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Gene: Rab35 (RAB35, member RAS oncogene family) Rattus norvegicus

Analyze

Symbol:

Rab35

Name:

RAB35, member RAS oncogene family

RGD ID:

1306362

Description:

Predicted to enable G protein activity and anion binding activity. Involved in cellular response to nerve growth factor stimulus and protein localization to endosome. Located in endosome membrane. Is active in synaptic vesicle membrane. Orthologous to human RAB35 (RAB35, member RAS oncogene family); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; aconitine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC288700; ras-related protein Rab-35

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RAB35 (RAB35, member RAS oncogene family)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Rab35 (RAB35, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rab35 (RAB35, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RAB35 (RAB35, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RAB35 (RAB35, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rab35 (RAB35, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RAB35 (RAB35, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RAB35 (RAB35, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rab35 (RAB35, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Rab35 (RAB35, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	RAB35 (RAB35, member RAS oncogene family)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rab35 (RAB35, member RAS oncogene family)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rab35b (RAB35, member RAS oncogene family b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rab35a (RAB35, member RAS oncogene family a)	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	rab-35	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Rab35	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rab35	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	rab35	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	46,627,302 - 46,642,815 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	46,627,864 - 46,645,426 (-)	Ensembl				GRCr8
mRatBN7.2	12	40,967,102 - 40,981,183 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	40,967,103 - 40,991,195 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	42,134,273 - 42,148,364 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	42,747,919 - 42,762,012 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	41,808,458 - 41,822,551 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	46,704,274 - 46,718,404 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	46,704,275 - 46,718,355 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	48,502,883 - 48,516,964 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	42,228,638 - 42,242,719 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	42,590,110 - 42,604,191 (-)	NCBI		Celera
RGSC_v3.1	12	42,092,026 - 42,106,107 (-)	NCBI
Cytogenetic Map	12	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-diaminodiphenylmethane (ISO)

6-propyl-2-thiouracil (EXP)

aconitine (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

ethanol (ISO)

folic acid (ISO)

FR900359 (ISO)

furan (EXP)

gentamycin (EXP)

ivermectin (ISO)

methapyrilene (ISO)

methimazole (EXP)

nitrates (ISO)

okadaic acid (ISO)

paracetamol (ISO)

silicon dioxide (ISO)

sodium fluoride (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

tamibarotene (ISO)

tetracycline (ISO)

thioacetamide (EXP)

thiram (ISO)

triphenyl phosphate (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antigen processing and presentation (IEA,ISO)

cellular response to nerve growth factor stimulus (IDA)

endocytic recycling (IBA)

endosomal transport (IEA,ISO,ISS)

intracellular protein localization (IEA,ISO)

mitotic cytokinesis (IEA,ISO)

neuron projection development (ISO,ISS)

plasma membrane to endosome transport (IEA,ISO)

protein localization to endosome (IEA,IMP,ISO,ISS)

protein transport (IEA)

Rab protein signal transduction (IEA)

Cellular Component

cell projection membrane (IEA,ISO)

clathrin-coated endocytic vesicle (IEA,ISO)

clathrin-coated pit (IEA,ISO)

clathrin-coated vesicle (IEA)

cytoplasmic vesicle (IEA)

endosome (IEA)

endosome membrane (IBA,IDA)

intercellular bridge (IEA,ISO)

melanosome (IEA)

plasma membrane (IBA,IEA,ISO,ISS)

synaptic vesicle membrane (EXP,IDA,IEP)

Molecular Function

G protein activity (IEA,ISO,ISS)

GDP binding (IEA,ISO,ISS)

GTP binding (IBA,IEA,ISO,ISS)

GTPase activity (IBA,IEA,ISO,ISS)

hydrolase activity (IEA)

metal ion binding (IEA)

nucleotide binding (IEA)

phosphatidylinositol-4,5-bisphosphate binding (IEA,ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rab35 establishes the EHD1-association site by coordinating two distinct effectors during neurite outgrowth.	Kobayashi H and Fukuda M, J Cell Sci. 2013 Jun 1;126(Pt 11):2424-35. doi: 10.1242/jcs.117846. Epub 2013 Apr 9.
4.	Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis.	Pavlos NJ, etal., J Neurosci. 2010 Oct 6;30(40):13441-53. doi: 10.1523/JNEUROSCI.0907-10.2010.
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15489334	PMID:16950109	PMID:17562788	PMID:18614015	PMID:19056867	PMID:19289122	PMID:19717423	PMID:20458337	PMID:20937701	PMID:21951725	PMID:22344257	PMID:24600047
PMID:24852758	PMID:25694427	PMID:27535913	PMID:28131823

Genomics

Comparative Map Data

Rab35
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	46,627,302 - 46,642,815 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	46,627,864 - 46,645,426 (-)	Ensembl				GRCr8
mRatBN7.2	12	40,967,102 - 40,981,183 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	40,967,103 - 40,991,195 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	42,134,273 - 42,148,364 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	42,747,919 - 42,762,012 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	41,808,458 - 41,822,551 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	46,704,274 - 46,718,404 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	46,704,275 - 46,718,355 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	48,502,883 - 48,516,964 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	42,228,638 - 42,242,719 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	42,590,110 - 42,604,191 (-)	NCBI		Celera
RGSC_v3.1	12	42,092,026 - 42,106,107 (-)	NCBI
Cytogenetic Map	12	q16	NCBI

RAB35
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	120,095,099 - 120,116,753 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	120,095,094 - 120,117,502 (-)	Ensembl			hg38	GRCh38
GRCh37	12	120,532,903 - 120,554,557 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	119,017,286 - 119,038,982 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	118,995,625 - 119,017,319	NCBI
Celera	12	120,166,012 - 120,187,759 (-)	NCBI		Celera
Cytogenetic Map	12	q24.23	NCBI
HuRef	12	117,542,010 - 117,563,709 (-)	NCBI		HuRef
CHM1_1	12	120,500,857 - 120,522,609 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	120,082,260 - 120,103,928 (-)	NCBI		T2T-CHM13v2.0

Rab35
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	115,769,953 - 115,785,217 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	115,769,967 - 115,785,795 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	115,631,904 - 115,647,158 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	115,631,908 - 115,647,736 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	116,081,996 - 116,097,167 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	115,892,986 - 115,908,157 (+)	NCBI		MGSCv36	mm8
Celera	5	112,733,510 - 112,748,639 (+)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	56.1	NCBI

Rab35
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955455	11,484,557 - 11,502,630 (+)	Ensembl
ChiLan1.0	NW_004955455	11,484,557 - 11,502,630 (+)	NCBI	ChiLan1.0	ChiLan1.0

RAB35
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	128,157,410 - 128,181,700 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	128,153,783 - 128,175,399 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	117,670,693 - 117,692,322 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	121,046,536 - 121,068,152 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2

RAB35
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	16,061,872 - 16,078,489 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	16,063,043 - 16,078,481 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	16,066,489 - 16,083,503 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	16,329,134 - 16,346,157 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	16,329,144 - 16,346,137 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	16,290,210 - 16,307,226 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	16,367,606 - 16,384,611 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	16,408,625 - 16,425,638 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Rab35
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	146,296,588 - 146,313,298 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936668	800,854 - 810,128 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936668	795,477 - 812,187 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RAB35
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	40,124,326 - 40,141,668 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	40,124,318 - 40,141,261 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	42,686,678 - 42,703,619 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RAB35
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	115,447,483 - 115,468,964 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	115,447,489 - 115,468,941 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	129,638,557 - 129,660,232 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rab35
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	13,520,254 - 13,537,651 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624747	13,520,228 - 13,538,664 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Rab35
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	38,178,582 - 38,193,276 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Rab35
266 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	364
Count of miRNA genes:	209
Interacting mature miRNAs:	246
Transcripts:	ENSRNOT00000030031
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	24805022	52308831	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
8693635	Alc28	Alcohol consumption QTL 28	2.7	0.439	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	50386405	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	25989355	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
1300162	Bp188	Blood pressure QTL 188	3.19		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	37764145	51558799	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
1600386	Calcic2	Intracellular calcium level QTL 2		0.001	platelet physiology trait (VT:0005464)	platelet intracellular calcium level (CMO:0000922)	12	33700432	46784661	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	17464979	46784661	Rat
1556747	Calcic1	Intracellular calcium level QTL 1		3.6	platelet calcium amount (VT:0010500)	platelet intracellular calcium level (CMO:0000922)	12	33700432	46784661	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	33700432	51558799	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
8693658	Alc33	Alcohol consumption QTL 33	2.1	0.68	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	49212240	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
631543	Bp83	Blood pressure QTL 83	5.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	44139558	52308831	Rat

Markers in Region

RH131658

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	40,967,284 - 40,967,496 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	46,704,457 - 46,704,668	NCBI	Rnor6.0
Rnor_5.0	12	48,503,066 - 48,503,277	UniSTS	Rnor5.0
RGSC_v3.4	12	42,228,821 - 42,229,032	UniSTS	RGSC3.4
Celera	12	42,590,293 - 42,590,504	UniSTS
Cytogenetic Map	12	q16	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	162	91	90	59	92	59	6	356	192	11	141	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001013046	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008769221	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271212	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271213	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC123425	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC085769	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000030031 ⟹ ENSRNOP00000029070

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	46,627,864 - 46,642,256 (-)	Ensembl
mRatBN7.2 Ensembl	12	40,967,103 - 40,981,310 (-)	Ensembl
Rnor_6.0 Ensembl	12	46,704,275 - 46,718,355 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103324 ⟹ ENSRNOP00000088611

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	46,627,864 - 46,641,837 (-)	Ensembl
mRatBN7.2 Ensembl	12	40,967,103 - 40,981,077 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106644 ⟹ ENSRNOP00000085013

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	46,627,864 - 46,645,426 (-)	Ensembl
mRatBN7.2 Ensembl	12	40,967,103 - 40,991,195 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000113162 ⟹ ENSRNOP00000081478

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	46,627,864 - 46,643,197 (-)	Ensembl
mRatBN7.2 Ensembl	12	40,967,103 - 40,982,459 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000114049 ⟹ ENSRNOP00000092476

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	46,627,864 - 46,637,592 (-)	Ensembl
mRatBN7.2 Ensembl	12	40,967,103 - 40,976,831 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000136793 ⟹ ENSRNOP00000101902

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	46,627,864 - 46,642,858 (-)	Ensembl

RefSeq Acc Id:

NM_001013046 ⟹ NP_001013064

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	46,627,863 - 46,641,944 (-)	NCBI
mRatBN7.2	12	40,967,102 - 40,981,183 (-)	NCBI
Rnor_6.0	12	46,704,274 - 46,718,355 (-)	NCBI
Rnor_5.0	12	48,502,883 - 48,516,964 (-)	NCBI
RGSC_v3.4	12	42,228,638 - 42,242,719 (-)	RGD
Celera	12	42,590,110 - 42,604,191 (-)	RGD

Sequence:

show sequence

CGGGAAGTGGATCCGCCGCTGCCGGAGCAGCCGGGAGGGAGCTGCGGATCCCGAGGCCAGTACC
GACCCCGCCCGCCCGCGCGCGCGCGCCGCCCCCGCCCGCCATGGCCCGGGACTACGACCACCTC
TTCAAGCTGCTCATCATCGGCGACAGCGGTGTGGGCAAGAGCAGCTTGCTGTTACGATTTGCAG
ACAACACCTTCTCAGGCAGCTACATCACCACAATCGGAGTGGATTTCAAGATCCGGACTGTGGA
GATCAACGGGGAGAAGGTGAAGCTGCAGATCTGGGACACTGCAGGGCAGGAGCGCTTCCGCACC
ATCACCTCTACGTATTATCGGGGGACCCACGGGGTCATTGTGGTTTACGATGTCACTAGTGCCG
AGTCCTTTGTCAATGTCAAGCGATGGCTTCATGAAATCAACCAGAACTGTGACGATGTGTGCCG
AATATTAGTGGGCAATAAGAATGACGACCCTGAGCGGAAGGTGGTAGAGACAGAAGACGCCTAC
AAATTTGCCGGGCAGATGGGGATCCAGCTCTTTGAGACCAGTGCCAAGGAGAACGTCAATGTGG
AAGAGATGTTCAACTGCATCACAGAGCTGGTTCTACGGGCAAAGAAAGACAACTTGGCCAAACA
GCAGCAGCAGCAACAGAACGATGTGGTGAAGCTCACCAAAAACAGTAAACGAAAGAAACGCTGC
TGCTAATGCCCCGCCCACCCACCGCAGAGACTGCACTGCACCTCCCAGCCTGAGGCCTCGGCGG
CTCTCGGGGACAGTCTCAGTCTAGTGCCGTTATTTAAAGAATTCTCTCCACGTTTTTTGTATCG
GGAGGCGCCATCGGCACTTCCTCTCCTTTCCCCTTGAGTGCCAAGAAGGTGTTGGACGAGCCTG
CCCTTCCCCACGGTGCCCTTTTCCCTGCCGAGGCGCCTGGACCTGGTGAGGACGCTGCCAGCTG
AGTGGACCGATTAACCAGTTTGTACATAGTGTATATTGCATTAACCAGCTGCACACCCTCAGCC
TGCTCTGGCTTTTGGCTCCTTCCGCCAACCTGCTGCAACAGACCCTCCCGAGCCCTCCACACCC
ATCTCGACGGCAGCTTCCTGAGGAGCCAACCTCGTGTCCTAGCTGAGTCCTTGGCCATCCCTGG
CCCATGGAGTGCACTCCACATGGCTCCTACCTACAGCTGCTCTGGGAACCTGGCCTCCACACAG
GCCCTAGGTCTTCAGTTCCACGAGGAACTCAGTCCTGCCCTTTTGGACAACAGGTTTCTCATTC
TGCCTTCTAGATGCCTCTGCTACAAACCCAGGGGGAGCCGCGGCTTCTCACTTACCCACCATGT
TTCAGTTCCTGCAGAAAGGTAGTGGCACACCTGTAGAGATGGAGCTTGCGAGGCGGAGGGGGGA
GCATTCTCTTAACAAATACAGCCAATGAGGCCAAATCAAACAAAGTTCCTCACAGTTATTTCCC
CGAGATGTGATTGGCTCAGCAGTCAGCAAACGTTGTGACTGTCCCACTTTGGGCTCAGTATTTT
TAGAAAAGGTGATGGCTTCTATTCAGTGCAGGGCCAGGCTCTCTCCCTTCTGTGGTAAAGGAAG
GCTTTGCACCCTCGTCCCTGTGCTCGAGAGCCTCCCGCTGGAGACAGTTTGTAATGGAGCACCA
GGCACCTGTGGCAGAGCCAGGGGGTTGCTGGGCTATGGGAAGACACTCCCAGGCTGGGACAGGT
AGCTTTTGCATTACTGACAGATCTGTTTTTAGTTATGAAGGTGGTAGGAAGATTTCTTAGCCAC
TGGGAAGTGGTAGTGGGGTTGGGGCAGCCAGTATTCACCTACCCCCGCCCCCAGCAGAGTAATC
TGCATTTGATTACTTCCCCCTTCCCCGGGACACTTGGTTGGTTCCCTTTCCCCTAAAGGATCAC
GTAACTCGGAAGAACTGATTTGGACATCATAATGTGTTTTATTAGACTTCCTTTCCTAGGCGAT
TTCCAGGCACAGTCCTGACTGGACAATCATCACAGAATACTGCAGATTTTCCATGTTAACACTG
TGGATGGGGTTTCAATCAATAAAACTGGGGCTTTCTTCTCAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063271212 ⟹ XP_063127282

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	46,627,302 - 46,642,815 (-)	NCBI

RefSeq Acc Id:

XM_063271213 ⟹ XP_063127283

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	46,629,264 - 46,642,035 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001013064	(Get FASTA)	NCBI Sequence Viewer
	XP_063127282	(Get FASTA)	NCBI Sequence Viewer
	XP_063127283	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH85769	(Get FASTA)	NCBI Sequence Viewer
	EDM13866	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000088611
	ENSRNOP00000101902
GenBank Protein	Q5U316	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001013064 ⟸ NM_001013046

- UniProtKB:

Q5U316 (UniProtKB/Swiss-Prot), A6J1S7 (UniProtKB/TrEMBL), A0A8I6A5F7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MARDYDHLFKLLIIGDSGVGKSSLLLRFADNTFSGSYITTIGVDFKIRTVEINGEKVKLQIWDT
AGQERFRTITSTYYRGTHGVIVVYDVTSAESFVNVKRWLHEINQNCDDVCRILVGNKNDDPERK
VVETEDAYKFAGQMGIQLFETSAKENVNVEEMFNCITELVLRAKKDNLAKQQQQQQNDVVKLTK
NSKRKKRCC

hide sequence

Ensembl Acc Id:

ENSRNOP00000029070 ⟸ ENSRNOT00000030031

Ensembl Acc Id:

ENSRNOP00000085013 ⟸ ENSRNOT00000106644

Ensembl Acc Id:

ENSRNOP00000081478 ⟸ ENSRNOT00000113162

Ensembl Acc Id:

ENSRNOP00000088611 ⟸ ENSRNOT00000103324

Ensembl Acc Id:

ENSRNOP00000092476 ⟸ ENSRNOT00000114049

RefSeq Acc Id:	XP_063127282 ⟸ XM_063271212
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZT09 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063127283 ⟸ XM_063271213
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSRNOP00000101902 ⟸ ENSRNOT00000136793

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5U316-F1-model_v2	AlphaFold	Q5U316	1-201	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698684

Promoter ID:

EPDNEW_R9209

Type:

multiple initiation site

Name:

Rab35_1

Description:

RAB35, member RAS oncogene family

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	46,718,350 - 46,718,410	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306362	AgrOrtholog
BioCyc Gene	G2FUF-19010	BioCyc
Ensembl Genes	ENSRNOG00000022014	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000103324	ENTREZGENE
	ENSRNOT00000136793	ENTREZGENE
Gene3D-CATH	3.40.50.300	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7135343	IMAGE-MGC_LOAD
InterPro	P-loop_NTPase	UniProtKB/Swiss-Prot
	Rab	UniProtKB/Swiss-Prot
	Rab35	UniProtKB/Swiss-Prot
	Small_GTP-bd_dom	UniProtKB/Swiss-Prot
	Small_GTPase	UniProtKB/Swiss-Prot
KEGG Report	rno:288700	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93682	IMAGE-MGC_LOAD
NCBI Gene	288700	ENTREZGENE
PANTHER	RAS-RELATED PROTEIN RAB	UniProtKB/Swiss-Prot
Pfam	Ras	UniProtKB/Swiss-Prot
PhenoGen	Rab35	PhenoGen
PRINTS	RASTRNSFRMNG	UniProtKB/Swiss-Prot
PROSITE	RAB	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000022014	RatGTEx
SMART	ARF	UniProtKB/Swiss-Prot
	RAB	UniProtKB/Swiss-Prot
	RAN	UniProtKB/Swiss-Prot
	RAS	UniProtKB/Swiss-Prot
	RHO	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZT09	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A0E0_RAT	UniProtKB/TrEMBL
	A0A8I6A5F7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6ADQ8_RAT	UniProtKB/TrEMBL
	A0A8L2QFM9_RAT	UniProtKB/TrEMBL
	A0ABK0LBK1_RAT	UniProtKB/TrEMBL
	A6J1S7	ENTREZGENE, UniProtKB/TrEMBL
	Q5U316	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Rab35	RAB35, member RAS oncogene family	Rab35_predicted	RAB35, member RAS oncogene family (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Rab35_predicted	RAB35, member RAS oncogene family (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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