Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Pcnx1 | Rat | (+)-catechin | multiple interactions | ISO | PCNX1 (Homo sapiens) | 6480464 | [Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of PCNX1 mRNA | CTD | PMID:24763279 | Pcnx1 | Rat | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PCNX1 mRNA] | CTD | PMID:31150632 | Pcnx1 | Rat | 1,2-dimethylhydrazine | increases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in increased expression of PCNX1 mRNA | CTD | PMID:22206623 | Pcnx1 | Rat | 1-naphthyl isothiocyanate | decreases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in decreased expression of PCNX1 mRNA | CTD | PMID:30723492 | Pcnx1 | Rat | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of PCNX1 mRNA | CTD | PMID:29097150 | Pcnx1 | Rat | 17alpha-ethynylestradiol | multiple interactions | ISO | Pcnx1 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PCNX1 mRNA | CTD | PMID:17942748 | Pcnx1 | Rat | 17alpha-ethynylestradiol | increases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of PCNX1 mRNA | CTD | PMID:17942748 | Pcnx1 | Rat | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of PCNX1 mRNA | CTD | PMID:32145629 | Pcnx1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PCNX1 mRNA | CTD | PMID:18796159|PMID:33387578|PMID:34747641 | Pcnx1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Pcnx1 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PCNX1 mRNA | CTD | PMID:17942748 | Pcnx1 | Rat | 4,4'-sulfonyldiphenol | decreases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | bisphenol S results in decreased expression of PCNX1 mRNA | CTD | PMID:39298647 | Pcnx1 | Rat | 4-hydroxyphenyl retinamide | decreases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of PCNX1 mRNA | CTD | PMID:28973697 | Pcnx1 | Rat | aflatoxin B1 | increases methylation | ISO | PCNX1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of PCNX1 intron | CTD | PMID:30157460 | Pcnx1 | Rat | all-trans-retinoic acid | increases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of PCNX1 mRNA | CTD | PMID:33167477 | Pcnx1 | Rat | aristolochic acid A | decreases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of PCNX1 mRNA | CTD | PMID:33212167 | Pcnx1 | Rat | arsane | affects methylation | ISO | PCNX1 (Homo sapiens) | 6480464 | Arsenic affects the methylation of PCNX1 gene | CTD | PMID:25304211 | Pcnx1 | Rat | arsenic atom | affects methylation | ISO | PCNX1 (Homo sapiens) | 6480464 | Arsenic affects the methylation of PCNX1 gene | CTD | PMID:25304211 | Pcnx1 | Rat | arsenite(3-) | multiple interactions | ISO | PCNX1 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to PCNX1 mRNA] | CTD | PMID:32406909 | Pcnx1 | Rat | atrazine | increases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | Atrazine results in increased expression of PCNX1 mRNA | CTD | PMID:22378314 | Pcnx1 | Rat | benzo[a]pyrene | affects methylation | ISO | PCNX1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of PCNX1 intron | CTD | PMID:30157460 | Pcnx1 | Rat | benzo[a]pyrene | multiple interactions | ISO | Pcnx1 (Mus musculus) | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of PCNX1 mRNA] | CTD | PMID:22228805 | Pcnx1 | Rat | benzo[a]pyrene | increases mutagenesis | ISO | PCNX1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased mutagenesis of PCNX1 gene | CTD | PMID:25435355 | Pcnx1 | Rat | benzo[a]pyrene | increases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of PCNX1 mRNA | CTD | PMID:22228805 | Pcnx1 | Rat | benzo[a]pyrene | decreases methylation | ISO | PCNX1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of PCNX1 3' UTR; Benzo(a)pyrene results in decreased methylation of more ... | CTD | PMID:27901495 | Pcnx1 | Rat | Benzo[ghi]perylene | increases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | 1,12-benzoperylene results in increased expression of PCNX1 mRNA | CTD | PMID:26377693 | Pcnx1 | Rat | beta-lapachone | increases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | beta-lapachone results in increased expression of PCNX1 mRNA | CTD | PMID:38218311 | Pcnx1 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PCNX1 mRNA | CTD | PMID:25181051|PMID:32145629 | Pcnx1 | Rat | bisphenol A | increases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | bisphenol A results in increased expression of PCNX1 mRNA | CTD | PMID:26063408 | Pcnx1 | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of PCNX1 gene | CTD | PMID:28505145 | Pcnx1 | Rat | bisphenol A | affects methylation | ISO | PCNX1 (Homo sapiens) | 6480464 | bisphenol A affects the methylation of PCNX1 gene | CTD | PMID:31601247 | Pcnx1 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PCNX1 mRNA | CTD | PMID:30816183|PMID:32528016 | Pcnx1 | Rat | Butylbenzyl phthalate | decreases methylation | ISO | Pcnx1 (Mus musculus) | 6480464 | butylbenzyl phthalate results in decreased methylation of PCNX1 intron | CTD | PMID:28392331 | Pcnx1 | Rat | cadmium dichloride | decreases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of PCNX1 mRNA | CTD | PMID:38568856 | Pcnx1 | Rat | caffeine | affects phosphorylation | ISO | PCNX1 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of PCNX1 protein | CTD | PMID:35688186 | Pcnx1 | Rat | carbon nanotube | decreases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in decreased expression of PCNX1 mRNA; Nanotubes, Carbon results in decreased more ... | CTD | PMID:25554681 | Pcnx1 | Rat | CGP 52608 | multiple interactions | ISO | PCNX1 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PCNX1 gene] | CTD | PMID:28238834 | Pcnx1 | Rat | chromium(6+) | affects expression | ISO | Pcnx1 (Mus musculus) | 6480464 | chromium hexavalent ion affects the expression of PCNX1 mRNA | CTD | PMID:28472532 | Pcnx1 | Rat | crocidolite asbestos | decreases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | Asbestos, Crocidolite results in decreased expression of PCNX1 mRNA | CTD | PMID:29523930 | Pcnx1 | Rat | crocidolite asbestos | decreases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | Asbestos, Crocidolite results in decreased expression of PCNX1 mRNA | CTD | PMID:29279043 | Pcnx1 | Rat | Dibutyl phosphate | affects expression | ISO | PCNX1 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of PCNX1 mRNA | CTD | PMID:37042841 | Pcnx1 | Rat | dorsomorphin | multiple interactions | ISO | PCNX1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Pcnx1 | Rat | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of PCNX1 mRNA | CTD | PMID:29391264 | Pcnx1 | Rat | epoxiconazole | affects expression | ISO | Pcnx1 (Mus musculus) | 6480464 | epoxiconazole affects the expression of PCNX1 mRNA | CTD | PMID:35436446 | Pcnx1 | Rat | ethanol | increases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | Ethanol results in increased expression of PCNX1 mRNA | CTD | PMID:30319688 | Pcnx1 | Rat | ethanol | affects splicing | ISO | Pcnx1 (Mus musculus) | 6480464 | Ethanol affects the splicing of PCNX1 mRNA | CTD | PMID:30319688 | Pcnx1 | Rat | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of PCNX1 mRNA | CTD | PMID:24136188 | Pcnx1 | Rat | formaldehyde | decreases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of PCNX1 mRNA | CTD | PMID:20655997 | Pcnx1 | Rat | FR900359 | increases phosphorylation | ISO | PCNX1 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of PCNX1 protein | CTD | PMID:37730182 | Pcnx1 | Rat | glafenine | decreases expression | EXP | | 6480464 | Glafenine results in decreased expression of PCNX1 mRNA | CTD | PMID:24136188 | Pcnx1 | Rat | methidathion | decreases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | methidathion results in decreased expression of PCNX1 mRNA | CTD | PMID:34813904 | Pcnx1 | Rat | methyl methanesulfonate | increases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of PCNX1 mRNA | CTD | PMID:23649840 | Pcnx1 | Rat | methylmercury chloride | decreases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of PCNX1 mRNA | CTD | PMID:28001369 | Pcnx1 | Rat | N,N-diethyl-m-toluamide | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of PCNX1 gene | CTD | PMID:33148267 | Pcnx1 | Rat | nefazodone | decreases expression | EXP | | 6480464 | nefazodone results in decreased expression of PCNX1 mRNA | CTD | PMID:24136188 | Pcnx1 | Rat | nickel atom | increases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | Nickel results in increased expression of PCNX1 mRNA | CTD | PMID:24768652|PMID:25583101 | Pcnx1 | Rat | nimesulide | decreases expression | EXP | | 6480464 | nimesulide results in decreased expression of PCNX1 mRNA | CTD | PMID:24136188 | Pcnx1 | Rat | ozone | multiple interactions | ISO | Pcnx1 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased more ... | CTD | PMID:34911549 | Pcnx1 | Rat | ozone | multiple interactions | ISO | PCNX1 (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of PCNX1 mRNA | CTD | PMID:35430440 | Pcnx1 | Rat | paracetamol | increases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of PCNX1 mRNA | CTD | PMID:22230336 | Pcnx1 | Rat | permethrin | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of PCNX1 gene | CTD | PMID:33148267 | Pcnx1 | Rat | SB 431542 | multiple interactions | ISO | PCNX1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Pcnx1 | Rat | silver atom | decreases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | Silver results in decreased expression of PCNX1 mRNA | CTD | PMID:27131904 | Pcnx1 | Rat | silver(0) | decreases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | Silver results in decreased expression of PCNX1 mRNA | CTD | PMID:27131904 | Pcnx1 | Rat | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of PCNX1 mRNA | CTD | PMID:31150632 | Pcnx1 | Rat | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PCNX1 mRNA] | CTD | PMID:31150632 | Pcnx1 | Rat | thimerosal | increases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | Thimerosal results in increased expression of PCNX1 mRNA | CTD | PMID:27188386 | Pcnx1 | Rat | thiram | increases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | Thiram results in increased expression of PCNX1 mRNA | CTD | PMID:38568856 | Pcnx1 | Rat | titanium dioxide | increases methylation | ISO | Pcnx1 (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of PCNX gene | CTD | PMID:35295148 | Pcnx1 | Rat | titanium dioxide | affects expression | ISO | Pcnx1 (Mus musculus) | 6480464 | titanium dioxide affects the expression of PCNX1 mRNA | CTD | PMID:17656681 | Pcnx1 | Rat | trichostatin A | increases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of PCNX1 mRNA | CTD | PMID:24935251 | Pcnx1 | Rat | tungsten | decreases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | Tungsten results in decreased expression of PCNX1 mRNA | CTD | PMID:30912803 | Pcnx1 | Rat | valproic acid | increases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of PCNX1 mRNA | CTD | PMID:19101580 | Pcnx1 | Rat | valproic acid | affects splicing | EXP | | 6480464 | Valproic Acid affects the splicing of PCNX1 mRNA | CTD | PMID:29427782 | Pcnx1 | Rat | valproic acid | multiple interactions | ISO | PCNX1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Pcnx1 | Rat | valproic acid | affects expression | ISO | PCNX1 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of PCNX1 mRNA | CTD | PMID:23179753 | Pcnx1 | Rat | valproic acid | decreases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of PCNX1 mRNA | CTD | PMID:24383497|PMID:24935251|PMID:26272509 | Pcnx1 | Rat | vincristine | increases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | Vincristine results in increased expression of PCNX1 mRNA | CTD | PMID:23649840 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















