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Gene: Pdcd1lg2 (programmed cell death 1 ligand 2) Rattus norvegicus

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Symbol:

Pdcd1lg2

Name:

programmed cell death 1 ligand 2

RGD ID:

1306403

Description:

Predicted to be involved in several processes, including cellular response to lipopolysaccharide; negative regulation of cytokine production; and regulation of T cell activation. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Orthologous to human PDCD1LG2 (programmed cell death 1 ligand 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC309304; PD-1 ligand 2; PD-L2; PDCD1 ligand 2; programmed death ligand 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PDCD1LG2 (programmed cell death 1 ligand 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Pdcd1lg2 (programmed cell death 1 ligand 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pdcd1lg2 (programmed cell death 1 ligand 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PDCD1LG2 (programmed cell death 1 ligand 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PDCD1LG2 (programmed cell death 1 ligand 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pdcd1lg2 (programmed cell death 1 ligand 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PDCD1LG2 (programmed cell death 1 ligand 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PDCD1LG2 (programmed cell death 1 ligand 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pdcd1lg2 (programmed cell death 1 ligand 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Pdcd1lg2 (programmed cell death 1 ligand 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PDCD1LG2 (programmed cell death 1 ligand 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pdcd1lg2 (programmed cell death 1 ligand 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:ch211-241b2.5	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER)
Danio rerio (zebrafish):	si:ch211-241b2.5	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	pdcd1lg2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	236,572,497 - 236,637,490 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	236,565,526 - 236,637,490 (+)	Ensembl				GRCr8
mRatBN7.2	1	227,158,941 - 227,223,938 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	227,158,941 - 227,223,938 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	235,560,639 - 235,625,650 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	242,490,304 - 242,555,322 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	235,308,069 - 235,373,343 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	247,562,202 - 247,629,279 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	247,562,202 - 247,627,193 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	254,810,377 - 254,876,025 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	233,090,444 - 233,156,412 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	224,309,877 - 224,374,794 (+)	NCBI		Celera
RGSC_v3.1	1	233,273,427 - 233,368,190 (+)	NCBI
Cytogenetic Map	1	q52	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autoimmune hepatitis (ISO)

Coxsackievirus Infections (ISO)

cutaneous leishmaniasis (ISO)

histoplasmosis (ISO)

pulmonary tuberculosis (ISO)

Sepsis (ISO)

Spinal Cord Injuries (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-palmitoylglycerol (ISO)

4,4'-sulfonyldiphenol (ISO)

5-fluorouracil (ISO)

all-trans-retinoic acid (ISO)

alpha-amanitin (ISO)

alpha-Zearalanol (EXP)

aripiprazole (ISO)

arsane (ISO)

arsenic atom (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (ISO)

carbon nanotube (ISO)

carboplatin (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

diiodine (ISO)

dimethylarsinous acid (ISO)

doxorubicin (ISO)

estriol (ISO)

flutamide (EXP)

folic acid (ISO)

fulvestrant (ISO)

gardiquimod (ISO)

lipopolysaccharide (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

oxaliplatin (ISO)

ozone (ISO)

PD 0325901 (ISO)

potassium dichromate (ISO)

protein kinase inhibitor (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

testosterone (EXP)

trimellitic anhydride (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adaptive immune response (IEA)

cell surface receptor signaling pathway (IBA)

cellular response to lipopolysaccharide (IBA)

immune response (IBA)

immune system process (IEA)

negative regulation of activated T cell proliferation (ISO)

negative regulation of interleukin-10 production (ISO)

negative regulation of T cell activation (ISO)

negative regulation of T cell proliferation (IBA,IEA,ISO)

negative regulation of T cell receptor signaling pathway (ISO)

negative regulation of type II interferon production (ISO)

positive regulation of T cell proliferation (IBA,ISO)

signal transduction (IEA)

T cell costimulation (IBA)

Cellular Component

external side of plasma membrane (IBA)

plasma membrane (IEA,ISO)

Molecular Function

protein binding (ISO)

receptor ligand activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Expression of programmed death 1 and its ligands in the liver of autoimmune hepatitis C57BL/6 mice.	Cao J, etal., Chin Med J (Engl). 2009 Aug 20;122(16):1941-6.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Dexmedetomidine Mitigates Microglia-Mediated Neuroinflammation through Upregulation of Programmed Cell Death Protein 1 in a Rat Spinal Cord Injury Model.	He H, etal., J Neurotrauma. 2018 Nov 1;35(21):2591-2603. doi: 10.1089/neu.2017.5625. Epub 2018 Jun 7.
5.	PD-L1 and PD-L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis.	Liang SC, etal., Eur J Immunol. 2006 Jan;36(1):58-64. doi: 10.1002/eji.200535458.
6.	The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum.	Lázár-Molnár E, etal., Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2658-63. doi: 10.1073/pnas.0711918105. Epub 2008 Feb 11.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Inhibiting the programmed death 1 pathway rescues Mycobacterium tuberculosis-specific interferon γ-producing T cells from apoptosis in patients with pulmonary tuberculosis.	Singh A, etal., J Infect Dis. 2013 Aug 15;208(4):603-15. doi: 10.1093/infdis/jit206. Epub 2013 May 9.
10.	Aberrant PD-1 ligand expression contributes to the myocardial inflammatory injury caused by Coxsackievirus B infection.	Wang T, etal., Antiviral Res. 2019 Jun;166:1-10. doi: 10.1016/j.antiviral.2019.03.007. Epub 2019 Mar 20.
11.	Lymphocyte subset expression and serum concentrations of PD-1/PD-L1 in sepsis - pilot study.	Wilson JK, etal., Crit Care. 2018 Apr 17;22(1):95. doi: 10.1186/s13054-018-2020-2.

Additional References at PubMed

PMID:11224527	PMID:11283156	PMID:12538684	PMID:17016562	PMID:23376485

Genomics

Comparative Map Data

Pdcd1lg2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	236,572,497 - 236,637,490 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	236,565,526 - 236,637,490 (+)	Ensembl				GRCr8
mRatBN7.2	1	227,158,941 - 227,223,938 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	227,158,941 - 227,223,938 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	235,560,639 - 235,625,650 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	242,490,304 - 242,555,322 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	235,308,069 - 235,373,343 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	247,562,202 - 247,629,279 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	247,562,202 - 247,627,193 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	254,810,377 - 254,876,025 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	233,090,444 - 233,156,412 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	224,309,877 - 224,374,794 (+)	NCBI		Celera
RGSC_v3.1	1	233,273,427 - 233,368,190 (+)	NCBI
Cytogenetic Map	1	q52	NCBI

PDCD1LG2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	5,510,531 - 5,571,282 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	5,510,491 - 5,571,282 (+)	Ensembl			hg38	GRCh38
GRCh37	9	5,510,531 - 5,571,282 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	5,500,570 - 5,560,398 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	9	5,500,569 - 5,560,398	NCBI
Celera	9	5,436,182 - 5,496,918 (+)	NCBI		Celera
Cytogenetic Map	9	p24.1	NCBI
HuRef	9	5,466,254 - 5,526,976 (+)	NCBI		HuRef
CHM1_1	9	5,510,742 - 5,571,459 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	5,515,648 - 5,576,398 (+)	NCBI		T2T-CHM13v2.0

Pdcd1lg2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	29,388,319 - 29,450,327 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	29,388,319 - 29,448,561 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	19	29,410,919 - 29,472,927 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	29,410,919 - 29,471,161 (+)	Ensembl			mm10	GRCm38
MGSCv37	19	29,485,409 - 29,547,417 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	19	29,476,955 - 29,537,158 (+)	NCBI		MGSCv36	mm8
Celera	19	30,187,250 - 30,249,414 (+)	NCBI		Celera
Cytogenetic Map	19	C1	NCBI
cM Map	19	23.93	NCBI

Pdcd1lg2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955434	9,540,047 - 9,559,335 (+)	NCBI	ChiLan1.0	ChiLan1.0

PDCD1LG2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	119,001,068 - 119,078,909 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	119,006,121 - 119,084,767 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	5,313,071 - 5,391,676 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	5,514,449 - 5,575,660 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	5,514,449 - 5,575,688 (+)	Ensembl			panPan2	panpan1.1

PDCD1LG2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	93,631,676 - 93,698,560 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	93,631,979 - 93,689,266 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	94,040,062 - 94,127,750 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	94,185,676 - 94,272,591 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	94,185,807 - 94,254,813 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	93,817,857 - 93,905,923 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	93,542,645 - 93,630,714 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	94,306,830 - 94,395,104 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Pdcd1lg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	141,737,769 - 141,782,738 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936539	190,637 - 234,873 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936539	190,583 - 229,936 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PDCD1LG2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	216,553,105 - 216,657,170 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	216,564,428 - 216,600,333 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

PDCD1LG2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	73,938,194 - 73,998,028 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	73,938,042 - 73,997,770 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	62,327,991 - 62,387,861 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pdcd1lg2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624736	10,049,428 - 10,056,849 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Pdcd1lg2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	29,490,638 - 29,555,660 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Pdcd1lg2
383 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	60
Count of miRNA genes:	55
Interacting mature miRNAs:	58
Transcripts:	ENSRNOT00000021614
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8693637	Alc29	Alcohol consumption QTL 29	2.7	0.258	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	1	217412367	243666627	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	160111531	262090437	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	160573753	266453731	Rat
1357335	Bw39	Body weight QTL 39	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	1	207243873	252243873	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	186658830	266453731	Rat
2293674	Bss39	Bone structure and strength QTL 39	7.1	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	1	210980612	255980612	Rat
61455	Niddm7	Non-insulin dependent diabetes mellitus QTL 7	5.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	223964326	248681945	Rat
61327	Eae7	Experimental allergic encephalomyelitis QTL 7	5.6		body mass (VT:0001259)	change in body weight (CMO:0002045)	1	226175591	270518180	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	205233991	267096252	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	218829748	263829748	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	186658830	266453731	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	205233991	267096252	Rat
1600397	Edcs4	Endometrial carcinoma susceptibility QTL 4	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	1	176288899	270518180	Rat
631838	Niddm36	Non-insulin dependent diabetes mellitus QTL 36		0.01	insulin secretion trait (VT:0003564)	calculated pancreatic islet insulin release measurement (CMO:0001217)	1	193964073	238964073	Rat
8693661	Alc34	Alcohol consumption QTL 34	2.2	0.611	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	1	217412367	238041033	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	162548015	270518180	Rat
152025235	Bw194	Body weight QTL 194	4.86		body mass (VT:0001259)		1	132966869	252856240	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	205233991	267096252	Rat
2293694	Bss38	Bone structure and strength QTL 38	7.05	0.0001	femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	1	210980612	255980612	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	152919152	268496042	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	160111531	262090437	Rat
1300145	Rf7	Renal function QTL 7	2.96		urine creatinine amount (VT:0010540)	urine creatinine level (CMO:0000125)	1	194575422	239575422	Rat
8655655	Arrd2	Age-related retinal degeneration QTL 2	7.79		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	193400541	238400541	Rat
734767	Niddm57	Non-insulin dependent diabetes mellitus QTL 57			body mass (VT:0001259)	body weight (CMO:0000012)	1	233480549	270108840	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	200449456	256003563	Rat
631215	Stl8	Serum triglyceride level QTL 8	9.27	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	1	234540191	270518180	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	146080545	243492863	Rat
631843	Bw116	Body weight QTL 116	4.1	0.016	abdominal adipose amount (VT:1000220)	abdominal fat pad weight (CMO:0000088)	1	233480549	270108840	Rat
731175	Uae20	Urinary albumin excretion QTL 20	3.5	0.0018	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	207163993	269633915	Rat
2300175	Bmd40	Bone mineral density QTL 40	15.4	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	1	210980612	255980612	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	266453731	Rat
724538	Kidm1	Kidney mass QTL 1	3.2		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	223134011	262090599	Rat
2293655	Bss36	Bone structure and strength QTL 36	10.66	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	210980612	255980612	Rat
1298084	Thym4	Thymus enlargement QTL 4	10.68		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	207243873	252243873	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	160111426	262090599	Rat
2314011	Gluco56	Glucose level QTL 56			blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	209203273	254203273	Rat
8552891	Epfw5	Epididymal fat weight QTL 5	4.4		epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	1	202543537	247543537	Rat
734769	Niddm58	Non-insulin dependent diabetes mellitus QTL 58			body mass (VT:0001259)	body weight (CMO:0000012)	1	225108840	270108840	Rat
724533	Rf51	Renal function QTL 51	5.3	0.0002	kidney plasma flow trait (VT:0005524)	renal plasma flow (CMO:0001914)	1	228180370	266453608	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	154961463	266453731	Rat
1358292	Cm37	Cardiac mass QTL 37	6.2	8e-07	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	1	205674651	250674651	Rat
61376	Bp42	Blood pressure QTL 42	23.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	207243873	252243873	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	208479811	269633915	Rat
70211	Niddm24	Non-insulin dependent diabetes mellitus QTL 24	3.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	224633915	269633915	Rat
724552	Glom2	Glomerulus QTL 2	3.3	0.0001	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	1	232312773	270518180	Rat
1358916	Kidm22	Kidney mass QTL 22	3.32		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	212738576	257738576	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	194786607	262083703	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	188241285	250779312	Rat
2292218	Kidm35	Kidney mass QTL 35			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	208798288	253798288	Rat
61400	Niddm1	Non-insulin dependent diabetes mellitus QTL 1	11		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	228180243	255849249	Rat
1300168	Bp170	Blood pressure QTL 170	2.76		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	192995199	237995199	Rat
61403	Niddm4	Non-insulin dependent diabetes mellitus QTL 4			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	201464383	246464383	Rat
1641926	Teswt2	Testicular weight QTL 2	2.82		testis mass (VT:1000644)	both testes wet weight (CMO:0000175)	1	203675682	248675682	Rat
631658	Cm7	Cardiac mass QTL 7	5.32	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	1	205674651	250674651	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	266453731	Rat
2293700	Bmd27	Bone mineral density QTL 27	6.6	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	210980612	255980612	Rat
2293701	Bmd34	Bone mineral density QTL 34	8.3	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	1	210980612	255980612	Rat
7387289	Uae45	Urinary albumin excretion QTL 45	2.86	0.0021	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	233204160	270518180	Rat
8655855	Arrd3	Age-related retinal degeneration QTL 3	3.07		lens clarity trait (VT:0001304)	cataract incidence/prevalence measurement (CMO:0001585)	1	193400541	238400541	Rat
1600374	Mcs17	Mammary carcinoma susceptibility QTL 17	3		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	207099883	252099883	Rat
6480786	Bw97	Body weight QTL 97	5.03		body mass (VT:0001259)	body weight (CMO:0000012)	1	234540191	237018045	Rat
1600363	Hc6	Hypercalciuria QTL 6	2.7		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	210980612	255980612	Rat
8693618	Alc25	Alcohol consumption QTL 25	3	0.28	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	1	217412367	238041033	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	185857683	270518180	Rat
2302040	Pia35	Pristane induced arthritis QTL 35	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	226175591	270518180	Rat
631669	Iddm9	Insulin dependent diabetes mellitus QTL 9	2.8	0.039	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	233349180	270518180	Rat
7394701	Uae46	Urinary albumin excretion QTL 46	3.6	0.0056	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	210980612	255980612	Rat
1598821	Rf55	Renal function QTL 55	6.3		renal blood flow trait (VT:2000006)	ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)	1	228174566	270518180	Rat

Markers in Region

D1Cebr6

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	227,193,527 - 227,193,669 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	247,596,785 - 247,596,926	NCBI	Rnor6.0
Rnor_5.0	1	254,845,615 - 254,845,756	UniSTS	Rnor5.0
RGSC_v3.4	1	233,125,026 - 233,125,167	UniSTS	RGSC3.4
Celera	1	224,344,390 - 224,344,531	UniSTS
Cytogenetic Map	1	q52	UniSTS

RH141444

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	227,223,455 - 227,223,650 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	247,626,712 - 247,626,905	NCBI	Rnor6.0
Rnor_5.0	1	254,875,544 - 254,875,737	UniSTS	Rnor5.0
RGSC_v3.4	1	233,155,931 - 233,156,124	UniSTS	RGSC3.4
Celera	1	224,374,313 - 224,374,506	UniSTS
RH 3.4 Map	1	1613.1	UniSTS
Cytogenetic Map	1	q52	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
15	12	50	86	53	51	21	89	21	6	284	171	10	58	69	81	30	4	4

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107582	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001438032	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001438033	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001438034	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006231209	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039079984	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039079989	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC096324	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC109391	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000021614 ⟹ ENSRNOP00000021615

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	236,572,497 - 236,637,490 (+)	Ensembl
mRatBN7.2 Ensembl	1	227,158,941 - 227,223,938 (+)	Ensembl
Rnor_6.0 Ensembl	1	247,562,202 - 247,627,193 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000133905 ⟹ ENSRNOP00000102353

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	236,565,526 - 236,637,490 (+)	Ensembl

RefSeq Acc Id:

NM_001107582 ⟹ NP_001101052

RefSeq Status:

INFERRED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	236,572,497 - 236,637,490 (+)	NCBI
mRatBN7.2	1	227,158,941 - 227,223,938 (+)	NCBI
Rnor_6.0	1	247,562,202 - 247,627,193 (+)	NCBI
Rnor_5.0	1	254,810,377 - 254,876,025 (+)	NCBI
RGSC_v3.4	1	233,090,444 - 233,156,412 (+)	RGD
Celera	1	224,309,877 - 224,374,794 (+)	RGD

Sequence:

show sequence

ACCACATCTTTTGTTCCCCCTTGTTGGTTATATCCTAATGTCAAATGTGGGCATACCTTTGTGG
CGCCCCCCTGTCTTCCAACCAGAGGGGATGCACTGGCTGCTCCTGTTGTGGACAGGTTTGGTTG
GTGGTGTAATTGGCTTCTGAGGAACCTGATACAAAGAGTGACTATGTGTAGCCTTTTCTCTGTG
TCTTTGTCTGACGAGTTGTGTTGAGTCCTGATATTGATACAGACCATGCTGCTCCTGCTGCTGA
TACTGAACCTGAGCTCGCAACTTCATCACATAGCAGCTTTATTCACGGTGACAGCCCCTAAGGA
GGTGTACACCGTAGACTTCGGCAGCAGTGTGAGCCTGGAGTGTGATTTTGACCGCAGAGAATGC
ACCGAGCTAGAAGGAATAAGAGCCAGTTTGCAGAAGGTAGAAAACGATACTTCTTCACAAAGTC
AAAGAGCCACCCTGCTGGAAGAGCTGCTTCCCCTGGGGAAGGCTTCGTTCCACATCCCCAGTGT
CCAAGTGAGAGATTCAGGGCAGTACCGTTGTCTGGTCATCTGCGGGGCCGCCTGGGACTACAAG
TACCTGACGGTGAAAGTCAAAGCTTCTTACGTGAGGATAGACACTGGGATCCTAGAGGTTCCAG
GGACAGGGGAGGTGCAGCTCATCTGCCAGGCTAGAGGTTACCCCCTAGCAGAAGTGTCCTGGCA
AAATGTCAGTGTTCCTGCCAACACCAGCCACATCAGGACCCCTGAAGGCCTCTACCAGGTCACC
AGTGTTCTGCGCCTGAAGCCTCAGCCTAACAGAAACTTCAGCTGCATGTTCTGGAATGCTCACA
TGAAGGAGCTTACTTCAGCCATCATTGACCCTCTGAGTTGGATGGAACCCAAAGTCCCCAGAAC
ACGGTCACTTCATGCTTTCATCCCGGCCTGCACTGTCGCTCTCATCTTCCTAGCCACAGTGATA
GCCCAGAGAAAGAGGCTCTGGGGAAAGCTGTATTCTAGAAAAAGATCTGAGCCTGCGGTCTTGG
GAGTTGGGAAGATCCAATAGGAAATCCTCAAGAGGCTTCTGGACTCAAAGTGAGAATCTAGCAG
AGCCGCCATTTGCACTTTTCGAATGCTGATCAGGAGCTTGCAGGACTGCCAAGACTGCCTTCCC
TTCCTCTCAAGACTCTCTCTGAACAAAAACAACCACAATGGCACCCTAGAGTCCTCCCTCCCCC
CCCCCCTGGGGATCCTGGACCCCAGTGAAGCCCTTCCTGGTTTCCAGGGTGAAAACAAAAGGAA
TTGTTCTTCCTCCTCCCCCTGCGTTCCACGGGGAGACAAGGAAATTCCCAGTTACTAAAATAGA
TTGTGTTGATAATAGAGTTTTTTAATATCTGTCATTTCCTCTGGGGATTTGGAAGTTTCAGAAA
GGGTTTTTAGTAAACAAAGTCATAACTGATGTGTTTCACTGCATCCTAGAATCCTGGCAGCCTC
TGAAGTTCTGATTATCAGGAAGCATTTGAGTACACAACTGTGGAATTTGTTTCTACTTTTCTTT
TTTTAAAGCTGAGTCACACAAGGCATTTGTTGTAACCTGTGATGTCACTGTTTATTGATCTCTT
CTCTTTCAACTACATTTTTT

hide sequence

RefSeq Acc Id:

XM_006231209 ⟹ XP_006231271

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	236,591,384 - 236,637,230 (+)	NCBI
mRatBN7.2	1	227,177,671 - 227,223,678 (+)	NCBI
Rnor_6.0	1	247,580,890 - 247,629,279 (+)	NCBI
Rnor_5.0	1	254,810,377 - 254,876,025 (+)	NCBI

Sequence:

show sequence

GTTCATCCTGCTCTCCAGAAAAGGCCCTGCGAGAAGCAAAAAGAGCAGCTCATTTGAATTCAGA
AAGAGTGCCTTCTTCCTCCTTGCTGTGCATAAGCTCTTCTCCAGAAAAGGAACCCACGGGCTCT
CTTCTTGTCTCTGCTACTCCATTGTCACCTGCATCTCCCACAAGATTTGATTCTGAGTCATTAC
CATGCTCTTGGGATGAGTTAAACTGGCGGAGACTGAGAAAGTGCACGGAGCCCGGAGACTCTCA
ATTGTCTGTTTCAGATTGATACAGACCATGCTGCTCCTGCTGCTGATACTGAACCTGAGCTCGC
AACTTCATCACATAGCAGCTTTATTCACGGTGACAGCCCCTAAGGAGGTGTACACCGTAGACTT
CGGCAGCAGTGTGAGCCTGGAGTGTGATTTTGACCGCAGAGAATGCACCGAGCTAGAAGGAATA
AGAGCCAGTTTGCAGAAGGTAGAAAACGATACTTCTTCACAAAGTCAAAGAGCCACCCTGCTGG
AAGAGCTGCTTCCCCTGGGGAAGGCTTCGTTCCACATCCCCAGTGTCCAAGTGAGAGATTCAGG
GCAGTACCGTTGTCTGGTCATCTGCGGGGCCGCCTGGGACTACAAGTACCTGACGGTGAAAGTC
AAAGCTTCTTACGTGAGGATAGACACTGGGATCCTAGAGGTTCCAGGGACAGGGGAGGTGCAGC
TCATCTGCCAGGCTAGAGGTTACCCCCTAGCAGAAGTGTCCTGGCAAAATGTCAGTGTTCCTGC
CAACACCAGCCACATCAGGACCCCTGAAGGCCTCTACCAGGTCACCAGTGTTCTGCGCCTGAAG
CCTCAGCCTAACAGAAACTTCAGCTGCATGTTCTGGAATGCTCACATGAAGGAGCTTACTTCAG
CCATCATTGACCCTCTGAGTTGGATGGAACCCAAAGTCCCCAGAACACGGTCACTTCATGCTTT
CATCCCGGCCTGCACTGTCGCTCTCATCTTCCTAGCCACAGTGATAGCCCAGAGAAAGAGGCTC
TGGGGAAAGCTGTATTCTAGAAAAAGATCTGAGCCTGCGGTCTTGGGAGTTGGGAAGATCCAAT
AGGAAATCCTCAAGAGGCTTCTGGACTCAAAGTGAGAATCTAGCAGAGCCGCCATTTGCACTTT
TCGAATGCTGATCAGGAGCTTGCAGGACTGCCAAGACTGCCTTCCCTTCCTCTCAAGACTCTCT
CTGAACAAAAACAACCACAATGGCACCCTAGAGTCCTCCCTCCCCCCCCCCCTGGGGATCCTGG
ACCCCAGTGAAGCCCTTCCTGGTTTCCAGGGTGAAAACAAAAGGAATTGTTCTTCCTCCTCCCC
CTGCGTTCCACGGGGAGACAAGGAAATTCCCAGTTACTAAAATAGATTGTGTTGATAATAGAGT
TTTTTAATATCTGTCATTTCCTCTGGGGATTTGGAAGTTTCAGAAAGGGTTTTTAGTAAACAAA
GTCATAACTGATGTGTTTCACTGCATCCTAGAATCCTGGCAGCCTCTGAAGTTCTGATTATCAG
GAAGCATTTGAGTACACAACTGTGGAATTTGTTTCTACTTTTCTTTTTTTAAAGCTGAGTCACA
CAAGGCATTTGTTGTAACCTGTGATGTCACTGTTTATTGATCTCTTCTCTTTCAACTACATTTT
TTAAGACGAAACGGTGTAGGGTTTTGTTGTTTTGTTGGTGGTGGTAGTGTTTCTCAGTGGTATC
ACTTTAAGAAAAAAAAAATCATCATGCCAGTTCTTTCTTTAGACGGTTCAGATGAGGAGCTGTA
ATCACCAGTCCCCCGAGCTAAGCCTTCTTCCCTAGCCTTCCGTGTGATTTTACGTTGAACGTTT
GTGTTGCTCTGTTTCTATAACTGTAATGTGGTGATGTCATTGTCGGGGCATTTGATGATGAGCA
TTCTGGAAGTCCTTTTGTAAGAGAAAAACCCTCTGAGCCCTACGTTCAGCCCCACTCACAGAGA
CACAGAGACAGGATCAATGCAATAAGCAAGAGGTTTCATGATCCAGTGCACTGGGGTGGCCCTG
TACTCAGGGCAGAGGCGACCTCAAAGAACAAAGGCCCACGCCCTTTATACTGTTTTTCAGGGTA
TAGGCTTTAGGTTACAGCATGAGTTGATTATTTCTCATTGGTGGGCCCTATTACCTTTTGAATT
CATTGGTGGCTGCCTATCGTCCTTTGAAGTCATTGGAGGCCCTTGGTGGGGAAGTATATTTGGC
ATGCAGTGGGGGTGATGAAGGACTCCTGCTAAGGGCAGCTACCTCATTTCCTGGAACAGGGTGT
TATCCTAAATTCCACCTGGTGTTTGGCTAAGGCAGCCTTTGTCTTTAAGTTTGAATCTTACACT
TTCAGGTTAGTGTTTGCGGGGGAGAGAGCTCAGAATACGGAATGGTGCTAACTTGAAGCTGGAG
GCATGGAATTAACTAACCTTTGGGCTACCCAAATGTGCACATTAGCTACCATGACATCTGTAGG
CTAGCAAGCTCTTTACCTAGTGTTTAGACTGAGCAGAATTTGGAGTCAATGAGCCCAAAAGGGT
GCAAAATTAAGATTTGAATTATGCATCTTATTTTATCACCATCTGCTCACGCGAAACAGAGAAT
ACCTTTGAAGCACAAAAATGTGATCGTTTATTTGAAACCTCTGAGGTACATACACTCAGATGCC
CTTTGCAGCAAGGTGTCTCTCTAAGATTCCTGTAGGGAAAGCAGCCCTACTCAGTACCAGACAG
CAGCCCTACTCAGTACCAGATAGCAGGACAGAGAGAAAAGTCTATGCTAGACCTCCCCTCTCAG
GTGTGTGATTGGCAGGCCAAACCCCGATTGCCAACCAGGGTTTGTCTGCTTTATTAGGAATCCA
GTGGCACTATGGATGCTGACAAAATGCCACCATCTCAGCCCTCACTGGGCTGTTTTCTAGGATA
TCAATAGAGAAAGGGCCAACTAGATCCAGTATCCTAAAATCCTGAGAGAAGAATATAAGTTAGC
GTGTCTCACTGTGATAAGTGTCCCTCTACATGATTGATCACATTAATATCTAACAATTACCAAA
TACTTACTATATGCCCAATTCTGTTGAGCATTTCATACACACCATTGGATGGAATTCTCTCAAA
ATCCTCAGAAAAGGGAATTATTAATACCTCCATAGGCAAGGAGCCCGGAGCCCAGCGAGGTTGG
TTGGGCAGTCTGGTTAAGGATGTCTGCTTTGTTTAGAAGGAAGTGAAAAAGAACATCAAACTCA
TATTTATTATAGCCCTGGTTATTAATGTACCTGGTTACCTGCTGGATGGGACATCAAGGTGGAC
TTTTGGCACTTGCATATGCCCGGTGTTATTTCGGCTAGTCACGGATTAATTTCACACTCACTGT
TTCCCAGACATGTGTAGGGGAAGTCCAGGTTCGGAGGGGCCTAAGATTCGTACTCTAGCTTAGT
TATCTAAGTCTTTAAATCCACCAGCTGACCTCCCCGCACATTAATTTCCCTATCTAAAGAGTGA
GCAGTAACCGAGTGATACCTCCTCCCTTCCCTTATCAGGCACTGTTGTGGGTAGGGTGCAATGA
ATACTTGATAAATATGTGTCCGTGTGAATCCCCACGTGCCAGCCGCTGTCCCCAATGCAAAAGC
AGCACAGCATTCAGACATCTCAGGCTGATTTATCAGCAGCGGATTTCTCCTAGCCCCATGCCTA
AAGAAACTTCCAGCCTAGATATGTTGTGTAGGTTTTGTGT

hide sequence

RefSeq Acc Id:

XM_039079984 ⟹ XP_038935912

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	236,591,384 - 236,637,230 (+)	NCBI
mRatBN7.2	1	227,177,696 - 227,223,678 (+)	NCBI

RefSeq Acc Id:

XM_039079989 ⟹ XP_038935917

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	236,608,982 - 236,637,230 (+)	NCBI
mRatBN7.2	1	227,196,023 - 227,223,678 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101052	(Get FASTA)	NCBI Sequence Viewer
	NP_001424961	(Get FASTA)	NCBI Sequence Viewer
	NP_001424962	(Get FASTA)	NCBI Sequence Viewer
	NP_001424963	(Get FASTA)	NCBI Sequence Viewer
	XP_006231271	(Get FASTA)	NCBI Sequence Viewer
	XP_038935912	(Get FASTA)	NCBI Sequence Viewer
	XP_038935917	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM13096	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000021615
	ENSRNOP00000021615.6
	ENSRNOP00000102353.1

RefSeq Acc Id:	NP_001101052 ⟸ NM_001107582
- Peptide Label:	precursor
- UniProtKB:	D4AAV6 (UniProtKB/TrEMBL), A6I0W5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLLLLLILNLSSQLHHIAALFTVTAPKEVYTVDFGSSVSLECDFDRRECTELEGIRASLQKVEN DTSSQSQRATLLEELLPLGKASFHIPSVQVRDSGQYRCLVICGAAWDYKYLTVKVKASYVRIDT GILEVPGTGEVQLICQARGYPLAEVSWQNVSVPANTSHIRTPEGLYQVTSVLRLKPQPNRNFSC MFWNAHMKELTSAIIDPLSWMEPKVPRTRSLHAFIPACTVALIFLATVIAQRKRLWGKLYSRKR SEPAVLGVGKIQ hide sequence

RefSeq Acc Id:

XP_006231271 ⟸ XM_006231209

- Peptide Label:

isoform X1

- Sequence:

show sequence

MLLLLLILNLSSQLHHIAALFTVTAPKEVYTVDFGSSVSLECDFDRRECTELEGIRASLQKVEN
DTSSQSQRATLLEELLPLGKASFHIPSVQVRDSGQYRCLVICGAAWDYKYLTVKVKASYVRIDT
GILEVPGTGEVQLICQARGYPLAEVSWQNVSVPANTSHIRTPEGLYQVTSVLRLKPQPNRNFSC
MFWNAHMKELTSAIIDPLSWMEPKVPRTRSLHAFIPACTVALIFLATVIAQRKRLWGKLYSRKR
SEPAVLGVGKIQ

hide sequence

Ensembl Acc Id:

ENSRNOP00000021615 ⟸ ENSRNOT00000021614

RefSeq Acc Id:	XP_038935912 ⟸ XM_039079984
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038935917 ⟸ XM_039079989
- Peptide Label:	isoform X3

Ensembl Acc Id:

ENSRNOP00000102353 ⟸ ENSRNOT00000133905

Protein Domains

Immunoglobulin

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4AAV6-F1-model_v2	AlphaFold	D4AAV6	1-268	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306403	AgrOrtholog
BioCyc Gene	G2FUF-55966	BioCyc
Ensembl Genes	ENSRNOG00000016136	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000021614	ENTREZGENE
	ENSRNOT00000021614.8	UniProtKB/TrEMBL
	ENSRNOT00000133905.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
InterPro	BTN3A2-like_Ig-C	UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	Ig_sub	UniProtKB/TrEMBL
	T-cell_Activation_Regulation	UniProtKB/TrEMBL
KEGG Report	rno:309304	UniProtKB/TrEMBL
NCBI Gene	309304	ENTREZGENE
PANTHER	PROGRAMMED CELL DEATH 1 LIGAND 2	UniProtKB/TrEMBL
	T-LYMPHOCYTE ACTIVATION ANTIGEN	UniProtKB/TrEMBL
Pfam	C2-set_3	UniProtKB/TrEMBL
PhenoGen	Pdcd1lg2	PhenoGen
RatGTEx	ENSRNOG00000016136	RatGTEx
SMART	SM00409	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48726	UniProtKB/TrEMBL
UniProt	A0ABK0LB91_RAT	UniProtKB/TrEMBL
	A6I0W5	ENTREZGENE, UniProtKB/TrEMBL
	D4AAV6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Pdcd1lg2	programmed cell death 1 ligand 2	Pdcd1lg2_predicted	programmed cell death 1 ligand 2 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Pdcd1lg2_predicted	programmed cell death 1 ligand 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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