Mrps12 (mitochondrial ribosomal protein S12) - Rat Genome Database

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Gene: Mrps12 (mitochondrial ribosomal protein S12) Rattus norvegicus
Analyze
Symbol: Mrps12
Name: mitochondrial ribosomal protein S12
RGD ID: 1306221
Description: Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial small ribosomal subunit. Predicted to be active in ribosome. Orthologous to human MRPS12 (mitochondrial ribosomal protein S12); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 28S ribosomal protein S12, mitochondrial; LOC292758; small ribosomal subunit protein uS12m
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,153,424 - 93,156,422 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl193,153,425 - 93,159,629 (-)EnsemblGRCr8
mRatBN7.2184,025,896 - 84,028,896 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,025,899 - 84,028,780 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx189,435,804 - 89,438,698 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,894,732 - 97,897,626 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,191,660 - 91,194,554 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0186,920,679 - 86,923,626 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,920,680 - 86,923,575 (-)Ensemblrn6Rnor6.0
Rnor_5.0188,101,811 - 88,104,707 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4183,845,161 - 83,848,056 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera178,418,331 - 78,421,225 (-)NCBICelera
RGSC_v3.1183,923,279 - 83,926,153 (-)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
translation  (IBA,IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14651853   PMID:18614015   PMID:22681889   PMID:25838379   PMID:34800366  


Genomics

Comparative Map Data
Mrps12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,153,424 - 93,156,422 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl193,153,425 - 93,159,629 (-)EnsemblGRCr8
mRatBN7.2184,025,896 - 84,028,896 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,025,899 - 84,028,780 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx189,435,804 - 89,438,698 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,894,732 - 97,897,626 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,191,660 - 91,194,554 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0186,920,679 - 86,923,626 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,920,680 - 86,923,575 (-)Ensemblrn6Rnor6.0
Rnor_5.0188,101,811 - 88,104,707 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4183,845,161 - 83,848,056 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera178,418,331 - 78,421,225 (-)NCBICelera
RGSC_v3.1183,923,279 - 83,926,153 (-)NCBI
Cytogenetic Map1q21NCBI
MRPS12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381938,930,944 - 38,933,168 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1938,930,923 - 38,933,183 (+)Ensemblhg38GRCh38
GRCh371939,421,584 - 39,423,808 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,113,188 - 44,115,500 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341944,113,433 - 44,115,497NCBI
Celera1936,223,777 - 36,226,089 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1935,867,947 - 35,870,259 (+)NCBIHuRef
CHM1_11939,421,743 - 39,424,055 (+)NCBICHM1_1
T2T-CHM13v2.01941,734,913 - 41,737,137 (+)NCBIT2T-CHM13v2.0
Mrps12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,439,066 - 28,441,246 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,439,066 - 28,441,245 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38728,739,641 - 28,741,821 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,739,641 - 28,741,820 (-)Ensemblmm10GRCm38
MGSCv37729,524,660 - 29,526,800 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36728,448,401 - 28,450,542 (-)NCBIMGSCv36mm8
Celera723,300,048 - 23,302,188 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map716.91NCBI
Mrps12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468600,309 - 603,652 (-)Ensembl
ChiLan1.0NW_004955468600,309 - 603,652 (-)NCBIChiLan1.0ChiLan1.0
MRPS12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22045,234,198 - 45,236,509 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11947,105,004 - 47,107,098 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01936,037,185 - 36,039,801 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11944,586,124 - 44,588,589 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1944,586,124 - 44,588,589 (+)EnsemblpanPan2panpan1.1
MRPS12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11114,189,101 - 114,192,557 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1114,188,996 - 114,192,410 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1113,590,587 - 113,594,248 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01114,788,811 - 114,792,470 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,788,863 - 114,792,276 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11114,346,558 - 114,350,219 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01113,979,732 - 113,983,393 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01114,975,466 - 114,979,126 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mrps12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,443,701 - 13,447,349 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366611,871,947 - 1,875,418 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366611,871,934 - 1,875,418 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRPS12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,728,551 - 47,736,050 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1647,728,518 - 47,732,042 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,276,419 - 43,278,223 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MRPS12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1633,551,812 - 33,554,266 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl633,551,679 - 33,554,575 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607311,574,309 - 11,576,763 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mrps12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479412,280,654 - 12,284,029 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462479412,280,613 - 12,284,035 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mrps12
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12167,265,735 - 167,268,846 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mrps12
9 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:35
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000027029
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat

Markers in Region
RH129132  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2184,025,947 - 84,026,162 (+)MAPPERmRatBN7.2
Rnor_6.0186,920,731 - 86,920,945NCBIRnor6.0
Rnor_5.0188,101,863 - 88,102,077UniSTSRnor5.0
RGSC_v3.4183,845,212 - 83,845,426UniSTSRGSC3.4
Celera178,418,382 - 78,418,596UniSTS
RH 3.4 Map1839.9UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027029   ⟹   ENSRNOP00000027029
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl193,153,425 - 93,156,320 (-)Ensembl
mRatBN7.2 Ensembl184,025,899 - 84,028,780 (-)Ensembl
Rnor_6.0 Ensembl186,920,680 - 86,923,575 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000146966   ⟹   ENSRNOP00000110114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl193,153,425 - 93,159,629 (-)Ensembl
RefSeq Acc Id: NM_001106239   ⟹   NP_001099709
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,153,425 - 93,156,320 (-)NCBI
mRatBN7.2184,025,897 - 84,028,792 (-)NCBI
Rnor_6.0186,920,680 - 86,923,575 (-)NCBI
Rnor_5.0188,101,811 - 88,104,707 (-)NCBI
RGSC_v3.4183,845,161 - 83,848,056 (-)RGD
Celera178,418,331 - 78,421,225 (-)RGD
Sequence:
RefSeq Acc Id: XM_006228651   ⟹   XP_006228713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,153,424 - 93,156,306 (-)NCBI
mRatBN7.2184,025,896 - 84,028,814 (-)NCBI
Rnor_6.0186,920,679 - 86,923,531 (-)NCBI
Rnor_5.0188,101,811 - 88,104,707 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006228652   ⟹   XP_006228714
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,153,424 - 93,156,422 (-)NCBI
mRatBN7.2184,025,896 - 84,028,896 (-)NCBI
Rnor_6.0186,920,679 - 86,923,626 (-)NCBI
Rnor_5.0188,101,811 - 88,104,707 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001099709   ⟸   NM_001106239
- UniProtKB: D3ZQX3 (UniProtKB/TrEMBL),   A6J9K4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228714   ⟸   XM_006228652
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006228713   ⟸   XM_006228651
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000027029   ⟸   ENSRNOT00000027029
Ensembl Acc Id: ENSRNOP00000110114   ⟸   ENSRNOT00000146966

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZQX3-F1-model_v2 AlphaFold D3ZQX3 1-139 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689879
Promoter ID:EPDNEW_R404
Type:initiation region
Name:Mrps12_1
Description:mitochondrial ribosomal protein S12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0186,923,561 - 86,923,621EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306221 AgrOrtholog
BioCyc Gene G2FUF-60228 BioCyc
Ensembl Genes ENSRNOG00000019949 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027029 ENTREZGENE
  ENSRNOT00000027029.6 UniProtKB/TrEMBL
  ENSRNOT00000146966.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.140 UniProtKB/TrEMBL
InterPro NA-bd_OB-fold UniProtKB/TrEMBL
  Ribosomal_S12/S23 UniProtKB/TrEMBL
  Ribosomal_S12_bac-type UniProtKB/TrEMBL
KEGG Report rno:292758 UniProtKB/TrEMBL
NCBI Gene 292758 ENTREZGENE
PANTHER Ribosomal_S12_23 UniProtKB/TrEMBL
Pfam Ribosomal_S12 UniProtKB/TrEMBL
PhenoGen Mrps12 PhenoGen
PRINTS RIBOSOMALS12 UniProtKB/TrEMBL
PROSITE RIBOSOMAL_S12 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019949 RatGTEx
Superfamily-SCOP Nucleic_acid_OB UniProtKB/TrEMBL
UniProt A0ABK0M531_RAT UniProtKB/TrEMBL
  A6J9K4 ENTREZGENE, UniProtKB/TrEMBL
  D3ZQX3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Mrps12  mitochondrial ribosomal protein S12   Mrps12_predicted  mitochondrial ribosomal protein S12 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mrps12_predicted  mitochondrial ribosomal protein S12 (predicted)      Symbol and Name status set to approved 70820 APPROVED