTAGATCGAATTAAGACCATAACATTTG
GCCTTCTGATTTGTGATGAGGGGCACCGGTTGAAGAACAGTGGTATTAAGACAACAGCAGCCCT
TTCTAGCCTCTCTTGTGAGAAGAGAGTAATTCTGACTGGTACCCCAGTTCAGAATGATTTGCAA
GAGTTTTTTGCATTAGTTGATTTTGTTAATCCAGGAATCTTAGGGTCTCTGTCATCTTATAGGA
GGATATATGAAGAGCCCATTGTTATGTCAAGAGAGCCTTCTGCTTCCAAGGAAGAGAGAGAGTT
AGGGGAGAGAAGAACAACTGAGCTCACACGCCTCACTGGATGTTTCATCCTTAGAAGAACTCAG
GAGGTCATCAATAAATATCTCCCCCCTAAGATAGAGAACGTAGTCTTTTGCCGACCAGGAGCAC
TGCAGATTGAGCTTTACCGAAAGCTGCTGAGTTCTCAATCTGTCAGGTTCTGTCTGCAAGGCCT
TTTGGGAAATAGTGCTCACCTCATTTGCATAGGCGCCCTGAAGAAGCTATGCAATCATCCTCGC
CTCTTGTTCAGCTTTGTGAAGGGTAAAGAATTTAACTCGAGTCGTGATGAAAATGAAGAAAGGA
GCCTTTGCCAAGGCTTGCTGACTGTGTTCCCTGCTGGCTACAACCTGCTGCAGCTCTCCGAGAG
CGAGTCAGGGAAACTACAGGTGTTAGTAAAGCTCCTGGCGGCGATCTCTGAACTTCGTCCCACT
GAAAAAGTGATTTTGGTATCCAACTACAGACAAACCTTGAATCTTTTAGAAGAAGTATGCAAGT
GTCATGGATATGCTTGTGCAAGACTTGATGGACAAACACCAGTCTCTCAAAGACAGCAAATTGT
TGATAATTTCAATAGTAAATACTCTACTGATTTTATTTTTTTATTAAGTTCAAAAGCTGGTGGT
GTGGGACTTAATCTTATTGGAGGATCTCACTTAATTCTTTATGATATTGATTGGAACCCAGCTA
CTGACATCCAGGCCATGGCTAGAGTGTGGAGAGACGGCCAGAAACACCCTGTCCATGTTTACAG
ACTCCTGACTACAGGTACAATAGAGGAAAAGATCTATCAAAGGCAGATCAGTAAGCAAGGCCTT
TCTGGGGCGGTTGTAGACCTAACCAGATCATCCGAACAGATCCAGTTTTCAGTGGAAGAGCTTA
AAAACTTGTTCACATTACATGAAAATTCACATTGTGTTACTCATGACCTGCTTGACTGTGAGTG
CACAGGAGAGAAAGATCACTCTGATGATGCGTCGGAAAACCCTGTCACCTCTAGACAGTGTCAG
CTTGGCCCTCAGAAGTCCAGCTCCTCGAGACCTCTGTCCATGTCACAGCTGAAGCAGTGGAAAC
ATTTTTCAGGAGACCATTTAAATCTCCCAGACCCATTTCTCGAAAGAATAAGGGAAAATGTGTC
CTTCTTTTTCCAGAATATAACCAACCAAGCTCCTGCCATCTAATGAAGGACCACTTTCCAACAT
TTCTGTACTCCCCTTAAAAATTAATATAGGAATTAACTGTAATCTTGAAAATGACAAAATTATT
TAAATTATAATAGTGAACTTTGTTTCACAATATGTCTATTTATGTACAATAAAA

hide sequence

RefSeq Acc Id:

XM_039109802 ⟹ XP_038965730

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	29,832,367 - 29,901,967 (+)	NCBI
mRatBN7.2	5	25,034,921 - 25,104,616 (+)	NCBI

RefSeq Acc Id:

XM_039109806 ⟹ XP_038965734

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	29,832,358 - 29,891,306 (+)	NCBI
mRatBN7.2	5	25,034,922 - 25,093,958 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001178684	(Get FASTA)	NCBI Sequence Viewer
	XP_038965730	(Get FASTA)	NCBI Sequence Viewer
	XP_038965734	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL98436	(Get FASTA)	NCBI Sequence Viewer
	EDL98437	(Get FASTA)	NCBI Sequence Viewer
	EDL98438	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000058084
	ENSRNOP00000058084.3
	ENSRNOP00000079617.1
	ENSRNOP00000086936.1
	ENSRNOP00000095798
	ENSRNOP00000095798.1

RefSeq Acc Id:

NP_001178684 ⟸ NM_001191755

- UniProtKB:

F1LYB7 (UniProtKB/TrEMBL), A6II66 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRRSAAPSQVRGNSSKKARFVPPGRSTTGVSKEISMSPEAKLVQGAHQSQGDAGVCSSNPWLTE
GSPVEMGDGARVDPLSPVHLASKEIIESKAQEEEASSLLKYFSVVWCKASKKKHKKWEGDAILI
VKGRSFILKDMEGKDIGRGMGYKFKELENVEEGQTLMLGGKEIEILGTVSAEDFNSGKCFQAGS
GSPAVPSSQAARKCFSNPFKSVCQSTQARRDRGNDWQNCKPRYDPYTPNALVMPRPDKSHQWAF
NRSCLPTVDVVIDPHLVRHLRPHQKDGVAFLYECVMGMRAVGKCGAILADEMGLGKTLQCISLI
WTLQCQGPYGGKPIVKRTLIVTPGSLVNNWRKEFQKWLGSERIKIFTVDQDHKVEEFINSAFHS
VLIISYEMLLRSLDRIKTITFGLLICDEGHRLKNSGIKTTAALSSLSCEKRVILTGTPVQNDLQ
EFFALVDFVNPGILGSLSSYRRIYEEPIVMSREPSASKEERELGERRTTELTRLTGCFILRRTQ
EVINKYLPPKIENVVFCRPGALQIELYRKLLSSQSVRFCLQGLLGNSAHLICIGALKKLCNHPR
LLFSFVKGKEFNSSRDENEERSLCQGLLTVFPAGYNLLQLSESESGKLQVLVKLLAAISELRPT
EKVILVSNYRQTLNLLEEVCKCHGYACARLDGQTPVSQRQQIVDNFNSKYSTDFIFLLSSKAGG
VGLNLIGGSHLILYDIDWNPATDIQAMARVWRDGQKHPVHVYRLLTTGTIEEKIYQRQISKQGL
SGAVVDLTRSSEQIQFSVEELKNLFTLHENSHCVTHDLLDCECTGEKDHSDDASENPVTSRQCQ
LGPQKSSSSRPLSMSQLKQWKHFSGDHLNLPDPFLERIRENVSFFFQNITNQAPAI

hide sequence

RefSeq Acc Id:

ENSRNOP00000058084 ⟸ ENSRNOT00000061370

RefSeq Acc Id:	XP_038965730 ⟸ XM_039109802
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6AM82 (UniProtKB/TrEMBL), A6II66 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038965734 ⟸ XM_039109806
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSRNOP00000095798 ⟸ ENSRNOT00000105229

RefSeq Acc Id:

ENSRNOP00000086936 ⟸ ENSRNOT00000094567

RefSeq Acc Id:

ENSRNOP00000077486 ⟸ ENSRNOT00000104030

RefSeq Acc Id:

ENSRNOP00000079617 ⟸ ENSRNOT00000097257

Protein Domains

Helicase ATP-binding Helicase C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1LYB7-F1-model_v2	AlphaFold	F1LYB7	1-888	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306507	AgrOrtholog
BioCyc Gene	G2FUF-41924	BioCyc
Ensembl Genes	ENSRNOG00000039949	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000061370	ENTREZGENE
	ENSRNOT00000061370.5	UniProtKB/TrEMBL
	ENSRNOT00000094567.1	UniProtKB/TrEMBL
	ENSRNOT00000097257.1	UniProtKB/TrEMBL
	ENSRNOT00000105229.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.10810	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
	SWI2/SNF2 ATPases, N-terminal domain	UniProtKB/TrEMBL
InterPro	DEAD-like_helicase	UniProtKB/TrEMBL
	Helicase_C	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	SNF2-like_sf	UniProtKB/TrEMBL
	SNF2/RAD54-like_C	UniProtKB/TrEMBL
	SNF2_N	UniProtKB/TrEMBL
NCBI Gene	313063	ENTREZGENE
PANTHER	DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED	UniProtKB/TrEMBL
	SNF2/RAD54 FAMILY MEMBER	UniProtKB/TrEMBL
Pfam	Helicase_C	UniProtKB/TrEMBL
	SNF2_N	UniProtKB/TrEMBL
PhenoGen	Rad54b	PhenoGen
PROSITE	HELICASE_ATP_BIND_1	UniProtKB/TrEMBL
	HELICASE_CTER	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000039949	RatGTEx
SMART	DEXDc	UniProtKB/TrEMBL
	HELICc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	A0A8I5ZND1_RAT	UniProtKB/TrEMBL
	A0A8I6A4U3_RAT	UniProtKB/TrEMBL
	A0A8I6AM82	ENTREZGENE, UniProtKB/TrEMBL
	A6II66	ENTREZGENE, UniProtKB/TrEMBL
	F1LYB7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-02-12	Rad54b	RAD54 homolog B	Rad54b	RAD54 homolog B (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-04-23	Rad54b	RAD54 homolog B (S. cerevisiae)	RGD1306507	similar to RAD54B homolog isoform 1; RAD54, S. cerevisiae, homolog of, B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1306507	similar to RAD54B homolog isoform 1; RAD54, S. cerevisiae, homolog of, B	RGD1306507_predicted	similar to RAD54B homolog isoform 1; RAD54, S. cerevisiae, homolog of, B (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-20	RGD1306507_predicted	similar to RAD54B homolog isoform 1; RAD54, S. cerevisiae, homolog of, B (predicted)	LOC313063_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC313063_predicted	similar to RAD54B homolog isoform 1; RAD54, S. cerevisiae, homolog of, B (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

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InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

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Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)