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Gene: Pea15 (proliferation and apoptosis adaptor protein 15) Rattus norvegicus

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Symbol:

Pea15

Name:

proliferation and apoptosis adaptor protein 15

RGD ID:

1306055

Description:

Predicted to be involved in negative regulation of D-glucose import and negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. Predicted to act upstream of or within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors. Predicted to be located in cytoplasm. Orthologous to human PEA15 (proliferation and apoptosis adaptor protein 15); INTERACTS WITH (+)-pilocarpine; 1,3-dinitrobenzene; 1-benzylpiperazine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

15 kDa phosphoprotein enriched in astrocytes; astrocytic phosphoprotein PEA-15; LOC364052; Pea15a; phosphoprotein enriched in astrocytes 15; phosphoprotein enriched in astrocytes 15A

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	87,190,189 - 87,199,811 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	87,187,295 - 87,199,859 (-)	Ensembl				GRCr8
mRatBN7.2	13	84,657,815 - 84,667,437 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	84,654,870 - 84,667,499 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	87,161,140 - 87,170,762 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	88,561,400 - 88,571,022 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	85,746,177 - 85,755,768 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	90,579,844 - 90,589,466 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	90,579,846 - 90,589,466 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	95,100,949 - 95,110,571 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	88,187,674 - 88,197,296 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	84,269,239 - 84,278,862 (-)	NCBI		Celera
RGSC_v3.1	13	88,376,559 - 88,386,180 (-)	NCBI
Cytogenetic Map	13	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-pilocarpine (EXP)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

1,3-dinitrobenzene (EXP)

1-benzylpiperazine (EXP)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dimethoxyphenol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (EXP,ISO)

4,4'-sulfonyldiphenol (EXP)

4-hydroperoxycyclophosphamide (ISO)

6-propyl-2-thiouracil (EXP)

acetohydrazide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (EXP,ISO)

AM-251 (ISO)

amitrole (EXP)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP,ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (EXP,ISO)

butanal (ISO)

Butylbenzyl phthalate (EXP)

cadmium dichloride (ISO)

caffeine (ISO)

calyculin A (ISO)

carbamazepine (ISO)

chloropicrin (ISO)

choline (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

deoxynivalenol (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

diazinon (EXP)

dibutyl phthalate (EXP)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

Evodiamine (ISO)

fenthion (ISO)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

furan (EXP)

furfural (ISO)

gentamycin (EXP)

hydrogen cyanide (ISO)

indometacin (ISO)

ivermectin (ISO)

ketoconazole (EXP)

L-methionine (ISO)

lead diacetate (ISO)

lead(0) (ISO)

Licochalcone B (ISO)

lithium chloride (EXP)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methimazole (EXP)

methyl methanesulfonate (ISO)

miconazole (ISO)

Muraglitazar (EXP)

N-methyl-N'-nitro-N-nitrosoguanidine (ISO)

N-nitrosodimethylamine (EXP)

nickel dichloride (EXP)

nitrates (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

phenylephrine (EXP)

phenylmercury acetate (ISO)

potassium cyanide (ISO)

propofol (EXP)

quercetin (ISO)

retinyl acetate (ISO)

SB 431542 (ISO)

selenium atom (ISO)

serpentine asbestos (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

Soman (EXP)

sulfadimethoxine (EXP)

sunitinib (ISO)

T-2 toxin (ISO)

tetrachloromethane (ISO)

theophylline (ISO)

thioacetamide (EXP)

thiram (ISO)

topotecan (EXP)

trichloroethene (EXP)

triptonide (ISO)

troglitazone (EXP)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

vincristine (ISO)

vitamin E (ISO)

zinc atom (ISO)

zinc(0) (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (IEA)

MAPK cascade (IEA)

negative regulation of D-glucose import across plasma membrane (IEA,ISO)

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (IBA,IEA,ISO)

regulation of apoptotic process (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (IEA,ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	The time course of unconditioned morphine-induced psychomotor sensitization mirrors the phosphorylation of FADD and MEK/ERK in rat striatum: role of PEA-15 as a FADD-ERK binding partner in striatal plasticity.	Ramos-Miguel A, etal., Eur Neuropsychopharmacol. 2010 Jan;20(1):49-64. Epub .
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Comprehensive gene review and curation	RGD comprehensive gene curation
8.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:9670003	PMID:10442631	PMID:10588860	PMID:15489334	PMID:18541525	PMID:21198825	PMID:26615958	PMID:28216548	PMID:29438777	PMID:31257496

Genomics

Comparative Map Data

Pea15
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	87,190,189 - 87,199,811 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	87,187,295 - 87,199,859 (-)	Ensembl				GRCr8
mRatBN7.2	13	84,657,815 - 84,667,437 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	84,654,870 - 84,667,499 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	87,161,140 - 87,170,762 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	88,561,400 - 88,571,022 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	85,746,177 - 85,755,768 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	90,579,844 - 90,589,466 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	90,579,846 - 90,589,466 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	95,100,949 - 95,110,571 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	88,187,674 - 88,197,296 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	84,269,239 - 84,278,862 (-)	NCBI		Celera
RGSC_v3.1	13	88,376,559 - 88,386,180 (-)	NCBI
Cytogenetic Map	13	q24	NCBI

PEA15
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	160,205,384 - 160,215,372 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	160,205,335 - 160,215,404 (+)	Ensembl			hg38	GRCh38
GRCh37	1	160,175,174 - 160,185,162 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	158,441,749 - 158,451,786 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	156,988,199 - 156,998,233	NCBI
Celera	1	133,243,885 - 133,253,922 (+)	NCBI		Celera
Cytogenetic Map	1	q23.2	NCBI
HuRef	1	131,531,764 - 131,541,800 (+)	NCBI		HuRef
CHM1_1	1	161,570,474 - 161,580,508 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	159,342,460 - 159,352,445 (+)	NCBI		T2T-CHM13v2.0

Pea15a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	172,024,295 - 172,034,298 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	172,024,295 - 172,034,371 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	172,196,728 - 172,206,804 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	172,196,728 - 172,206,804 (-)	Ensembl			mm10	GRCm38
MGSCv37	1	174,126,860 - 174,136,912 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	174,033,404 - 174,043,456 (-)	NCBI		MGSCv36	mm8
Celera	1	175,052,693 - 175,062,710 (-)	NCBI		Celera
Cytogenetic Map	1	H3	NCBI
cM Map	1	79.54	NCBI

Pea15
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	11,981,960 - 11,991,427 (+)	Ensembl
ChiLan1.0	NW_004955468	11,981,956 - 11,991,427 (+)	NCBI	ChiLan1.0	ChiLan1.0

PEA15
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	89,636,651 - 89,646,766 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	89,376,622 - 89,386,695 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	135,559,273 - 135,569,392 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	139,480,394 - 139,490,503 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	139,480,394 - 139,490,503 (+)	Ensembl			panPan2	panpan1.1

PEA15
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	22,001,702 - 22,004,728 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	22,003,143 - 22,198,158 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	22,074,770 - 22,082,493 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	22,118,147 - 22,125,882 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	38	22,119,583 - 22,127,442 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	38	22,022,939 - 22,030,627 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	38	22,419,258 - 22,426,936 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	22,828,944 - 22,836,659 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Pea15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	6,327,709 - 6,338,155 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936740	416,355 - 426,801 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936740	416,355 - 426,801 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PEA15
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	90,263,604 - 90,276,147 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	4	90,263,600 - 90,276,142 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	98,204,998 - 98,215,557 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PEA15
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	3,731,658 - 3,741,614 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	3,733,549 - 3,741,585 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	2,789,304 - 2,799,288 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pea15
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	1,041,647 - 1,051,048 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624794	1,041,647 - 1,051,108 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Pea15
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	51,309,384 - 51,319,236 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Pea15
85 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	589
Count of miRNA genes:	261
Interacting mature miRNAs:	330
Transcripts:	ENSRNOT00000070812
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	48639634	93639634	Rat
10755495	Bp387	Blood pressure QTL 387	3.78		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37216241	90057603	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	38975045	103588154	Rat
8655951	Rf63	Renal function QTL 63	12.2		blood urea nitrogen amount (VT:0005265)	plasma urea nitrogen level (CMO:0000586)	13	71610804	109350286	Rat
4889606	Gluco63	Glucose level QTL 63	2.86	0.003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	83286150	109350286	Rat
8655945	Rf61	Renal function QTL 61	3.6		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	13	71610804	89333251	Rat
71119	Thym2	Thymus enlargement QTL 2	3.8		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	13	48749814	87285480	Rat
1331783	Bp221	Blood pressure QTL 221	3.72886		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	71610804	89333251	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	72984506	99745408	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	67635937	109350286	Rat
1300166	Kidm6	Kidney mass QTL 6	3.93		kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	13	71610804	89333251	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	7421791	87286911	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
724564	Uae11	Urinary albumin excretion QTL 11	5.7		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	13	47354258	94285672	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
738027	Lnnr6	Liver neoplastic nodule remodeling QTL 6	3.3		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	65613454	109350286	Rat
7387280	Uae43	Urinary albumin excretion QTL 43	5.69	0.4174	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	68983334	109350286	Rat
738026	Lnnr5	Liver neoplastic nodule remodeling QTL 5	3.29		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	62424592	88113509	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	67635937	109350286	Rat
1576318	Schws5	Schwannoma susceptibility QTL 5		0.0351	nervous system integrity trait (VT:0010566)	post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)	13	64497900	109350286	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	64375743	109350286	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	67635937	109350286	Rat

Markers in Region

RH132632

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	84,658,600 - 84,658,802 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	90,580,630 - 90,580,831	NCBI	Rnor6.0
Rnor_5.0	13	95,101,735 - 95,101,936	UniSTS	Rnor5.0
RGSC_v3.4	13	88,188,460 - 88,188,661	UniSTS	RGSC3.4
Celera	13	84,270,025 - 84,270,226	UniSTS
RH 3.4 Map	13	553.5	UniSTS
Cytogenetic Map	13	q24	UniSTS

RH132968

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	84,668,811 - 84,668,993 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	90,590,840 - 90,591,021	NCBI	Rnor6.0
Rnor_5.0	13	95,111,945 - 95,112,126	UniSTS	Rnor5.0
RGSC_v3.4	13	88,198,670 - 88,198,851	UniSTS	RGSC3.4
Celera	13	84,280,236 - 84,280,417	UniSTS
RH 3.4 Map	13	554.8	UniSTS
Cytogenetic Map	13	q24	UniSTS

BI286597

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	84,657,985 - 84,658,139 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	90,580,015 - 90,580,168	NCBI	Rnor6.0
Rnor_5.0	13	95,101,120 - 95,101,273	UniSTS	Rnor5.0
RGSC_v3.4	13	88,187,845 - 88,187,998	UniSTS	RGSC3.4
Celera	13	84,269,410 - 84,269,563	UniSTS
RH 3.4 Map	13	564.4	UniSTS
Cytogenetic Map	13	q24	UniSTS

G49234

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	84,661,219 - 84,661,357 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	90,583,249 - 90,583,386	NCBI	Rnor6.0
Rnor_5.0	13	95,104,354 - 95,104,491	UniSTS	Rnor5.0
RGSC_v3.4	13	88,191,079 - 88,191,216	UniSTS	RGSC3.4
Celera	13	84,272,644 - 84,272,781	UniSTS
Cytogenetic Map	13	q24	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001013231	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC095300	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ243949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC085766	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ229416	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ235065	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000070812 ⟹ ENSRNOP00000064962

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	87,190,191 - 87,199,859 (-)	Ensembl
mRatBN7.2 Ensembl	13	84,657,900 - 84,667,486 (-)	Ensembl
Rnor_6.0 Ensembl	13	90,579,846 - 90,589,466 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094381 ⟹ ENSRNOP00000090417

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	87,187,295 - 87,199,811 (-)	Ensembl
mRatBN7.2 Ensembl	13	84,654,870 - 84,667,499 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111137 ⟹ ENSRNOP00000091255

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	84,657,815 - 84,667,452 (-)	Ensembl

RefSeq Acc Id:

NM_001013231 ⟹ NP_001013249

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	87,190,189 - 87,199,811 (-)	NCBI
mRatBN7.2	13	84,657,815 - 84,667,437 (-)	NCBI
Rnor_6.0	13	90,579,844 - 90,589,466 (-)	NCBI
Rnor_5.0	13	95,100,949 - 95,110,571 (-)	NCBI
RGSC_v3.4	13	88,187,674 - 88,197,296 (-)	RGD
Celera	13	84,269,239 - 84,278,862 (-)	RGD

Sequence:

show sequence

CCGGAGCCAAGGAGCAGGCTCCAGACGCTGCTTAGGAACCGGGGATCCGGGAGTGCCCGCACCC
TGAGCTCTCAGCTCCGGAGGCGTCATGGCAGAGTACGGGACTCTCCTTCAGGACCTGACCAACA
ACATCACCCTTGAAGATCTGGAACAGCTCAAGTCAGCCTGCAAGGAGGACATCCCCAGTGAGAA
GAGTGAAGAGATCACTACAGGCAGTGCCTGGTTTAGCTTCCTGGAGAGCCACAACAAGCTGGAC
AAAGACAACCTCTCCTACATTGAGCACATCTTTGAGATCTCCCGCCGTCCTGACCTACTCACGA
TGGTGGTTGACTACAGAACCCGTGTGCTGAAGATCTCTGAGGAGGATGAGCTGGACACCAAGCT
AACCCGTATCCCCAGCGCCAAGAAGTACAAAGACATTATCCGGCAGCCCTCTGAGGAAGAAATC
ATCAAATTGGCTCCCCCACCAAAGAAGGCCTGAGCAAGGGGGAGGAAGAGGAGGAAGGTTGGAT
CTTCATCAGACCACTCCCTTCCCCATCCTCAATGGGAGGGGCTAGGGCAACACCCTGCTCCGTA
CCCACTTACTAACTTGGTCCTAACCCTTACTATGCGCGTGTGTGTGCGTGTGCGCACGCTCTGG
CTGTCTGTCTGTCTAGCTCATCTAGTTCCTCCTCCTCATGAGGGGATTGGAGTCAAGGGAGGGG
GGCTTAGCTGCCCCCACTGTAAGGGGAGGTGGACGCTTTTTCTATGTAAACAGAAACTGGCACA
CTCCTCCTCCTCTCCTCTCCTCCACTCTTCCCCACATCTTTAAAGTATGGAAGCAGAAAGGGCC
TGCGTTTTCCCACACTGAGGAGCTATGGTGAAGATGAGGTATGGCGGAGATGATTAGATCTAAA
GAAAACCAGTGGGGAAGGAAGGTCAAGAGGCTACCCAACCTCCACCTGAAGGGGCTCCTGAGTG
CCAGCGGGCCCTCCTTTATGCCCTTGTTACGGGCCTGGGATGTGGATAAGCAGAGATCCTAATG
AGAAGACCACTAGCTCCTTTCCTGGTCCCAAAGATCAAACCCCAGTGGAGAAGCCAGCTTTTGA
TGTCCCCAACTTCTGCTCTGGAGAGACTATGCTGGGACCATGCACTGCTGAGCCTGAGCCAGGG
ATGCAGGCAGAGACAGGCCCACTCTCGCTCCTCAGTTTCTAGATACAGACTGTTGGGATATACT
GACCCGGAGCCTAGGAATTGGGGAATGAGATCCCTTAGGTTTTAACCGCAACCTGCAGAGTCCC
AAAATGGGTATTGTAGGCAACCTTTCCACTTTCCAGTTCGGAATTCTCCAAGCAAGAGATAAGT
TAACGACAGTGTTTCCTTTGCACTGACTACCACCCCATTCAATCCAGGAAGGGACTGGTCACCT
TTCTCATTTGGGTTTGTGAATGCCACACAGCCAAGCCACTAGAGTACAGTGAGTGAACCCAGCC
TCCTCCCTGTCCCAAGATGCCCTTCCCCATCTTGACCGTGCTAACTGTGTGTACATATATATTC
TACATATATGTATATTAAACCCGCACTGCCATGTCTGCCCTTTTTTGTGGTTTTTAGCATTAAC
TTATTGTCTAGGCCAGAGCGGGAGTGGGAGGGGAATGCCACAGTAAAGGGAGTGGCAGAGCCAA
ATTGCTAAGTAGTCAAAACAGAAAACATTTCCACCAATCACAACAAACATTGCATTTACATTTG
AGCTAAGAGACAATTTAGAAAAAGTTGAAGGTAGGAGCTTTTAGGATGTGGGAGCAAAACTTCA
CAGGGAAGGGAGGACCAGCTGTCAGAAGAGGGCTCTTGAAGCCAGACTGGCTAGAGCACCCTCA
CTTCCTAGCTGAGCCCAGTTTGCCCATCTCCTCTGGCCACTGCTGCAGACACCTGCCTTAACAC
ACACACCTCTAAGACTCCAGTTTTGCCTTAAAGGCCCTTCCTAAGTCTCCCTAGTCCTGCCTGG
CATCTCCTTTGAGACAAGAAATCCTTGTACAACTGGGAGAAAGGAACTATGGGCAACATCCTTC
CATCTGGGGTGTTACGTGAGAGCAGGAGTTAAGACGGAGGCTTTCCTTATGAAGACACAGGAGA
GAGAGAGGGTGCTTCTCAGCAGTTTCTCTGTAAGGCAAAAAACACAAACCTTAAACACACTAAC
CTGCCCTAATACACTCACCTACCCTGCTACCCTCGTGCTGCTGTGAGGTTGCCCCTAGCCTGTG
TTCCTCTGTCTGCAGCGTGCACGGCCTTGTTCTAACCCTGGAATAAAGGTGACTGACTGTACTG
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001013249	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH85766	(Get FASTA)	NCBI Sequence Viewer
	CAB51573	(Get FASTA)	NCBI Sequence Viewer
	EDL94690	(Get FASTA)	NCBI Sequence Viewer
	EDL94691	(Get FASTA)	NCBI Sequence Viewer
	EDL94692	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000091255.1
GenBank Protein	Q5U318	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001013249 ⟸ NM_001013231
- UniProtKB:	Q78ZC9 (UniProtKB/Swiss-Prot), Q5U318 (UniProtKB/Swiss-Prot), A6JG35 (UniProtKB/TrEMBL), A0A8I6AA10 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAEYGTLLQDLTNNITLEDLEQLKSACKEDIPSEKSEEITTGSAWFSFLESHNKLDKDNLSYIE HIFEISRRPDLLTMVVDYRTRVLKISEEDELDTKLTRIPSAKKYKDIIRQPSEEEIIKLAPPPK KA hide sequence

Ensembl Acc Id:

ENSRNOP00000064962 ⟸ ENSRNOT00000070812

Ensembl Acc Id:

ENSRNOP00000090417 ⟸ ENSRNOT00000094381

Ensembl Acc Id:

ENSRNOP00000091255 ⟸ ENSRNOT00000111137

Protein Domains

DED

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5U318-F1-model_v2	AlphaFold	Q5U318	1-130	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699021

Promoter ID:

EPDNEW_R9546

Type:

initiation region

Name:

Pea15_1

Description:

proliferation and apoptosis adaptor protein 15

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	90,589,511 - 90,589,571	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306055	AgrOrtholog
BioCyc Gene	G2FUF-17329	BioCyc
Ensembl Genes	ENSRNOG00000046996	Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000111137.1	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.533.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7190459	IMAGE-MGC_LOAD
InterPro	DEATH-like_dom_sf	UniProtKB/Swiss-Prot
	DED_dom	UniProtKB/Swiss-Prot
	PEA15	UniProtKB/Swiss-Prot
KEGG Report	rno:364052	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93673	IMAGE-MGC_LOAD
NCBI Gene	364052	ENTREZGENE
PANTHER	ASTROCYTIC PHOSPHOPROTEIN PEA-15	UniProtKB/Swiss-Prot
	DED DOMAIN-CONTAINING PROTEIN	UniProtKB/Swiss-Prot
Pfam	DED	UniProtKB/Swiss-Prot
PhenoGen	Pea15	PhenoGen
PROSITE	DED	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000046996	RatGTEx
SMART	DED	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF47986	UniProtKB/Swiss-Prot
UniProt	A0A8I6AA10	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2QXM0_RAT	UniProtKB/TrEMBL
	A6JG34_RAT	UniProtKB/TrEMBL
	A6JG35	ENTREZGENE, UniProtKB/TrEMBL
	A6JG36_RAT	UniProtKB/TrEMBL
	PEA15_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q78ZC9	ENTREZGENE
UniProt Secondary	Q78ZC9	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-08-22	Pea15	proliferation and apoptosis adaptor protein 15	Pea15	phosphoprotein enriched in astrocytes 15	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-01-22	Pea15	phosphoprotein enriched in astrocytes 15	Pea15a	phosphoprotein enriched in astrocytes 15A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-06	Pea15a	phosphoprotein enriched in astrocytes 15A	Pea15	phosphoprotein enriched in astrocytes 15	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Pea15	phosphoprotein enriched in astrocytes 15	Pea15_predicted	phosphoprotein enriched in astrocytes 15 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Pea15_predicted	phosphoprotein enriched in astrocytes 15 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD