Spryd7 (SPRY domain containing 7) - Rat Genome Database

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Gene: Spryd7 (SPRY domain containing 7) Rattus norvegicus
Analyze
Symbol: Spryd7
Name: SPRY domain containing 7
RGD ID: 1306437
Description: Orthologous to human SPRYD7 (SPRY domain containing 7); INTERACTS WITH 6-propyl-2-thiouracil; acetamide; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: chronic lymphocytic leukemia deletion region gene 6 protein homolog; CLL deletion region gene 6 protein homolog; Clld6; LOC290303; MGC95134; RGD1306437; similar to RIKEN cDNA 6330409N04; SPRY domain-containing protein 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81539,883,237 - 39,903,770 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1539,883,238 - 39,903,674 (-)EnsemblGRCr8
mRatBN7.21535,707,185 - 35,727,704 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1535,707,060 - 35,727,509 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1537,572,038 - 37,592,361 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01538,722,665 - 38,742,988 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01537,167,870 - 37,188,193 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01541,871,144 - 41,890,879 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1541,870,762 - 41,890,716 (-)Ensemblrn6Rnor6.0
Rnor_5.01545,673,595 - 45,693,135 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41540,683,644 - 40,703,967 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1535,403,400 - 35,423,722 (-)NCBICelera
RGSC_v3.11540,699,344 - 40,719,667 (-)NCBI
Cytogenetic Map15p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334  


Genomics

Comparative Map Data
Spryd7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81539,883,237 - 39,903,770 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1539,883,238 - 39,903,674 (-)EnsemblGRCr8
mRatBN7.21535,707,185 - 35,727,704 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1535,707,060 - 35,727,509 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1537,572,038 - 37,592,361 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01538,722,665 - 38,742,988 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01537,167,870 - 37,188,193 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01541,871,144 - 41,890,879 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1541,870,762 - 41,890,716 (-)Ensemblrn6Rnor6.0
Rnor_5.01545,673,595 - 45,693,135 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41540,683,644 - 40,703,967 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1535,403,400 - 35,423,722 (-)NCBICelera
RGSC_v3.11540,699,344 - 40,719,667 (-)NCBI
Cytogenetic Map15p12NCBI
SPRYD7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381349,912,702 - 49,936,340 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1349,912,702 - 49,936,490 (-)Ensemblhg38GRCh38
GRCh371350,486,838 - 50,510,476 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361349,384,843 - 49,408,477 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341349,384,842 - 49,408,477NCBI
Celera1331,541,570 - 31,565,352 (-)NCBICelera
Cytogenetic Map13q14.2NCBI
HuRef1331,280,759 - 31,304,881 (-)NCBIHuRef
CHM1_11350,454,546 - 50,478,329 (-)NCBICHM1_1
T2T-CHM13v2.01349,133,330 - 49,156,970 (-)NCBIT2T-CHM13v2.0
Spryd7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391461,769,300 - 61,794,335 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1461,769,442 - 61,794,335 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381461,531,851 - 61,556,886 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1461,531,993 - 61,556,886 (-)Ensemblmm10GRCm38
MGSCv371462,153,142 - 62,175,723 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361460,488,415 - 60,510,996 (-)NCBIMGSCv36mm8
Celera1459,301,831 - 59,324,417 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.05NCBI
Spryd7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554313,303,091 - 3,324,994 (-)Ensembl
ChiLan1.0NW_0049554313,303,091 - 3,330,360 (-)NCBIChiLan1.0ChiLan1.0
SPRYD7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21451,356,242 - 51,379,734 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11350,007,503 - 50,030,983 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01331,053,278 - 31,076,746 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11349,801,309 - 49,824,463 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1349,801,309 - 49,824,463 (-)EnsemblpanPan2panpan1.1
SPRYD7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1221,929,814 - 1,947,506 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl221,849,634 - 1,945,276 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha221,958,685 - 1,976,702 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0221,919,587 - 1,937,225 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl221,919,291 - 1,937,221 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1221,829,191 - 1,847,216 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0221,878,466 - 1,896,259 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0221,896,811 - 1,914,827 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Spryd7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945159,427,470 - 159,455,104 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365652,908,169 - 2,939,232 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365652,911,523 - 2,939,151 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPRYD7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1117,848,852 - 17,872,257 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11117,849,011 - 17,870,090 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21118,186,983 - 18,208,062 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPRYD7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1327,832,306 - 27,890,996 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605716,032,762 - 16,051,987 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spryd7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247484,766,113 - 4,788,061 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Spryd7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11262,861,708 - 62,886,590 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Spryd7
112 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:19
Count of miRNA genes:19
Interacting mature miRNAs:19
Transcripts:ENSRNOT00000020419
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
D15Uia10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21535,718,973 - 35,719,210 (+)MAPPERmRatBN7.2
Rnor_6.01541,882,149 - 41,882,385NCBIRnor6.0
Rnor_5.01545,684,600 - 45,684,836UniSTSRnor5.0
RGSC_v3.41540,695,432 - 40,695,668UniSTSRGSC3.4
Celera1535,415,187 - 35,415,423UniSTS
Cytogenetic Map15p12UniSTS
RH139347  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21535,706,818 - 35,706,982 (+)MAPPERmRatBN7.2
mRatBN7.21535,706,818 - 35,706,979 (+)MAPPERmRatBN7.2
Rnor_6.01541,866,644 - 41,866,806NCBIRnor6.0
Rnor_6.01541,870,776 - 41,870,939NCBIRnor6.0
Celera1535,403,034 - 35,403,197UniSTS
Cytogenetic Map15p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000020419   ⟹   ENSRNOP00000020419
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1539,883,238 - 39,903,674 (-)Ensembl
mRatBN7.2 Ensembl1535,707,060 - 35,727,496 (-)Ensembl
Rnor_6.0 Ensembl1541,870,762 - 41,890,716 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105762   ⟹   ENSRNOP00000081939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1539,883,510 - 39,903,560 (-)Ensembl
mRatBN7.2 Ensembl1535,707,458 - 35,727,509 (-)Ensembl
RefSeq Acc Id: NM_001009635   ⟹   NP_001009635
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,883,237 - 39,903,560 (-)NCBI
mRatBN7.21535,707,185 - 35,727,509 (-)NCBI
Rnor_6.01541,871,144 - 41,890,684 (-)NCBI
Rnor_5.01545,673,595 - 45,693,135 (-)NCBI
RGSC_v3.41540,683,644 - 40,703,967 (-)RGD
Celera1535,403,400 - 35,423,722 (-)RGD
Sequence:
RefSeq Acc Id: XM_017599625   ⟹   XP_017455114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,883,510 - 39,903,770 (-)NCBI
mRatBN7.21535,707,458 - 35,727,704 (-)NCBI
Rnor_6.01541,871,417 - 41,890,879 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001009635 (Get FASTA)   NCBI Sequence Viewer  
  XP_017455114 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88471 (Get FASTA)   NCBI Sequence Viewer  
  EDL85280 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000020419
  ENSRNOP00000020419.3
  ENSRNOP00000081939
GenBank Protein Q5M7T2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001009635   ⟸   NM_001009635
- UniProtKB: Q5M7T2 (UniProtKB/Swiss-Prot),   A6K6C0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455114   ⟸   XM_017599625
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZTJ5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020419   ⟸   ENSRNOT00000020419
Ensembl Acc Id: ENSRNOP00000081939   ⟸   ENSRNOT00000105762
Protein Domains
B30.2/SPRY

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5M7T2-F1-model_v2 AlphaFold Q5M7T2 1-196 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699745
Promoter ID:EPDNEW_R10269
Type:initiation region
Name:Spryd7_1
Description:SPRY domain containing 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01541,890,702 - 41,890,762EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306437 AgrOrtholog
BioCyc Gene G2FUF-13497 BioCyc
Ensembl Genes ENSRNOG00000015095 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020419 ENTREZGENE
  ENSRNOT00000020419.6 UniProtKB/Swiss-Prot
  ENSRNOT00000105762 ENTREZGENE
Gene3D-CATH 2.60.120.920 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7128422 IMAGE-MGC_LOAD
InterPro B30.2/SPRY UniProtKB/Swiss-Prot
  B30.2/SPRY_sf UniProtKB/Swiss-Prot
  ConA-like_dom_sf UniProtKB/Swiss-Prot
  SPRY_dom UniProtKB/Swiss-Prot
  SPRYD7 UniProtKB/Swiss-Prot
KEGG Report rno:290303 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95134 IMAGE-MGC_LOAD
NCBI Gene 290303 ENTREZGENE
PANTHER PTHR20951 UniProtKB/Swiss-Prot
  SPRY DOMAIN-CONTAINING PROTEIN 7 UniProtKB/Swiss-Prot
Pfam SPRY UniProtKB/Swiss-Prot
PhenoGen Spryd7 PhenoGen
PROSITE B302_SPRY UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015095 RatGTEx
SMART SPRY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot
UniProt A0A8I5ZTJ5 ENTREZGENE, UniProtKB/TrEMBL
  A6K6C0 ENTREZGENE, UniProtKB/TrEMBL
  Q5M7T2 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Spryd7  SPRY domain containing 7  RGD1306437  similar to RIKEN cDNA 6330409N04  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1306437  similar to RIKEN cDNA 6330409N04  RGD1306437_predicted  similar to RIKEN cDNA 6330409N04 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1306437_predicted  similar to RIKEN cDNA 6330409N04 (predicted)  LOC290303_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC290303_predicted  similar to RIKEN cDNA 6330409N04 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL