Paxx (PAXX, non-homologous end joining factor) - Rat Genome Database

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Gene: Paxx (PAXX, non-homologous end joining factor) Rattus norvegicus
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Symbol: Paxx
Name: PAXX, non-homologous end joining factor
RGD ID: 1306215
Description: Predicted to enable DNA polymerase binding activity; molecular adaptor activity; and protein homodimerization activity. Predicted to be involved in double-strand break repair via nonhomologous end joining. Predicted to be part of Ku70:Ku80 complex and nonhomologous end joining complex. Predicted to be active in nucleus and site of double-strand break. Orthologous to human PAXX (PAXX non-homologous end joining factor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC296565; LOC296565; RGD1306215; similar to hypothetical protein MGC36831; uncharacterized protein C9orf142 homolog; uncharacterized protein LOC296565
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,672,906 - 28,676,252 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl328,672,906 - 28,674,466 (-)EnsemblGRCr8
mRatBN7.238,274,762 - 8,276,322 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,274,762 - 8,276,521 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx311,379,836 - 11,381,396 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,966,060 - 19,967,620 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,155,908 - 18,157,468 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,678,987 - 2,681,668 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,678,956 - 2,680,622 (-)Ensemblrn6Rnor6.0
Rnor_5.032,660,400 - 2,662,025 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.433,625,547 - 3,627,090 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera33,099,865 - 3,101,408 (-)NCBICelera
RGSC_v3.133,625,550 - 3,627,166 (-)NCBI
Cytogenetic Map3p13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
Ku70:Ku80 complex  (IEA,ISO)
nonhomologous end joining complex  (IBA,IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
site of double-strand break  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8634083   PMID:12477932   PMID:23376485   PMID:25574025   PMID:25670504   PMID:25941166  


Genomics

Comparative Map Data
Paxx
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,672,906 - 28,676,252 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl328,672,906 - 28,674,466 (-)EnsemblGRCr8
mRatBN7.238,274,762 - 8,276,322 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,274,762 - 8,276,521 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx311,379,836 - 11,381,396 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,966,060 - 19,967,620 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,155,908 - 18,157,468 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,678,987 - 2,681,668 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,678,956 - 2,680,622 (-)Ensemblrn6Rnor6.0
Rnor_5.032,660,400 - 2,662,025 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.433,625,547 - 3,627,090 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera33,099,865 - 3,101,408 (-)NCBICelera
RGSC_v3.133,625,550 - 3,627,166 (-)NCBI
Cytogenetic Map3p13NCBI
PAXX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389136,992,422 - 136,993,976 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9136,992,403 - 136,994,074 (+)Ensemblhg38GRCh38
GRCh379139,886,874 - 139,888,428 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,006,691 - 139,008,249 (+)NCBIBuild 36Build 36hg18NCBI36
Celera9110,399,180 - 110,400,738 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,345,976 - 109,347,534 (+)NCBIHuRef
CHM1_19140,035,627 - 140,037,185 (+)NCBICHM1_1
T2T-CHM13v2.09149,226,833 - 149,228,387 (+)NCBIT2T-CHM13v2.0
Paxx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,345,132 - 25,352,666 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,345,153 - 25,351,106 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38225,455,120 - 25,462,654 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,455,141 - 25,461,094 (-)Ensemblmm10GRCm38
MGSCv37225,315,008 - 25,316,614 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36225,281,497 - 25,283,103 (-)NCBIMGSCv36mm8
Celera225,186,977 - 25,188,583 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map217.27NCBI
Paxx
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,017,971 - 5,019,489 (+)Ensembl
ChiLan1.0NW_0049555135,017,971 - 5,019,489 (+)NCBIChiLan1.0ChiLan1.0
PAXX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,404,868 - 2,406,487 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan192,407,205 - 2,408,794 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09108,052,793 - 108,055,298 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19137,021,230 - 137,022,812 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,021,230 - 137,022,805 (+)EnsemblpanPan2panpan1.1
PAXX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,637,735 - 48,639,289 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,637,731 - 48,639,239 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha947,851,392 - 47,852,948 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0949,515,823 - 49,517,381 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,515,819 - 49,517,325 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,292,036 - 48,293,594 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,590,753 - 48,592,303 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,638,112 - 48,639,666 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Paxx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,422,235 - 202,423,802 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936669951,261 - 952,769 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936669951,256 - 952,804 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAXX
(Sus scrofa - pig)		 No map positions available.
PAXX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,200,945 - 1,202,628 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,201,116 - 1,202,505 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660584,098,761 - 4,102,845 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Paxx
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760913,574 - 914,708 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624760912,953 - 914,793 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Paxx
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1511,721,526 - 11,723,706 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Paxx
9 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:28
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000020806
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
RH134408  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8328,673,001 - 28,673,286 (+)Marker Load Pipeline
mRatBN7.238,274,857 - 8,275,142 (+)MAPPERmRatBN7.2
Rnor_6.032,679,083 - 2,679,367NCBIRnor6.0
Rnor_5.032,660,496 - 2,660,780UniSTSRnor5.0
RGSC_v3.433,625,641 - 3,625,925UniSTSRGSC3.4
Celera33,099,959 - 3,100,243UniSTS
Cytogenetic Map3p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 1 58 147 72 79 50 82 50 6 307 162 11 134 81 90 29 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000020806   ⟹   ENSRNOP00000020806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl328,672,906 - 28,674,466 (-)Ensembl
mRatBN7.2 Ensembl38,274,762 - 8,276,521 (-)Ensembl
Rnor_6.0 Ensembl32,678,956 - 2,680,622 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113013   ⟹   ENSRNOP00000084756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl328,672,908 - 28,674,466 (-)Ensembl
mRatBN7.2 Ensembl38,274,766 - 8,276,239 (-)Ensembl
RefSeq Acc Id: NM_001399307   ⟹   NP_001386236
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,672,908 - 28,674,466 (-)NCBI
mRatBN7.238,274,764 - 8,276,322 (-)NCBI
RefSeq Acc Id: NM_001399308   ⟹   NP_001386237
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,672,908 - 28,674,466 (-)NCBI
mRatBN7.238,274,764 - 8,276,322 (-)NCBI
RefSeq Acc Id: NM_001399309   ⟹   NP_001386238
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,672,906 - 28,674,466 (-)NCBI
mRatBN7.238,274,762 - 8,276,322 (-)NCBI
RefSeq Acc Id: XM_039104717   ⟹   XP_038960645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,672,908 - 28,676,252 (-)NCBI
mRatBN7.238,274,762 - 8,276,242 (-)NCBI
Ensembl Acc Id: ENSRNOP00000020806   ⟸   ENSRNOT00000020806
RefSeq Acc Id: XP_038960645   ⟸   XM_039104717
- Peptide Label: isoform X1
- UniProtKB: G3V7Z0 (UniProtKB/TrEMBL),   B2RYB2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084756   ⟸   ENSRNOT00000113013
RefSeq Acc Id: NP_001386238   ⟸   NM_001399309
- Peptide Label: isoform 3
- UniProtKB: G3V7Z0 (UniProtKB/TrEMBL),   B2RYB2 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001386237   ⟸   NM_001399308
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001386236   ⟸   NM_001399307
- Peptide Label: isoform 1
- UniProtKB: A6JT64 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2QC22-F1-model_v2 AlphaFold A0A0G2QC22 1-205 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691880
Promoter ID:EPDNEW_R2404
Type:initiation region
Name:Paxx_1
Description:PAXX, non-homologous end joining factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.032,680,464 - 2,680,524EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306215 AgrOrtholog
BioCyc Gene G2FUF-50451 BioCyc
Ensembl Genes ENSRNOG00000015294 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020806.9 UniProtKB/TrEMBL
  ENSRNOT00000113013 ENTREZGENE
  ENSRNOT00000113013.2 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7930772 IMAGE-MGC_LOAD
InterPro DUF4610 UniProtKB/TrEMBL
  PAXX_N UniProtKB/TrEMBL
MGC_CLONE MGC:188415 IMAGE-MGC_LOAD
NCBI Gene 296565 ENTREZGENE
PANTHER PROTEIN PAXX UniProtKB/TrEMBL
  PTHR28586 UniProtKB/TrEMBL
Pfam DUF4610 UniProtKB/TrEMBL
PhenoGen Paxx PhenoGen
RatGTEx ENSRNOG00000015294 RatGTEx
UniProt A0A0G2QC22_RAT UniProtKB/TrEMBL
  A0A8I6A089_RAT UniProtKB/TrEMBL
  A6JT64 ENTREZGENE, UniProtKB/TrEMBL
  B2RYB2 ENTREZGENE, UniProtKB/TrEMBL
  G3V7Z0 ENTREZGENE
UniProt Secondary G3V7Z0 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-20 Paxx  PAXX, non-homologous end joining factor  RGD1306215  similar to hypothetical protein MGC36831  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1306215  similar to hypothetical protein MGC36831   RGD1306215_predicted  similar to hypothetical protein MGC36831 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1306215_predicted  similar to hypothetical protein MGC36831 (predicted)  LOC296565_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC296565_predicted  similar to hypothetical protein MGC36831 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL