Exosc8 (exosome component 8) - Rat Genome Database

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Gene: Exosc8 (exosome component 8) Rattus norvegicus
Analyze
Symbol: Exosc8
Name: exosome component 8
RGD ID: 1306169
Description: Predicted to enable identical protein binding activity and mRNA 3'-UTR AU-rich region binding activity. Predicted to be involved in RNA metabolic process. Predicted to be located in cytoplasm and nucleolus. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 1C. Orthologous to human EXOSC8 (exosome component 8); PARTICIPATES IN RNA degradation pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: exosome complex component RRP43; exosome complex exonuclease RRP43; LOC295050
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82141,080,568 - 141,087,112 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2141,080,568 - 141,087,229 (-)EnsemblGRCr8
mRatBN7.22138,930,405 - 138,937,009 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2138,930,405 - 138,936,928 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2145,504,656 - 145,511,199 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02143,616,682 - 143,623,225 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02138,248,517 - 138,255,060 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02143,925,643 - 143,932,240 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2143,925,546 - 143,931,940 (-)Ensemblrn6Rnor6.0
Rnor_5.02160,331,306 - 160,337,857 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42143,954,943 - 143,961,239 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2133,415,207 - 133,421,503 (-)NCBICelera
RGSC_v3.12143,905,006 - 143,911,553 (-)NCBI
Cytogenetic Map2q26NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-hexachlorocyclohexane  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
calcitriol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
deguelin  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
fenpyroximate  (ISO)
folic acid  (ISO)
Heptachlor epoxide  (ISO)
inulin  (ISO)
L-methionine  (ISO)
lucanthone  (ISO)
menadione  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
nickel sulfate  (ISO)
Nutlin-3  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
propiconazole  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thifluzamide  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15231747   PMID:16912217   PMID:17174896   PMID:17545563   PMID:20531389   PMID:22871113   PMID:25416956  


Genomics

Comparative Map Data
Exosc8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82141,080,568 - 141,087,112 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2141,080,568 - 141,087,229 (-)EnsemblGRCr8
mRatBN7.22138,930,405 - 138,937,009 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2138,930,405 - 138,936,928 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2145,504,656 - 145,511,199 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02143,616,682 - 143,623,225 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02138,248,517 - 138,255,060 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02143,925,643 - 143,932,240 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2143,925,546 - 143,931,940 (-)Ensemblrn6Rnor6.0
Rnor_5.02160,331,306 - 160,337,857 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42143,954,943 - 143,961,239 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2133,415,207 - 133,421,503 (-)NCBICelera
RGSC_v3.12143,905,006 - 143,911,553 (-)NCBI
Cytogenetic Map2q26NCBI
EXOSC8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381337,000,786 - 37,009,614 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1336,998,816 - 37,025,881 (+)Ensemblhg38GRCh38
GRCh371337,574,923 - 37,583,751 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361336,472,917 - 36,481,538 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341336,472,916 - 36,481,533NCBI
Celera1318,641,920 - 18,650,994 (+)NCBICelera
Cytogenetic Map13q13.3NCBI
HuRef1318,386,195 - 18,395,269 (+)NCBIHuRef
CHM1_11337,542,228 - 37,551,301 (+)NCBICHM1_1
T2T-CHM13v2.01336,219,982 - 36,228,811 (+)NCBIT2T-CHM13v2.0
Exosc8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39354,636,099 - 54,642,469 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl354,636,099 - 54,642,814 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38354,728,679 - 54,735,364 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl354,728,678 - 54,735,393 (-)Ensemblmm10GRCm38
MGSCv37354,532,601 - 54,539,286 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36354,816,609 - 54,823,322 (-)NCBIMGSCv36mm8
Celera354,450,363 - 54,457,048 (-)NCBICelera
Cytogenetic Map3CNCBI
cM Map325.6NCBI
Exosc8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554319,049,896 - 9,058,264 (-)Ensembl
ChiLan1.0NW_0049554319,048,210 - 9,058,079 (-)NCBIChiLan1.0ChiLan1.0
EXOSC8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21436,520,654 - 36,529,766 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11327,626,152 - 27,635,938 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01318,208,074 - 18,217,426 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11336,638,238 - 36,647,273 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1336,638,406 - 36,647,273 (+)EnsemblpanPan2panpan1.1
EXOSC8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1253,698,399 - 3,708,342 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl253,698,483 - 3,769,683 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha253,728,510 - 3,738,439 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0253,796,701 - 3,806,631 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl253,796,785 - 3,868,011 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1253,699,634 - 3,709,602 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0253,690,760 - 3,700,868 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0253,762,772 - 3,772,753 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Exosc8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945164,836,513 - 164,839,471 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647231,112,767 - 31,115,639 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647231,112,733 - 31,115,639 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EXOSC8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1112,817,110 - 12,825,843 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11112,817,081 - 12,825,847 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21112,775,507 - 12,784,038 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EXOSC8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1315,520,122 - 15,529,101 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl315,519,804 - 15,529,014 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605728,755,523 - 28,764,658 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Exosc8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624776223,236 - 230,620 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624776223,236 - 230,572 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Exosc8
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1399,669,705 - 99,676,272 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Exosc8
17 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:24
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000017993
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)2105628029150628029Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2124103798154505346Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2120039407159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2120039407151869825Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2104957381149957381Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2120339555165339555Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2114032149150226270Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)2114440891159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2116804572161804572Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat

Markers in Region
RH129336  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22138,930,450 - 138,930,948 (+)MAPPERmRatBN7.2
mRatBN7.2562,498,224 - 62,498,442 (+)MAPPERmRatBN7.2
Rnor_6.0563,918,395 - 63,918,612NCBIRnor6.0
Rnor_6.02143,925,689 - 143,926,186NCBIRnor6.0
Rnor_5.0568,435,750 - 68,435,967UniSTSRnor5.0
Rnor_5.02160,337,315 - 160,337,812UniSTSRnor5.0
RGSC_v3.42143,954,988 - 143,955,485UniSTSRGSC3.4
RGSC_v3.4564,850,065 - 64,850,282UniSTSRGSC3.4
Celera565,096,714 - 65,096,931UniSTS
Celera2133,415,252 - 133,415,749UniSTS
RH 3.4 Map2860.6UniSTS
Cytogenetic Map2q26UniSTS
Cytogenetic Map5q22UniSTS
AA924460  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2562,498,132 - 62,498,305 (+)MAPPERmRatBN7.2
mRatBN7.22138,930,587 - 138,931,503 (+)MAPPERmRatBN7.2
Rnor_6.02143,925,826 - 143,926,741NCBIRnor6.0
Rnor_6.0563,918,303 - 63,918,475NCBIRnor6.0
Rnor_5.0568,435,658 - 68,435,830UniSTSRnor5.0
Rnor_5.02160,336,760 - 160,337,675UniSTSRnor5.0
RGSC_v3.42143,955,125 - 143,956,040UniSTSRGSC3.4
RGSC_v3.4564,849,973 - 64,850,145UniSTSRGSC3.4
Celera565,096,851 - 65,097,023UniSTS
Celera2133,415,389 - 133,416,304UniSTS
RH 3.4 Map5409.7UniSTS
Cytogenetic Map2q26UniSTS
Cytogenetic Map5q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 91 59 6 355 191 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000081705   ⟹   ENSRNOP00000073348
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2141,080,568 - 141,087,052 (-)Ensembl
mRatBN7.2 Ensembl2138,930,405 - 138,936,928 (-)Ensembl
Rnor_6.0 Ensembl2143,925,546 - 143,931,316 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086214   ⟹   ENSRNOP00000073903
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2141,080,568 - 141,087,007 (-)Ensembl
mRatBN7.2 Ensembl2138,930,406 - 138,936,702 (-)Ensembl
Rnor_6.0 Ensembl2143,925,644 - 143,931,940 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101091   ⟹   ENSRNOP00000088748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2141,080,568 - 141,085,868 (-)Ensembl
mRatBN7.2 Ensembl2138,930,405 - 138,935,705 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107413   ⟹   ENSRNOP00000093727
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2141,080,568 - 141,087,229 (-)Ensembl
mRatBN7.2 Ensembl2138,930,405 - 138,936,922 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111232   ⟹   ENSRNOP00000097501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2138,930,405 - 138,934,932 (-)Ensembl
RefSeq Acc Id: NM_001399221   ⟹   NP_001386150
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,080,568 - 141,087,097 (-)NCBI
mRatBN7.22138,930,405 - 138,936,934 (-)NCBI
RefSeq Acc Id: XM_039102009   ⟹   XP_038957937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,081,691 - 141,087,112 (-)NCBI
mRatBN7.22138,931,600 - 138,937,007 (-)NCBI
Ensembl Acc Id: ENSRNOP00000073348   ⟸   ENSRNOT00000081705
Ensembl Acc Id: ENSRNOP00000073903   ⟸   ENSRNOT00000086214
RefSeq Acc Id: XP_038957937   ⟸   XM_039102009
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000093727   ⟸   ENSRNOT00000107413
Ensembl Acc Id: ENSRNOP00000088748   ⟸   ENSRNOT00000101091
Ensembl Acc Id: ENSRNOP00000097501   ⟸   ENSRNOT00000111232
RefSeq Acc Id: NP_001386150   ⟸   NM_001399221
- UniProtKB: A6JVC8 (UniProtKB/TrEMBL),   D4AE98 (UniProtKB/TrEMBL)
Protein Domains
Exoribonuclease phosphorolytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K5A0-F1-model_v2 AlphaFold A0A0G2K5A0 1-243 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306169 AgrOrtholog
BioCyc Gene G2FUF-53076 BioCyc
Ensembl Genes ENSRNOG00000051623 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000081705.3 UniProtKB/TrEMBL
  ENSRNOT00000086214.3 UniProtKB/TrEMBL
  ENSRNOT00000101091.2 UniProtKB/TrEMBL
  ENSRNOT00000107413 ENTREZGENE
  ENSRNOT00000107413.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.230.70 UniProtKB/TrEMBL
InterPro ExoRNase_PH_dom1 UniProtKB/TrEMBL
  ExoRNase_PH_dom2 UniProtKB/TrEMBL
  ExoRNase_PH_dom2_sf UniProtKB/TrEMBL
  Exosome_comp_Rrp42_subfam UniProtKB/TrEMBL
  PNPase/RNase_PH_dom UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/TrEMBL
  Rrp43 UniProtKB/TrEMBL
NCBI Gene 295050 ENTREZGENE
PANTHER EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN UniProtKB/TrEMBL
  PTHR11097:SF9 UniProtKB/TrEMBL
Pfam RNase_PH UniProtKB/TrEMBL
  RNase_PH_C UniProtKB/TrEMBL
PhenoGen Exosc8 PhenoGen
RatGTEx ENSRNOG00000051623 RatGTEx
Superfamily-SCOP 3_ExoRNase UniProtKB/TrEMBL
  SSF54211 UniProtKB/TrEMBL
UniProt A0A0G2K5A0_RAT UniProtKB/TrEMBL
  A0A8I6AAC4_RAT UniProtKB/TrEMBL
  A0A8I6AXF8_RAT UniProtKB/TrEMBL
  A6JVC8 ENTREZGENE, UniProtKB/TrEMBL
  D4AE98 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Exosc8  exosome component 8   Exosc8_predicted  exosome component 8 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Exosc8_predicted  exosome component 8 (predicted)      Symbol and Name status set to approved 70820 APPROVED