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Gene: Htra4 (HtrA serine peptidase 4) Rattus norvegicus

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Symbol:

Htra4

Name:

HtrA serine peptidase 4

RGD ID:

1306242

Description:

Predicted to enable identical protein binding activity and serine-type endopeptidase activity. Predicted to be involved in positive regulation of apoptotic process; programmed cell death; and proteolysis. Predicted to be located in extracellular region. Orthologous to human HTRA4 (HtrA serine peptidase 4); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

high-temperature requirement factor A4; LOC306564; probable serine protease HTRA4; RGD1306242; serine protease HTR4; similar to Probable serine protease HTRA4 precursor

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HTRA4 (HtrA serine peptidase 4)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Htra4 (HtrA serine peptidase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Htra4 (HtrA serine peptidase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	HTRA4 (HtrA serine peptidase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	HTRA4 (HtrA serine peptidase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Htra4 (HtrA serine peptidase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HTRA4 (HtrA serine peptidase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	HTRA4 (HtrA serine peptidase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Htra4 (HtrA serine peptidase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Htra4 (HtrA serine peptidase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	HTRA4 (HtrA serine peptidase 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Htra4 (HtrA serine peptidase 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	htra4 (HtrA serine peptidase 4)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	HtrA2	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	HtrA2	Alliance	DIOPT (OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	htra4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	htra4	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	73,704,255 - 73,717,722 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	16	73,704,184 - 73,717,722 (+)	Ensembl				GRCr8
mRatBN7.2	16	67,001,605 - 67,015,074 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	67,001,605 - 67,015,074 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	16	72,278,796 - 72,292,263 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	75,684,765 - 75,698,232 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	70,931,287 - 70,944,763 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	71,784,819 - 71,802,765 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	71,787,966 - 71,802,763 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	71,438,259 - 71,451,530 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	16	71,424,709 - 71,438,884 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	16	64,906,135 - 64,919,639 (+)	NCBI		Celera
RGSC_v3.1	16	71,425,090 - 71,438,477 (+)	NCBI
Cytogenetic Map	16	q12.4	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

2,6-dinitrotoluene (EXP)

3,7-dihydropurine-6-thione (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

allethrin (EXP)

amphetamine (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenic trichloride (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

copper atom (EXP)

copper(0) (EXP)

cyhalothrin (EXP)

cypermethrin (EXP)

decabromodiphenyl ether (ISO)

doxorubicin (ISO)

fenvalerate (EXP)

fipronil (ISO)

fulvestrant (ISO)

gold atom (ISO)

gold(0) (ISO)

L-serine (ISO)

lead diacetate (ISO)

malathion (ISO)

mercaptopurine (EXP)

microcystin-LR (EXP)

N,N-diethyl-m-toluamide (ISO)

nitrofen (EXP)

ozone (ISO)

perfluorooctane-1-sulfonic acid (ISO)

purine-6-thiol (EXP)

pyrethrins (EXP)

T-2 toxin (EXP)

tetrachloromethane (EXP)

titanium dioxide (ISO)

Triptolide (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of apoptotic process (IBA)

programmed cell death (IBA)

proteolysis (IBA,IEA,ISO)

Cellular Component

extracellular region (IEA)

Molecular Function

endopeptidase activity (IEA,ISO)

hydrolase activity (IEA)

identical protein binding (IEA,ISO)

peptidase activity (IEA)

protein binding (ISO)

serine-type endopeptidase activity (IBA,IEA)

serine-type peptidase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:18387192

Genomics

Comparative Map Data

Htra4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	73,704,255 - 73,717,722 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	16	73,704,184 - 73,717,722 (+)	Ensembl				GRCr8
mRatBN7.2	16	67,001,605 - 67,015,074 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	67,001,605 - 67,015,074 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	16	72,278,796 - 72,292,263 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	75,684,765 - 75,698,232 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	70,931,287 - 70,944,763 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	71,784,819 - 71,802,765 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	71,787,966 - 71,802,763 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	71,438,259 - 71,451,530 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	16	71,424,709 - 71,438,884 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	16	64,906,135 - 64,919,639 (+)	NCBI		Celera
RGSC_v3.1	16	71,425,090 - 71,438,477 (+)	NCBI
Cytogenetic Map	16	q12.4	NCBI

HTRA4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	38,974,228 - 38,988,663 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	38,974,228 - 38,988,663 (+)	Ensembl			hg38	GRCh38
GRCh37	8	38,831,747 - 38,846,182 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	38,950,854 - 38,964,801 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	8	38,950,853 - 38,964,801	NCBI
Celera	8	37,783,269 - 37,797,679 (+)	NCBI		Celera
Cytogenetic Map	8	p11.22	NCBI
HuRef	8	37,364,830 - 37,379,022 (+)	NCBI		HuRef
CHM1_1	8	39,033,728 - 39,048,258 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	39,251,369 - 39,265,805 (+)	NCBI		T2T-CHM13v2.0

Htra4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	25,514,944 - 25,529,160 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	25,514,945 - 25,528,978 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	25,024,928 - 25,038,962 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	25,024,929 - 25,038,962 (-)	Ensembl			mm10	GRCm38
MGSCv37	8	26,135,400 - 26,149,434 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	26,490,473 - 26,504,507 (-)	NCBI		MGSCv36	mm8
Celera	8	26,491,899 - 26,506,023 (-)	NCBI		Celera
Cytogenetic Map	8	A2	NCBI
cM Map	8	13.7	NCBI

Htra4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955463	14,525,489 - 14,536,918 (+)	Ensembl
ChiLan1.0	NW_004955463	14,525,798 - 14,536,948 (+)	NCBI	ChiLan1.0	ChiLan1.0

HTRA4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	57,536,623 - 57,551,056 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	33,254,067 - 33,268,537 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	38,275,582 - 38,290,058 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	35,450,447 - 35,465,078 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	35,450,447 - 35,465,078 (+)	Ensembl			panPan2	panpan1.1

HTRA4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	26,558,426 - 26,568,570 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	26,558,399 - 26,563,254 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	27,077,924 - 27,089,718 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	28,387,990 - 28,399,796 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	28,388,478 - 28,399,751 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	26,683,757 - 26,693,477 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	27,258,412 - 27,270,186 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	27,296,714 - 27,308,507 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Htra4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	49,168,793 - 49,180,461 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936710	2,280,714 - 2,292,468 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936710	2,280,804 - 2,292,399 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HTRA4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	15	47,610,580 - 47,625,889 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	54,684,452 - 54,698,832 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HTRA4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	36,991,074 - 37,009,362 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	36,992,958 - 37,008,829 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666052	4,971,155 - 4,986,218 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Htra4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624780	4,620,771 - 4,633,181 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624780	4,620,040 - 4,633,390 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Htra4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	13	61,421,636 - 61,435,178 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Htra4
43 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	81
Count of miRNA genes:	63
Interacting mature miRNAs:	77
Transcripts:	ENSRNOT00000022166
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2300163	Bmd64	Bone mineral density QTL 64	5.3	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	16	44455123	89455123	Rat
70215	Niddm29	Non-insulin dependent diabetes mellitus QTL 29	3.54		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	16	36928782	81928782	Rat
1578768	Stresp22	Stress response QTL 22	2.8		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	16	41992064	86992064	Rat
7205510	Activ5	Activity QTL 5	3.78	0.00028	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	49099196	91442908	Rat
631525	Pia14	Pristane induced arthritis QTL 14	4.4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	16	62414464	75736480	Rat
1357403	Slep4	Serum leptin concentration QTL 4	3.91		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	32361043	77361043	Rat
8694453	Bw172	Body weight QTL 172	8.33	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	16	31058039	76058039	Rat
7411648	Foco22	Food consumption QTL 22	15	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	59428714	91442908	Rat
1298529	Arunc1	Aerobic running capacity QTL 1	4		exercise endurance trait (VT:0002332)	longest distance run on treadmill (CMO:0001406)	16	34398294	79398294	Rat
6903294	Stl30	Serum triglyceride level QTL 30	2.6	0.0013	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	16	31885271	76885271	Rat
2293690	Bss45	Bone structure and strength QTL 45	5.13	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	16	44455123	89455123	Rat
8694364	Abfw7	Abdominal fat weight QTL 7	12.22	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	16	59428714	91442908	Rat
8694429	Bw164	Body weight QTL 164	5	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	16	59428714	91442908	Rat

Markers in Region

RH128869

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	67,001,148 - 67,001,353 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	71,787,510 - 71,787,714	NCBI	Rnor6.0
Rnor_5.0	16	71,437,803 - 71,438,007	UniSTS	Rnor5.0
RGSC_v3.4	16	71,424,253 - 71,424,457	UniSTS	RGSC3.4
Celera	16	64,905,679 - 64,905,883	UniSTS
RH 3.4 Map	16	621.71	UniSTS
Cytogenetic Map	16	q12.4	UniSTS

AI598828

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	67,000,714 - 67,000,920 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	71,787,076 - 71,787,281	NCBI	Rnor6.0
Rnor_5.0	16	71,437,369 - 71,437,574	UniSTS	Rnor5.0
RGSC_v3.4	16	71,423,819 - 71,424,024	UniSTS	RGSC3.4
Celera	16	64,905,245 - 64,905,450	UniSTS
RH 3.4 Map	16	621.3	UniSTS
Cytogenetic Map	16	q12.4	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	66	149	90	89	58	81	58	6	330	180	11	125	68	92	31	16	16

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107321	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017600147	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473970	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223449	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000080084 ⟹ ENSRNOP00000070978

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	16	73,704,184 - 73,717,722 (+)	Ensembl
mRatBN7.2 Ensembl	16	67,001,605 - 67,015,074 (+)	Ensembl
Rnor_6.0 Ensembl	16	71,787,966 - 71,802,763 (+)	Ensembl

RefSeq Acc Id:

NM_001107321 ⟹ NP_001100791

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	73,704,255 - 73,717,722 (+)	NCBI
mRatBN7.2	16	67,001,605 - 67,015,074 (+)	NCBI
Rnor_6.0	16	71,787,966 - 71,802,763 (+)	NCBI
Rnor_5.0	16	71,438,259 - 71,451,530 (+)	NCBI
RGSC_v3.4	16	71,424,709 - 71,438,884 (+)	RGD
Celera	16	64,906,135 - 64,919,639 (+)	RGD

Sequence:

show sequence

TCTGTCCTTTATAAAGTCTGGAGGCCGGCAGAGGCAGCATCCAGGCCAGGAAAAGAACGTGTTG
CTCATTTCGGCCCAGTTGTGAGCCCAGAGTGAACTGGAAAAGTAGAATCAACGATGTCAAGGAG
CAAGATGAGCTCCCAGCGGTTGTGGGCTGTGCGAGCACAGTTTCTCTTGCTGTGGCTGCTGCTC
TGGGCCGCGCCTGTTCCGTGGGCTGAGGCCAGGAGGTCTAGAGTCTCCTTGCCCTGCCCGGACG
CCTGCGATCCCACGCGCTGCCCGCCTCTGCCTAGCTGCTCGGCCGGCTCGGCGCTAGTGCCAGA
TCGCTGCGGCTGCTGCCAAGTGTGCGCCGCGGTCGAGGGCCAGGAGTGTGGCGGGGCGCGGGGC
CGGCCGTGCGTCCCGGGGCTGCGCTGCGGCGCCCCGTTCTCCCGGGAGCCCTCAGGGCGCGCGT
GGCTGGGCACCTGCGGTTGCGCGGAGGGTGCAGAGGGCGCGGCGGTGTGCGGCAGCGACGGGCG
CACTTACCCCAGCCTGTGCGCGCTCCGCAAGGAGAACCGAGCGGCTCGCCAGCGGGGTGCGCTC
CCGGCTGTGCCAGTGCAGAAAGGTGCCTGCGGCGACTCAGGGACCACAAGAGCAGGGCGGCTCC
GGACAAAGTACAACTTCATCGCTGCCGTGGTGGAGAAGGTGGCACCGTCTGTGGTTCACTTGCA
GCTGTTCCGCAGATCACCTCTCACCAACCAGGAAATCCCTTCATCCAGCGGTTCCGGGTTCATA
GTGTCTGAGGATGGCCTCATTGTCACCAATGCCCATGTCCTCACCAACCAGCAGAAGATCCAGG
TAGAGCTCCAGAACGGGGCTCAGTATGAAGCCACTGTCAAAGACATCGACCATAAACTGGACCT
TGCACTGATTAAGATCGAGCCAGATACTGACCTTCCAGTACTGTTGCTGGGAAGATCCTCTGAC
CTCCGGGCCGGAGAGTTTGTGGTGGCTTTGGGTAGCCCATTTTCCCTGCAGAACACTGTGACTG
CCGGGATTGTCAGCACCACACAGAGAGGCGGCAAAGAGTTGGGACTGAAGGACTCAGACATAGA
CTATATCCAGACGGACGCCATCATTAACCACGGAAATTCTGGGGGTCCACTGGTGAACTTGGAT
GGCGATGTGATCGGTATAAACACCCTGAAGGTGACCGCAGGGATCTCTTTTGCAATCCCCTCAG
ATAGGATCAGACAGTTCCTGGCAGACTATCATGAGCGCCAGTTGAAAGGAAAGGCTCCCTTGCA
GAAGAAATACCTGGGTCTTAGAATGTTGCCCCTCACTCTGAACCTCCTTCAGGAAATGAAGAGG
CAAGATCCCGATTTCCCTGATGTGAGCTCTGGAGTTTTTGTATATGAAGTGATTCAAGGATCGG
CCGCTGCAAGCTCGGGGTTGAGAGACCATGATGTAATTGTCAGCATAAACGGGCAGCCTGTCAC
GACCACAACCGATGTCATTGAAGCTGTTAAGGACAATGCCTTTCTCTCCATCATTGTTCTTCGA
GGAAGCCAAACCTTGTTTCTGACAGTCACACCTGAAATAATCAATTAAGCACCTTACTTTGAGA
AACTGCCTAGCAAAACCAGTTATATTACCTGGTTTCTATCGAAGACGAACCAGAGATGGCAGGT
TCTTCTGGGTATCAAGAAAAGTGGATGCTTTAAATGTATAAGTACATGTGTGTGTGATACACAC
ACTCGTGCACATGTGTACACACGTGTATACACACACACACACACACACACACACACACACACAC
ACACACATTCTCATGGATCCTGAGGGATTAAGCATGCTCTTCTACTACAAAAACTTTCGTGACT
CAAGTGGCCGCAGCTATGGTGATCAGAGAAAAAGTAAAGACAGTAAGAATGGGAAAACAGGAGA
CTCCTAACTAAATCTTCACAGGGTGCTTTACTTACCGTCTATATAGCCACTAACTGATATGTCA
CACACATGTACAAACAATCTACCTACTAGATCTGAATCTGGAGTAAAGAGGCAATCATGTTTTA
AATAACACCCCTCTGTATGCTGAATTTCCCGGGGTATATCCACTTTGGGCCAGGGTTTGTGGAT
AGAAAGGTCGTCAACTCTAAGATAGATTACAACTGATGACGTCAGACCACCACACAGGAATATG
ACCATTTTAGCGGTAGAAACTATCCTGGACCTCTGGTGTTTCTGAGAATGTCTTCTATTAAAAC
AATTTTTTGAACCATT

hide sequence

Protein Sequences


Protein RefSeqs	NP_001100791	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	D3ZKF5	(Get FASTA)	NCBI Sequence Viewer
	EDM09047	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000070978
	ENSRNOP00000070978.2

RefSeq Acc Id:	NP_001100791 ⟸ NM_001107321
- Peptide Label:	precursor
- UniProtKB:	D3ZKF5 (UniProtKB/Swiss-Prot), A0A0G2JZB1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSRSKMSSQRLWAVRAQFLLLWLLLWAAPVPWAEARRSRVSLPCPDACDPTRCPPLPSCSAGSA LVPDRCGCCQVCAAVEGQECGGARGRPCVPGLRCGAPFSREPSGRAWLGTCGCAEGAEGAAVCG SDGRTYPSLCALRKENRAARQRGALPAVPVQKGACGDSGTTRAGRLRTKYNFIAAVVEKVAPSV VHLQLFRRSPLTNQEIPSSSGSGFIVSEDGLIVTNAHVLTNQQKIQVELQNGAQYEATVKDIDH KLDLALIKIEPDTDLPVLLLGRSSDLRAGEFVVALGSPFSLQNTVTAGIVSTTQRGGKELGLKD SDIDYIQTDAIINHGNSGGPLVNLDGDVIGINTLKVTAGISFAIPSDRIRQFLADYHERQLKGK APLQKKYLGLRMLPLTLNLLQEMKRQDPDFPDVSSGVFVYEVIQGSAAASSGLRDHDVIVSING QPVTTTTDVIEAVKDNAFLSIIVLRGSQTLFLTVTPEIIN hide sequence

Ensembl Acc Id:

ENSRNOP00000070978 ⟸ ENSRNOT00000080084

Protein Domains

IGFBP N-terminal PDZ

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZKF5-F1-model_v2	AlphaFold	D3ZKF5	1-488	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306242	AgrOrtholog
BioCyc Gene	G2FUF-10953	BioCyc
Ensembl Genes	ENSRNOG00000061160	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000080084	ENTREZGENE
	ENSRNOT00000080084.2	UniProtKB/Swiss-Prot
Gene3D-CATH	2.30.42.10	UniProtKB/Swiss-Prot
	2.40.10.120	UniProtKB/Swiss-Prot
	3.30.60.30	UniProtKB/Swiss-Prot
	4.10.40.20	UniProtKB/Swiss-Prot
InterPro	Growth_fac_rcpt_cys_sf	UniProtKB/Swiss-Prot
	IGFBP-like	UniProtKB/Swiss-Prot
	Kazal_dom	UniProtKB/Swiss-Prot
	Kazal_dom_sf	UniProtKB/Swiss-Prot
	PDZ	UniProtKB/Swiss-Prot
	PDZ_6	UniProtKB/Swiss-Prot
	PDZ_sf	UniProtKB/Swiss-Prot
	Peptidase_S1_PA	UniProtKB/Swiss-Prot
	Peptidase_S1C	UniProtKB/Swiss-Prot
KEGG Report	rno:306564	UniProtKB/Swiss-Prot
NCBI Gene	306564	ENTREZGENE
PANTHER	SERINE PROTEASE FAMILY S1C HTRA-RELATED	UniProtKB/Swiss-Prot
	SERINE PROTEASE HTRA4	UniProtKB/Swiss-Prot
Pfam	IGFBP	UniProtKB/Swiss-Prot
	Kazal_2	UniProtKB/Swiss-Prot
	PDZ_6	UniProtKB/Swiss-Prot
	Trypsin_2	UniProtKB/Swiss-Prot
PhenoGen	Htra4	PhenoGen
PRINTS	PROTEASES2C	UniProtKB/Swiss-Prot
PROSITE	IGFBP_N_2	UniProtKB/Swiss-Prot
	PDZ	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000061160	RatGTEx
SMART	KAZAL	UniProtKB/Swiss-Prot
	PDZ	UniProtKB/Swiss-Prot
	SM00121	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF100895	UniProtKB/Swiss-Prot
	SSF50156	UniProtKB/Swiss-Prot
	SSF50494	UniProtKB/Swiss-Prot
	SSF57184	UniProtKB/Swiss-Prot
UniProt	A0A0G2JZB1	ENTREZGENE, UniProtKB/TrEMBL
	D3ZKF5	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Htra4	HtrA serine peptidase 4	Htra4_predicted	HtrA serine peptidase 4 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Htra4_predicted	HtrA serine peptidase 4 (predicted)	RGD1306242_predicted	similar to Probable serine protease HTRA4 precursor (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-20	RGD1306242_predicted	similar to Probable serine protease HTRA4 precursor (predicted)	LOC306564_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC306564_predicted	similar to Probable serine protease HTRA4 precursor (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD