Vrk1 (VRK serine/threonine kinase 1) - Rat Genome Database

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Gene: Vrk1 (VRK serine/threonine kinase 1) Rattus norvegicus
Analyze
Symbol: Vrk1
Name: VRK serine/threonine kinase 1
RGD ID: 1306069
Description: Predicted to enable several functions, including histone binding activity; histone kinase activity; and nucleosomal DNA binding activity. Predicted to be involved in several processes, including Cajal body organization; Golgi disassembly; and positive regulation of protein localization to chromatin. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in Cajal body; Golgi stack; and chromatin. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 10 and pontocerebellar hypoplasia type 1A. Orthologous to human VRK1 (VRK serine/threonine kinase 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC362779; serine/threonine-protein kinase VRK1; vaccinia related kinase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86130,679,400 - 130,746,089 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6130,679,515 - 130,746,752 (+)EnsemblGRCr8
mRatBN7.26124,914,770 - 124,981,508 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6124,914,855 - 124,981,436 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6125,035,687 - 125,102,303 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06125,330,983 - 125,397,599 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06124,692,652 - 124,759,212 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06129,835,788 - 129,902,839 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6129,835,919 - 129,902,793 (+)Ensemblrn6Rnor6.0
Rnor_5.06139,031,607 - 139,098,569 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46130,181,610 - 130,249,361 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6122,475,358 - 122,561,934 (+)NCBICelera
RGSC_v3.16130,185,356 - 130,253,107 (+)NCBI
Cytogenetic Map6q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
Cajal body  (IEA,ISO)
chromatin  (IEA,ISO)
cytoplasm  (IBA,IEA)
cytosol  (IEA,ISO)
Golgi stack  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14645249   PMID:17938195   PMID:19103756   PMID:21543316   PMID:22194607   PMID:22572157  


Genomics

Comparative Map Data
Vrk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86130,679,400 - 130,746,089 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6130,679,515 - 130,746,752 (+)EnsemblGRCr8
mRatBN7.26124,914,770 - 124,981,508 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6124,914,855 - 124,981,436 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6125,035,687 - 125,102,303 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06125,330,983 - 125,397,599 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06124,692,652 - 124,759,212 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06129,835,788 - 129,902,839 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6129,835,919 - 129,902,793 (+)Ensemblrn6Rnor6.0
Rnor_5.06139,031,607 - 139,098,569 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46130,181,610 - 130,249,361 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6122,475,358 - 122,561,934 (+)NCBICelera
RGSC_v3.16130,185,356 - 130,253,107 (+)NCBI
Cytogenetic Map6q32NCBI
VRK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381496,797,382 - 96,881,609 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1496,797,304 - 96,954,846 (+)Ensemblhg38GRCh38
GRCh371497,263,719 - 97,347,946 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361496,333,437 - 96,417,704 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341496,333,467 - 96,417,693NCBI
Celera1477,319,099 - 77,403,366 (+)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1477,447,214 - 77,531,474 (+)NCBIHuRef
CHM1_11497,202,026 - 97,286,310 (+)NCBICHM1_1
T2T-CHM13v2.01491,029,172 - 91,113,426 (+)NCBIT2T-CHM13v2.0
Vrk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912105,976,398 - 106,044,578 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12105,976,487 - 106,043,685 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm39 Ensembl12106,047,382 - 106,054,920 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3812106,010,139 - 106,078,318 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12106,010,228 - 106,077,426 (+)Ensemblmm10GRCm38
MGSCv3712107,248,473 - 107,315,620 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612106,411,313 - 106,478,460 (+)NCBIMGSCv36mm8
Celera12107,246,468 - 107,313,845 (+)NCBICelera
Cytogenetic Map12E- F1NCBI
cM Map1256.37NCBI
Vrk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543818,508,769 - 18,595,704 (+)Ensembl
ChiLan1.0NW_00495543818,508,915 - 18,595,104 (+)NCBIChiLan1.0ChiLan1.0
VRK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21597,960,220 - 98,044,561 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11497,176,724 - 97,261,065 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01477,429,970 - 77,514,217 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11496,783,489 - 96,831,954 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1496,756,397 - 96,831,954 (+)EnsemblpanPan2panpan1.1
VRK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1865,444,404 - 65,551,348 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl865,443,949 - 65,551,151 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha864,961,338 - 65,068,324 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0865,718,203 - 65,825,229 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl865,717,954 - 65,825,232 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1865,390,164 - 65,497,054 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0865,451,536 - 65,558,390 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0865,775,210 - 65,882,284 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Vrk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086408,985,074 - 9,071,452 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366041,011,052 - 1,097,403 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366041,011,048 - 1,097,388 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VRK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7117,942,973 - 118,028,923 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.17117,942,929 - 118,025,991 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27125,203,973 - 125,310,693 (+)NCBISscrofa10.2Sscrofa10.2susScr3
VRK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12474,686,102 - 74,770,496 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2474,686,111 - 74,770,874 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605361,835,736 - 61,920,212 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vrk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247346,595,814 - 6,678,081 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247346,595,827 - 6,678,139 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Vrk1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v17123,660,493 - 123,723,762 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Vrk1
297 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:177
Count of miRNA genes:112
Interacting mature miRNAs:119
Transcripts:ENSRNOT00000036035
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat

Markers in Region
BF416556  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26124,921,695 - 124,921,788 (+)MAPPERmRatBN7.2
Rnor_6.06129,842,260 - 129,842,352NCBIRnor6.0
Rnor_5.06139,037,990 - 139,038,082UniSTSRnor5.0
RGSC_v3.46130,188,403 - 130,188,495UniSTSRGSC3.4
Celera6122,482,134 - 122,482,226UniSTS
Cytogenetic Map6q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001012194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC079130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000036035   ⟹   ENSRNOP00000029546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6130,679,515 - 130,745,913 (+)Ensembl
mRatBN7.2 Ensembl6124,914,855 - 124,981,436 (+)Ensembl
Rnor_6.0 Ensembl6129,835,919 - 129,902,793 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098742   ⟹   ENSRNOP00000090784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6130,679,515 - 130,741,394 (+)Ensembl
mRatBN7.2 Ensembl6124,914,911 - 124,977,374 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100741   ⟹   ENSRNOP00000093032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6124,914,890 - 124,981,246 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102103   ⟹   ENSRNOP00000084211
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6124,914,911 - 124,981,125 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104154   ⟹   ENSRNOP00000077410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6130,679,515 - 130,746,752 (+)Ensembl
mRatBN7.2 Ensembl6124,914,911 - 124,981,125 (+)Ensembl
RefSeq Acc Id: NM_001012194   ⟹   NP_001012194
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,679,531 - 130,746,089 (+)NCBI
mRatBN7.26124,914,901 - 124,981,463 (+)NCBI
Rnor_6.06129,835,919 - 129,902,794 (+)NCBI
Rnor_5.06139,031,607 - 139,098,569 (+)NCBI
RGSC_v3.46130,181,610 - 130,249,361 (+)RGD
Celera6122,475,358 - 122,561,934 (+)RGD
Sequence:
RefSeq Acc Id: XM_006240530   ⟹   XP_006240592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,679,446 - 130,746,089 (+)NCBI
mRatBN7.26124,914,796 - 124,981,508 (+)NCBI
Rnor_6.06129,835,881 - 129,902,839 (+)NCBI
Rnor_5.06139,031,607 - 139,098,569 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240531   ⟹   XP_006240593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,679,454 - 130,746,089 (+)NCBI
mRatBN7.26124,914,822 - 124,981,508 (+)NCBI
Rnor_6.06129,835,895 - 129,902,839 (+)NCBI
Rnor_5.06139,031,607 - 139,098,569 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240532   ⟹   XP_006240594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,679,400 - 130,746,089 (+)NCBI
mRatBN7.26124,914,770 - 124,981,508 (+)NCBI
Rnor_6.06129,836,250 - 129,902,839 (+)NCBI
Rnor_5.06139,031,607 - 139,098,569 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039112534   ⟹   XP_038968462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,679,400 - 130,746,089 (+)NCBI
mRatBN7.26124,914,770 - 124,981,508 (+)NCBI
RefSeq Acc Id: XM_039112535   ⟹   XP_038968463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,679,509 - 130,746,089 (+)NCBI
mRatBN7.26124,914,832 - 124,981,508 (+)NCBI
RefSeq Acc Id: XM_039112536   ⟹   XP_038968464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,679,513 - 130,746,089 (+)NCBI
mRatBN7.26124,914,832 - 124,981,508 (+)NCBI
RefSeq Acc Id: XM_039112537   ⟹   XP_038968465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,679,520 - 130,746,089 (+)NCBI
mRatBN7.26124,914,831 - 124,981,508 (+)NCBI
RefSeq Acc Id: XM_039112538   ⟹   XP_038968466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,679,479 - 130,746,089 (+)NCBI
mRatBN7.26124,914,832 - 124,981,508 (+)NCBI
RefSeq Acc Id: XM_039112540   ⟹   XP_038968468
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,679,448 - 130,746,089 (+)NCBI
mRatBN7.26124,914,806 - 124,981,508 (+)NCBI
RefSeq Acc Id: XM_039112541   ⟹   XP_038968469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,690,693 - 130,746,089 (+)NCBI
mRatBN7.26124,926,067 - 124,981,508 (+)NCBI
RefSeq Acc Id: XM_039112543   ⟹   XP_038968471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,679,446 - 130,746,089 (+)NCBI
mRatBN7.26124,914,795 - 124,981,257 (+)NCBI
RefSeq Acc Id: XM_063262129   ⟹   XP_063118199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,679,483 - 130,746,089 (+)NCBI
RefSeq Acc Id: XM_063262130   ⟹   XP_063118200
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,679,454 - 130,746,089 (+)NCBI
RefSeq Acc Id: XM_063262131   ⟹   XP_063118201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,679,452 - 130,746,089 (+)NCBI
RefSeq Acc Id: XM_063262132   ⟹   XP_063118202
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,679,471 - 130,746,089 (+)NCBI
RefSeq Acc Id: XM_063262133   ⟹   XP_063118203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86130,679,500 - 130,746,089 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001012194 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420945 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420946 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420947 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420948 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420949 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420950 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420951 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420952 (Get FASTA)   NCBI Sequence Viewer  
  XP_006240592 (Get FASTA)   NCBI Sequence Viewer  
  XP_006240593 (Get FASTA)   NCBI Sequence Viewer  
  XP_006240594 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968462 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968463 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968464 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968465 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968466 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968468 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968469 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968471 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118199 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118200 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118201 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118202 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118203 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79130 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000029546
  ENSRNOP00000029546.6
  ENSRNOP00000077410.2
  ENSRNOP00000090784.2
RefSeq Acc Id: NP_001012194   ⟸   NM_001012194
- UniProtKB: Q6AYA2 (UniProtKB/TrEMBL),   A0A8I6AIR3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240592   ⟸   XM_006240530
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006240593   ⟸   XM_006240531
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006240594   ⟸   XM_006240532
- Peptide Label: isoform X1
- UniProtKB: Q6AYA2 (UniProtKB/TrEMBL),   A0A8I6AIR3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000029546   ⟸   ENSRNOT00000036035
RefSeq Acc Id: XP_038968462   ⟸   XM_039112534
- Peptide Label: isoform X1
- UniProtKB: Q6AYA2 (UniProtKB/TrEMBL),   A0A8I6AIR3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968471   ⟸   XM_039112543
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038968468   ⟸   XM_039112540
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038968465   ⟸   XM_039112537
- Peptide Label: isoform X1
- UniProtKB: Q6AYA2 (UniProtKB/TrEMBL),   A0A8I6AIR3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968463   ⟸   XM_039112535
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038968464   ⟸   XM_039112536
- Peptide Label: isoform X1
- UniProtKB: Q6AYA2 (UniProtKB/TrEMBL),   A0A8I6AIR3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968466   ⟸   XM_039112538
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038968469   ⟸   XM_039112541
- Peptide Label: isoform X1
- UniProtKB: Q6AYA2 (UniProtKB/TrEMBL),   A0A8I6AIR3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000077410   ⟸   ENSRNOT00000104154
Ensembl Acc Id: ENSRNOP00000093032   ⟸   ENSRNOT00000100741
Ensembl Acc Id: ENSRNOP00000084211   ⟸   ENSRNOT00000102103
Ensembl Acc Id: ENSRNOP00000090784   ⟸   ENSRNOT00000098742
RefSeq Acc Id: XP_063118201   ⟸   XM_063262131
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063118200   ⟸   XM_063262130
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AIR3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118202   ⟸   XM_063262132
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AIR3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118199   ⟸   XM_063262129
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063118203   ⟸   XM_063262133
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AIR3 (UniProtKB/TrEMBL),   Q6AYA2 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYA2-F1-model_v2 AlphaFold Q6AYA2 1-414 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694818
Promoter ID:EPDNEW_R5340
Type:initiation region
Name:Vrk1_1
Description:vaccinia related kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06129,835,903 - 129,835,963EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306069 AgrOrtholog
BioCyc Gene G2FUF-36324 BioCyc
Ensembl Genes ENSRNOG00000005274 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036035 ENTREZGENE
  ENSRNOT00000036035.6 UniProtKB/TrEMBL
  ENSRNOT00000098742.2 UniProtKB/TrEMBL
  ENSRNOT00000104154.2 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7127355 IMAGE-MGC_LOAD
InterPro CK1_Ser-Thr_kinase UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:362779 UniProtKB/TrEMBL
MGC_CLONE MGC:94140 IMAGE-MGC_LOAD
NCBI Gene 362779 ENTREZGENE
PANTHER CASEIN KINASE-RELATED UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Vrk1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005274 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I5XW39_RAT UniProtKB/TrEMBL
  A0A8I6AD98_RAT UniProtKB/TrEMBL
  A0A8I6AIR3 ENTREZGENE
  Q6AYA2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F7ENT3 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-24 Vrk1  VRK serine/threonine kinase 1  Vrk1  vaccinia related kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Vrk1  vaccinia related kinase 1  Vrk1_predicted  vaccinia related kinase 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Vrk1_predicted  vaccinia related kinase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED