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Gene: Dcaf4 (DDB1 and CUL4 associated factor 4) Rattus norvegicus

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Symbol:

Dcaf4

Name:

DDB1 and CUL4 associated factor 4

RGD ID:

1306241

Description:

Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Orthologous to several human genes including DCAF4 (DDB1 and CUL4 associated factor 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

DDB1- and CUL4-associated factor 4; LOC362762; WD repeat domain 21; Wdr21

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DCAF4 (DDB1 and CUL4 associated factor 4)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Dcaf4 (DDB1 and CUL4 associated factor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dcaf4 (DDB1 and CUL4 associated factor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DCAF4 (DDB1 and CUL4 associated factor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DCAF4 (DDB1 and CUL4 associated factor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dcaf4 (DDB1 and CUL4 associated factor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DCAF4 (DDB1 and CUL4 associated factor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DCAF4 (DDB1 and CUL4 associated factor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dcaf4 (DDB1 and CUL4 associated factor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Dcaf4 (DDB1 and CUL4 associated factor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	DCAF4L2 (DDB1 and CUL4 associated factor 4 like 2)	HGNC	Ensembl, OrthoDB, Panther, PhylomeDB, Treefam
Homo sapiens (human):	DCAF4L1 (DDB1 and CUL4 associated factor 4 like 1)	HGNC	OrthoDB, Panther, PhylomeDB, Treefam
Alliance orthologs ³
Homo sapiens (human):	DCAF4 (DDB1 and CUL4 associated factor 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	DCAF4 (DDB1 and CUL4 associated factor 4)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dcaf4 (DDB1 and CUL4 associated factor 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	DCAF4L1 (DDB1 and CUL4 associated factor 4 like 1)	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Homo sapiens (human):	DCAF4L2 (DDB1 and CUL4 associated factor 4 like 2)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Homo sapiens (human):	DCAF4L2 (DDB1 and CUL4 associated factor 4 like 2)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	wdr21 (WD repeat domain 21)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F47D12.9	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	F47D12.9	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dcaf4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dcaf4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	108,885,970 - 108,912,116 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	108,885,932 - 108,912,110 (+)	Ensembl				GRCr8
mRatBN7.2	6	103,154,847 - 103,180,992 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	103,154,867 - 103,180,982 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	103,316,576 - 103,342,696 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	103,615,789 - 103,641,909 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	102,985,265 - 103,011,381 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	107,001,763 - 107,027,466 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	107,001,763 - 107,027,456 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	118,513,776 - 118,539,582 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	107,468,810 - 107,494,910 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	100,985,587 - 101,011,685 (+)	NCBI		Celera
RGSC_v3.1	6	107,477,989 - 107,498,033 (+)	NCBI
Cytogenetic Map	6	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-palmitoylglycerol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP)

Butylbenzyl phthalate (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chrysene (ISO)

cisplatin (ISO)

clofibric acid (EXP)

coumestrol (ISO)

cyclosporin A (ISO)

DDE (ISO)

dibenz[a,h]anthracene (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

Enterolactone (ISO)

entinostat (ISO)

etoposide (ISO)

fluorescein 5-isothiocyanate (ISO)

folic acid (ISO)

gallic acid (ISO)

gentamycin (EXP)

glyphosate (EXP)

hydrogen peroxide (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methapyrilene (ISO)

methimazole (EXP)

methoxychlor (EXP)

mitomycin C (ISO)

N-methyl-N-nitrosourea (ISO)

N-nitrosodiethylamine (EXP)

panobinostat (ISO)

paracetamol (EXP)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

temozolomide (ISO)

testosterone (ISO)

tetraphene (ISO)

thimerosal (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

Cul4-RING E3 ubiquitin ligase complex (IBA,ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:16949367

Genomics

Comparative Map Data

Dcaf4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	108,885,970 - 108,912,116 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	108,885,932 - 108,912,110 (+)	Ensembl				GRCr8
mRatBN7.2	6	103,154,847 - 103,180,992 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	103,154,867 - 103,180,982 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	103,316,576 - 103,342,696 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	103,615,789 - 103,641,909 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	102,985,265 - 103,011,381 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	107,001,763 - 107,027,466 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	107,001,763 - 107,027,456 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	118,513,776 - 118,539,582 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	107,468,810 - 107,494,910 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	100,985,587 - 101,011,685 (+)	NCBI		Celera
RGSC_v3.1	6	107,477,989 - 107,498,033 (+)	NCBI
Cytogenetic Map	6	q31	NCBI

DCAF4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	72,926,464 - 72,962,098 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	72,926,358 - 72,962,098 (+)	Ensembl			hg38	GRCh38
GRCh37	14	73,393,172 - 73,428,806 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	72,462,838 - 72,496,110 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	14	72,462,837 - 72,496,109	NCBI
Celera	14	53,456,192 - 53,489,495 (+)	NCBI		Celera
Cytogenetic Map	14	q24.2	NCBI
HuRef	14	53,559,113 - 53,592,426 (+)	NCBI		HuRef
CHM1_1	14	73,331,211 - 73,364,518 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	67,132,127 - 67,167,702 (+)	NCBI		T2T-CHM13v2.0

Dcaf4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	83,567,145 - 83,588,768 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	83,567,240 - 83,588,694 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	12	83,520,447 - 83,541,994 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	83,520,466 - 83,541,920 (+)	Ensembl			mm10	GRCm38
MGSCv37	12	84,861,416 - 84,882,944 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	12	84,415,831 - 84,431,665 (+)	NCBI		MGSCv36	mm8
Celera	12	84,966,523 - 84,988,356 (+)	NCBI		Celera
Cytogenetic Map	12	D1	NCBI
cM Map	12	38.75	NCBI

Dcaf4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955523	2,396,049 - 2,411,931 (-)	Ensembl
ChiLan1.0	NW_004955523	2,395,834 - 2,421,337 (-)	NCBI	ChiLan1.0	ChiLan1.0

DCAF4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	74,038,096 - 74,078,890 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	73,254,624 - 73,295,835 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	53,507,629 - 53,540,838 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	72,372,344 - 72,405,045 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	72,372,344 - 72,405,045 (+)	Ensembl			panPan2	panpan1.1

DCAF4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	46,319,251 - 46,349,337 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	46,329,910 - 46,348,472 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	45,999,478 - 46,029,529 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	46,541,174 - 46,571,233 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	46,541,413 - 46,571,227 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	46,209,255 - 46,239,304 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	46,225,214 - 46,255,267 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	46,616,545 - 46,646,588 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Dcaf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	29,768,427 - 29,793,100 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936488	2,275,795 - 2,302,661 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936488	2,275,887 - 2,300,601 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DCAF4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	7	96,288,760 - 96,319,279 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	102,076,060 - 102,106,568 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DCAF4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	50,173,492 - 50,215,641 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	50,186,309 - 50,207,946 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666053	38,352,365 - 38,387,876 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dcaf4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624734	28,446,644 - 28,480,021 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Dcaf4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	7	97,626,552 - 97,641,228 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Dcaf4
176 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	40
Count of miRNA genes:	40
Interacting mature miRNAs:	40
Transcripts:	ENSRNOT00000011378
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2293088	Iddm28	Insulin dependent diabetes mellitus QTL 28	5.21		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	6	68767270	135411972	Rat
1331799	Bp211	Blood pressure QTL 211	3.66407		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	88019181	136741135	Rat
1358355	Srcrt4	Stress Responsive Cort QTL 4	6.39		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	106095977	147156653	Rat
61329	Eae9	Experimental allergic encephalomyelitis QTL 9	3.7		body mass (VT:0001259)	change in body weight (CMO:0002045)	6	84490437	129490437	Rat
2313399	Anxrr28	Anxiety related response QTL 28			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	6	101593607	138161926	Rat
1331725	Bp212	Blood pressure QTL 212	3.52475		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	99437079	125323237	Rat
1331789	Rf37	Renal function QTL 37	3.224		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	86494122	112380234	Rat
1331722	Thshl1	Thyroid stimulating hormone level QTL 1	11.7	0.0001	blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	6	99708426	112483760	Rat
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	71278722	116278722	Rat
70176	Mcsm1	Mammary carcinoma susceptibility modifier QTL 1			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	64367996	109367996	Rat
1581563	Uae33	Urinary albumin excretion QTL 33			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	93560258	136550638	Rat
10054138	Gmadr3	Adrenal mass QTL 3	3.68	0.00045	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	6	90871046	135871046	Rat
1641917	Colcr5	Colorectal carcinoma resistance QTL 5	3.18	0.0009	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	6	98944780	143944780	Rat
61414	Pia3	Pristane induced arthritis QTL 3	4.5		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	6	100704576	136029228	Rat
724524	Uae2	Urinary albumin excretion QTL 2	2.7	0.0005	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	79198463	144254945	Rat
737827	Hcar11	Hepatocarcinoma resistance QTL 11	4.4		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	6	46050607	116278722	Rat
2303624	Vencon5	Ventilatory control QTL 5	4.45		respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	6	93778632	138778632	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	20859430	113082285	Rat
2293837	Kiddil1	Kidney dilation QTL 1	3.7		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	86867923	110125012	Rat
2293842	Kiddil3	Kidney dilation QTL 3	4.3		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	86867923	110125012	Rat
10054123	Srcrt6	Stress Responsive Cort QTL 6	2.5	0.0043	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	90871046	135871046	Rat
724536	Uae7	Urinary albumin excretion QTL 7	3.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	93560258	136550638	Rat
1576302	Schws4	Schwannoma susceptibility QTL 4		0.0078	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	78204640	123204640	Rat
1581550	Pur8	Proteinuria QTL 8			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	93560258	136550638	Rat
1300075	Glom7	Glomerulus QTL 7	5.6	0.0000002	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	6	76937178	121937178	Rat
12801471	Schws9	Schwannoma susceptibility QTL 9			nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	101593607	146593607	Rat

Markers in Region

RH134517

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	103,180,541 - 103,180,744 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	107,027,016 - 107,027,218	NCBI	Rnor6.0
Rnor_5.0	6	118,514,024 - 118,514,226	UniSTS	Rnor5.0
RGSC_v3.4	6	107,494,470 - 107,494,672	UniSTS	RGSC3.4
Celera	6	101,011,245 - 101,011,447	UniSTS
RH 3.4 Map	6	736.9	UniSTS
Cytogenetic Map	6	q24	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	92	59	6	356	192	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108716	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006240347	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112513	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063262119	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473982	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000011378 ⟹ ENSRNOP00000011378

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	108,885,932 - 108,912,110 (+)	Ensembl
mRatBN7.2 Ensembl	6	103,154,867 - 103,180,982 (+)	Ensembl
Rnor_6.0 Ensembl	6	107,001,763 - 107,027,456 (+)	Ensembl

RefSeq Acc Id:

NM_001108716 ⟹ NP_001102186

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	108,885,994 - 108,912,106 (+)	NCBI
mRatBN7.2	6	103,154,867 - 103,180,982 (+)	NCBI
Rnor_6.0	6	107,001,763 - 107,027,456 (+)	NCBI
Rnor_5.0	6	118,513,776 - 118,539,582 (-)	NCBI
RGSC_v3.4	6	107,468,810 - 107,494,910 (+)	RGD
Celera	6	100,985,587 - 101,011,685 (+)	RGD

Sequence:

show sequence

AAAGAACCGGTCGCTTTAGTCCTATGGGCTGCGACAACACAGAACATGGGTGTCTTTCCGGATC
TTCGCACGCCTCTGGGTACTCCAGGCCAGCCGTGTTGTGTCTGAGAGGACCGTCTGCGCAGGAA
CAGAAATGGATAAGAACATCTGGACGAGTAGGAGAAGACGAGGGCGAAGCCACCACCGTAGCCC
TGCCCTCAGGCAGTGTGATTCCAGTGAGAGGTACACCTCAGGGGCGTCTCAGAGCTCGCAAGAT
TCCGGCCACCATGATGTTGAGTGCCCATCAACCTCGTCCAGCAAAGCTGGAGAGTCTTCAGTGC
CAGACCTTCCAGGTTTTTACTTTGACCCTGAGAAGAACCGATACTTCCGTTTGCTCCCGGGTCA
TAACAACTGCAACCCCCTCACGAAGGAGGGCATCCAGCTCAAGGAGATGGAGAGCAGGAGGCTG
CAGCTGCTGCAGCAAGAGGACAAGCAGAAAAAGAAAATTGCCAGAGTGGGATTTAATGCATCGT
CCATCCTACGGAAAAATCAGCTGGGTTTTCTCAACTTCTCCAGTTATTGCCGTCTCTCCCACGA
GCTTCGGGTGGCCTGCATGGAGAGGAAAAAGGTAGAGATTCAGAGCTCAGACCCTTCAGCTCTG
GCGAGTGACCGCTTTAACTTCATCCTGGCAGACACTACCAGTGACCGCCTCTTCACGGTGAATG
ACGTCAAAATCGGAGGCTCCAAGTACGGCATCATCAGCCTGCAGGGTCTGAAGGCCCCCACGTT
CGAGGTGCACATGCACGAGAACCTGTACTTTACCAACAGGAAGGTGAACTCTGTGTGCTGGGCC
TCACTCAATCACTTGGACTCCCACATTCTGCTGTGCCTCATGGGCCTTGCAGAGACGCCAGGCT
GTGCCACCTTGCTCCCAGCATCACTGTTTGTCAGCAGTCACCAAGGTACCGACCAGCCTGGCAT
GCTGTGTAGTTTCCGGATCCCTGGGGCCTGGTCCTGTGCCTGGTCCTTGAACGTCCAGGCAAAT
AACTGCTTCAGTACAGGTTTGTCTCGGAGGGTCCTGCTGACCAACGTGGTGACAGGACACCGGC
AGTCATATTGGACCAACAGTGACGTCTTGGCCCAGCAGTTTGCAGTCAAGACTCCTTTGCTGTT
TAATGGCTGTCGTTCTGGGGAGATCTTTGCCATTGACCTGCGTTCTCCAAGTCAAGCCAAGGGC
TGGAAGGCTACTCAAATCTTCCATGACTCAGCAGTGACCTCTGTGCAGGTCTTCAAGGAGGAGC
AGTACCTGATGGCGTCAGACATGGCTGGAAAGATCAAGCTGTGGGACCTGAGAGCCACTAAATG
TGTGAGACAATACGAAGGTCACGTGAATGAGTACGCCTACCTGCCACTGCATATGCACGAGGAG
GAAGGAATCCTGGTGGCAGTGGGCCAAGACTGCTACACAAGAATCTGGAGCCTCCATGATGCCC
GGCTGCTCAGAACCATACCTTCTCCATGCCCGACCTCCAAGGCCAACATTCCCAGTGTGGCCTT
CTCTCCTCGGCTTGGGGGCCCCCGGGGAGCCCCAGGGCTGCTCATGGCTGTCCAGCAGGACCTT
TACTGTTTCCCATACAGCTCGTCCTGTCCAGATGGTCTGAAGGAGGGCAGGTGGGAGCCCTCTT
CTGTTTCTAAGGAGGACATTTTATAAACGGCGCTTGCTGTTCAGATGGAGTCCTTCAGCCTCGG
GCAGAATGCAAAGTGACTGACTCAGGAGCTGGAGAGATGGCTCAATGGTTAAGCATGGGCTGCT
CTTCCGGAGGTCCCAGGTTCAATTCCCACCAACCACATGGCAGCTCACACCCATCTCAGAATCC
GGCACCCTCTTCTGATCTCCTTGGCACCAGGCACACACGATATATGAATAGAACATAACAGGCA
AAACACCCATACACATAAAATAAAATTTTTTTTCAATTTTCTAATTTTGTCAAAGTACATTATG
TGGAACAATGTCAATAAAGGCTCAGAGCACGAAAGGCCT

hide sequence

RefSeq Acc Id:

XM_006240347 ⟹ XP_006240409

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	108,885,970 - 108,912,116 (+)	NCBI
mRatBN7.2	6	103,154,847 - 103,180,992 (+)	NCBI
Rnor_6.0	6	107,001,764 - 107,027,466 (+)	NCBI
Rnor_5.0	6	118,513,776 - 118,539,582 (-)	NCBI

Sequence:

show sequence

AAGAACCGGTCGCTTTAGTCCTATGGGCTGCGACAACACAGAACATGGGTGTCTTTCCGGATCT
TCGCACGCCTCTGGGTACTCCAGGCCAGCCGTGTTGTGTCTGAGAGGACCGTCTGCGCAGGAAC
AGAAATGGATAAGAACATCTGGACGAGTAGGAGAAGACGAGGGCGAAGCCACCACCGTAGCCCT
GCCCTCAGGCAGTGTGATTCCAGTGAGAGGTACACCTCAGGGGCGTCTCAGAGCTCGCAAGATT
CCGGCCACCATGATGTTGAGTGCCCATCAACCTCGTCCAGCAAAGCTGGAGAGTCTTCAGTGCC
AGACCTTCCAGGTTTTTACTTTGACCCTGAGAAGAACCGATACTTCCGTTTGCTCCCGGGTCAT
AACAACTGCAACCCCCTCACGAAGGAGGGCATCCAGCTCAAGGAGATGGAGAGCAGGAGGCTGC
AGCTGCTGCAGCAAGAGGACAAGCAGAAAAAGAAAATTGCCAGAGTGGGATTTAATGCATCGTC
CATCCTACGGAAAAATCAGCTGGGTTTTCTCAACTTCTCCAGTTATTGCCGTCTCTCCCACGAG
CTTCGGGTGGCCTGCATGGAGAGGAAAAAGGTAGAGATTCAGAGCTCAGACCCTTCAGCTCTGG
CGAGTGACCGCTTTAACTTCATCCTGGCAGACACTACCAGTGACCGCCTCTTCACGGTGAATGA
CGTCAAAATCGGAGGCTCCAAGTACGGCATCATCAGCCTGCAGGGTCTGAAGGCCCCCACGTTC
GAGGTGCACATGCACGAGAACCTGTACTTTACCAACAGGAAGGTGAACTCTGTGTGCTGGGCCT
CACTCAATCACTTGGACTCCCACATTCTGCTGTGCCTCATGGGCCTTGCAGAGACGCCAGGCTG
TGCCACCTTGCTCCCAGCATCACTGTTTGTCAGCAGTCACCAAGCAGGTACCGACCAGCCTGGC
ATGCTGTGTAGTTTCCGGATCCCTGGGGCCTGGTCCTGTGCCTGGTCCTTGAACGTCCAGGCAA
ATAACTGCTTCAGTACAGGTTTGTCTCGGAGGGTCCTGCTGACCAACGTGGTGACAGGACACCG
GCAGTCATATTGGACCAACAGTGACGTCTTGGCCCAGCAGTTTGCAGTCAAGACTCCTTTGCTG
TTTAATGGCTGTCGTTCTGGGGAGATCTTTGCCATTGACCTGCGTTCTCCAAGTCAAGCCAAGG
GCTGGAAGGCTACTCAAATCTTCCATGACTCAGCAGTGACCTCTGTGCAGGTCTTCAAGGAGGA
GCAGTACCTGATGGCGTCAGACATGGCTGGAAAGATCAAGCTGTGGGACCTGAGAGCCACTAAA
TGTGTGAGACAATACGAAGGTCACGTGAATGAGTACGCCTACCTGCCACTGCATATGCACGAGG
AGGAAGGAATCCTGGTGGCAGTGGGCCAAGACTGCTACACAAGAATCTGGAGCCTCCATGATGC
CCGGCTGCTCAGAACCATACCTTCTCCATGCCCGACCTCCAAGGCCAACATTCCCAGTGTGGCC
TTCTCTCCTCGGCTTGGGGGCCCCCGGGGAGCCCCAGGGCTGCTCATGGCTGTCCAGCAGGACC
TTTACTGTTTCCCATACAGCTCGTCCTGTCCAGATGGTCTGAAGGAGGGCAGGTGGGAGCCCTC
TTCTGTTTCTAAGGAGGACATTTTATAAACGGCGCTTGCTGTTCAGATGGAGTCCTTCAGCCTC
GGGCAGAATGCAAAGTGACTGACTCAGGAGCTGGAGAGATGGCTCAATGGTTAAGCATGGGCTG
CTCTTCCGGAGGTCCCAGGTTCAATTCCCACCAACCACATGGCAGCTCACACCCATCTCAGAAT
CCGGCACCCTCTTCTGATCTCCTTGGCACCAGGCACACACGATATATGAATAGAACATAACAGG
CAAAACACCCATACACATAAAATAAAATTTTTTTTCAATTTTCTAATTTTGTCAAAGTACATTA
TGTGGAACAATGTCAATAAAGGCTCAGAGCACGAAAGGCCTTGCCATAAAA

hide sequence

RefSeq Acc Id:

XM_039112513 ⟹ XP_038968441

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	108,903,023 - 108,912,116 (+)	NCBI
mRatBN7.2	6	103,171,899 - 103,180,992 (+)	NCBI

RefSeq Acc Id:

XM_063262119 ⟹ XP_063118189

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	108,891,960 - 108,912,116 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102186	(Get FASTA)	NCBI Sequence Viewer
	XP_006240409	(Get FASTA)	NCBI Sequence Viewer
	XP_038968441	(Get FASTA)	NCBI Sequence Viewer
	XP_063118189	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL81444	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000011378
	ENSRNOP00000011378.6

RefSeq Acc Id:

NP_001102186 ⟸ NM_001108716

- UniProtKB:

A6JDQ0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDKNIWTSRRRRGRSHHRSPALRQCDSSERYTSGASQSSQDSGHHDVECPSTSSSKAGESSVPD
LPGFYFDPEKNRYFRLLPGHNNCNPLTKEGIQLKEMESRRLQLLQQEDKQKKKIARVGFNASSI
LRKNQLGFLNFSSYCRLSHELRVACMERKKVEIQSSDPSALASDRFNFILADTTSDRLFTVNDV
KIGGSKYGIISLQGLKAPTFEVHMHENLYFTNRKVNSVCWASLNHLDSHILLCLMGLAETPGCA
TLLPASLFVSSHQGTDQPGMLCSFRIPGAWSCAWSLNVQANNCFSTGLSRRVLLTNVVTGHRQS
YWTNSDVLAQQFAVKTPLLFNGCRSGEIFAIDLRSPSQAKGWKATQIFHDSAVTSVQVFKEEQY
LMASDMAGKIKLWDLRATKCVRQYEGHVNEYAYLPLHMHEEEGILVAVGQDCYTRIWSLHDARL
LRTIPSPCPTSKANIPSVAFSPRLGGPRGAPGLLMAVQQDLYCFPYSSSCPDGLKEGRWEPSSV
SKEDIL

hide sequence

RefSeq Acc Id:	XP_006240409 ⟸ XM_006240347
- Peptide Label:	isoform X1
- UniProtKB:	D4A7F7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDKNIWTSRRRRGRSHHRSPALRQCDSSERYTSGASQSSQDSGHHDVECPSTSSSKAGESSVPD LPGFYFDPEKNRYFRLLPGHNNCNPLTKEGIQLKEMESRRLQLLQQEDKQKKKIARVGFNASSI LRKNQLGFLNFSSYCRLSHELRVACMERKKVEIQSSDPSALASDRFNFILADTTSDRLFTVNDV KIGGSKYGIISLQGLKAPTFEVHMHENLYFTNRKVNSVCWASLNHLDSHILLCLMGLAETPGCA TLLPASLFVSSHQAGTDQPGMLCSFRIPGAWSCAWSLNVQANNCFSTGLSRRVLLTNVVTGHRQ SYWTNSDVLAQQFAVKTPLLFNGCRSGEIFAIDLRSPSQAKGWKATQIFHDSAVTSVQVFKEEQ YLMASDMAGKIKLWDLRATKCVRQYEGHVNEYAYLPLHMHEEEGILVAVGQDCYTRIWSLHDAR LLRTIPSPCPTSKANIPSVAFSPRLGGPRGAPGLLMAVQQDLYCFPYSSSCPDGLKEGRWEPSS VSKEDIL hide sequence

Ensembl Acc Id:

ENSRNOP00000011378 ⟸ ENSRNOT00000011378

RefSeq Acc Id:	XP_038968441 ⟸ XM_039112513
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063118189 ⟸ XM_063262119
- Peptide Label:	isoform X2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A7F7-F1-model_v2	AlphaFold	D4A7F7	1-518	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694712

Promoter ID:

EPDNEW_R5236

Type:

initiation region

Name:

Dcaf4_1

Description:

DDB1 and CUL4 associated factor 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	107,001,803 - 107,001,863	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306241	AgrOrtholog
BioCyc Gene	G2FUF-36857	BioCyc
Ensembl Genes	ENSRNOG00000008399	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000011378	ENTREZGENE
	ENSRNOT00000011378.8	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
InterPro	CUL4-DDB1_E3_ligase_receptor	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
KEGG Report	rno:362762	UniProtKB/TrEMBL
NCBI Gene	362762	ENTREZGENE
PANTHER	DDB1 AND CUL4-ASSOCIATED FACTOR 4	UniProtKB/TrEMBL
	DDB1- AND CUL4-ASSOCIATED FACTOR 4-RELATED	UniProtKB/TrEMBL
Pfam	Beta-prop_DCAF4	UniProtKB/TrEMBL
PhenoGen	Dcaf4	PhenoGen
PROSITE	WD_REPEATS_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000008399	RatGTEx
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	WD40_like	UniProtKB/TrEMBL
UniProt	A6JDQ0	ENTREZGENE, UniProtKB/TrEMBL
	D4A7F7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2010-01-14	Dcaf4	DDB1 and CUL4 associated factor 4	Wdr21	WD repeat domain 21	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Wdr21	WD repeat domain 21	Wdr21_predicted	WD repeat domain 21 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Wdr21_predicted	WD repeat domain 21 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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