Tmprss11g (transmembrane protease, serine 11G) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Tmprss11g (transmembrane protease, serine 11G) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Tmprss11g
Name: transmembrane protease, serine 11G
RGD ID: 1306446
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Located in plasma membrane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Desc4; LOC289546; RGD1306446; serine protease Desc4; similar to RIKEN cDNA 9930032O22 gene; transmembrane protease serine 11G
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81421,901,004 - 21,942,064 (+)NCBIGRCr8
mRatBN7.21421,546,087 - 21,587,258 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1421,546,189 - 21,587,258 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1421,893,220 - 21,934,001 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01423,212,148 - 23,252,927 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01421,743,216 - 21,784,008 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01423,166,633 - 23,207,327 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1423,166,633 - 23,207,327 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01423,058,672 - 23,097,346 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41423,196,890 - 23,240,419 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11423,196,889 - 23,240,419 (+)NCBI
Celera1421,020,752 - 21,060,937 (+)NCBICelera
Cytogenetic Map14p21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and characterisation of DESC4, a new transmembrane serine protease. Behrens M, etal., Cell Mol Life Sci. 2004 Nov;61(22):2866-77.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19149666  


Genomics

Variants

.
Variants in Tmprss11g
322 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:296
Count of miRNA genes:110
Interacting mature miRNAs:132
Transcripts:ENSRNOT00000042727, ENSRNOT00000060109
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system hemolymphoid system reproductive system respiratory system
High
Medium
Low 2 3 3
Below cutoff 2 5 5 2 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000060109   ⟹   ENSRNOP00000056857
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1421,546,189 - 21,587,258 (+)Ensembl
Rnor_6.0 Ensembl1423,166,633 - 23,207,327 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094471   ⟹   ENSRNOP00000083178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1421,568,274 - 21,587,258 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100035   ⟹   ENSRNOP00000082644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1421,546,189 - 21,587,258 (+)Ensembl
RefSeq Acc Id: NM_001008554   ⟹   NP_001008554
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81421,901,004 - 21,942,064 (+)NCBI
mRatBN7.21421,546,189 - 21,587,258 (+)NCBI
Rnor_6.01423,166,633 - 23,207,327 (+)NCBI
Rnor_5.01423,058,672 - 23,097,346 (+)NCBI
RGSC_v3.41423,196,890 - 23,240,419 (+)RGD
Celera1421,020,752 - 21,060,937 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001008554 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE84572 (Get FASTA)   NCBI Sequence Viewer  
  CAE84986 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000056857
  ENSRNOP00000056857.3
  ENSRNOP00000082644.1
  ENSRNOP00000083178.1
  ENSRNOP00055022742
  ENSRNOP00060017620
  ENSRNOP00065005436
GenBank Protein Q5QSK2 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001008554   ⟸   NM_001008554
- UniProtKB: Q5NJM5 (UniProtKB/Swiss-Prot),   Q5QSK2 (UniProtKB/Swiss-Prot),   D3ZIU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000056857   ⟸   ENSRNOT00000060109
RefSeq Acc Id: ENSRNOP00000082644   ⟸   ENSRNOT00000100035
RefSeq Acc Id: ENSRNOP00000083178   ⟸   ENSRNOT00000094471
Protein Domains
Peptidase S1   SEA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5QSK2-F1-model_v2 AlphaFold Q5QSK2 1-417 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306446 AgrOrtholog
BioCyc Gene G2FUF-16074 BioCyc
Ensembl Genes ENSRNOG00000029964 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055016616 UniProtKB/Swiss-Prot
  ENSRNOG00060013047 UniProtKB/Swiss-Prot
  ENSRNOG00065005288 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000060109 ENTREZGENE
  ENSRNOT00000060109.4 UniProtKB/TrEMBL
  ENSRNOT00000094471.1 UniProtKB/TrEMBL
  ENSRNOT00000100035.1 UniProtKB/TrEMBL
  ENSRNOT00055028258 UniProtKB/Swiss-Prot
  ENSRNOT00060022233 UniProtKB/Swiss-Prot
  ENSRNOT00065007810 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.70.960 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Pept_S1A_HAT/DESC1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:289546 UniProtKB/Swiss-Prot
NCBI Gene 289546 ENTREZGENE
PANTHER ACROSIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HYALIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tmprss11g PhenoGen
PIRSF TMPRSS11ABCDE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029964 RatGTEx
  ENSRNOG00055016616 RatGTEx
  ENSRNOG00060013047 RatGTEx
  ENSRNOG00065005288 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF82671 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZUB5_RAT UniProtKB/TrEMBL
  A0A8I5ZVE5_RAT UniProtKB/TrEMBL
  D3ZIU4 ENTREZGENE, UniProtKB/TrEMBL
  Q5NJM5 ENTREZGENE
  Q5QSK2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q5NJM5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-09-13 Tmprss11g  transmembrane protease, serine 11G  RGD1306446  similar to RIKEN cDNA 9930032O22 gene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1306446  similar to RIKEN cDNA 9930032O22 gene  RGD1306446_predicted  similar to RIKEN cDNA 9930032O22 gene (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1306446_predicted  similar to RIKEN cDNA 9930032O22 gene (predicted)  LOC289546_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC289546_predicted  similar to RIKEN cDNA 9930032O22 gene (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL