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Gene: Socs4 (suppressor of cytokine signaling 4) Rattus norvegicus

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Symbol:

Socs4

Name:

suppressor of cytokine signaling 4

RGD ID:

1306503

Description:

Predicted to be involved in cytokine-mediated signaling pathway. Orthologous to human SOCS4 (suppressor of cytokine signaling 4); PARTICIPATES IN Jak-Stat signaling pathway; insulin signaling pathway; type 2 diabetes mellitus pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC305828

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SOCS4 (suppressor of cytokine signaling 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Socs4 (suppressor of cytokine signaling 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Socs4 (suppressor of cytokine signaling 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SOCS4 (suppressor of cytokine signaling 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SOCS4 (suppressor of cytokine signaling 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Socs4 (suppressor of cytokine signaling 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SOCS4 (suppressor of cytokine signaling 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SOCS4 (suppressor of cytokine signaling 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Socs4 (suppressor of cytokine signaling 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Socs4 (suppressor of cytokine signaling 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SOCS4 (suppressor of cytokine signaling 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Socs4 (suppressor of cytokine signaling 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	socs4 (suppressor of cytokine signaling 4)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	socs4 (suppressor of cytokine signaling 4)	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Socs36E	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Socs36E	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	socs4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	23,003,130 - 23,017,615 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	15	23,002,883 - 23,022,499 (+)	Ensembl				GRCr8
mRatBN7.2	15	20,523,406 - 20,537,889 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	20,523,183 - 20,542,494 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	15	23,304,045 - 23,318,530 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	24,262,007 - 24,276,492 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	22,512,018 - 22,526,496 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	24,056,383 - 24,070,868 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	24,056,383 - 24,070,857 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	15	27,997,125 - 28,011,610 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	15	23,229,083 - 23,243,568 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	15	20,917,934 - 20,932,419 (+)	NCBI		Celera
RGSC_v3.1	15	23,244,704 - 23,258,735 (+)	NCBI
Cytogenetic Map	15	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

pre-malignant neoplasm (ISO)

Reperfusion Injury (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

acetamide (EXP)

acrolein (ISO)

aflatoxin B1 (ISO)

alpha-pinene (ISO)

avobenzone (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

Butylbenzyl phthalate (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

cycloheximide (ISO)

cyclosporin A (ISO)

cylindrospermopsin (ISO)

Dibutyl phosphate (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

formaldehyde (ISO)

glyphosate (ISO)

hydroquinone O-beta-D-glucopyranoside (ISO)

leflunomide (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

ozone (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

quercetin (ISO)

resveratrol (ISO)

silver atom (ISO)

silver(0) (ISO)

simvastatin (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

xylitol (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

intracellular signal transduction (IEA)

negative regulation of epidermal growth factor-activated receptor activity (ISO)

negative regulation of signal transduction (IEA)

protein ubiquitination (IEA)

Molecular Function

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

insulin signaling pathway (IEA)

Jak-Stat signaling pathway (IEA,ISO)

type 2 diabetes mellitus pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Comprehensive gene review and curation	RGD comprehensive gene curation
5.	Modulation of signal transducers and activators of transcription (STAT) factor pathways during focal cerebral ischaemia: a gene expression array study in rat hippocampus after middle cerebral artery occlusion.	Sun SL, etal., Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1097-101.
6.	Inhibitors of cytokine signal transduction.	Wormald S and Hilton DJ, J Biol Chem 2004 Jan 9;279(2):821-4. Epub 2003 Nov 7.

Additional References at PubMed

PMID:12477932	PMID:15590694

Genomics

Comparative Map Data

Socs4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	23,003,130 - 23,017,615 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	15	23,002,883 - 23,022,499 (+)	Ensembl				GRCr8
mRatBN7.2	15	20,523,406 - 20,537,889 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	20,523,183 - 20,542,494 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	15	23,304,045 - 23,318,530 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	24,262,007 - 24,276,492 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	22,512,018 - 22,526,496 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	24,056,383 - 24,070,868 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	24,056,383 - 24,070,857 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	15	27,997,125 - 28,011,610 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	15	23,229,083 - 23,243,568 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	15	20,917,934 - 20,932,419 (+)	NCBI		Celera
RGSC_v3.1	15	23,244,704 - 23,258,735 (+)	NCBI
Cytogenetic Map	15	p14	NCBI

SOCS4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	55,027,236 - 55,049,489 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	55,027,120 - 55,049,489 (+)	Ensembl			hg38	GRCh38
GRCh37	14	55,493,954 - 55,516,207 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	54,563,594 - 54,585,960 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	14	54,563,593 - 54,585,957	NCBI
Celera	14	35,543,338 - 35,565,701 (+)	NCBI		Celera
Cytogenetic Map	14	q22.3	NCBI
HuRef	14	35,656,555 - 35,678,835 (+)	NCBI		HuRef
CHM1_1	14	55,432,461 - 55,454,827 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	49,232,425 - 49,254,678 (+)	NCBI		T2T-CHM13v2.0

Socs4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	47,514,377 - 47,533,559 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	47,514,388 - 47,533,559 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	14	47,276,920 - 47,296,102 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	47,276,931 - 47,296,102 (+)	Ensembl			mm10	GRCm38
MGSCv37	14	47,896,818 - 47,911,266 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	14	46,199,020 - 46,213,468 (+)	NCBI		MGSCv36	mm8
Celera	14	43,463,746 - 43,478,181 (+)	NCBI		Celera
Cytogenetic Map	14	C1	NCBI
cM Map	14	24.6	NCBI

Socs4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	8,527,291 - 8,528,616 (-)	Ensembl
ChiLan1.0	NW_004955409	8,522,540 - 8,539,551 (-)	NCBI	ChiLan1.0	ChiLan1.0

SOCS4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	56,148,799 - 56,171,201 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	55,365,332 - 55,387,709 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	35,614,238 - 35,636,531 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	53,890,043 - 53,911,227 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	53,904,783 - 53,906,105 (+)	Ensembl			panPan2	panpan1.1

SOCS4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	30,892,663 - 30,898,896 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	30,648,526 - 30,667,659 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	31,139,073 - 31,158,412 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	31,139,292 - 31,155,995 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	30,742,868 - 30,761,975 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	30,819,420 - 30,838,823 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	31,184,322 - 31,203,430 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Socs4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	74,336,511 - 74,355,624 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936697	110,952 - 129,686 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936697	110,637 - 129,767 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SOCS4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	184,379,086 - 184,398,898 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	184,379,017 - 184,398,902 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	204,886,200 - 204,906,104 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SOCS4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	32,198,438 - 32,227,240 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	32,220,800 - 32,222,122 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666053	20,442,274 - 20,463,992 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Socs4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624731	14,359,837 - 14,382,738 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624731	14,356,719 - 14,382,738 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Socs4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	12	75,759,552 - 75,764,504 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Socs4
42 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	393
Count of miRNA genes:	222
Interacting mature miRNAs:	251
Transcripts:	ENSRNOT00000015120
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1641913	Colcr2	Colorectal carcinoma resistance QTL 2	6.57	0.0197	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	15	2315759	47315759	Rat
61424	Scl1	Serum cholesterol level QTL 1	7.7	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	15	19155762	87086765	Rat
10401805	Kidm51	Kidney mass QTL 51			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	15	2785923	47785923	Rat
5684946	Bss98	Bone structure and strength QTL 98	3.9	0.0026	tibia strength trait (VT:1000284)	tibia ultimate force (CMO:0001734)	15	1	39411584	Rat
1354657	Despr13	Despair related QTL 13		0.0022	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	15	1	32342855	Rat
2317750	Glom26	Glomerulus QTL 26	4.3		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	15	14926594	71614418	Rat
1641887	Alcrsp14	Alcohol response QTL 14			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	15	1	44836456	Rat
631550	Bw7	Body weight QTL 7	3.6		body mass (VT:0001259)	body weight (CMO:0000012)	15	22336351	67336351	Rat
738017	Hcas7	Hepatocarcinoma susceptibility QTL 7	2.91		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	15	2315759	53331089	Rat
10755503	Bp391	Blood pressure QTL 391	2.37		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	15	22728353	42072050	Rat
5685002	Bss103	Bone structure and strength QTL 103	2.8		tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	15	16911521	32439851	Rat
2324620	Coatc3	Coat color QTL 3			coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	15	22336351	52597086	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	92	59	6	356	192	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107256	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC168879	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474040	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000015120 ⟹ ENSRNOP00000015120

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	15	24,056,383 - 24,070,857 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105464 ⟹ ENSRNOP00000088978

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	15	23,002,883 - 23,022,453 (+)	Ensembl
mRatBN7.2 Ensembl	15	20,523,183 - 20,542,494 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000152731 ⟹ ENSRNOP00000111469

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	15	23,002,919 - 23,022,499 (+)	Ensembl

RefSeq Acc Id:

NM_001107256 ⟹ NP_001100726

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	23,003,130 - 23,017,615 (+)	NCBI
mRatBN7.2	15	20,523,406 - 20,537,889 (+)	NCBI
Rnor_6.0	15	24,056,383 - 24,070,868 (+)	NCBI
Rnor_5.0	15	27,997,125 - 28,011,610 (+)	NCBI
RGSC_v3.4	15	23,229,083 - 23,243,568 (+)	RGD
Celera	15	20,917,934 - 20,932,419 (+)	RGD

Sequence:

show sequence

CTTGAGCGAGCGCCGGGTGATGGCGATGGTGATGGCGGCAGTCCCTCGGACAGCTCCGGTTGAG
CTGTGCTCAGAGAGATCCGTCAAGAAAGTGCCCAGAAGAAACCTCCTCTCAGAAAATCTGAAAA
CACAGTATTTATAACACTGGAAATTGTAAAGAATTCATTTAAAATGGCTGAAAACAATAGTAAA
AATGTAGATGTGCGGCCTAAAACAAGTCGGAGTAGAAGTGCTGACAGGAAGGACGGTTATGTGT
GGAGTGGAAAGAAGTTATCTTGGTCCAGAAAGAGTGAGAGCTGTTCTGAGTCTGAGGCCGTAGG
TACTCTTGAGAGCGTTGAAATCCCTCTGAGGAGCCAGGAAAGGGAACTTAGCTGTTCGTCCATT
GAGTTGGACTTGGATCATTCCTGTGGGCATAGATTTTTAGGCCGATCCCTTAAACAGAAACTGC
AAGATGCCGTGGGGCAGTGTTTTCCTATAAGGAACTGTGGTGCTCGCCACTCTCCAGGGCTTCC
ATCTAAAAGAACGATTCACATCAGTGAGCTCATGCTAGACAAGTGCCCTTTCCCACCTCCATCA
GACTTAGCCTTTAGGTGGCATTTTATTAAACGGCACACTGTTGCTCTGAGTTCCAGTTCAGATG
AATGGGTGAGCACAGACCTGTGTGAGAGGAGGCCGAGAGATGCTCAGCTGAAACGAAGAAGCAC
AGAAGACGACATACCCTGTTTCTCACATACCAGTGTCCAGCCGTGTGTCATAACTACCAACAGT
GCTTCATGTGCAGGTGGTCATGTGACCGGTTCTCTGATGAACTTGGTCACCGACAATAGCATGG
AAGACGGTGATATGGACTCAGAGGATGAAATTATAACACTGTGCACAAGCTCCAGGAAAAGGAA
CAAGCCCAGATGGGAAACGGATGACGGCATCCTGCAATTGGAGGCACCTCCTAAGTTCCACACC
CAGATTGATTACGTGCACTGCCTTGTCCCAGACCTCCTCCAGATCAGTAACAACCCGTGCTACT
GGGGGGTTATGGACAAATACGCAGCCGAGGCTCTGCTAGAAGGAAAGCCAGAGGGCACCTTTTT
ACTTCGAGATTCAGCCCAGGAAGATTATTTATTCTCTGTTAGTTTTAGGCGCTACAGTCGTTCT
CTTCACGCTAGAATTGAACAGTGGAATCATAACTTCAGCTTTGACGCCCACGATCCCTGTGTCT
TCCATTCTCCCGATATTACTGGGCTCCTAGAGCATTATAAGGACCCAAGTGCCTGCATGTTCTT
TGAGCCACTTTTATCCACTCCGTTAATCCGGACTTTCCCCTTTTCCTTGCAGCACATTTGCAGG
ACAGTTATTTGTAACTGTACAACGTACGATGGCATCGATGCCCTTCCAATTCCTTCTCCTATGA
AATTGTACCTGAAGGAATACCATTACAAATCAAAAGTTAGGCTACTCAGGATTGACGTGCCAGA
GCCACAGTGACGTGGAGAGGTTAGAATGTCCACCCGCGAACATAGGTTCATTCAATAGTTCATT
TTTCTTATGCCTCTTTGAATTTTTGTACAAAGGCAGTTGGAATCCAAAATAAAACCGTGCCCTA
AGTTTTAATTCCAGATCAATTTTTTTTTTCTGATAGACTTGTTATATTTTAAGCAGGTGATTCG
TTTTTGTTTTTACCATGTAAATTGTATACTTTTCCTTTAATTTGCATATGGTCCAGGCACATTT
GCAATTTCAAGGCATCGAGTACACATTTGAATATTCTGTATTTTTTTAAACAATCTTATGCTCT
TTCCTACGTGTGAAATAGTTTGCTAATCTATGCTGTCAGTGTTCTTATCTGACAGAATGGTTAC
CTATCCTCTTTATTTTGAAACTCTTTAGTAAAGATGAGCATTATAATCAACCCATTACAATGTA
ACTGATTTTTGTCATTTGCTAATAGGGATGTTAAACAACAAAATGATTTAAAATGGAGCTTAAC
ATATTTTCCTTTTAAATATTAACTAAAACAAAAAAAAAAAAAAAAAAAAAAAA

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Protein Sequences


Protein RefSeqs	NP_001100726	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68879	(Get FASTA)	NCBI Sequence Viewer
	EDL88347	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000088978
	ENSRNOP00000088978.1
	ENSRNOP00000111469.1

RefSeq Acc Id:

NP_001100726 ⟸ NM_001107256

- UniProtKB:

B5DF08 (UniProtKB/TrEMBL), A6KE42 (UniProtKB/TrEMBL), A0A8I6A963 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAENNSKNVDVRPKTSRSRSADRKDGYVWSGKKLSWSRKSESCSESEAVGTLESVEIPLRSQER
ELSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQCFPIRNCGARHSPGLPSKRTIHISELMLDK
CPFPPPSDLAFRWHFIKRHTVALSSSSDEWVSTDLCERRPRDAQLKRRSTEDDIPCFSHTSVQP
CVITTNSASCAGGHVTGSLMNLVTDNSMEDGDMDSEDEIITLCTSSRKRNKPRWETDDGILQLE
APPKFHTQIDYVHCLVPDLLQISNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVS
FRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGLLEHYKDPSACMFFEPLLSTPLIRTFPF
SLQHICRTVICNCTTYDGIDALPIPSPMKLYLKEYHYKSKVRLLRIDVPEPQ

hide sequence

Ensembl Acc Id:

ENSRNOP00000015120 ⟸ ENSRNOT00000015120

Ensembl Acc Id:

ENSRNOP00000088978 ⟸ ENSRNOT00000105464

Ensembl Acc Id:

ENSRNOP00000111469 ⟸ ENSRNOT00000152731

Protein Domains

SH2 SOCS box

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B5DF08-F1-model_v2	AlphaFold	B5DF08	1-436	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306503	AgrOrtholog
BioCyc Gene	G2FUF-14155	BioCyc
Ensembl Genes	ENSRNOG00000011377	Ensembl
	ENSRNOG00000068183	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000105464	ENTREZGENE
	ENSRNOT00000105464.2	UniProtKB/TrEMBL
	ENSRNOT00000152731.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.505.10	UniProtKB/TrEMBL
InterPro	SH2	UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/TrEMBL
	SOCS	UniProtKB/TrEMBL
	SOCS4_SH2	UniProtKB/TrEMBL
	SOCS_box_dom_like	UniProtKB/TrEMBL
	SOCS_C	UniProtKB/TrEMBL
KEGG Report	rno:305828	UniProtKB/TrEMBL
NCBI Gene	305828	ENTREZGENE
PANTHER	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT	UniProtKB/TrEMBL
	PTHR10155:SF21	UniProtKB/TrEMBL
Pfam	SH2	UniProtKB/TrEMBL
	SOCS	UniProtKB/TrEMBL
	SOCS_box	UniProtKB/TrEMBL
PhenoGen	Socs4	PhenoGen
PROSITE	SH2	UniProtKB/TrEMBL
	SOCS	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000011377	RatGTEx
	ENSRNOG00000068183	RatGTEx
SMART	SH2	UniProtKB/TrEMBL
	SOCS	UniProtKB/TrEMBL
	SOCS_box	UniProtKB/TrEMBL
Superfamily-SCOP	SSF158235	UniProtKB/TrEMBL
	SSF55550	UniProtKB/TrEMBL
UniProt	A0A8I6A963	ENTREZGENE, UniProtKB/TrEMBL
	A6KE42	ENTREZGENE, UniProtKB/TrEMBL
	B5DF08	ENTREZGENE
UniProt Secondary	B5DF08	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Socs4	suppressor of cytokine signaling 4	Socs4_predicted	suppressor of cytokine signaling 4 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Socs4_predicted	suppressor of cytokine signaling 4 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)