Tmem150c (transmembrane protein 150C) - Rat Genome Database

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Gene: Tmem150c (transmembrane protein 150C) Rattus norvegicus
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Symbol: Tmem150c
Name: transmembrane protein 150C
RGD ID: 1306105
Description: Predicted to enable mechanosensitive monoatomic cation channel activity. Predicted to be involved in cellular response to mechanical stimulus and proprioception. Predicted to be located in lysosomal membrane. Predicted to be active in plasma membrane. Orthologous to human TMEM150C (transmembrane protein 150C); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC360916; RGD1306105; similar to RIKEN cDNA 2610318G18
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8149,759,028 - 9,829,588 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl149,752,716 - 9,829,588 (+)EnsemblGRCr8
mRatBN7.2149,454,999 - 9,525,300 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl149,508,515 - 9,525,298 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx149,427,697 - 9,497,590 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01410,727,572 - 10,797,431 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0149,424,175 - 9,494,040 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01411,094,655 - 11,166,323 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1411,095,163 - 11,166,428 (+)Ensemblrn6Rnor6.0
Rnor_5.01411,038,785 - 11,110,144 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41410,810,825 - 10,827,609 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera149,557,191 - 9,626,529 (+)NCBICelera
RGSC_v3.11410,737,180 - 10,827,607 (+)NCBI
Cytogenetic Map14p22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
lysosomal membrane  (IEA)
plasma membrane  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:25608530   PMID:27321926  


Genomics

Comparative Map Data
Tmem150c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8149,759,028 - 9,829,588 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl149,752,716 - 9,829,588 (+)EnsemblGRCr8
mRatBN7.2149,454,999 - 9,525,300 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl149,508,515 - 9,525,298 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx149,427,697 - 9,497,590 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01410,727,572 - 10,797,431 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0149,424,175 - 9,494,040 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01411,094,655 - 11,166,323 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1411,095,163 - 11,166,428 (+)Ensemblrn6Rnor6.0
Rnor_5.01411,038,785 - 11,110,144 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41410,810,825 - 10,827,609 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera149,557,191 - 9,626,529 (+)NCBICelera
RGSC_v3.11410,737,180 - 10,827,607 (+)NCBI
Cytogenetic Map14p22NCBI
TMEM150C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38482,483,176 - 82,562,253 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl482,483,170 - 82,562,357 (-)Ensemblhg38GRCh38
GRCh37483,404,329 - 83,483,406 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36483,624,628 - 83,702,150 (-)NCBIBuild 36Build 36hg18NCBI36
Celera480,696,582 - 80,774,150 (-)NCBICelera
Cytogenetic Map4q21.22NCBI
HuRef479,146,347 - 79,223,812 (-)NCBIHuRef
CHM1_1483,381,776 - 83,459,611 (-)NCBICHM1_1
T2T-CHM13v2.0485,812,454 - 85,891,532 (-)NCBIT2T-CHM13v2.0
Tmem150c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395100,225,731 - 100,313,463 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5100,225,731 - 100,307,667 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm39 Ensembl5100,263,102 - 100,307,946 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385100,077,872 - 100,165,607 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5100,077,872 - 100,159,808 (-)Ensemblmm10GRCm38
MGSCv375100,506,891 - 100,588,827 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365100,318,174 - 100,400,110 (-)NCBIMGSCv36mm8
Celera597,392,866 - 97,479,279 (-)NCBICelera
Cytogenetic Map5E4NCBI
cM Map548.46NCBI
Tmem150c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554336,560,628 - 6,628,525 (-)Ensembl
ChiLan1.0NW_0049554336,560,628 - 6,628,525 (-)NCBIChiLan1.0ChiLan1.0
TMEM150C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2347,510,199 - 47,603,990 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1447,699,396 - 47,787,624 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0441,643,173 - 41,730,814 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1447,494,120 - 47,571,212 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl447,552,096 - 47,571,212 (+)EnsemblpanPan2panpan1.1
TMEM150C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1326,465,047 - 6,552,492 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl326,466,035 - 6,539,078 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3235,331,163 - 35,416,805 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0326,488,112 - 6,573,846 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl326,488,115 - 6,559,175 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1326,559,741 - 6,645,448 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0326,424,597 - 6,513,703 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03233,452,884 - 33,538,339 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tmem150c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244052855,794,862 - 5,860,181 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367381,956,488 - 2,022,899 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367382,006,254 - 2,022,906 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM150C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8135,687,934 - 135,765,934 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18135,684,681 - 135,764,608 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28145,058,351 - 145,136,003 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM150C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1730,867,177 - 30,951,903 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl730,865,915 - 30,887,665 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660379,428,957 - 9,516,483 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem150c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247578,422,872 - 8,444,442 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247578,372,847 - 8,442,429 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tmem150c
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11110,318,633 - 10,391,829 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tmem150c
496 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:227
Count of miRNA genes:150
Interacting mature miRNAs:181
Transcripts:ENSRNOT00000003076
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14395787821572472Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14395787818558812Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14111334906Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14117877928Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 78 59 6 340 178 11 143 79 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000003076   ⟹   ENSRNOP00000003076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl149,752,716 - 9,829,588 (+)Ensembl
mRatBN7.2 Ensembl149,508,515 - 9,525,298 (+)Ensembl
Rnor_6.0 Ensembl1411,095,163 - 11,166,428 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000138364   ⟹   ENSRNOP00000110270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl149,759,422 - 9,829,579 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000153392   ⟹   ENSRNOP00000110724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl149,758,563 - 9,829,588 (+)Ensembl
RefSeq Acc Id: NM_001108354   ⟹   NP_001101824
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8149,759,637 - 9,829,588 (+)NCBI
mRatBN7.2149,455,347 - 9,525,300 (+)NCBI
Rnor_6.01411,095,537 - 11,166,323 (+)NCBI
Rnor_5.01411,038,785 - 11,110,144 (+)NCBI
RGSC_v3.41410,810,825 - 10,827,609 (+)RGD
Celera149,557,191 - 9,626,529 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006250670   ⟹   XP_006250732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8149,759,028 - 9,829,583 (+)NCBI
mRatBN7.2149,454,999 - 9,525,299 (+)NCBI
Rnor_6.01411,094,977 - 11,166,322 (+)NCBI
Rnor_5.01411,038,785 - 11,110,144 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063273331   ⟹   XP_063129401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8149,812,347 - 9,829,583 (+)NCBI
RefSeq Acc Id: XM_063273332   ⟹   XP_063129402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8149,815,609 - 9,829,583 (+)NCBI
RefSeq Acc Id: NP_001101824   ⟸   NM_001108354
- UniProtKB: B5DFH9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006250732   ⟸   XM_006250670
- Peptide Label: isoform X1
- UniProtKB: B5DFH9 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003076   ⟸   ENSRNOT00000003076
RefSeq Acc Id: XP_063129401   ⟸   XM_063273331
- Peptide Label: isoform X1
- UniProtKB: B5DFH9 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063129402   ⟸   XM_063273332
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000110270   ⟸   ENSRNOT00000138364
Ensembl Acc Id: ENSRNOP00000110724   ⟸   ENSRNOT00000153392

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DFH9-F1-model_v2 AlphaFold B5DFH9 1-249 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306105 AgrOrtholog
BioCyc Gene G2FUF-16391 BioCyc
Ensembl Genes ENSRNOG00000002258 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003076.8 UniProtKB/Swiss-Prot
  ENSRNOT00000138364 ENTREZGENE
InterPro DRAM/TMEM150_Autophagy_Mod UniProtKB/Swiss-Prot
  Frag1/DRAM/Sfk1 UniProtKB/Swiss-Prot
KEGG Report rno:360916 UniProtKB/Swiss-Prot
NCBI Gene 360916 ENTREZGENE
PANTHER FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED UniProtKB/Swiss-Prot
  TRANSMEMBRANE PROTEIN 150C UniProtKB/Swiss-Prot
Pfam Frag1 UniProtKB/Swiss-Prot
PhenoGen Tmem150c PhenoGen
RatGTEx ENSRNOG00000002258 RatGTEx
UniProt A0ABK0M6L8_RAT UniProtKB/TrEMBL
  B5DFH9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-02-12 Tmem150c  transmembrane protein 150C  RGD1306105  similar to RIKEN cDNA 2610318G18   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1306105  similar to RIKEN cDNA 2610318G18   RGD1306105_predicted  similar to RIKEN cDNA 2610318G18 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1306105_predicted  similar to RIKEN cDNA 2610318G18 (predicted)  LOC360916_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC360916_predicted  similar to RIKEN cDNA 2610318G18 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL