Tfap2b (transcription factor AP-2 beta) - Rat Genome Database

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Gene: Tfap2b (transcription factor AP-2 beta) Rattus norvegicus
Analyze
Symbol: Tfap2b
Name: transcription factor AP-2 beta
RGD ID: 1306321
Description: Enables chromatin binding activity. Involved in response to xenobiotic stimulus. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Char syndrome and patent ductus arteriosus. Orthologous to human TFAP2B (transcription factor AP-2 beta); INTERACTS WITH 1,2-dimethylhydrazine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC301285; Tcfap2b; transcription factor AP-2-beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8929,282,703 - 29,312,568 (+)NCBIGRCr8
mRatBN7.2921,786,251 - 21,816,054 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl921,786,258 - 21,814,520 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx930,275,269 - 30,304,651 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0935,415,401 - 35,444,816 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0933,717,660 - 33,747,055 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0925,410,669 - 25,440,568 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl925,410,669 - 25,440,411 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0924,271,604 - 24,302,855 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4918,052,402 - 18,082,202 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1918,049,775 - 18,079,184 (+)NCBI
Celera919,374,332 - 19,403,772 (+)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Tfap2bRatInsulin Resistance  ISOTFAP2B (Homo sapiens)1601544 RGD 
Tfap2bRatpatent ductus arteriosus susceptibilityISOTFAP2B (Homo sapiens)1601543Char Syndrome more ...RGD 
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Original Reference(s)
Tfap2bRatChar syndrome  ISOTFAP2B (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10368122 more ...
Tfap2bRatCraniosynostosis Syndrome, Autosomal Recessive  ISOTFAP2B (Homo sapiens)8554872ClinVar Annotator: match by term: Craniosynostosis syndromeClinVarPMID:31292255
Tfap2bRatgenetic disease  ISOTFAP2B (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:15684060 more ...
Tfap2bRatHypertelorism  ISOTFAP2B (Homo sapiens)8554872ClinVar Annotator: match by term: HypertelorismClinVarPMID:10802654 more ...
Tfap2bRatintestinal pseudo-obstruction  ISOTFAP2B (Homo sapiens)8554872ClinVar Annotator: match by term: Chronic intestinal pseudoobstructionClinVarPMID:25741868
Tfap2bRatPatent Ductus Arteriosus 2  ISOTFAP2B (Homo sapiens)8554872ClinVar Annotator: match by term: Patent ductus arteriosus 2ClinVarPMID:15684060 more ...
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Original Reference(s)
Tfap2bRatBody Weight  ISOTFAP2B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22344219
Tfap2bRatChar syndrome  ISOTFAP2B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Tfap2bRatCongenital Hand Deformities  ISOTFAP2B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:10802654
Tfap2bRatCraniofacial Abnormalities  ISOTFAP2B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:10802654
Tfap2bRatpatent ductus arteriosus  ISOTFAP2B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:10802654 and PMID:19336370
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Original Reference(s)
Tfap2bRatangle-closure glaucoma  ISSTfap2b (Mus musculus)13592920 MouseDO 
Tfap2bRatChar syndrome  ISSTfap2b (Mus musculus)13592920OMIM:169100MouseDO 
Tfap2bRatpatent ductus arteriosus  ISSTfap2b (Mus musculus)13592920OMIM:607411MouseDO 
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Original Reference(s)
Tfap2bRatChar syndrome  ISOTFAP2B (Homo sapiens)7240710 OMIM 
Tfap2bRatPatent Ductus Arteriosus 2  ISOTFAP2B (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Tfap2bRat1,1-dichloroethene decreases expressionISOTfap2b (Mus musculus)6480464vinylidene chloride results in decreased expression of TFAP2B mRNACTDPMID:26682919
Tfap2bRat1,2-dimethylhydrazine multiple interactionsEXP 6480464[APC protein affects the susceptibility to 1 and 2-Dimethylhydrazine] which results in decreased expression of TFAP2B mRNACTDPMID:27840820
Tfap2bRat1,2-dimethylhydrazine decreases expressionISOTfap2b (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of TFAP2B mRNACTDPMID:22206623
Tfap2bRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOTfap2b (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of TFAP2B mRNACTDPMID:24058054
Tfap2bRat2,4-dibromophenyl 2,4,5-tribromophenyl ether decreases expressionISOTFAP2B (Homo sapiens)64804642 more ...CTDPMID:26705709
Tfap2bRat3-chloropropane-1,2-diol decreases expressionEXP 6480464alpha-Chlorohydrin results in decreased expression of TFAP2B mRNACTDPMID:28522335
Tfap2bRat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOTfap2b (Mus musculus)6480464[Palmitic Acid co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of TFAP2B mRNA more ...CTDPMID:34968464
Tfap2bRat4,4'-sulfonyldiphenol decreases expressionISOTfap2b (Mus musculus)6480464bisphenol S results in decreased expression of TFAP2B mRNACTDPMID:30951980
Tfap2bRat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of TFAP2B mRNACTDPMID:25825206
Tfap2bRat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of TFAP2B mRNACTDPMID:30047161
Tfap2bRataflatoxin B1 decreases methylationISOTFAP2B (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of TFAP2B geneCTDPMID:27153756
Tfap2bRatall-trans-retinoic acid decreases expressionISOTFAP2B (Homo sapiens)6480464Tretinoin results in decreased expression of TFAP2B mRNACTDPMID:23724009
Tfap2bRatalpha-Zearalanol multiple interactionsEXP 6480464[Zeranol co-treated with perfluorooctanoic acid] results in increased expression of TFAP2B mRNACTDPMID:35163327
Tfap2bRatamitrole decreases expressionEXP 6480464Amitrole results in decreased expression of TFAP2B mRNACTDPMID:30047161
Tfap2bRatAroclor 1254 decreases expressionISOTfap2b (Mus musculus)6480464Chlorodiphenyl (54% Chlorine) results in decreased expression of TCFAP2B mRNACTDPMID:23650126
Tfap2bRatarotinoid acid multiple interactionsISOTFAP2B (Homo sapiens)6480464[4-(2-(5 more ...CTDPMID:34480604
Tfap2bRatatrazine decreases expressionISOTFAP2B (Homo sapiens)6480464Atrazine results in decreased expression of TFAP2B mRNACTDPMID:22378314
Tfap2bRatbelinostat increases expressionISOTFAP2B (Homo sapiens)6480464belinostat results in increased expression of TFAP2B mRNACTDPMID:26272509
Tfap2bRatbelinostat multiple interactionsISOTFAP2B (Homo sapiens)6480464[NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFAP2B mRNACTDPMID:27188386
Tfap2bRatbenzalkonium chloride multiple interactionsISOTfap2b (Mus musculus)6480464[IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of TFAP2B mRNACTDPMID:30171875

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Biological Process
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Original Reference(s)
Tfap2bRataorta morphogenesis involved_inISSUniProtKB:Q613131600115GO_REF:0000024UniProtGO_REF:0000024
Tfap2bRataorta morphogenesis involved_inISOTfap2b (Mus musculus)1624291 PMID:21829553RGDPMID:21829553
Tfap2bRataorta morphogenesis involved_inIEAUniProtKB:Q61313 and ensembl:ENSMUSP000000270591600115GO_REF:0000107EnsemblGO_REF:0000107
Tfap2bRatcollecting duct development involved_inISSUniProtKB:Q613131600115GO_REF:0000024UniProtGO_REF:0000024
Tfap2bRatcollecting duct development involved_inIEAUniProtKB:Q61313 and ensembl:ENSMUSP000000270591600115GO_REF:0000107EnsemblGO_REF:0000107
Tfap2bRatcollecting duct development involved_inISOTfap2b (Mus musculus)1624291 PMID:12695560RGDPMID:12695560
Tfap2bRatdistal tubule development involved_inISSUniProtKB:Q613131600115GO_REF:0000024UniProtGO_REF:0000024
Tfap2bRatdistal tubule development involved_inISOTfap2b (Mus musculus)1624291 PMID:12695560RGDPMID:12695560
Tfap2bRatdistal tubule development involved_inIEAUniProtKB:Q61313 and ensembl:ENSMUSP000000270591600115GO_REF:0000107EnsemblGO_REF:0000107
Tfap2bRatductus arteriosus closure involved_inISSUniProtKB:Q613131600115GO_REF:0000024UniProtGO_REF:0000024
Tfap2bRatductus arteriosus closure involved_inIEAUniProtKB:Q61313 and ensembl:ENSMUSP000000270591600115GO_REF:0000107EnsemblGO_REF:0000107
Tfap2bRatductus arteriosus closure involved_inISOTfap2b (Mus musculus)1624291 PMID:18635823 and PMID:21829553RGDPMID:18635823 and PMID:21829553
Tfap2bRatfat cell differentiation involved_inISOTFAP2B (Homo sapiens)1624291 PMID:16373396RGDPMID:16373396
Tfap2bRatfat cell differentiation involved_inIEAUniProtKB:Q61313 and ensembl:ENSMUSP000000270591600115GO_REF:0000107EnsemblGO_REF:0000107
Tfap2bRatfat cell differentiation involved_inISOTfap2b (Mus musculus)1624291 PMID:15940393RGDPMID:15940393
Tfap2bRatfat cell differentiation involved_inIEAUniProtKB:Q92481 and ensembl:ENSP000003772651600115GO_REF:0000107EnsemblGO_REF:0000107
Tfap2bRatforelimb morphogenesis involved_inISSUniProtKB:Q613131600115GO_REF:0000024UniProtGO_REF:0000024
Tfap2bRatforelimb morphogenesis involved_inIEAUniProtKB:Q61313 and ensembl:ENSMUSP000000270591600115GO_REF:0000107EnsemblGO_REF:0000107
Tfap2bRatforelimb morphogenesis involved_inISOTfap2b (Mus musculus)1624291 PMID:21829553RGDPMID:21829553
Tfap2bRatgene expression involved_inIEAUniProtKB:Q61313 and ensembl:ENSMUSP000000270591600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component

  
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Original Reference(s)
Tfap2bRatnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Tfap2bRatnucleus located_inIEAInterPro:IPR004979 and InterPro:IPR0081221600115GO_REF:0000002InterProGO_REF:0000002
Tfap2bRatnucleus located_inIEAUniProtKB:Q92481 and ensembl:ENSP000003772651600115GO_REF:0000107EnsemblGO_REF:0000107
Tfap2bRatnucleus located_inISOTfap2b (Mus musculus)1624291 PMID:25187989RGDPMID:25187989
Tfap2bRatnucleus is_active_inIBAFB:FBgn0261953 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tfap2bRatnucleus located_inIEAUniProtKB:Q61313 and ensembl:ENSMUSP000000270591600115GO_REF:0000107EnsemblGO_REF:0000107
Tfap2bRatnucleus located_inISOTFAP2B (Homo sapiens)1624291 PMID:20607706RGDPMID:20607706
Tfap2bRatnucleus located_inISSUniProtKB:Q924811600115GO_REF:0000024UniProtGO_REF:0000024

Molecular Function
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Tfap2bRatchromatin binding  IDA 5147969 RGD 
Tfap2bRatcis-regulatory region sequence-specific DNA binding enablesISOTFAP2B (Homo sapiens)1624291 PMID:16373396RGDPMID:16373396
Tfap2bRatcis-regulatory region sequence-specific DNA binding enablesIEAUniProtKB:Q92481 and ensembl:ENSP000003772651600115GO_REF:0000107EnsemblGO_REF:0000107
Tfap2bRatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
Tfap2bRatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOTFAP2B (Homo sapiens)1624291 PMID:7559606RGDPMID:7559606
Tfap2bRatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:Q92481 and ensembl:ENSP000003772651600115GO_REF:0000107EnsemblGO_REF:0000107
Tfap2bRatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOTfap2b (Mus musculus)1624291 PMID:21829553 and PMID:7555706RGDPMID:21829553 and PMID:7555706
Tfap2bRatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:Q61313 and ensembl:ENSMUSP000000270591600115GO_REF:0000107EnsemblGO_REF:0000107
Tfap2bRatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIBAMGI:104671 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tfap2bRatDNA-binding transcription factor activity enablesISSUniProtKB:Q924811600115GO_REF:0000024UniProtGO_REF:0000024
Tfap2bRatDNA-binding transcription factor activity enablesIEAUniProtKB:Q92481 and ensembl:ENSP000003772651600115GO_REF:0000107EnsemblGO_REF:0000107
Tfap2bRatDNA-binding transcription factor activity enablesIEAInterPro:IPR004979 and InterPro:IPR0081221600115GO_REF:0000002InterProGO_REF:0000002
Tfap2bRatDNA-binding transcription factor activity enablesISOTFAP2B (Homo sapiens)1624291 PMID:11505339 more ...RGDPMID:11505339 more ...
Tfap2bRatDNA-binding transcription factor activity, RNA polymerase II-specific enablesISOTfap2b (Mus musculus)1624291 PMID:21829553RGDPMID:21829553
Tfap2bRatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIEAUniProtKB:Q61313 and ensembl:ENSMUSP000000270591600115GO_REF:0000107EnsemblGO_REF:0000107
Tfap2bRatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIEAUniProtKB:Q92481 and ensembl:ENSP000003772651600115GO_REF:0000107EnsemblGO_REF:0000107
Tfap2bRatDNA-binding transcription factor activity, RNA polymerase II-specific enablesISOTFAP2B (Homo sapiens)1624291 PMID:7555706RGDPMID:7555706
Tfap2bRatDNA-binding transcription factor activity, RNA polymerase II-specific enablesISSUniProtKB:Q613131600115GO_REF:0000024UniProtGO_REF:0000024
Tfap2bRatprotein binding enablesISOTFAP2B (Homo sapiens)1624291UniProtKB:P61981 more ...RGDPMID:11694877 more ...
Tfap2bRatprotein binding enablesISOTfap2b (Mus musculus)1624291PR:Q6VUP9 more ...RGDPMID:11694877 and PMID:14572467
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Reference Title
Reference Citation
1. Brainstem levels of transcription factor AP-2 in rat are changed after treatment with phenelzine, but not with citalopram. Berggard C, etal., BMC Pharmacol. 2005 Jan 21;5(1):1.
2. Chronic pharmacological treatment with certain antidepressants alters the expression and DNA-binding activity of transcription factor AP-2. Damberg M, etal., Life Sci. 2000 Dec 29;68(6):669-78.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Transcription factor AP-2beta regulates the neurotransmitter phenotype and maturation of chromaffin cells. Hong SJ, etal., Mol Cell Neurosci. 2011 Jan;46(1):245-51. Epub 2010 Sep 27.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Functional dissection of an AP-2 beta2 appendage-binding sequence within the autosomal recessive hypercholesterolemia protein. Mishra SK, etal., J Biol Chem. 2005 May 13;280(19):19270-80. Epub 2005 Feb 22.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Decrease in the AP-2 DNA-binding activity and in the protein expression of AP-2 alpha and AP-2 beta in frontal cortex of rats treated with lithium for 6 weeks. Rao JS, etal., Neuropsychopharmacology. 2005 Nov;30(11):2006-13.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Mutations in TFAP2B cause Char syndrome, a familial form of patent ductus arteriosus. Satoda M, etal., Nat Genet. 2000 May;25(1):42-6.
15. The transcription factor AP-2beta causes cell enlargement and insulin resistance in 3T3-L1 adipocytes. Tao Y, etal., Endocrinology. 2006 Apr;147(4):1685-96. Epub 2005 Dec 22.
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PMID:7555706   PMID:7559606   PMID:9271117   PMID:11505339   PMID:11694877   PMID:12072434   PMID:12169688   PMID:12695560   PMID:15940393   PMID:16373396   PMID:17525748   PMID:19325541  
PMID:20448150   PMID:20607706   PMID:21539825   PMID:21829553  



Tfap2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8929,282,703 - 29,312,568 (+)NCBIGRCr8
mRatBN7.2921,786,251 - 21,816,054 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl921,786,258 - 21,814,520 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx930,275,269 - 30,304,651 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0935,415,401 - 35,444,816 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0933,717,660 - 33,747,055 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0925,410,669 - 25,440,568 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl925,410,669 - 25,440,411 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0924,271,604 - 24,302,855 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4918,052,402 - 18,082,202 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1918,049,775 - 18,079,184 (+)NCBI
Celera919,374,332 - 19,403,772 (+)NCBICelera
Cytogenetic Map9q13NCBI
TFAP2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38650,818,355 - 50,847,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl650,818,723 - 50,847,619 (+)EnsemblGRCh38hg38GRCh38
GRCh37650,786,584 - 50,815,332 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36650,894,398 - 50,923,285 (+)NCBINCBI36Build 36hg18NCBI36
Build 34650,894,541 - 50,919,634NCBI
Celera652,342,514 - 52,371,233 (+)NCBICelera
Cytogenetic Map6p12.3NCBI
HuRef650,517,924 - 50,546,498 (+)NCBIHuRef
CHM1_1650,789,288 - 50,818,174 (+)NCBICHM1_1
T2T-CHM13v2.0650,660,443 - 50,690,369 (+)NCBIT2T-CHM13v2.0
Tfap2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39119,279,132 - 19,309,071 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl119,279,138 - 19,308,800 (+)EnsemblGRCm39 Ensembl
GRCm38119,208,908 - 19,238,845 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl119,208,914 - 19,238,576 (+)EnsemblGRCm38mm10GRCm38
MGSCv37119,198,995 - 19,228,815 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36119,194,128 - 19,223,948 (+)NCBIMGSCv36mm8
Celera119,103,515 - 19,133,268 (+)NCBICelera
Cytogenetic Map1A3NCBI
cM Map16.19NCBI
Tfap2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554117,142,607 - 7,170,467 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554117,143,095 - 7,171,285 (-)NCBIChiLan1.0ChiLan1.0
TFAP2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2565,292,098 - 65,635,311 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1661,157,412 - 61,512,510 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0650,376,157 - 50,406,740 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1651,635,899 - 51,664,691 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl651,635,899 - 51,664,691 (+)Ensemblpanpan1.1panPan2
TFAP2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11218,544,176 - 18,574,300 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1218,544,446 - 18,572,902 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1218,436,730 - 18,462,495 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01219,041,005 - 19,071,021 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1219,041,155 - 19,069,637 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11218,549,889 - 18,575,642 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01218,654,100 - 18,679,842 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01218,791,560 - 18,817,345 (+)NCBIUU_Cfam_GSD_1.0
Tfap2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494654,075,431 - 54,104,213 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364769,857,773 - 9,884,784 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364769,855,992 - 9,884,788 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TFAP2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl744,745,827 - 44,770,606 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1744,745,653 - 44,774,563 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2751,206,179 - 51,235,198 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TFAP2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11721,599,570 - 21,629,757 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1721,604,067 - 21,628,489 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604450,760,129 - 50,788,887 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tfap2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248555,355,239 - 5,381,477 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248555,353,347 - 5,381,454 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Tfap2b
188 total Variants

Predicted Target Of
Summary Value
Count of predictions:739
Count of miRNA genes:290
Interacting mature miRNAs:370
Transcripts:ENSRNOT00000030912
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 20 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat

1 to 10 of 20 rows
Tcfap2b  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2921,811,442 - 21,811,921 (+)MAPPERmRatBN7.2
Rnor_6.0925,436,224 - 25,436,702NCBIRnor6.0
Rnor_5.0924,298,653 - 24,299,131UniSTSRnor5.0
RGSC_v3.4918,078,000 - 18,078,478UniSTSRGSC3.4
Celera919,399,570 - 19,400,048UniSTS
Cytogenetic Map9q13UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 3 25 113 59 57 27 23 27 6 150 68 93 45 57 30



Ensembl Acc Id: ENSRNOT00000030912   ⟹   ENSRNOP00000030726
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl921,789,325 - 21,811,605 (+)Ensembl
Rnor_6.0 Ensembl925,410,669 - 25,440,384 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090920   ⟹   ENSRNOP00000075514
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl921,786,258 - 21,814,520 (+)Ensembl
Rnor_6.0 Ensembl925,410,717 - 25,440,411 (+)Ensembl
RefSeq Acc Id: NM_001106896   ⟹   NP_001100366
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8929,283,003 - 29,312,568 (+)NCBI
mRatBN7.2921,786,485 - 21,816,054 (+)NCBI
Rnor_6.0925,410,669 - 25,440,426 (+)NCBI
Rnor_5.0924,271,604 - 24,302,855 (+)NCBI
RGSC_v3.4918,052,402 - 18,082,202 (+)RGD
Celera919,374,332 - 19,403,772 (+)RGD
Sequence:
RefSeq Acc Id: NM_001413770   ⟹   NP_001400699
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8929,283,003 - 29,312,568 (+)NCBI
mRatBN7.2921,786,485 - 21,816,054 (+)NCBI
RefSeq Acc Id: XM_008766927   ⟹   XP_008765149
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8929,282,709 - 29,312,564 (+)NCBI
mRatBN7.2921,786,251 - 21,815,785 (+)NCBI
Rnor_6.0925,410,691 - 25,440,568 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063266871   ⟹   XP_063122941
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8929,282,703 - 29,312,564 (+)NCBI
RefSeq Acc Id: XM_063266872   ⟹   XP_063122942
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8929,283,129 - 29,312,564 (+)NCBI
RefSeq Acc Id: XR_010054581
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8929,282,709 - 29,312,564 (+)NCBI
1 to 11 of 11 rows
Protein RefSeqs NP_001100366 (Get FASTA)   NCBI Sequence Viewer  
  NP_001400699 (Get FASTA)   NCBI Sequence Viewer  
  XP_008765149 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122941 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122942 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM18662 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000030726.4
  ENSRNOP00000075514
  ENSRNOP00000075514.1
  ENSRNOP00000109016
  ENSRNOP00000109688
1 to 11 of 11 rows
RefSeq Acc Id: NP_001100366   ⟸   NM_001106896
- Peptide Label: isoform 2
- UniProtKB: D4A505 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765149   ⟸   XM_008766927
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000075514   ⟸   ENSRNOT00000090920
Ensembl Acc Id: ENSRNOP00000030726   ⟸   ENSRNOT00000030912
RefSeq Acc Id: NP_001400699   ⟸   NM_001413770
- Peptide Label: isoform 1
- UniProtKB: A0A0G2KAT2 (UniProtKB/TrEMBL)
Transcription factor AP-2 C-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2KAT2-F1-model_v2 AlphaFold A0A0G2KAT2 1-459 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696575
Promoter ID:EPDNEW_R7096
Type:initiation region
Name:Tfap2b_1
Description:transcription factor AP-2 beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0925,410,755 - 25,410,815EPDNEW


1 to 20 of 20 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-28045 BioCyc
Ensembl Genes ENSRNOG00000011823 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000030912.5 UniProtKB/TrEMBL
  ENSRNOT00000090920 ENTREZGENE
  ENSRNOT00000090920.2 UniProtKB/TrEMBL
  ENSRNOT00000145492 ENTREZGENE
  ENSRNOT00000173914 ENTREZGENE
InterPro TF_AP2 UniProtKB/TrEMBL
  TF_AP2_beta UniProtKB/TrEMBL
  TF_AP2_C UniProtKB/TrEMBL
NCBI Gene 301285 ENTREZGENE
PANTHER PTHR10812:SF14 UniProtKB/TrEMBL
  TF_AP2 UniProtKB/TrEMBL
Pfam TF_AP-2 UniProtKB/TrEMBL
PhenoGen Tfap2b PhenoGen
PRINTS AP2BTNSCPFCT UniProtKB/TrEMBL
  AP2TNSCPFCT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011823 RatGTEx
UniProt A0A0G2KAT2 ENTREZGENE, UniProtKB/TrEMBL
  D4A505 ENTREZGENE, UniProtKB/TrEMBL
1 to 20 of 20 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-06-09 Tfap2b  transcription factor AP-2 beta  Tcfap2b  transcription factor AP-2 beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Tcfap2b  transcription factor AP-2 beta   Tcfap2b_predicted  transcription factor AP-2 beta (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tcfap2b_predicted  transcription factor AP-2 beta (predicted)      Symbol and Name status set to approved 70820 APPROVED