Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (1->4)-beta-D-glucan | multiple interactions | ISO | Lhx6 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of LHX6 mRNA | CTD | PMID:36331819 | 17beta-estradiol | multiple interactions | ISO | LHX6 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of LHX6 mRNA | CTD | PMID:30165855 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Lhx6 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of LHX6 mRNA | CTD | PMID:21570461 and PMID:24058054 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of LHX6 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Lhx6 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of LHX6 mRNA | CTD | PMID:19770486 and PMID:28922406 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Lhx6 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of LHX6 mRNA | CTD | PMID:26251327 | 4,4'-diaminodiphenylmethane | affects expression | ISO | Lhx6 (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane affects the expression of LHX6 mRNA | CTD | PMID:18648102 | 4-hydroxyphenyl retinamide | increases expression | ISO | Lhx6 (Mus musculus) | 6480464 | Fenretinide results in increased expression of LHX6 mRNA | CTD | PMID:28973697 | 5-aza-2'-deoxycytidine | decreases expression | ISO | Lhx6 (Mus musculus) | 6480464 | Decitabine results in decreased expression of LHX6 mRNA | CTD | PMID:27915011 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of LHX6 mRNA | CTD | PMID:24780913 and PMID:25825206 | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of LHX6 mRNA | CTD | PMID:31881176 | aflatoxin B1 | decreases expression | ISO | Lhx6 (Mus musculus) | 6480464 | Aflatoxin B1 results in decreased expression of LHX6 mRNA | CTD | PMID:19770486 | aflatoxin B1 | increases expression | ISO | LHX6 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of LHX6 mRNA | CTD | PMID:21641981 | Aflatoxin B2 alpha | increases methylation | ISO | LHX6 (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of LHX6 intron | CTD | PMID:30157460 | all-trans-retinoic acid | decreases expression | ISO | Lhx6 (Mus musculus) | 6480464 | Tretinoin results in decreased expression of LHX6 mRNA | CTD | PMID:16000160 | all-trans-retinoic acid | decreases expression | ISO | LHX6 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of LHX6 mRNA | CTD | PMID:33167477 | amosite asbestos | decreases methylation | ISO | LHX6 (Homo sapiens) | 6480464 | Asbestos and Amosite results in decreased methylation of LHX6 promoter | CTD | PMID:29626692 | arsenite(3-) | increases methylation | ISO | LHX6 (Homo sapiens) | 6480464 | arsenite results in increased methylation of LHX6 promoter | CTD | PMID:23974009 | arsenous acid | decreases expression | ISO | LHX6 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of LHX6 mRNA | CTD | PMID:15761015 | atrazine | increases expression | ISO | LHX6 (Homo sapiens) | 6480464 | Atrazine results in increased expression of LHX6 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | decreases expression | ISO | Lhx6 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of LHX6 mRNA | CTD | PMID:19770486 | benzo[a]pyrene | affects methylation | ISO | LHX6 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of LHX6 intron | CTD | PMID:30157460 | benzo[a]pyrene | increases methylation | ISO | LHX6 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of LHX6 3' UTR | CTD | PMID:27901495 | benzo[e]pyrene | increases methylation | ISO | LHX6 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of LHX6 intron | CTD | PMID:30157460 | bis(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of LHX6 promoter | CTD | PMID:23359474 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of LHX6 promoter | CTD | PMID:23359474 | bisphenol A | increases expression | ISO | Lhx6 (Mus musculus) | 6480464 | bisphenol A results in increased expression of LHX6 mRNA | CTD | PMID:32156529 | bisphenol A | decreases methylation | ISO | LHX6 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of LHX6 gene | CTD | PMID:31601247 | bisphenol A | affects methylation | ISO | Lhx6 (Mus musculus) | 6480464 | bisphenol A affects the methylation of LHX6 promoter | CTD | PMID:27334623 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of LHX6 mRNA | CTD | PMID:25181051 | butanal | increases expression | ISO | LHX6 (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of LHX6 mRNA | CTD | PMID:26079696 | choline | multiple interactions | ISO | Lhx6 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of LHX6 mRNA more ... | CTD | PMID:20938992 | cisplatin | increases expression | ISO | LHX6 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of LHX6 mRNA | CTD | PMID:27392435 | copper(II) sulfate | increases expression | ISO | LHX6 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of LHX6 mRNA | CTD | PMID:19549813 | crocidolite asbestos | decreases methylation | ISO | LHX6 (Homo sapiens) | 6480464 | Asbestos and Crocidolite results in decreased methylation of LHX6 promoter | CTD | PMID:29626692 | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of LHX6 mRNA | CTD | PMID:26577399 | cyclosporin A | decreases expression | ISO | Lhx6 (Mus musculus) | 6480464 | Cyclosporine results in decreased expression of LHX6 mRNA | CTD | PMID:19770486 | diarsenic trioxide | decreases expression | ISO | LHX6 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of LHX6 mRNA | CTD | PMID:15761015 | dibutyl phthalate | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of LHX6 promoter | CTD | PMID:23359474 | ethanol | multiple interactions | ISO | Lhx6 (Mus musculus) | 6480464 | Ethanol affects the expression of and affects the splicing of LHX6 mRNA | CTD | PMID:30319688 | folic acid | multiple interactions | ISO | Lhx6 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of LHX6 mRNA more ... | CTD | PMID:20938992 | folic acid | increases expression | ISO | Lhx6 (Mus musculus) | 6480464 | Folic Acid results in increased expression of LHX6 mRNA | CTD | PMID:25629700 | furan | decreases expression | EXP | | 6480464 | furan results in decreased expression of LHX6 mRNA | CTD | PMID:25539665 | genistein | increases expression | ISO | Lhx6 (Mus musculus) | 6480464 | Genistein results in increased expression of LHX6 mRNA | CTD | PMID:32186404 | hydrogen peroxide | affects expression | ISO | LHX6 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of LHX6 mRNA | CTD | PMID:20044591 | inulin | multiple interactions | ISO | Lhx6 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of LHX6 mRNA | CTD | PMID:36331819 | L-methionine | multiple interactions | ISO | Lhx6 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of LHX6 mRNA more ... | CTD | PMID:20938992 | menadione | affects expression | ISO | LHX6 (Homo sapiens) | 6480464 | Vitamin K 3 affects the expression of LHX6 mRNA | CTD | PMID:20044591 | methapyrilene | increases methylation | ISO | LHX6 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of LHX6 intron | CTD | PMID:30157460 | niclosamide | increases expression | ISO | LHX6 (Homo sapiens) | 6480464 | Niclosamide results in increased expression of LHX6 mRNA | CTD | PMID:36318118 | paracetamol | affects expression | ISO | Lhx6 (Mus musculus) | 6480464 | Acetaminophen affects the expression of LHX6 mRNA | CTD | PMID:17562736 | pentanal | increases expression | ISO | LHX6 (Homo sapiens) | 6480464 | pentanal results in increased expression of LHX6 mRNA | CTD | PMID:26079696 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Lhx6 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of LHX6 mRNA more ... | CTD | PMID:36331819 | phenobarbital | increases expression | ISO | Lhx6 (Mus musculus) | 6480464 | Phenobarbital results in increased expression of LHX6 mRNA | CTD | PMID:19482888 | phenobarbital | multiple interactions | ISO | Lhx6 (Mus musculus) | 6480464 | NR1I3 protein affects the reaction [Phenobarbital results in increased expression of LHX6 mRNA] | CTD | PMID:19482888 | pirinixic acid | increases expression | ISO | Lhx6 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of LHX6 mRNA | CTD | PMID:23811191 | potassium dichromate | decreases expression | ISO | Lhx6 (Mus musculus) | 6480464 | Potassium Dichromate results in decreased expression of LHX6 mRNA | CTD | PMID:23608068 | propanal | increases expression | ISO | LHX6 (Homo sapiens) | 6480464 | propionaldehyde results in increased expression of LHX6 mRNA | CTD | PMID:26079696 | resveratrol | multiple interactions | ISO | LHX6 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of LHX6 mRNA | CTD | PMID:23557933 | sodium arsenite | affects methylation | ISO | LHX6 (Homo sapiens) | 6480464 | sodium arsenite affects the methylation of LHX6 gene | CTD | PMID:28589171 | sodium arsenite | increases expression | ISO | Lhx6 (Mus musculus) | 6480464 | sodium arsenite results in increased expression of LHX6 mRNA | CTD | PMID:37682722 | sotorasib | multiple interactions | ISO | LHX6 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LHX6 mRNA | CTD | PMID:36139627 | tamoxifen | decreases expression | ISO | Lhx6 (Mus musculus) | 6480464 | Tamoxifen results in decreased expression of LHX6 mRNA | CTD | PMID:25123088 | temozolomide | decreases expression | ISO | LHX6 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of LHX6 mRNA | CTD | PMID:31758290 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of LHX6 mRNA | CTD | PMID:31150632 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of LHX6 mRNA | CTD | PMID:34492290 | titanium dioxide | increases expression | ISO | Lhx6 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of LHX6 mRNA | CTD | PMID:29264374 | trametinib | multiple interactions | ISO | LHX6 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LHX6 mRNA | CTD | PMID:36139627 | trichloroethene | increases expression | ISO | Lhx6 (Mus musculus) | 6480464 | Trichloroethylene results in increased expression of LHX6 mRNA | CTD | PMID:25549359 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of LHX6 mRNA | CTD | PMID:33387578 | triptonide | increases expression | ISO | Lhx6 (Mus musculus) | 6480464 | triptonide results in increased expression of LHX6 mRNA | CTD | PMID:33045310 | valproic acid | decreases methylation | ISO | LHX6 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of LHX6 gene | CTD | PMID:29154799 | |