Mymk (myomaker, myoblast fusion factor) - Rat Genome Database

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Gene: Mymk (myomaker, myoblast fusion factor) Rattus norvegicus
Analyze
Symbol: Mymk
Name: myomaker, myoblast fusion factor
RGD ID: 1306074
Description: Predicted to be involved in myoblast fusion; plasma membrane fusion; and positive regulation of skeletal muscle hypertrophy. Predicted to act upstream of or within myoblast fusion involved in skeletal muscle regeneration. Predicted to be located in Golgi membrane and plasma membrane. Human ortholog(s) of this gene implicated in Carey-Fineman-Ziter syndrome 1. Orthologous to human MYMK (myomaker, myoblast fusion factor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; 1,2-dimethylhydrazine (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC296601; LOC296601; RGD1306074; similar to RIKEN cDNA 1110002H13; Tmem8c; transmembrane protein 8C
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8330,786,443 - 30,795,374 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl330,786,443 - 30,795,374 (-)EnsemblGRCr8
mRatBN7.2310,388,363 - 10,397,294 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,388,361 - 10,397,343 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx313,453,976 - 13,462,907 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0322,039,374 - 22,048,305 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0320,294,674 - 20,303,605 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.035,608,243 - 5,617,689 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,608,243 - 5,617,225 (-)Ensemblrn6Rnor6.0
Rnor_5.0310,970,626 - 10,979,608 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.435,957,947 - 5,966,929 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera35,186,642 - 5,195,624 (-)NCBICelera
RGSC_v3.135,958,805 - 5,967,234 (-)NCBI
Cytogenetic Map3p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
Golgi membrane  (IEA,ISO)
membrane  (IEA)
plasma membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23868259   PMID:25085416   PMID:28186492   PMID:28386024   PMID:28681861   PMID:28860190   PMID:30197239  


Genomics

Comparative Map Data
Mymk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8330,786,443 - 30,795,374 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl330,786,443 - 30,795,374 (-)EnsemblGRCr8
mRatBN7.2310,388,363 - 10,397,294 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,388,361 - 10,397,343 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx313,453,976 - 13,462,907 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0322,039,374 - 22,048,305 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0320,294,674 - 20,303,605 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.035,608,243 - 5,617,689 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,608,243 - 5,617,225 (-)Ensemblrn6Rnor6.0
Rnor_5.0310,970,626 - 10,979,608 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.435,957,947 - 5,966,929 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera35,186,642 - 5,195,624 (-)NCBICelera
RGSC_v3.135,958,805 - 5,967,234 (-)NCBI
Cytogenetic Map3p12NCBI
MYMK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389133,514,586 - 133,524,959 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9133,514,586 - 133,528,612 (-)Ensemblhg38GRCh38
GRCh379136,379,708 - 136,390,081 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369135,369,579 - 135,379,787 (-)NCBIBuild 36Build 36hg18NCBI36
Cytogenetic Map9q34.2NCBI
HuRef9105,880,949 - 105,891,314 (-)NCBIHuRef
CHM1_19136,529,867 - 136,540,211 (-)NCBICHM1_1
T2T-CHM13v2.09145,728,593 - 145,738,968 (-)NCBIT2T-CHM13v2.0
Mymk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39226,951,648 - 26,962,173 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl226,951,648 - 26,962,191 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38227,061,636 - 27,072,161 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl227,061,636 - 27,072,179 (-)Ensemblmm10GRCm38
MGSCv37226,917,156 - 26,927,681 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36226,883,682 - 26,894,170 (-)NCBIMGSCv36mm8
Celera226,764,277 - 26,775,219 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.21NCBI
Mymk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555132,833,234 - 2,842,325 (-)Ensembl
ChiLan1.0NW_0049555132,835,466 - 2,842,325 (-)NCBIChiLan1.0ChiLan1.0
MYMK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2115,808,338 - 5,838,538 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan195,810,674 - 5,840,870 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09104,638,011 - 104,668,204 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19133,248,761 - 133,259,631 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9133,248,761 - 133,259,631 (-)EnsemblpanPan2panpan1.1
MYMK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1949,905,580 - 49,919,849 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl949,907,228 - 49,921,007 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha949,188,745 - 49,200,929 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0950,781,759 - 50,793,959 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl950,781,326 - 50,791,690 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1949,543,510 - 49,555,688 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0949,885,340 - 49,897,530 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0949,963,490 - 49,975,710 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mymk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947199,961,922 - 199,970,359 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366693,404,704 - 3,413,136 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366693,404,729 - 3,413,123 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYMK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1273,101,678 - 273,111,727 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11273,101,674 - 273,111,721 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21307,075,501 - 307,086,445 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYMK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1124,611,952 - 4,623,373 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl124,612,268 - 4,622,381 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666058366,360 - 377,331 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mymk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247601,934,699 - 1,941,149 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247601,934,223 - 1,941,176 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Mymk
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v159,586,521 - 9,595,699 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mymk
97 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:27
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000008327
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
RH141400  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2310,388,536 - 10,388,745 (+)MAPPERmRatBN7.2
Rnor_6.035,608,419 - 5,608,627NCBIRnor6.0
Rnor_5.0310,970,802 - 10,971,010UniSTSRnor5.0
RGSC_v3.435,958,123 - 5,958,331UniSTSRGSC3.4
Celera35,186,818 - 5,187,026UniSTS
Cytogenetic Map3p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 9 37 35 52 51 34 18 34 6 159 79 9 15 34 42 17 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000008327   ⟹   ENSRNOP00000008327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl330,786,443 - 30,795,374 (-)Ensembl
mRatBN7.2 Ensembl310,388,361 - 10,397,343 (-)Ensembl
Rnor_6.0 Ensembl35,608,243 - 5,617,225 (-)Ensembl
RefSeq Acc Id: NM_001399315   ⟹   NP_001386244
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,786,443 - 30,795,374 (-)NCBI
mRatBN7.2310,388,363 - 10,397,294 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001386244 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93444 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008327
  ENSRNOP00000008327.3
Ensembl Acc Id: ENSRNOP00000008327   ⟸   ENSRNOT00000008327
RefSeq Acc Id: NP_001386244   ⟸   NM_001399315

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZQN5-F1-model_v2 AlphaFold D3ZQN5 1-228 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306074 AgrOrtholog
BioCyc Gene G2FUF-50308 BioCyc
Ensembl Genes ENSRNOG00000006142 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008327 ENTREZGENE
  ENSRNOT00000008327.5 UniProtKB/TrEMBL
NCBI Gene 296601 ENTREZGENE
PhenoGen Mymk PhenoGen
RatGTEx ENSRNOG00000006142 RatGTEx
UniProt A6JTK3_RAT UniProtKB/TrEMBL
  D3ZQN5_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-18 Mymk  myomaker, myoblast fusion factor  Tmem8c  transmembrane protein 8C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-09-15 Tmem8c  transmembrane protein 8C  RGD1306074  similar to RIKEN cDNA 1110002H13  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1306074  similar to RIKEN cDNA 1110002H13   RGD1306074_predicted  similar to RIKEN cDNA 1110002H13 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1306074_predicted  similar to RIKEN cDNA 1110002H13 (predicted)  LOC296601_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC296601_predicted  similar to RIKEN cDNA 1110002H13 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL