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Gene: Blvrb (biliverdin reductase B) Rattus norvegicus

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Symbol:

Blvrb

Name:

biliverdin reductase B

RGD ID:

1306080

Description:

Predicted to enable biliverdin reductase [NAD(P)H] activity; peptidyl-cysteine S-nitrosylase activity; and riboflavin reductase (NADPH) activity. Predicted to be involved in heme catabolic process; megakaryocyte differentiation; and negative regulation of insulin receptor signaling pathway. Predicted to act upstream of or within insulin receptor signaling pathway. Located in terminal bouton. Orthologous to human BLVRB (biliverdin reductase B); PARTICIPATES IN porphyrin and chlorophyll metabolic pathway; riboflavin metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acrylamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

biliverdin reductase B (flavin reductase (NADPH)); flavin reductase; flavin reductase (NADPH); LOC292737; NADPH-dependent diaphorase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BLVRB (biliverdin reductase B)	RGD	RGD
Mus musculus (house mouse):	Blvrb (biliverdin reductase B)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Blvrb (biliverdin reductase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BLVRB (biliverdin reductase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BLVRB (biliverdin reductase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Blvrb (biliverdin reductase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BLVRB (biliverdin reductase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	BLVRB (biliverdin reductase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Blvrb (biliverdin reductase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Blvrb (biliverdin reductase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	BLVRB (biliverdin reductase B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	BLVRB (biliverdin reductase B)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Blvrb (biliverdin reductase B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Blvrb (biliverdin reductase B)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	blvrb (biliverdin reductase B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	blvrb (biliverdin reductase B)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG9471	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG9471	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	YMR090W	Alliance	DIOPT (Ensembl Compara\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	blvrb	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	blvrb	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	91,866,258 - 91,883,921 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	91,866,258 - 91,884,225 (+)	Ensembl				GRCr8
mRatBN7.2	1	82,738,646 - 82,756,312 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	82,738,695 - 82,770,375 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	88,141,751 - 88,159,098 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	96,628,789 - 96,646,213 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	89,897,608 - 89,914,955 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	84,256,063 - 84,273,726 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	84,256,159 - 84,274,075 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	85,468,772 - 85,490,833 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	82,528,943 - 82,546,606	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	77,153,671 - 77,171,142 (+)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chemical and Drug Induced Liver Injury (ISO)

esophagus squamous cell carcinoma (ISO)

Stomach Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-butoxyethanol (ISO)

2-hydroxypropanoic acid (ISO)

2-tert-butylhydroquinone (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

5-aza-2'-deoxycytidine (ISO)

5-fluorouracil (ISO)

acrylamide (EXP)

actinomycin D (ISO)

afimoxifene (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

andrographolide (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

asperentin (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

bortezomib (ISO)

buspirone (EXP)

buta-1,3-diene (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

calycosin (ISO)

cannabidiol (ISO)

cefaloridine (EXP)

CGP 52608 (ISO)

chloroprene (ISO)

chlorpyrifos (ISO)

ciglitazone (ISO)

cisplatin (ISO)

clofibrate (EXP)

cobalt dichloride (EXP)

copper atom (ISO)

copper(0) (ISO)

copper(II) chloride (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

cyclophosphamide (EXP)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

diethyl maleate (ISO)

diquat (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

endosulfan (EXP)

entinostat (ISO)

epoxiconazole (ISO)

ethanol (EXP,ISO)

ethyl methanesulfonate (ISO)

finasteride (EXP)

flutamide (EXP)

formaldehyde (ISO)

furan (EXP)

furfural (ISO)

glafenine (EXP)

hypochlorous acid (ISO)

inulin (ISO)

isotretinoin (ISO)

ivermectin (ISO)

lead diacetate (ISO)

lead(0) (ISO)

leflunomide (EXP)

Licochalcone B (ISO)

lidocaine (EXP)

lipopolysaccharide (ISO)

menadione (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

microcystin-LR (ISO)

mycotoxin (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-methyl-N'-nitro-N-nitrosoguanidine (ISO)

N-nitrosodiethylamine (ISO)

N-nitrosodimethylamine (ISO)

N-nitrosomorpholine (EXP)

nefazodone (EXP)

neoechinulin A (ISO)

nimesulide (EXP)

Nonylphenol (EXP)

Nutlin-3 (ISO)

ochratoxin A (ISO)

okadaic acid (ISO)

oxaliplatin (EXP)

ozone (ISO)

p-chloromercuribenzoic acid (ISO)

paraquat (ISO)

pentachlorophenol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

phenethyl isothiocyanate (EXP)

phenobarbital (ISO)

phosgene (ISO)

pirinixic acid (ISO)

quercetin (EXP)

rac-lactic acid (ISO)

rotenone (EXP,ISO)

SB 431542 (ISO)

selenium atom (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (EXP,ISO)

sodium chloride (ISO)

sodium dodecyl sulfate (ISO)

sterigmatocystin (ISO)

succimer (ISO)

sunitinib (ISO)

temozolomide (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

TMC-120A (ISO)

topotecan (EXP)

trichloroethene (ISO)

triclosan (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

tris(2-butoxyethyl) phosphate (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

animal organ morphogenesis (ISO)

bone marrow development (ISO)

cell fate specification (ISO)

cellular response to stress (ISO)

erythrocyte differentiation (ISO)

heme catabolic process (ISO)

hemopoiesis (ISO)

homeostasis of number of cells (ISO)

megakaryocyte differentiation (ISO)

membrane lipid catabolic process (ISO)

negative regulation of insulin receptor signaling pathway (IEA,ISO)

reactive oxygen species biosynthetic process (ISO)

Cellular Component

cytoplasm (IEA,ISO)

cytosol (ISO)

terminal bouton (IDA,ISO)

Molecular Function

biliverdin reductase [NAD(P)H] activity (ISO)

oxidoreductase activity (IEA)

peptidyl-cysteine S-nitrosylase activity (IEA,ISO)

protein binding (ISO)

riboflavin reductase (NADPH) activity (ISO)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

porphyrin and chlorophyll metabolic pathway (IEA)

riboflavin metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Nitric oxide synthase localized in a subpopulation of vestibular efferents with NADPH diaphorase histochemistry and nitric oxide synthase immunohistochemistry.	Lysakowski A and Singer M, J Comp Neurol. 2000 Nov 27;427(4):508-21.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:7929092	PMID:11224564	PMID:12477932	PMID:19056867	PMID:20876213	PMID:23376485

Genomics

Comparative Map Data

Blvrb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	91,866,258 - 91,883,921 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	91,866,258 - 91,884,225 (+)	Ensembl				GRCr8
mRatBN7.2	1	82,738,646 - 82,756,312 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	82,738,695 - 82,770,375 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	88,141,751 - 88,159,098 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	96,628,789 - 96,646,213 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	89,897,608 - 89,914,955 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	84,256,063 - 84,273,726 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	84,256,159 - 84,274,075 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	85,468,772 - 85,490,833 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	82,528,943 - 82,546,606	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	77,153,671 - 77,171,142 (+)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

BLVRB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	40,447,768 - 40,465,745 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	40,447,765 - 40,465,826 (-)	Ensembl			hg38	GRCh38
GRCh37	19	40,953,675 - 40,971,652 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	45,645,541 - 45,663,516 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	45,645,540 - 45,663,517	NCBI
Celera	19	37,753,251 - 37,771,296 (-)	NCBI		Celera
Cytogenetic Map	19	q13.2	NCBI
HuRef	19	37,389,108 - 37,406,845 (-)	NCBI		HuRef
CHM1_1	19	40,953,363 - 40,971,359 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	43,268,426 - 43,286,397 (-)	NCBI		T2T-CHM13v2.0

Blvrb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	27,147,403 - 27,165,406 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	27,147,403 - 27,165,569 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	7	27,447,978 - 27,465,981 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	27,447,978 - 27,466,144 (+)	Ensembl			mm10	GRCm38
MGSCv37	7	28,232,997 - 28,251,000 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	7	27,156,738 - 27,174,741 (+)	NCBI		MGSCv36	mm8
Celera	7	22,030,292 - 22,048,354 (+)	NCBI		Celera
Cytogenetic Map	7	A3	NCBI
cM Map	7	15.9	NCBI

Blvrb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955578	813,480 - 838,151 (+)	Ensembl
ChiLan1.0	NW_004955578	813,834 - 834,675 (+)	NCBI	ChiLan1.0	ChiLan1.0

BLVRB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	46,710,915 - 46,728,689 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	48,581,558 - 48,601,334 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	37,496,344 - 37,516,127 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	46,007,321 - 46,025,120 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	46,007,321 - 46,025,120 (-)	Ensembl			panPan2	panpan1.1

BLVRB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	113,244,484 - 113,258,170 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	113,244,503 - 113,258,073 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	112,646,444 - 112,660,113 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	113,842,860 - 113,856,535 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	113,842,878 - 113,856,438 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	113,402,155 - 113,415,836 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	113,034,647 - 113,048,316 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	114,028,608 - 114,042,276 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Blvrb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	14,380,932 - 14,390,059 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936661	2,808,950 - 2,818,178 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936661	2,808,998 - 2,818,123 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BLVRB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	48,715,199 - 48,728,389 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	48,715,540 - 48,728,433 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	44,463,504 - 44,476,949 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BLVRB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	34,902,632 - 34,925,105 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	34,902,598 - 34,925,100 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666073	13,019,457 - 13,042,205 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Blvrb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624925	432,137 - 452,903 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624925	432,137 - 452,946 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Blvrb
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	168,478,587 - 168,496,334 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Blvrb
172 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	53
Count of miRNA genes:	44
Interacting mature miRNAs:	50
Transcripts:	ENSRNOT00000031026
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578649	Bmd8	Bone mineral density QTL 8	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	51940904	101229020	Rat
1582234	Gluco18	Glucose level QTL 18	3.4	0.0003	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	87889942	132889942	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	51941022	208479811	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	39728272	132889942	Rat
1358192	Ept13	Estrogen-induced pituitary tumorigenesis QTL 13	3.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	86622262	131622262	Rat
6903308	Scl36	Serum cholesterol QTL 36	2	0.0125	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	58769992	103769992	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	51940904	168768703	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	66077886	111077886	Rat
1331800	Scl25	Serum cholesterol level QTL 25	3.013		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	87785026	142582336	Rat
7421628	Bp361	Blood pressure QTL 361		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	83019780	128019780	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	66404680	111404680	Rat
10054135	Gmadr2	Adrenal mass QTL 2	1.97	0.0129	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	86993904	131993904	Rat
152025249	Scl82	Serum cholesterol level QTL 82	4.77		blood cholesterol amount (VT:0000180)		1	52891222	109116986	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
631512	Scl6	Serum cholesterol level QTL 6	9.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	81269860	99645535	Rat
7411712	Strs4	Sensitivity to stroke QTL 4	8.7		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	1	87558587	132558587	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	66009857	160501508	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
1302788	Scl19	Serum cholesterol QTL 19	4.6	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	66400974	132889942	Rat
1549903	Bp267	Blood pressure QTL 267			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	84107164	115183752	Rat
2313083	Bmd74	Bone mineral density QTL 74	4	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	91302413	136302413	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	51511344	153680016	Rat
61342	Bp27	Blood pressure QTL 27	3.4	0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	65405637	96805205	Rat

Markers in Region

BF417815

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	82,743,865 - 82,743,968 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	84,261,282 - 84,261,384	NCBI	Rnor6.0
Rnor_5.0	1	85,478,389 - 85,478,491	UniSTS	Rnor5.0
Rnor_5.0	1	85,473,885 - 85,473,987	UniSTS	Rnor5.0
RGSC_v3.4	1	82,534,162 - 82,534,264	UniSTS	RGSC3.4
Celera	1	77,158,708 - 77,158,810	UniSTS
RH 3.4 Map	1	826.8	UniSTS
Cytogenetic Map	1	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	160	91	90	59	92	59	6	356	192	11	139	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106236	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008759117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC118914	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC168943	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228106	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230737	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232598	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000031026 ⟹ ENSRNOP00000035090

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	82,738,697 - 82,760,893 (+)	Ensembl
Rnor_6.0 Ensembl	1	84,256,159 - 84,274,075 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095629 ⟹ ENSRNOP00000092544

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	82,738,697 - 82,760,893 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111934 ⟹ ENSRNOP00000079598

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	82,738,762 - 82,770,375 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000118035 ⟹ ENSRNOP00000081240

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	91,866,258 - 91,884,225 (+)	Ensembl
mRatBN7.2 Ensembl	1	82,738,695 - 82,756,685 (+)	Ensembl

RefSeq Acc Id:

NM_001106236 ⟹ NP_001099706

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	91,866,258 - 91,883,921 (+)	NCBI
mRatBN7.2	1	82,738,646 - 82,756,312 (+)	NCBI
Rnor_6.0	1	84,256,063 - 84,273,726 (+)	NCBI
Rnor_5.0	1	85,468,772 - 85,490,833 (+)	NCBI
RGSC_v3.4	1	82,528,943 - 82,546,606 (+)	RGD
Celera	1	77,153,671 - 77,171,142 (+)	RGD

Sequence:

show sequence

GTGGAGTCGGAGGCGGGAAACGTCGTCTGGCCCCGCCCCCTCCTTCTGTGTGGAGGAGAACGCG
CTGCGCGCCCCACCTTGCAGCTACTGGGTTCCCGCGCGTCCTCGGAGTTCTCAGCTTTTCGGGC
CCTGGACCCTGCAACATGGCTGTCAAGAAGATCGCGATCTTCGGTGCCACCGGAAGGACCGGGC
TCACCACACTGGCGCAGGCGGTGCAAGCAGGTTACGAGGTGACGGTGCTGGTTCGAGATTCCAG
CAGGTTACCGTCAGAGGGGCCCCAGCCAGCCCACGTGGTGGTGGGAGATGTTCTGCAGGCGGGC
GATGTGGACAAGACTGTGGCTGGACAGGATGCCGTCATCGTGCTACTGGGCACTGGCAACGACC
TCAGTCCTACTACAGTAATGTCCGAGGGCACCCGGAACATTGTGGCAGCCATGAAGGCACATGG
AGTGGACAAGGTCGTGGCCTGCACCTCGGCCTTCCTACTCTGGGACCCGAGCAAGGTGCCCCCT
CGCCTACAGGACGTGACCGATGACCACATCCGGATGCATAAGATTCTGGAGGAGTCAGGACTGA
AGTACGTGGCTGTAATGCCCCCACACATTGGGGACCAACCACTAACCGGGGCCTACACAGTGAC
CCTGGATGGACGAGGGCCCTCGAGGGTCATATCCAAGCATGATCTGGGTCACTTCATGCTACGG
TGCCTCACCACCCATGAGTATGACGGACAGAAGACCTACCCTTCCCACCAGTATGACTAGGACC
CTGGCCCTGGCTGGGAGGGTCCCATCCTGAGAAATGGCACACATGGAGGGATCAATACATTTTT
AGCCAAGAACTTCAAATTCTTTCAGAAAACCTAATCCTAATTTTCCTCTGTC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001099706	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68943	(Get FASTA)	NCBI Sequence Viewer
	EDM07956	(Get FASTA)	NCBI Sequence Viewer
	EDM07957	(Get FASTA)	NCBI Sequence Viewer
	EDM07958	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000081240
	ENSRNOP00000081240.1

RefSeq Acc Id:

NP_001099706 ⟸ NM_001106236

- UniProtKB:

B5DF65 (UniProtKB/TrEMBL), A6J9C6 (UniProtKB/TrEMBL), A0A8I5ZUN1 (UniProtKB/TrEMBL), F7FKS7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAVKKIAIFGATGRTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPQPAHVVVGDVLQAGDVDKT
VAGQDAVIVLLGTGNDLSPTTVMSEGTRNIVAAMKAHGVDKVVACTSAFLLWDPSKVPPRLQDV
TDDHIRMHKILEESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHDLGHFMLRCLTTH
EYDGQKTYPSHQYD

hide sequence

Ensembl Acc Id:

ENSRNOP00000035090 ⟸ ENSRNOT00000031026

Ensembl Acc Id:

ENSRNOP00000079598 ⟸ ENSRNOT00000111934

Ensembl Acc Id:

ENSRNOP00000081240 ⟸ ENSRNOT00000118035

Ensembl Acc Id:

ENSRNOP00000092544 ⟸ ENSRNOT00000095629

Protein Domains

NAD(P)-binding

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B5DF65-F1-model_v2	AlphaFold	B5DF65	1-206	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13689850

Promoter ID:

EPDNEW_R375

Type:

initiation region

Name:

Blvrb_1

Description:

biliverdin reductase B

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	84,256,149 - 84,256,209	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306080	AgrOrtholog
BioCyc Gene	G2FUF-60310	BioCyc
Ensembl Genes	ENSRNOG00000024410	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000118035	ENTREZGENE
	ENSRNOT00000118035.2	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	NAD(P)-bd_dom	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
	Polyketide_Oxido-like	UniProtKB/TrEMBL
KEGG Report	rno:292737	UniProtKB/TrEMBL
NCBI Gene	292737	ENTREZGENE
PANTHER	FLAVIN REDUCTASE (NADPH)	UniProtKB/TrEMBL
	FLAVIN REDUCTASE (NADPH)	UniProtKB/TrEMBL
Pfam	NAD_binding_10	UniProtKB/TrEMBL
PhenoGen	Blvrb	PhenoGen
RatGTEx	ENSRNOG00000024410	RatGTEx
Superfamily-SCOP	SSF51735	UniProtKB/TrEMBL
UniProt	A0A8I5ZUN1	ENTREZGENE, UniProtKB/TrEMBL
	A6J9C6	ENTREZGENE, UniProtKB/TrEMBL
	B5DF65	ENTREZGENE
	F7FKS7	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	B5DF65	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-12-01	Blvrb	biliverdin reductase B	Blvrb	biliverdin reductase B (flavin reductase (NADPH))	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Blvrb	biliverdin reductase B (flavin reductase (NADPH))	Blvrb_predicted	biliverdin reductase B (flavin reductase (NADPH)) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Blvrb_predicted	biliverdin reductase B (flavin reductase (NADPH)) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)