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Gene: Cyb5r1 (cytochrome b5 reductase 1) Rattus norvegicus

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Symbol:

Cyb5r1

Name:

cytochrome b5 reductase 1

RGD ID:

1306084

Description:

Predicted to enable FAD binding activity and cytochrome-b5 reductase activity, acting on NAD(P)H. Predicted to be involved in sterol biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in mitochondrion. Orthologous to human CYB5R1 (cytochrome b5 reductase 1); PARTICIPATES IN amino sugar metabolic pathway; nucleotide sugar metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

b5R.1; LOC304805; MGC109264; NAD(P)H:quinone oxidoreductase type 3, polypeptide A2; NADH-cytochrome b5 reductase 1; Nqo3a2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CYB5R1 (cytochrome b5 reductase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Cyb5r1 (cytochrome b5 reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	LOC102004351 (NADH-cytochrome b5 reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LOC100967245 (NADH-cytochrome b5 reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CYB5R1 (cytochrome b5 reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	LOC101966914 (NADH-cytochrome b5 reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CYB5R1 (cytochrome b5 reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CYB5R1 (cytochrome b5 reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	LOC101709232 (NADH-cytochrome b5 reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	LOC116911328 (NADH-cytochrome b5 reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	HMGB1 (high mobility group box 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	CYB5R1 (cytochrome b5 reductase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cyb5r1 (cytochrome b5 reductase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cyb5r1 (cytochrome b5 reductase 1)	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	AIM33	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	AIM33	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG5946	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	CBR1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	T05H4.4	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	hpo-19	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PGA3	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PGA3	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cyb5r1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	48,401,061 - 48,407,466 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	48,399,106 - 48,407,465 (+)	Ensembl				GRCr8
mRatBN7.2	13	45,849,017 - 45,855,458 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	45,849,091 - 45,855,458 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	48,456,333 - 48,462,746 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	49,744,401 - 49,750,816 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	47,009,283 - 47,015,699 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	51,229,697 - 51,236,447 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	51,229,890 - 51,236,463 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	56,286,655 - 56,293,107 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	47,347,756 - 47,354,161 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	46,177,040 - 46,183,445 (+)	NCBI		Celera
RGSC_v3.1	13	47,361,798 - 47,368,203 (+)	NCBI
Cytogenetic Map	13	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

2,4-dinitrotoluene (EXP)

2,6-dimethoxyphenol (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-Hydroxybenzophenone (ISO)

acetamide (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

bisphenol AF (EXP,ISO)

bisphenol F (ISO)

bortezomib (ISO)

Brodifacoum (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

casticin (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

choline (ISO)

cisplatin (ISO)

clozapine (ISO)

cobalt dichloride (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

Cuprizon (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

dorsomorphin (ISO)

Enterolactone (ISO)

flutamide (ISO)

folic acid (ISO)

formaldehyde (ISO)

furfural (ISO)

GSK-J4 (ISO)

haloperidol (ISO)

hydralazine (ISO)

indometacin (ISO)

L-methionine (ISO)

lead(0) (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

menadione (ISO)

methyl methanesulfonate (ISO)

motexafin gadolinium (ISO)

N-methyl-4-phenylpyridinium (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

propanal (ISO)

propiconazole (ISO)

resveratrol (ISO)

rotenone (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

sodium fluoride (ISO)

sunitinib (ISO)

T-2 toxin (EXP)

tamoxifen (ISO)

tetrachloromethane (ISO)

thapsigargin (EXP,ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zinc acetate (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

lipid metabolic process (IEA)

steroid biosynthetic process (IEA)

steroid metabolic process (IEA)

sterol biosynthetic process (IEA)

Cellular Component

endoplasmic reticulum membrane (IEA)

membrane (IEA)

mitochondrion (IBA,ISO)

Molecular Function

cytochrome-b5 reductase activity, acting on NAD(P)H (IBA,IEA)

cytochrome-b5 reductase activity, acting on NADH (IEA)

FAD binding (IBA)

oxidoreductase activity (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

amino sugar metabolic pathway (IEA)

nucleotide sugar metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:18614015	PMID:19199708	PMID:19946888	PMID:20833797	PMID:22200675	PMID:24270810

Genomics

Comparative Map Data

Cyb5r1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	48,401,061 - 48,407,466 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	48,399,106 - 48,407,465 (+)	Ensembl				GRCr8
mRatBN7.2	13	45,849,017 - 45,855,458 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	45,849,091 - 45,855,458 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	48,456,333 - 48,462,746 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	49,744,401 - 49,750,816 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	47,009,283 - 47,015,699 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	51,229,697 - 51,236,447 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	51,229,890 - 51,236,463 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	56,286,655 - 56,293,107 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	47,347,756 - 47,354,161 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	46,177,040 - 46,183,445 (+)	NCBI		Celera
RGSC_v3.1	13	47,361,798 - 47,368,203 (+)	NCBI
Cytogenetic Map	13	q13	NCBI

CYB5R1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	202,961,873 - 202,967,257 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	202,961,118 - 202,967,277 (-)	Ensembl			hg38	GRCh38
GRCh37	1	202,931,001 - 202,936,385 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	201,197,624 - 201,203,027 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	199,662,660 - 199,668,061	NCBI
Celera	1	176,060,247 - 176,065,650 (-)	NCBI		Celera
Cytogenetic Map	1	q32.1	ENTREZGENE
HuRef	1	174,096,692 - 174,102,062 (-)	NCBI		HuRef
CHM1_1	1	204,353,240 - 204,358,642 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	202,224,599 - 202,229,982 (-)	NCBI		T2T-CHM13v2.0

Cyb5r1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	134,333,519 - 134,339,476 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	134,333,297 - 134,339,478 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	134,405,781 - 134,411,738 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	134,405,559 - 134,411,740 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	136,302,567 - 136,308,315 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	136,222,401 - 136,228,149 (+)	NCBI		MGSCv36	mm8
Celera	1	137,012,972 - 137,018,722 (+)	NCBI		Celera
Cytogenetic Map	1	E4	NCBI
cM Map	1	58.21	NCBI

LOC102004351
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	38,955,997 - 38,965,127 (-)	Ensembl
ChiLan1.0	NW_004955406	38,958,766 - 38,964,597 (-)	NCBI	ChiLan1.0	ChiLan1.0

LOC100967245
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	46,410,785 - 46,416,239 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	46,377,829 - 46,383,261 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	178,563,539 - 178,568,997 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	182,858,966 - 182,864,381 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	182,858,966 - 182,864,381 (-)	Ensembl			panPan2	panpan1.1

CYB5R1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	232,280 - 237,496 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	232,098 - 237,031 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	289,882 - 292,411 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	242,003 - 247,223 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	242,023 - 247,220 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	233,378 - 235,907 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	342,440 - 344,977 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	365,428 - 367,957 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

LOC101966914
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	72,415,587 - 72,421,490 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936567	1,650,255 - 1,656,683 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936567	1,650,304 - 1,655,618 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CYB5R1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	24,925,410 - 24,931,917 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	10	24,926,167 - 24,931,772 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	29,284,348 - 29,289,916 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CYB5R1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	26,437,439 - 26,442,851 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	26,437,334 - 26,444,110 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666055	27,214,111 - 27,219,539 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

LOC101709232
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624807	7,886,558 - 7,892,903 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624807	7,887,415 - 7,892,667 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

LOC116911328
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	1,293,276 - 1,299,361 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Cyb5r1
77 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	56
Count of miRNA genes:	46
Interacting mature miRNAs:	54
Transcripts:	ENSRNOT00000060669
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10755495	Bp387	Blood pressure QTL 387	3.78		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37216241	90057603	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	11866254	56866254	Rat
6893344	Cm79	Cardiac mass QTL 79	1.5	0.04	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	46272922	51216694	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	38975045	103588154	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	39924693	84924693	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	24853925	69853925	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	39968211	83286298	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	17468282	62468282	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	7421791	87286911	Rat
1331784	Bp222	Blood pressure QTL 222	2.944		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	24335432	55601132	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37087983	82087983	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	40983585	85983585	Rat
724564	Uae11	Urinary albumin excretion QTL 11	5.7		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	13	47354258	94285672	Rat
2302275	Gluco37	Glucose level QTL 37	3.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	13	12448421	48744906	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
4145117	Mcs27	Mammary carcinoma susceptibility QTL 27		0.0001	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	13	45990077	50392939	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	26244808	71244808	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	33794096	78794096	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	39924693	84924693	Rat
2303563	Bw89	Body weight QTL 89	6		body mass (VT:0001259)	body weight (CMO:0000012)	13	34834947	79834947	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
2301962	Cm72	Cardiac mass QTL 72	4.12		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	13	33794096	60914504	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	39814726	84814726	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	39968211	84968211	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	26244808	71244808	Rat
12879472	Bp399	Blood pressure QTL 399			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	47780418	50392939	Rat
11530006	Niddm72	Non-insulin dependent diabetes mellitus QTL 72		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	38286298	83286298	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	17711336	62711336	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	11866254	56866254	Rat

Markers in Region

AU048745

Rat Assembly	Chr	Position (strand)	Source
Cytogenetic Map	5	q32	UniSTS
Cytogenetic Map	13	q24	UniSTS
Cytogenetic Map	6	q32	UniSTS
Cytogenetic Map	17	p12	UniSTS
Cytogenetic Map	16	p14	UniSTS
Cytogenetic Map	13	q26	UniSTS
Cytogenetic Map	10	q22	UniSTS
Cytogenetic Map	7	q11	UniSTS
Cytogenetic Map	8	q24	UniSTS
Cytogenetic Map	5	q21	UniSTS
Cytogenetic Map	4	q24	UniSTS
Cytogenetic Map	2	q11	UniSTS
Cytogenetic Map	1	q54	UniSTS
Cytogenetic Map	1	q36	UniSTS
Cytogenetic Map	18	p11	UniSTS
Cytogenetic Map	13	q13	UniSTS
Cytogenetic Map	10	q24	UniSTS
Cytogenetic Map	8	q31	UniSTS
Cytogenetic Map	3	q21	UniSTS
Cytogenetic Map	13	p13	UniSTS
Cytogenetic Map	1	q21	UniSTS
Cytogenetic Map	11	q23	UniSTS
Cytogenetic Map	10	q31	UniSTS
Cytogenetic Map	16	q12.2	UniSTS
Cytogenetic Map	3	q24	UniSTS
Cytogenetic Map	5	q36	UniSTS
Cytogenetic Map	3	p13	UniSTS

AI236231

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	45,855,364 - 45,855,455 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	51,236,354 - 51,236,444	NCBI	Rnor6.0
Rnor_5.0	13	56,293,014 - 56,293,104	UniSTS	Rnor5.0
RGSC_v3.4	13	47,354,068 - 47,354,158	UniSTS	RGSC3.4
Celera	13	46,183,352 - 46,183,442	UniSTS
Cytogenetic Map	13	q13	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	92	59	6	356	192	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001013126	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090716	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001840777	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC106215	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC089945	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000060669 ⟹ ENSRNOP00000057400

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	48,401,064 - 48,407,461 (+)	Ensembl
mRatBN7.2 Ensembl	13	45,849,091 - 45,855,458 (+)	Ensembl
Rnor_6.0 Ensembl	13	51,229,890 - 51,236,463 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000136149 ⟹ ENSRNOP00000103704

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	48,399,106 - 48,407,465 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000161324 ⟹ ENSRNOP00000109785

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	48,401,061 - 48,407,462 (+)	Ensembl

RefSeq Acc Id:

NM_001013126 ⟹ NP_001013144

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	48,401,061 - 48,407,466 (+)	NCBI
mRatBN7.2	13	45,849,051 - 45,855,458 (+)	NCBI
Rnor_6.0	13	51,230,042 - 51,236,447 (+)	NCBI
Rnor_5.0	13	56,286,655 - 56,293,107 (+)	NCBI
RGSC_v3.4	13	47,347,756 - 47,354,161 (+)	RGD
Celera	13	46,177,040 - 46,183,445 (+)	RGD

Sequence:

show sequence

ATTGTGGGATCTGTCCGCCCTAGCGGAGCCGAACGGCGCTAGTCATGGGGATCCAGCCGAGCCC
GGTCTTGCTAGCCTCTCTGGGGGTGGGGCTGTTTACCCTGTTCGGCCTGGCTCTGGGTACCTAC
TTGGTTCGAAGATCCCGCCGGCCACAGGTCACTCTCCAGGACCCGGATGAGAAGTACCTGCTGC
GATTGCTGGACAAGACGACAGTGAGCCACAACACCAGGAGGTTCCGCTTTGCCCTGCCCACCGC
CCACCACATTCTGGGGCTGCCTGTGGGTAAGCACGTCTACCTCTCTGCCCGAATTGATGGCAGT
CAGGTCATCAGGCCTTACACTCCTGTCACCAGCGATGAAGACCAGGGCTATGTAGATCTTGTCA
TCAAGGTTTATCTGAAAGGTGTGCACCCCAAATTTTCTGAAGGAGGGAAGATGTCTCAGTACCT
GGATAGCCTGAAGATTGGGGATGTGGTGGAGTTCCGGGGGCCGAGTGGGTTGCTCAGTTATGCT
GGGAAAGGGAATTTTAACATTCAGCCCAACAAAAAATCCCCACCTGAACTGCGAGTGGCTAAGA
AATTGGGAATGATTGCTGGCGGGACAGGAATCACCCCAATGCTGCAGCTGATCCGGGCCATCTT
GAAAGTCCCTGAAGATCCAACCCAGTGCTTTCTGCTTTTTGCCAACCAGACTGAAAAGGACATA
ATCCTGCGGGAGGACCTAGAGGAGCTGCAGGCCCAATATCCTATCCGCTTTAAGCTCTGGTTCA
CCCTGGACTACCCTCCAGAAGACTGGACCTACAGCAAGGGCTTTGTTACCGCCGACATGATCCA
GGAGCACCTGCCTGCCCCAGCAGAGGATGTGCTGCTGCTGCTTTGTGGGCCACCACCTATGGTA
CAGCTGGCCTGCCACCCGAACCTGGATAAGCTGGGCTATTCACAGAAGATGCGATTCACCTACT
GAGCACCGAGAGGCCTCCCTATCCCGTGTGTGCAGTTGTCCCTAGTCGATTCTCCAACACCAAG
AGGCCGCCTAGGGCCCTTGCTGAGAGCATCAGCCCTTGGTGTCTCATCCCGGAATCTGGGTGCT
TGCAGAAGCAACACTCCCCCAGCTATGGTAGAAGCAGGTCAAGGCTAAGTCACTCCCTTGCAAC
TTCCCTTATCGTAATCTCCTTGTGATAAAAGGTCCAGATGAGGCTCAAGGAGCAGTCTCTAGGG
CCAGAAAGAAGGGAGCATTTGTTACAAGGCTACCTAGTTTTTGAGAGCGTCATGGTCACCTCTG
TGACCGTGGTGAAATGGATGGACTGGACAGCATATTTTGCTCTATCCTCAGCATTTCACCCACT
ACTTAAATGAGTACAGGCTGAGCAGGCTTATATACACAGTCCTACAGAAACCGTAGAAAAGCAA
TTATTTGCCAGAATTCTAAACCTCAGAGGTTTAGGGATGTGTGTGTGTGTGTGTGTGTGTGTGT
GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAG
AGAGAGAGAGAGTGATCAGCCCCTGCCCAGGCTGGAGTGAAATGGTTACCCGCAACTTAAGATT
ACTGCTTGTACAAGGAGTATCTGGCTGTTAAATAAATGGAGCTAAGGCCCTGATGATCTCAAGG
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039090716 ⟹ XP_038946644

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	48,401,389 - 48,407,466 (+)	NCBI
mRatBN7.2	13	45,849,373 - 45,855,458 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001013144	(Get FASTA)	NCBI Sequence Viewer
	XP_038946644	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH89945	(Get FASTA)	NCBI Sequence Viewer
	EDM09729	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000057400
GenBank Protein	Q5EB81	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001013144 ⟸ NM_001013126

- UniProtKB:

Q5EB81 (UniProtKB/Swiss-Prot), A6ICB8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGIQPSPVLLASLGVGLFTLFGLALGTYLVRRSRRPQVTLQDPDEKYLLRLLDKTTVSHNTRRF
RFALPTAHHILGLPVGKHVYLSARIDGSQVIRPYTPVTSDEDQGYVDLVIKVYLKGVHPKFSEG
GKMSQYLDSLKIGDVVEFRGPSGLLSYAGKGNFNIQPNKKSPPELRVAKKLGMIAGGTGITPML
QLIRAILKVPEDPTQCFLLFANQTEKDIILREDLEELQAQYPIRFKLWFTLDYPPEDWTYSKGF
VTADMIQEHLPAPAEDVLLLLCGPPPMVQLACHPNLDKLGYSQKMRFTY

hide sequence

Ensembl Acc Id:

ENSRNOP00000057400 ⟸ ENSRNOT00000060669

RefSeq Acc Id:	XP_038946644 ⟸ XM_039090716
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000109785 ⟸ ENSRNOT00000161324

Ensembl Acc Id:

ENSRNOP00000103704 ⟸ ENSRNOT00000136149

Protein Domains

FAD-binding FR-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5EB81-F1-model_v2	AlphaFold	Q5EB81	1-305	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698830

Promoter ID:

EPDNEW_R9355

Type:

initiation region

Name:

Cyb5r1_1

Description:

cytochrome b5 reductase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	51,230,045 - 51,230,105	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306084	AgrOrtholog
BioCyc Gene	G2FUF-18235	BioCyc
Ensembl Genes	ENSRNOG00000003973	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000060669	ENTREZGENE
Gene3D-CATH	3.40.50.80	UniProtKB/Swiss-Prot
	Translation factors	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7311492	IMAGE-MGC_LOAD
InterPro	CBR-like	UniProtKB/Swiss-Prot
	Cbr1-like_FAD-bd_dom	UniProtKB/Swiss-Prot
	FAD-bd_FR_type	UniProtKB/Swiss-Prot
	Flavoprot_Pyr_Nucl_cyt_Rdtase	UniProtKB/Swiss-Prot
	FNR_nucleotide-bd	UniProtKB/Swiss-Prot
	OxRdtase_FAD/NAD-bd	UniProtKB/Swiss-Prot
	Riboflavin_synthase-like_b-brl	UniProtKB/Swiss-Prot
KEGG Report	rno:304805	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:109264	IMAGE-MGC_LOAD
NCBI Gene	304805	ENTREZGENE
PANTHER	NADH-CYTOCHROME B5 REDUCTASE 1	UniProtKB/Swiss-Prot
	PTHR19370	UniProtKB/Swiss-Prot
Pfam	FAD_binding_6	UniProtKB/Swiss-Prot
	NAD_binding_1	UniProtKB/Swiss-Prot
PhenoGen	Cyb5r1	PhenoGen
PRINTS	CYTB5RDTASE	UniProtKB/Swiss-Prot
	FPNCR	UniProtKB/Swiss-Prot
PROSITE	FAD_FR	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000003973	RatGTEx
Superfamily-SCOP	SSF52343	UniProtKB/Swiss-Prot
	SSF63380	UniProtKB/Swiss-Prot
UniProt	A0ABK0LJI2_RAT	UniProtKB/TrEMBL
	A0ABK0M118_RAT	UniProtKB/TrEMBL
	A6ICB8	ENTREZGENE, UniProtKB/TrEMBL
	G3V9S0_RAT	UniProtKB/TrEMBL
	NB5R1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Cyb5r1	cytochrome b5 reductase 1	Nqo3a2	NAD(P)H:quinone oxidoreductase type 3, polypeptide A2	Symbol and Name updated	1299863	APPROVED
2005-12-06	Nqo3a2	NAD(P)H:quinone oxidoreductase type 3, polypeptide A2	Nqo3a2_predicted	NAD(P)H:quinone oxidoreductase type 3, polypeptide A2 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Nqo3a2_predicted	NAD(P)H:quinone oxidoreductase type 3, polypeptide A2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)