Mnda (myeloid cell nuclear differentiation antigen) - Rat Genome Database

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Gene: Mnda (myeloid cell nuclear differentiation antigen) Rattus norvegicus
Analyze
Symbol: Mnda
Name: myeloid cell nuclear differentiation antigen
RGD ID: 1306089
Description: Predicted to enable double-stranded DNA binding activity and transcription coregulator activity. Predicted to be involved in several processes, including activation of immune response; cellular response to cytokine stimulus; and negative regulation of B cell proliferation. Predicted to act upstream of or within several processes, including inner ear development; positive regulation of osteoblast differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nuclear inclusion body; nuclear periphery; and nuclear speck. Predicted to be active in cytosol; nucleolus; and nucleoplasm. Orthologous to several human genes including PYHIN1 (pyrin and HIN domain family member 1); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ifi204; interferon activated gene 204; LOC304988; rHin-3
RGD Orthologs
Human
Mouse
Mouse
Bonobo
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81388,550,224 - 88,567,892 (-)NCBIGRCr8
mRatBN7.21386,017,888 - 86,035,556 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1386,017,892 - 86,034,201 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1388,525,833 - 88,543,479 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01389,926,105 - 89,943,751 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01387,110,842 - 87,128,488 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01392,073,664 - 92,091,335 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1392,073,668 - 92,089,980 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01396,545,815 - 96,606,181 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41389,752,997 - 89,770,167 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11389,941,881 - 89,959,051 (-)NCBI
Celera1385,620,545 - 85,638,000 (-)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclophosphamide  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dichlorine  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ferric oxide  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
fructose  (ISO)
furan  (EXP)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
metam  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nitrofen  (EXP)
nonanoic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12513910   PMID:15557274   PMID:15896773   PMID:17875758   PMID:19056867   PMID:19158679   PMID:21795542   PMID:23012479   PMID:31505169  


Genomics

Comparative Map Data
Mnda
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81388,550,224 - 88,567,892 (-)NCBIGRCr8
mRatBN7.21386,017,888 - 86,035,556 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1386,017,892 - 86,034,201 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1388,525,833 - 88,543,479 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01389,926,105 - 89,943,751 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01387,110,842 - 87,128,488 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01392,073,664 - 92,091,335 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1392,073,668 - 92,089,980 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01396,545,815 - 96,606,181 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41389,752,997 - 89,770,167 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11389,941,881 - 89,959,051 (-)NCBI
Celera1385,620,545 - 85,638,000 (-)NCBICelera
Cytogenetic Map13q24NCBI
MNDA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381158,831,351 - 158,849,502 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1158,831,351 - 158,849,506 (+)EnsemblGRCh38hg38GRCh38
GRCh371158,801,141 - 158,819,292 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361157,067,792 - 157,085,894 (+)NCBINCBI36Build 36hg18NCBI36
Build 341155,614,240 - 155,632,343NCBI
Celera1131,871,536 - 131,889,615 (+)NCBICelera
Cytogenetic Map1q23.1NCBI
HuRef1130,158,445 - 130,176,628 (+)NCBIHuRef
CHM1_11160,197,828 - 160,215,889 (+)NCBICHM1_1
T2T-CHM13v2.01157,968,444 - 157,986,571 (+)NCBIT2T-CHM13v2.0
Ifi211
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391173,723,907 - 173,740,650 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1173,723,911 - 173,740,612 (-)EnsemblGRCm39 Ensembl
GRCm381173,896,339 - 173,913,087 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1173,896,345 - 173,913,046 (-)EnsemblGRCm38mm10GRCm38
MGSCv371175,826,486 - 175,843,053 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361175,733,030 - 175,749,597 (-)NCBIMGSCv36mm8
Cytogenetic Map1H3NCBI
cM Map180.74NCBI
Ifi204
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391173,574,859 - 173,594,606 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1173,574,859 - 173,594,509 (-)EnsemblGRCm39 Ensembl
GRCm381173,747,293 - 173,767,069 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1173,747,293 - 173,766,943 (-)EnsemblGRCm38mm10GRCm38
MGSCv371175,677,424 - 175,697,050 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361175,583,971 - 175,603,592 (-)NCBIMGSCv36mm8
Celera1176,611,290 - 176,630,307 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map180.63NCBI
MNDA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2190,997,756 - 91,015,719 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1190,741,647 - 90,759,598 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01134,190,768 - 134,208,723 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11137,981,896 - 137,999,850 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1137,992,523 - 137,999,587 (+)Ensemblpanpan1.1panPan2
LOC488622
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13822,874,345 - 22,892,362 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3822,889,707 - 22,929,512 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03822,999,619 - 23,039,476 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13822,763,164 - 22,802,846 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03823,298,079 - 23,337,779 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03823,728,891 - 23,768,811 (-)NCBIUU_Cfam_GSD_1.0
MNDA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1205,079,633 - 5,124,967 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl205,079,632 - 5,095,868 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660384,226,792 - 4,271,918 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Mnda
102 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:199
Count of miRNA genes:129
Interacting mature miRNAs:140
Transcripts:ENSRNOT00000036040
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1302791Stl29Serum triglyceride level QTL 293.30.0011blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)138473078886800898Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat

Markers in Region
RH128603  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map13566.2UniSTS
Cytogenetic Map13q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 45 55 87 86 55 25 55 6 206 93 35 41 54 31

Sequence


Ensembl Acc Id: ENSRNOT00000036040   ⟹   ENSRNOP00000029762
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1386,017,892 - 86,034,201 (-)Ensembl
Rnor_6.0 Ensembl1392,073,668 - 92,089,980 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097344   ⟹   ENSRNOP00000076437
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1386,020,410 - 86,034,201 (-)Ensembl
RefSeq Acc Id: NM_001012029   ⟹   NP_001012029
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81388,550,224 - 88,567,892 (-)NCBI
mRatBN7.21386,017,888 - 86,035,556 (-)NCBI
Rnor_6.01392,073,664 - 92,091,335 (-)NCBI
Rnor_5.01396,545,815 - 96,606,181 (-)NCBI
RGSC_v3.41389,752,997 - 89,770,167 (-)RGD
Celera1385,620,545 - 85,638,000 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001012029 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH85891 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000029762.3
  ENSRNOP00000076437.1
RefSeq Acc Id: NP_001012029   ⟸   NM_001012029
- UniProtKB: Q5U2R8 (UniProtKB/TrEMBL),   A0A8I5Y087 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000029762   ⟸   ENSRNOT00000036040
Ensembl Acc Id: ENSRNOP00000076437   ⟸   ENSRNOT00000097344
Protein Domains
HIN-200   Pyrin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U2R8-F1-model_v2 AlphaFold Q5U2R8 1-438 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306089 AgrOrtholog
BioCyc Gene G2FUF-17270 BioCyc
Ensembl Genes ENSRNOG00000003486 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036040.4 UniProtKB/TrEMBL
  ENSRNOT00000097344.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  2.40.50.140 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7192620 IMAGE-MGC_LOAD
InterPro DEATH-like_dom_sf UniProtKB/TrEMBL
  HIN-200 UniProtKB/TrEMBL
  HIN200/IF120x UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
  Pyrin UniProtKB/TrEMBL
KEGG Report rno:304988 UniProtKB/TrEMBL
MGC_CLONE MGC:94687 IMAGE-MGC_LOAD
NCBI Gene 304988 ENTREZGENE
PANTHER PTHR12200 UniProtKB/TrEMBL
  PYRIN AND HIN DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
Pfam HIN UniProtKB/TrEMBL
  PAAD_DAPIN UniProtKB/TrEMBL
PhenoGen Mnda PhenoGen
PROSITE DAPIN UniProtKB/TrEMBL
  HIN_200 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003486 RatGTEx
SMART PYRIN UniProtKB/TrEMBL
Superfamily-SCOP HIN-2000 domain-like UniProtKB/TrEMBL
UniProt A0A8I5Y087 ENTREZGENE, UniProtKB/TrEMBL
  Q5U2R8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-09 Mnda  myeloid cell nuclear differentiation antigen  Ifi204  interferon activated gene 204  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Ifi204  interferon activated gene 204  Mnda  myeloid cell nuclear differentiation antigen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Mnda  myeloid cell nuclear differentiation antigen  Mnda_predicted  myeloid cell nuclear differentiation antigen (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Mnda_predicted  myeloid cell nuclear differentiation antigen (predicted)      Symbol and Name status set to approved 70820 APPROVED